LOCUS       NM_019121               2946 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory subunit 37 (PPP1R37),
            mRNA.
ACCESSION   NM_019121 XM_001722969 XM_001723010 XM_001724714 XM_003118775
            XM_003118776 XM_003118777 XM_003118778 XM_003118779 XM_003119730
            XM_003119731 XM_003119732 XM_003119733 XM_003119734 XM_003120946
            XM_003120947 XM_003120948 XM_003120949 XM_003120950
VERSION     NM_019121.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2946)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2946)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2946)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2946)
  AUTHORS   Yadav,L., Tamene,F., Goos,H., van Drogen,A., Katainen,R.,
            Aebersold,R., Gstaiger,M. and Varjosalo,M.
  TITLE     Systematic Analysis of Human Protein Phosphatase Interactions and
            Dynamics
  JOURNAL   Cell Syst 4 (4), 430-444 (2017)
   PUBMED   28330616
REFERENCE   5  (bases 1 to 2946)
  AUTHORS   Heroes,E., Lesage,B., Gornemann,J., Beullens,M., Van Meervelt,L.
            and Bollen,M.
  TITLE     The PP1 binding code: a molecular-lego strategy that governs
            specificity
  JOURNAL   FEBS J 280 (2), 584-595 (2013)
   PUBMED   22360570
  REMARK    Review article
REFERENCE   6  (bases 1 to 2946)
  AUTHORS   Miyashita,A., Koike,A., Jun,G., Wang,L.S., Takahashi,S.,
            Matsubara,E., Kawarabayashi,T., Shoji,M., Tomita,N., Arai,H.,
            Asada,T., Harigaya,Y., Ikeda,M., Amari,M., Hanyu,H., Higuchi,S.,
            Ikeuchi,T., Nishizawa,M., Suga,M., Kawase,Y., Akatsu,H., Kosaka,K.,
            Yamamoto,T., Imagawa,M., Hamaguchi,T., Yamada,M., Morihara,T.,
            Takeda,M., Takao,T., Nakata,K., Fujisawa,Y., Sasaki,K.,
            Watanabe,K., Nakashima,K., Urakami,K., Ooya,T., Takahashi,M.,
            Yuzuriha,T., Serikawa,K., Yoshimoto,S., Nakagawa,R., Kim,J.W.,
            Ki,C.S., Won,H.H., Na,D.L., Seo,S.W., Mook-Jung,I., St
            George-Hyslop,P., Mayeux,R., Haines,J.L., Pericak-Vance,M.A.,
            Yoshida,M., Nishida,N., Tokunaga,K., Yamamoto,K., Tsuji,S.,
            Kanazawa,I., Ihara,Y., Schellenberg,G.D., Farrer,L.A. and Kuwano,R.
  CONSRTM   Alzheimer Disease Genetics Consortium
  TITLE     SORL1 is genetically associated with late-onset Alzheimer's disease
            in Japanese, Koreans and Caucasians
  JOURNAL   PLoS One 8 (4), e58618 (2013)
   PUBMED   23565137
  REMARK    Erratum:[PLoS One. 2013;8(7).
            doi:10.1371/annotation/fcb56ea7-d32a-4e45-818d-39cef330c731.
            Moriaha, Takashi [corrected to Morihara, Takashi]]
REFERENCE   7  (bases 1 to 2946)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   8  (bases 1 to 2946)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011489.6 and AC005757.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019121.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1065090.1,
                                           SRR3476690.16603.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221462.9/ ENSP00000221462.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               AC011489.6         121682-122030
            350-447             AC005757.1         3132-3229
            448-493             AC005757.1         4854-4899
            494-594             AC005757.1         5124-5224
            595-714             AC005757.1         5940-6059
            715-865             AC005757.1         6679-6829
            866-1021            AC005757.1         6921-7076
            1022-1134           AC005757.1         8139-8251
            1135-1276           AC005757.1         9472-9613
            1277-1443           AC005757.1         9712-9878
            1444-2140           AC005757.1         9971-10667
            2141-2231           AC005757.1         11008-11098
            2232-2946           AC005757.1         11189-11903
FEATURES             Location/Qualifiers
     source          1..2946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2946
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /note="protein phosphatase 1 regulatory subunit 37"
                     /db_xref="GeneID:284352"
                     /db_xref="HGNC:HGNC:27607"
     exon            1..349
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..2223
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /note="leucine-rich repeat-containing protein 68; leucine
                     rich repeat containing 68"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 37"
                     /protein_id="NP_061994.1"
                     /db_xref="CCDS:CCDS56096.1"
                     /db_xref="GeneID:284352"
                     /db_xref="HGNC:HGNC:27607"
                     /translation="MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAK
                     RVTFPSDEDIVSGAVEPKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEF
                     TDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDGASALFDMIEY
                     YESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIR
                     SSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNC
                     SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQS
                     LETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLL
                     RLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNG
