LOCUS       NM_206858               2234 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens PPP1R2 family member B (PPP1R2B), mRNA.
ACCESSION   NM_206858 XM_018216
VERSION     NM_206858.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2234)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2234)
  AUTHORS   Korrodi-Gregorio,L., Abrantes,J., Muller,T., Melo-Ferreira,J.,
            Marcus,K., da Cruz e Silva,O.A., Fardilha,M. and Esteves,P.J.
  TITLE     Not so pseudo: the evolutionary history of protein phosphatase 1
            regulatory subunit 2 and related pseudogenes
  JOURNAL   BMC Evol Biol 13, 242 (2013)
   PUBMED   24195737
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2234)
  AUTHORS   Korrodi-Gregorio,L., Ferreira,M., Vintem,A.P., Wu,W., Muller,T.,
            Marcus,K., Vijayaraghavan,S., Brautigan,D.L., da Cruz E Silva,O.A.,
            Fardilha,M. and da Cruz E Silva,E.F.
  TITLE     Identification and characterization of two distinct PPP1R2 isoforms
            in human spermatozoa
  JOURNAL   BMC Cell Biol 14, 15 (2013)
   PUBMED   23506001
  REMARK    GeneRIF: PPP1R2P3 protein binds directly to PPP1CC and that this
            inhibitor cannot be phosphorylated by GSK3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2234)
  AUTHORS   Fardilha,M., Esteves,S.L., Korrodi-Gregorio,L., Vintem,A.P.,
            Domingues,S.C., Rebelo,S., Morrice,N., Cohen,P.T., da Cruz e
            Silva,O.A. and da Cruz e Silva,E.F.
  TITLE     Identification of the human testis protein phosphatase 1
            interactome
  JOURNAL   Biochem Pharmacol 82 (10), 1403-1415 (2011)
   PUBMED   21382349
REFERENCE   5  (bases 1 to 2234)
  AUTHORS   Ceulemans,H., Stalmans,W. and Bollen,M.
  TITLE     Regulator-driven functional diversification of protein
            phosphatase-1 in eukaryotic evolution
  JOURNAL   Bioessays 24 (4), 371-381 (2002)
   PUBMED   11948623
  REMARK    Review article
REFERENCE   6  (bases 1 to 2234)
  AUTHORS   Sanseau,P., Jackson,A., Alderton,R.P., Beck,S., Senger,G.,
            Sheer,D., Kelly,A. and Trowsdale,J.
  TITLE     Cloning and characterization of human phosphatase inhibitor-2
            (IPP-2) sequences
  JOURNAL   Mamm Genome 5 (8), 490-496 (1994)
   PUBMED   7949733
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011414.4 and BC066922.1.
            
            On May 17, 2019 this sequence version replaced NM_206858.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC066922.1, SRR6380201.76080.9
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000522232.3/ ENSP00000490297.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-561               AC011414.4         106679-107239
            562-2234            BC066922.1         319-1991
FEATURES             Location/Qualifiers
     source          1..2234
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..2234
                     /gene="PPP1R2B"
                     /gene_synonym="PPP1R2P3"
                     /note="PPP1R2 family member B"
                     /db_xref="GeneID:153743"
                     /db_xref="HGNC:HGNC:16318"
     exon            1..2234
                     /gene="PPP1R2B"
                     /gene_synonym="PPP1R2P3"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..886
                     /gene="PPP1R2B"
                     /gene_synonym="PPP1R2P3"
                     /note="protein phosphatase 1, regulatory subunit 2
                     pseudogene 3; protein phosphatase inhibitor 2-like protein
                     3; protein phosphatase 1 regulatory inhibitor subunit 2
                     pseudogene 3"
                     /codon_start=1
                     /product="protein phosphatase inhibitor 2 family member B"
