LOCUS       NM_014811               4951 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory subunit 26 (PPP1R26),
            mRNA.
ACCESSION   NM_014811
VERSION     NM_014811.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4951)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4951)
  AUTHORS   Zheng,T., Lu,M., Wang,T., Zhang,C. and Du,X.
  TITLE     NRBE3 promotes metastasis of breast cancer by down-regulating
            E-cadherin expression
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1865 (12), 1869-1877 (2018)
   PUBMED   30262434
  REMARK    GeneRIF: Results show that up-regulation of NRBE3 is correlated
            with lymphatic metastasis in human breast cancer (BC) tissues.
            Ectopic expression of NRBE3 promotes migration and invasion in BC
            cells. Accordingly, its knockdown inhibits migration and invasion
            in BC cells and lung metastasis in vivo.
REFERENCE   3  (bases 1 to 4951)
  AUTHORS   Wang,Y., Zheng,Z., Zhang,J., Wang,Y., Kong,R., Liu,J., Zhang,Y.,
            Deng,H., Du,X. and Ke,Y.
  TITLE     A Novel Retinoblastoma Protein (RB) E3 Ubiquitin Ligase (NRBE3)
            Promotes RB Degradation and Is Transcriptionally Regulated by E2F1
            Transcription Factor
  JOURNAL   J Biol Chem 290 (47), 28200-28213 (2015)
   PUBMED   26442585
  REMARK    GeneRIF: identified NRBE3 as a novel ubiquitin E3 ligase for RB
            that might play a role as a potential oncoprotein in human cancers
REFERENCE   4  (bases 1 to 4951)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   5  (bases 1 to 4951)
  AUTHORS   Yang,L., Zhao,J., Lu,W., Li,Y., Du,X., Ning,T., Lu,G. and Ke,Y.
  TITLE     KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic
            potential
  JOURNAL   Biochem Biophys Res Commun 334 (3), 884-890 (2005)
   PUBMED   16053918
  REMARK    GeneRIF: we showed that KIAA0649 mRNA is widely expressed in human
            multiple tissues and cell lines. We have also demonstrated that
            KIAA0649 has oncogenic characteristics: it enhances colony
            formation, allows anchorage-independent growth.
REFERENCE   6  (bases 1 to 4951)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   7  (bases 1 to 4951)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL161452.19.
            
            On Nov 22, 2018 this sequence version replaced NM_014811.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB014549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356818.7/ ENSP00000349274.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               AL161452.19        78875-79115         c
            242-374             AL161452.19        76082-76214         c
            375-507             AL161452.19        74815-74947         c
            508-4951            AL161452.19        70005-74448         c
FEATURES             Location/Qualifiers
     source          1..4951
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..4951
                     /gene="PPP1R26"
                     /gene_synonym="KIAA0649; NRBE3"
                     /note="protein phosphatase 1 regulatory subunit 26"
                     /db_xref="GeneID:9858"
                     /db_xref="HGNC:HGNC:29089"