                     CKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSD
                     SDSDGEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGH
                     KVFVVTRVESPPERAEPPASPTPPSPPPPPSPPASPSLPPAGAIDTRDTGSSEPQPPP
                     EPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHELSCSKNEKELEELLLEA
                     SQESGQETL"
     exon            350..447
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /inference="alignment:Splign:2.1.0"
     exon            448..493
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /inference="alignment:Splign:2.1.0"
     exon            494..594
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /inference="alignment:Splign:2.1.0"
     exon            595..714
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /inference="alignment:Splign:2.1.0"
     exon            715..865
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1021
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1134
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1276
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1443
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..2140
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2231
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2946
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2921..2926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /note="hexamer: AATAAA"
     polyA_site      2946
                     /gene="PPP1R37"
                     /gene_synonym="LRRC68"
                     /note="major polyA site"
ORIGIN      
        1 gacgactacg accactagga gagcggacgg aggcggcgcc tgaagcggcg gcggagccca
       61 tgccccggga cggcgggcgg acccggagag acaaatccgg ggcccggggc atgtccccgg
      121 ggcccccgtg aggaggcggc ggcggctatg gagatcgcgc cgcaggaggc gccgcccgtg
      181 ccgggcgcgg acggcgacat tgaagaggcc ccagctgagg ccgggtctcc cagccccgcg
      241 tcgccccccg ccgatgggcg cctcaaggct gcagccaagc gcgtcacatt cccgtccgac
      301 gaggatatcg tgtctggagc agtggagccc aaagacccct ggagacatgc ccagaatgtg
      361 accgtggacg aggtcatcgg cgcctacaag caggcctgcc agaagctgaa ctgcaggcag
      421 atccccaagc tcctcaggca gctgcaggaa ttcacagacc tcgggcaccg cctcgactgt
      481 ctggacctga aaggtgagaa gcttgactac aagacctgtg aggccctgga agaggtcttc
      541 aagaggctgc agttcaaggt cgtggacctg gagcagacaa acctggatga agatggtgcc
      601 tcggccctct tcgacatgat cgagtactac gagtcggcca cccacctcaa catctccttc
      661 aacaagcaca tcggcacccg gggctggcag gcggccgccc acatgatgcg caagacgagc
      721 tgcctgcagt atctggacgc ccgcaacacg cccctgctgg accactcggc gcccttcgtg
      781 gcccgtgccc tgcgcatccg cagcagcctg gcagtgctgc acttggagaa cgccagcctg
      841 tcggggcggc ccctcatgct gctcgccacg gccctgaaga tgaacatgaa cctgcgggag
      901 ctgtacctgg cggacaacaa gctcaacggc ctgcaggact cggcccagct gggtaacctg
      961 ctcaagttca actgctccct gcagatcctg gacctccgga acaaccacgt gctagactcg
     1021 ggtctggcct acatctgcga gggcctcaag gagcagagga aggggctggt gaccctggtg
     1081 ctgtggaaca accagctcac gcacacaggc atggccttcc tgggcatgac actgccgcac
     1141 actcagagcc tggagacgct gaacctgggc cacaacccca tcgggaacga gggtgtgcgg
     1201 cacctcaaga acgggctcat cagcaaccgc agcgtgctgc gcctcgggct ggcctccacc
     1261 aagctcacgt gcgagggcgc ggtggcggtg gcggagttca tcgctgagag cccccgcctc
     1321 ctgagactgg accttcggga gaacgagatc aagacaggcg ggctcatggc actgtcgttg
     1381 gccctcaagg tgaaccactc actgctgcgc ctggacctcg accgtgaacc caagaaagag
     1441 gcggtgaaga gcttcatcga gacgcagaag gcgctgctgg ccgagatcca gaacggctgc
     1501 aagcgcaact tggtgctggc gcgggagagg gaggagaagg agcagccgcc acagctgtcg
     1561 gcctccatgc ctgagaccac cgccaccgag ccccagcccg acgacgagcc cgccgctggg
     1621 gtgcagaacg gggcccccag ccccgcaccc agcccggact cagactcaga ctcggactcg
     1681 gatggggagg aagaggagga agaggaaggg gagagggacg agaccccctg tcctgccctg
     1741 gtgcccccca cggactccct gggccctggg gacaggagtc ccccaggcag cccctccaca
     1801 cccaccgagc agcggatttc cgtgtccagc ccgggccggg gccacaaggt gtttgtggtg
     1861 acccgggtgg agagcccgcc cgagagggca gagccccctg cgtcccccac ccctccctct
     1921 cccccacccc ctccctcccc acccgcctca ccttccctac caccagccgg ggccattgac
     1981 acccgggaca cagggtcctc tgagcctcag ccaccaccgg agccgcctcg gtcagggcca
     2041 ccactgccca acggcctgaa gcccgagttc gccctggcac tgccccctga gccgcccccg
     2101 gggcctgagg tcaagggggg cagctgcggc ctggagcacg aactgagctg ctccaagaac
     2161 gagaaggagc tcgaggagct gcttctggaa gccagtcagg aatccgggca ggagacactg
     2221 tgacacttta gttccctttt tccggtcggt ctgcgatgag ctgaggccag agccatgaga
     2281 atctgctcac cttcccccca gccttcctga ggcccaggat gccaggggtg ggggccattc
     2341 tggggccccc ctccccccac agcaacacta caaggggtgc aggagctaca gggagtggcc
     2401 ctccgcgcgt gactcaagca cttctattta tgagcccagc actggaagac tctgggggtg
     2461 aatgggagga gggggagcag gaggaggagg aggtctccaa ggacatcagg cgcctgttct
     2521 ggaggggcca ggcttgccct gcggagggca ggcgtcctgg gtggtggtgg gatggtcccc
     2581 tgtggccccg ggcacagggc cgggcaggca gcctggtgcc ggagaggcgg tgcgtgctgg
     2641 tggtggttga gatgcacaga acagccccag acagcgcagg ccgggcaggg tggggggatg
     2701 ggagcagagg atcagagctt tctttttctc aagtgcaata aatctatcag ggagctgggg
     2761 cgggagcagc cggcactccg ggaccctgct gtccaggcca ctggaggctg cgccctgaga
     2821 ggcactacag ccctttgggg gcgagtggca tgggtgtggg tgagggtggg cagagggctg
     2881 gggctactcc tgtcggtgca actctgttca caccttttct aataaactgg ggctgggttc
     2941 actttg
//