                     /protein_id="NP_996740.2"
                     /db_xref="CCDS:CCDS87340.1"
                     /db_xref="GeneID:153743"
                     /db_xref="HGNC:HGNC:16318"
                     /translation="MAASTASHRPIKGILKNKTSTTSSMVASAEQPRRSVDEELSKKS
                     QKWDEINILATYHPADKGYGLMKIDEPSPPYHSMMGDDEDACRDTETTEAMAPDILAK
                     KLAAAEGLEPKYRIQEQESSGEEDSDLSPEEREKKRQFEMRRKLHYNEGLNIKLARQL
                     ISKDLHDDDEDEEMLETADGESMNTEESNQGSTPSDQQQNKLRSS"
     regulatory      1509..1514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R2B"
                     /gene_synonym="PPP1R2P3"
                     /note="hexamer: AATAAA"
     polyA_site      1533
                     /gene="PPP1R2B"
                     /gene_synonym="PPP1R2P3"
                     /note="major polyA site"
ORIGIN      
        1 ggagctctag gccggcatct ctccgcgagc cgcgggtcaa gtgccggcgg ctaatggtgc
       61 gcgaggagcc gccacccatt cggcgttggc tctggcgtcg gggtcgttgt gacaaccgct
      121 ccagtagccg tttccgaggc agcaggtgcg gccgctttag ccctgagcgg gctctgcggc
      181 tgcctgcgag tctctgctgt gccgaccctt ctcttcgcgg accccacgcc aagcagcgac
      241 cctgaggcga cagccggagc gcccggcaat ggcggcctcg acggcctccc accggcccat
      301 caaggggatc ttgaagaaca agacctctac gacttcctct atggtggcgt cggccgaaca
      361 gccccgcagg agtgtcgacg aggagctgag caaaaaatcc cagaagtggg atgaaattaa
      421 catcttggcg acctatcatc cagcagacaa aggctatggt ttaatgaaaa tagatgaacc
      481 aagccctcct taccatagta tgatgggtga tgatgaagat gcgtgtaggg acaccgagac
      541 cactgaagcc atggcgccag acatcctagc caagaaatta gctgctgctg aaggcttgga
      601 gccaaagtac cggattcagg aacaagaaag cagtggagag gaggatagtg acctctcacc
      661 tgaagaacga gaaaaaaagc gacaatttga aatgagaagg aagcttcact acaatgaagg
      721 actcaatatc aaactagcca gacaattaat ttcaaaagac ctacatgatg atgatgaaga
      781 tgaagaaatg ttagagactg cagatggaga aagcatgaat acggaagaat caaatcaagg
      841 atctactcca agtgaccaac agcaaaacaa attacgaagt tcatagaaga gatttgttca
      901 acactgcaat tgtttgttag atataaaccc tgtgactata atacattgct tcttgttctc
      961 cacaattcat gacttaagta ccaaaatgca taccagttat tatatattgc caagaattaa
     1021 atgataaact tagagactaa ttagactgaa aatgcctaat tgatatatat attcttatgc
     1081 ctagtacttt accacaaata cagtgtaata tcatcagtcc aaaactgcat tactttcata
     1141 agaacactgg ttaatttgta taagatatta tagagctttt tatgctttag aagttaagca
     1201 atatctttgg gggggaacta atttattttc atcactcgaa atgtggtagc tcttacaaag
     1261 tttgttgatt tgttttttta aaaatcaaaa gccagttgaa caacaggata tatagactta
     1321 taaatattca agctgaatcg tattttaaca cttctcttca acttgatttg tctgtttaat
     1381 tgaaaagaat tgtaagagtt actgttgcat tttctgacct actaccttta aaattcctgt
     1441 tgagtttctt tgtgtttaca aggaaaggac tgaacttttt ctcatcaaaa ctagcttttt
     1501 tccccacaaa taaattatca ggttaaactt tcaccaatgt ctgctctgtt ttttggcagg
     1561 gggtttgttt gtttttgttt tttaatgttt ttggtacact gggcagactt cagagcagtt
     1621 ttttaaaaaa taaatattct aatgtagcta tctcgccatt ccctttaaat acctgtctta
     1681 acctcctgct tttatttcct actcctttcc acacatacac acacaatctt ttacctttta
     1741 aaggatcatt aagattgtca cgacattagg aactctttct gtcactcttc tgtcatttgc
     1801 tgctgtgtgg aaattcttat tttgaccatc aatgcctatg aattcttcta atacatgaag
     1861 aaaatagatt gagtagcagc agtactatag gcaggaaata cagtttaact gctgaatttc
     1921 tatgcctctc gatttacaga ttgctaatta aattgctatt attagtttgg cttaattaga
     1981 cttaagaaaa caaccgaggg tttttttttg ttttttgagg gttttctttg catgagaatt
     2041 gtatgtaacc agtgatatga ttattcctga atgtacagac agaagtaagc ctggacattt
     2101 tttaatttaa aaactttaaa tagtccctgc tttaagggaa tatgataatg tatactatga
     2161 caaatgtact ttattcctct aacgcagtaa gaattatgtg gaatattttc cttaaacgaa
     2221 gtgcaggaaa gccc
//