                     /db_xref="MIM:614056"
     exon            1..241
                     /gene="PPP1R26"
                     /gene_synonym="KIAA0649; NRBE3"
                     /inference="alignment:Splign:2.1.0"
     exon            242..374
                     /gene="PPP1R26"
                     /gene_synonym="KIAA0649; NRBE3"
                     /inference="alignment:Splign:2.1.0"
     exon            375..507
                     /gene="PPP1R26"
                     /gene_synonym="KIAA0649; NRBE3"
                     /inference="alignment:Splign:2.1.0"
     exon            508..4951
                     /gene="PPP1R26"
                     /gene_synonym="KIAA0649; NRBE3"
                     /inference="alignment:Splign:2.1.0"
     CDS             570..4199
                     /gene="PPP1R26"
                     /gene_synonym="KIAA0649; NRBE3"
                     /note="1A6/DRIM (down-regulated in metastasis) interacting
                     protein; DRIM/UTP20 interacting protein"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 26"
                     /protein_id="NP_055626.3"
                     /db_xref="CCDS:CCDS6988.1"
                     /db_xref="GeneID:9858"
                     /db_xref="HGNC:HGNC:29089"
                     /db_xref="MIM:614056"
                     /translation="MFLMNASPVVALQSKWEAFGPPGSCRFPRCFSEADEGVESASVS
                     ARVQMLISTLQRDGAARGTSDERAAQRGHRAEGCHDARPAAKPTVHKEPPALAVCGLV
                     ADFDPMGEEETTDFGPLVLDSDSDDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAA
                     QPSRAAGGGSRCKPEPAHGSAPTALCPPKLVPGSGGGPGSQVGSSKDQGSASPVSVSS
                     DDSFEQSIRAEIEQFLNEKRQHETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVH
                     RQGLLGVQKEFAFRKPPRLAKMNVQPRSLRSKVTTTQENEGSTKPATPCRPSEAAQNK
                     GGIKRSASAARRGKRVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQRV
                     QLREERAPDPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLL
                     KETKAPPPASPASRSEFVERSSCRADTSAELMCAEAILDISKTILPAPVEGSDGSLSA
                     SPLFYSPNVPSRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPL
                     LPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGGHVRPSTPKKMQEVVKDGSQDADHS
                     QGRAEPGHERRDLPIQGKASEALGGEGTARGPGDTRMSQGQGKTDEARRLDEKESSED
                     KSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQTHFLEQLGGLRR
                     DWKDRGPPVLKSCLSKSKRDSGEGPGKKPPSVFGSTAERMRQEGAASQDAALAFRVRR
                     PASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSS
                     EVQAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLRGTESAGAQ
                     GTAGLFSQGGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGAEPA
                     AKSAFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSPGAERDAGAQADRTPPWSDF
                     AHQSRLPSPWVLRSEGRDAVWRGGVGSERDKGSEGPARGLPSLPLAGFSPLLSTQLFH
                     FGKGVSWGGRQAGLFSPHLGLPLQGPSFSAFREAQAGPSPVFGSPHLLAKKDGGPWPT
                     RKAQAGLSLHDRRSSGSEESILDLRYRRRVNRDDQEQDALGSDASDFSDTSTEDSGGS
                     SVVKV"
     regulatory      4931..4936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R26"
                     /gene_synonym="KIAA0649; NRBE3"
