LOCUS       NM_025210                798 bp    mRNA    linear   PRI 25-SEP-2024
DEFINITION  Homo sapiens PPP1R2 family member C (PPP1R2C), mRNA.
ACCESSION   NM_025210 NR_002191
VERSION     NM_025210.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 798)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 798)
  AUTHORS   Korrodi-Gregorio,L., Abrantes,J., Muller,T., Melo-Ferreira,J.,
            Marcus,K., da Cruz e Silva,O.A., Fardilha,M. and Esteves,P.J.
  TITLE     Not so pseudo: the evolutionary history of protein phosphatase 1
            regulatory subunit 2 and related pseudogenes
  JOURNAL   BMC Evol Biol 13, 242 (2013)
   PUBMED   24195737
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 798)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   4  (bases 1 to 798)
  AUTHORS   Ceulemans,H., Stalmans,W. and Bollen,M.
  TITLE     Regulator-driven functional diversification of protein
            phosphatase-1 in eukaryotic evolution
  JOURNAL   Bioessays 24 (4), 371-381 (2002)
   PUBMED   11948623
  REMARK    GeneRIF: A streamlined nomenclature for human primary regulators of
            type-1 protein phosphatase (PP1) genes and pseudogenes is proposed.
            Review article
REFERENCE   5  (bases 1 to 798)
  AUTHORS   Liu,H.T., Lin,T.H., Kuo,H.C., Chen,Y.C., Tsay,H.J., Jeng,H.H.,
            Tsai,P.C., Shie,F.K., Chen,J.H. and Huang,H.B.
  TITLE     Identification of the alternative splice products encoded by the
            human protein phosphatase inhibitor-1 gene
  JOURNAL   Biochem Biophys Res Commun 291 (5), 1293-1296 (2002)
   PUBMED   11883959
  REMARK    GeneRIF: inhibitor-1beta consisted of 132 amino acids of which the
            N-terminal 61 amino acid sequences were identical to inhibitor-1
            while the sequence after residue-61 was markedly different.
REFERENCE   6  (bases 1 to 798)
  AUTHORS   Shirato,H., Shima,H., Sakashita,G., Nakano,T., Ito,M., Lee,E.Y. and
            Kikuchi,K.
  TITLE     Identification and characterization of a novel protein inhibitor of
            type 1 protein phosphatase
  JOURNAL   Biochemistry 39 (45), 13848-13855 (2000)
   PUBMED   11076525
REFERENCE   7  (bases 1 to 798)
  AUTHORS   Sanseau,P., Jackson,A., Alderton,R.P., Beck,S., Senger,G.,
            Sheer,D., Kelly,A. and Trowsdale,J.
  TITLE     Cloning and characterization of human phosphatase inhibitor-2
            (IPP-2) sequences
  JOURNAL   Mamm Genome 5 (8), 490-496 (1994)
   PUBMED   7949733
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB044137.1.
            
            On May 17, 2019 this sequence version replaced NM_025210.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR5189667.400340.1, AB044137.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378131.4/ ENSP00000490336.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-798               AB044137.1         73-870
FEATURES             Location/Qualifiers
     source          1..798
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.3"
     gene            1..798
                     /gene="PPP1R2C"
                     /gene_synonym="I-4; PPP1R2P9"
                     /note="PPP1R2 family member C"
                     /db_xref="GeneID:80316"
                     /db_xref="HGNC:HGNC:16324"
                     /db_xref="MIM:301017"
     exon            1..798
                     /gene="PPP1R2C"
                     /gene_synonym="I-4; PPP1R2P9"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..693
                     /gene="PPP1R2C"
                     /gene_synonym="I-4; PPP1R2P9"
                     /note="type 1 protein phosphatase inhibitor; protein
                     phosphatase 1 regulatory inhibitor subunit 2-like 9;
                     putative type-1 protein phosphatase inhibitor 4; protein
                     phosphatase 1 regulatory inhibitor subunit 2 pseudogene 9;
                     PPP1R2 family member B; PPP1R2C family member C"
                     /codon_start=1
                     /product="protein phosphatase inhibitor 2 family member C"
                     /protein_id="NP_079486.1"
                     /db_xref="CCDS:CCDS87739.1"
                     /db_xref="GeneID:80316"
                     /db_xref="HGNC:HGNC:16324"
                     /db_xref="MIM:301017"
                     /translation="MSASTSSHRPIKGILKNKSSSGSSVATSGQQSGGTIQDVKRKKS
                     QKWDESSILAAHRATYRDYDLMKANEPGTSYMSVQDNGEDSVRDVEGEDSVRGVEGKE
                     ATDASDHSCEVDEQESSEAYMRKILLHKQEKKRQFEMRRRLHYNEELNIKLARQLMWK
                     ELQSEDNENEETPQGTNEEKTAAEESEEAPLTGGLQTQSCDP"
     regulatory      777..782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R2C"
                     /gene_synonym="I-4; PPP1R2P9"
                     /note="hexamer: AATACA"
     polyA_site      798
                     /gene="PPP1R2C"
                     /gene_synonym="I-4; PPP1R2P9"
                     /note="major polyA site"
ORIGIN      
        1 acagaccgcc ctgcagtttc agactggagg gcggtggacg gctactcagc ggcccaactc
       61 tctcgcagcc cttctctccg caaaatgtca gcctccacct cctcgcaccg gcccatcaag
      121 gggatcctga aaaacaaaag ctcgtcgggt tcctcggtgg cgacttccgg tcagcagtct
      181 ggagggacta ttcaagatgt gaagagaaag aaatcccaaa agtgggacga atcaagcatc
      241 cttgcggcac accgcgcaac gtacagagat tacgatttaa tgaaggcaaa tgagcccggc
      301 acttcctaca tgagtgtgca agataatggg gaagattcag tgcgcgatgt cgaaggagaa
      361 gattcagtgc gtggtgtcga aggaaaggaa gccaccgatg cttccgacca cagctgtgag
      421 gtggacgagc aagagagcag tgaggcctac atgagaaaaa tcctcctcca caaacaggag
      481 aaaaagcggc agttcgaaat gagaagaagg cttcactaca acgaagaatt gaacatcaaa
      541 ttagctagac aattaatgtg gaaagagcta caaagtgaag ataatgaaaa cgaagaaacg
      601 ccacaaggca cgaacgaaga gaagactgct gcggaagaat cagaggaagc tcctctgacc
      661 ggtggactgc aaacccagtc atgcgaccct tagaagatgc ctgcttcacc cttgcaattg
      721 tttgtgaata tgtgacgctt agaagatatc tgcttcaccc ttgcaattgt ttgtgaaata
      781 caaaccttgt tactgtaa
//
