LOCUS       NM_001007533             799 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory subunit 27 (PPP1R27),
            mRNA.
ACCESSION   NM_001007533 XM_371086
VERSION     NM_001007533.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 799)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 799)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA894509.1, BC112094.1, BI826571.1 and AA722724.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001007533.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF434846.1, ERR279839.5022.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330261.5/ ENSP00000331065.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                DA894509.1         1-57
            58-614              BC112094.1         1-557
            615-794             BI826571.1         236-415
            795-799             AA722724.1         7-11                c
FEATURES             Location/Qualifiers
     source          1..799
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..799
                     /gene="PPP1R27"
                     /gene_synonym="DYSFIP1"
                     /note="protein phosphatase 1 regulatory subunit 27"
                     /db_xref="GeneID:116729"
                     /db_xref="HGNC:HGNC:16813"
     exon            1..287
                     /gene="PPP1R27"
                     /gene_synonym="DYSFIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..562
                     /gene="PPP1R27"
                     /gene_synonym="DYSFIP1"
                     /note="dysferlin-interacting protein 1 (toonin); dysferlin
                     interacting protein 1"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 27"
                     /protein_id="NP_001007534.1"
                     /db_xref="CCDS:CCDS32767.1"
                     /db_xref="GeneID:116729"
                     /db_xref="HGNC:HGNC:16813"
                     /translation="MPSRTARYARYSPRQRRRRMLADRSVRFPNDVLFLDHIRQGDLE
                     QVGRFIRTRKVSLATIHPSGLAALHEAVLSGNLECVKLLVKYGADIHQRDEAGWTPLH
                     IACSDGYPDIARYLISLGADRDATNDDGDLPSDLIDPDYKELVELFKGTTMD"
     exon            288..438
                     /gene="PPP1R27"
                     /gene_synonym="DYSFIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..799
                     /gene="PPP1R27"
                     /gene_synonym="DYSFIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      754..759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R27"
                     /gene_synonym="DYSFIP1"
                     /note="hexamer: AATAAA"
     polyA_site      799
                     /gene="PPP1R27"
                     /gene_synonym="DYSFIP1"
                     /note="major polyA site"
ORIGIN      
        1 cgacaggagc cctcaagctg atctggtcgg gaccggatac attattaacc ccagtgcagt
       61 agggtcccca ggggcaacct gccccacagc gcccaagatg cctagcagaa ctgcccgcta
      121 tgcccgctac agcccacggc agcggcggcg gcggatgctg gctgatcgca gcgtgcgttt
      181 ccctaatgat gtcctgttct tggaccacat ccggcagggt gacctggagc aggtggggcg
      241 cttcatccgg actcggaaag tctccctggc caccatccac ccctcaggcc tggccgcctt
      301 gcatgaagcc gtgctctctg gaaacctgga atgcgtgaag ctgctggtca aatacggggc
      361 tgacattcac cagcgagatg aggcgggctg gacacccctg cacattgcct gcagcgatgg
      421 gtaccctgac atagccaggt accttatctc cctgggagcg gacagggatg caaccaacga
      481 cgatggcgac ctgccctccg acctcatcga cccggactac aaggagctgg tggagctctt
      541 caaagggacc acgatggact gagccagctt tgcccgcccg cccccgcgcc cagggccgcc
      601 tccctggaga agccgcgcgt cgcccatggg ccagcacgtg ccccacccgt gggccagggg
      661 cggccggacc cgtccctcca cgaccccgcc acccctccta ggcctggctt tgtccccagg
      721 tgaatttttt actgtgacac tttttacttt ttcaataaac gtgactccca ggtgaggggg
      781 cctgggtcta cacacgtgg
//