                     /note="hexamer: AATAAA"
     polyA_site      4951
                     /gene="PPP1R26"
                     /gene_synonym="KIAA0649; NRBE3"
                     /note="major polyA site"
ORIGIN      
        1 cccctcccgc gcttcccacg gcgcggcccg ggcgcggggc ggcggcagcg gcggcgcgcg
       61 gggaggcggg gaggcggggg gcccggccgg acgcccctgc gccccctccc cgcgccccgg
      121 ccgagggcgg agcgcgctgg ccctgcagcc tccggcccgc ccccggcccg ccgcctcccc
      181 cgggacgtgg gacgcgggcg caggcggggt ccgcgcggcg ggcggcgggg gacgggcgga
      241 gtcaaaagtc tattgaaaaa gcagagagag aatgcctcgg tgtgtaagtg gagtgatgag
      301 gacctgatct ctgggccgtg tgggaacact ggctgccatt tcatcacagt caacctggac
      361 tcacagaatt tcaagagctt gtcggttggg tcaagaatga acctacgcat gacggcgtgc
      421 tgatcctggg tttctagtca tcctttttaa gctgcaaaga agcatttgca gacgttgtct
      481 catgggtacc gcttgccaac tttggaggat gtgaagccgg tagagaaata aagcatcgcc
      541 cctctgcgcg cccctccccg tctgctagaa tgtttctcat gaacgcttct ccagtggttg
      601 ctctccagtc caaatgggag gcctttggcc cgccagggag ctgtaggttc cccaggtgct
      661 tctcggaggc tgacgagggc gtggagagcg cgtcggtgag cgcccgggtg cagatgctta
      721 tcagcactct gcagcgcgac ggggctgctc ggggcaccag cgatgagcgc gccgcacaga
      781 ggggccacag ggcagaggga tgccacgacg ccaggccggc tgccaagccc accgtgcaca
      841 aggagccacc cgcgttggct gtctgtggtc tcgttgctga ctttgacccc atgggggagg
      901 aggaaactac agactttggc ccgttggtgc tagattcaga cagtgatgat tccgtggaca
      961 gggacattga ggaggccatc caggagtacc tgaaggcaaa gagtggagcc gcacagcccg
     1021 gggccggcgg ggcccagcca ggtgcagccc agccttccag ggccgcaggc ggaggcagta
     1081 gatgtaagcc ggaaccggct cacggcagtg ccccgactgc cctgtgtccc ccaaaacttg
     1141 tacctggatc aggtggtggc cccggcagcc aggtgggatc cagcaaggac cagggctccg
     1201 cctccccggt cagtgtgagc agcgatgact ccttcgagca gagcatcagg gcggaaatag
     1261 aacagtttct gaatgagaag agacagcatg agacccaaaa atgtgatggg tcagtggaga
     1321 agaaaccaga cacaaatgaa aattccgcca agtcactctt gaaatcccac caagagccgc
     1381 ctacaaaggt ggtgcatcgg cagggcctgc tgggcgtcca gaaggagttt gccttccgca
     1441 aacctccccg gttagcgaag atgaacgtcc agcccagaag cctcaggtcc aaggtcacaa
     1501 ccacgcagga gaacgagggc agcacgaagc cggcaacccc ctgccgccct tcagaagcag
     1561 cacagaataa aggtgggatc aaaaggagcg ccagcgctgc aaggagggga aagcgagtca
     1621 tgagtgcggc acaggcgtcc gaggcgtccg actccagcag cgacgatggc attgaggagg
     1681 ccatccagct gtaccagctg cagaaaacac gcaaggaggc cgacggggac ctgccccaga
     1741 gggtccaact ccgagaggag agagcgcctg accctcccgc acacagcaca agcagtgcca
     1801 caaaaagtgc cttgcccgag acccacagga aaacacccag caagaagaag ctagtggcca
     1861 ccaagaccat ggaccctggt ccagggggcc tggacactga ccatgccccc aagctcctga
     1921 aggaaaccaa agctccacct ccagcgagcc ctgcttccag gagtgagttt gtggaacggt
     1981 cctcgtgccg ggcggacaca tctgctgagc tgatgtgtgc agaagcaatc ctggacatct
     2041 ccaagacgat cctgccggcc cctgtagagg gcagtgacgg gtccctgtcc gcaagcccac
     2101 tcttctactc cccgaacgtg ccttcccgct ctgacggcga cagtagctcc gtggacagcg
     2161 atgacagcat cgagcaggaa atccggacat ttttggccct aaaggcgcag tcagggagtt
     2221 tgctggccag aggtgagagc tgcccgcagg ctgcccaggg tccacttttg ccgcctggcc
     2281 tcaacagcca gaccggcggc cacaagaccc ctctctctaa aacaccagac ccactgctgg
     2341 gctgcaaaag gaagcgtaga ggtggtggcc atgtgaggcc atccacgccc aagaaaatgc
     2401 aggaggtggt gaaagacggt agccaggatg ccgaccacag ccaggggaga gctgagcccg
     2461 gccatgagag gcgagacctg cccatccagg gcaaagccag tgaggccctg ggaggggagg
     2521 gcaccgccag gggccctggc gacactcgca tgtcacaggg ccagggtaag acagacgagg
     2581 caaggcgcct agacgagaaa gagagctctg aagacaaaag cagctccctg gacagtgacg
     2641 aggacctgga cacagccatc aaggacttgt taaggtccaa gcgaaagctc aagaagaggt
     2701 gcagggagcc cagggctgcg tgcaggaaga aggtcaggtt cagcacagcc cagacgcact
     2761 tcttggagca gctgggcggg ctccggagag actggaaaga caggggcccg ccagtgctga
     2821 agagctgcct ctccaagtcc aagagagaca gtggcgaggg tcctgggaag aaacccccca
     2881 gtgtctttgg cagcacggca gagaggatga ggcaggaggg tgccgcgagc caggacgcgg
     2941 ccctggcctt ccgggtgagg agacccgcct ccgcctctgc ctccgaaggg aatccattcc
     3001 ccagggagtc ccagggccca gctcccagcc ccggctccct gtctgatgac agcagttcag
     3061 tggacagcaa cgacagcatc gaactggaga ttaggaagtt tttggcggaa aaggccaagg
     3121 agtcagtgag cagttcagaa gttcaggcag agggccccac cgctcttggg acagggggcc
     3181 cagccaggcc agaggtgctg tgcaggaagg agcctgcccc accgcctggc gtgtgcacac
     3241 gcagccagag ggccaggggg gtcccacatc tggccgaagg gcttcgaggc acagagagcg
     3301 caggagcaca gggcacagct ggtctgttca gccagggcgg gaaggggctc cctgctgctc
     3361 ctgcccgagg ggatccggtg ccgcccagga gcaccagcgg cggtgtctcc gccaaggggc
     3421 tctcagtgag caggagaaat gtttacgttc acaaagacca gagcccacga ggggctgagc
     3481 ctgctgccaa aagtgctttt ggtcagctgc ccagctgtgc cacagcgggc accgaggcag
     3541 gaggcgccag aggaaccttt cacatgggct gcgggagccc gagcttcctg acccccagcc
     3601 cgggagcgga gagggacgct ggagcccagg ccgaccgcac accgccctgg agcgacttcg
     3661 cccaccagag tcggctgccc agcccgtggg tgctgcgctc cgaaggcaga gatgcagtgt
     3721 ggaggggggg cgtcgggagc gagagagaca aggggtccga gggccccgcc cggggcctgc
     3781 ccagcctgcc ccttgcgggc ttctcgccgc tgctgtccac ccagctcttc cactttggaa
     3841 agggtgtctc ctgggggggc aggcaggctg gcctcttcag cccccacctg gggctgcctc
     3901 tgcagggccc ctccttctcg gccttcaggg aggcccaggc cggacccagc cctgtctttg
     3961 gaagcccaca cttgctggca aagaaggacg gcggcccctg gccaaccagg aaggcacagg
     4021 cagggctgag tttgcatgac aggaggagct cgggctcgga ggaaagcatt ttagacctga
     4081 ggtatcgacg aagggtcaac agggatgacc aggagcagga cgccttgggc agtgacgcca
     4141 gtgacttcag cgacacctcc acggaggaca gtggcggcag ctcagtagtg aaggtctaag
     4201 ccctcgagct gtgggttcgc gtcctgggtt gcgtgcattc gtggaaagcg gcgtagccgt
     4261 gcgtgtgtgt gatggttccg tggctgcaag gaagggaaac agtctattat acatagccct
     4321 gtatatatgt acaccaacat gaaactttta tttaacagac gtgtcctggt aaatatgatt
     4381 tttgtagctt tttgtaaatt atttaaagtg atgtaaaaga tatttttgga aaatactgtt
     4441 gttcaatttt gtagggtgtt cctaactgca gttttctgtg ttctgcatac aagtcttagc
     4501 ttaggaaaca tttggttctt accatcacag ccaggttcac agaggctctg atgctttttg
     4561 gttgattgct ggtgagaatg gccggcggtg gctgcagtgg tagcctgagg aaggccaagc
     4621 tgccctccct gggaatcact cagatgcccc aagatgtccg ttgggaagct cccaggacag
     4681 cactttttat acagaggaca ccgcctcggc cccacgtcct tagaggccag agcacatctg
     4741 aaaactgcaa tcacagccgt ccgctggaaa aacgtttcga agcacagtgg ccagcgagcg
     4801 agcacgtggc tactccctgt tgcatgtcaa atccacacag atgtcagcgg cagctgctcg
     4861 gcagcccagc cctgggcctg ggtgggttca tgtccaatct tgttcgatca ctagatgatt
     4921 ctaacatcga aataaacctc tttttatatg g
//
