LOCUS       NM_001080545            1049 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C
            (PPP1R1C), transcript variant 3, mRNA.
ACCESSION   NM_001080545 XM_933420
VERSION     NM_001080545.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1049)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1049)
  AUTHORS   Zeng,Q.Y., Huang,Y., Zeng,L.J., Huang,M., Huang,Y.Q. and Zhu,Q.F.
  TITLE     Sensitization of cervical carcinoma cells to paclitaxel by an IPP5
            active mutant
  JOURNAL   Asian Pac J Cancer Prev 15 (19), 8337-8343 (2014)
   PUBMED   25339026
  REMARK    GeneRIF: IPP5 mutations are associated with response to paclitaxel
            in cervical cancer.
REFERENCE   3  (bases 1 to 1049)
  AUTHORS   Zeng,Q.Y., Zeng,L.J., Huang,Y., Huang,Y.Q., Zhu,Q.F. and Liao,Z.H.
  TITLE     8-60hIPP5(m)-induced G2/M cell cycle arrest involves activation of
            ATM/p53/p21(cip1/waf1) pathways and delayed cyclin B1 nuclear
            translocation
  JOURNAL   Asian Pac J Cancer Prev 15 (9), 4101-4107 (2014)
   PUBMED   24935604
  REMARK    GeneRIF: The data demonstrate a novel role for 8-60hIPP5(m) in the
            control of G2/M cell cycle progression, a process that involves the
            activation of ATM/p53/p21cip1/waf1/Cdc2/ cyclin B1 pathways.
REFERENCE   4  (bases 1 to 1049)
  AUTHORS   Zeng,Q., Huang,Y., Zeng,L., Huang,Y., Cai,D. and Zhang,H.
  TITLE     IPP5, a novel inhibitor of protein phosphatase 1, suppresses tumor
            growth and progression of cervical carcinoma cells by inducing G2/M
            arrest
  JOURNAL   Cancer Genet 205 (9), 442-452 (2012)
   PUBMED   22939397
  REMARK    GeneRIF: The effect of IPP5 on tumor growth and the underlying
            molecular mechanisms were investigated by overexpression of IPP5 in
            HeLa cells, a human cervical carcinoma cell line.
REFERENCE   5  (bases 1 to 1049)
  AUTHORS   Zeng,Q., Huang,Y., Zeng,L., Lan,X., Huang,Y., He,S. and Zhang,H.
  TITLE     Effect of IPP5, a novel inhibitor of PP1, on apoptosis and the
            underlying mechanisms involved
  JOURNAL   Biotechnol Appl Biochem 54 (4), 231-238 (2009)
   PUBMED   19874272
  REMARK    GeneRIF: Overexpression of active mutant IPP5 inhibited
            anchorage-dependent growth and induced apoptosis in HeLa cells,
            which may be attributed to the up-regulation of p21, p53 and
            Bcl-2-antagonist/killer, and down-regulation of Bcl-2 and Bcl-X(L).
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1049)
  AUTHORS   Ceulemans,H., Stalmans,W. and Bollen,M.
  TITLE     Regulator-driven functional diversification of protein
            phosphatase-1 in eukaryotic evolution
  JOURNAL   Bioessays 24 (4), 371-381 (2002)
   PUBMED   11948623
  REMARK    Review article
REFERENCE   7  (bases 1 to 1049)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009962.11, AC064837.6 and AC011291.8.
            
            On Aug 13, 2020 this sequence version replaced NM_001080545.2.
            
            Summary: Protein phosphatase-1 (PP1) is a major serine/threonine
            phosphatase that regulates a variety of cellular functions. PP1
            consists of a catalytic subunit (see PPP1CA; MIM 176875) and
            regulatory subunits that determine the subcellular localization of
            PP1 or regulate its function. PPP1R1C belongs to a group of PP1
            inhibitory subunits that are themselves regulated by
            phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by
            OMIM, Feb 2010].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the 5' coding region and differs in the 3' UTR
            compared to variant 1. The resulting protein is shorter compared to
            isoform 1. Variants 2 and 3 encode the same protein (isoform 2).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI467918.1, SRR1803611.341185.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2151741
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682840.1/ ENSP00000507052.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               AC009962.11        155854-156192
            340-400             AC009962.11        157840-157900
            401-438             AC064837.6         55931-55968
            439-499             AC064837.6         58220-58280
            500-1049            AC011291.8         1839-2388
FEATURES             Location/Qualifiers
     source          1..1049
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.3-q32.1"
     gene            1..1049
                     /gene="PPP1R1C"
                     /gene_synonym="IPP5"
                     /note="protein phosphatase 1 regulatory inhibitor subunit
                     1C"
                     /db_xref="GeneID:151242"
                     /db_xref="HGNC:HGNC:14940"
                     /db_xref="MIM:613240"
     exon            1..339
                     /gene="PPP1R1C"
                     /gene_synonym="IPP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..588
                     /gene="PPP1R1C"
                     /gene_synonym="IPP5"
                     /note="isoform 2 is encoded by transcript variant 3;
                     protein phosphatase 1 regulatory subunit 1A; PP1 inhibitor
                     protein 5; inhibitor-5 of protein phosphatase 1; protein
                     phosphatase 1 regulatory subunit 1C"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 1C
                     isoform 2"
                     /protein_id="NP_001074014.1"
                     /db_xref="CCDS:CCDS46468.1"
                     /db_xref="GeneID:151242"
                     /db_xref="HGNC:HGNC:14940"
                     /db_xref="MIM:613240"
                     /translation="MEPNSPKKIQFAVPVFQSQIAPEAAEQIRKRRPTPASLVILNEH
                     NPPEIDDKRGPNTQGELQNASPKQRKQSVYTPPTIKGVKHLKGQNESAFPEEEEGTNE
                     REEQRDH"
     exon            340..400
                     /gene="PPP1R1C"
                     /gene_synonym="IPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            401..438
                     /gene="PPP1R1C"
                     /gene_synonym="IPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            439..499
                     /gene="PPP1R1C"
                     /gene_synonym="IPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            500..1049
                     /gene="PPP1R1C"
                     /gene_synonym="IPP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      958..963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R1C"
                     /gene_synonym="IPP5"
                     /note="hexamer: AATAAA"
     polyA_site      978
                     /gene="PPP1R1C"
                     /gene_synonym="IPP5"
                     /note="major polyA site"
     regulatory      1031..1036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R1C"
                     /gene_synonym="IPP5"
                     /note="hexamer: AATAAA"
     polyA_site      1049
                     /gene="PPP1R1C"
                     /gene_synonym="IPP5"
ORIGIN      
        1 attgttcctt tctgtattgt gctgagagga tccaagggat tggtggggga acaggcaagc
       61 caggcatcac cgtggatgtt gaagaagggg gttactcaaa cctcggcatc ttcacttgct
      121 cgatctggaa ttacagctat ttattacgaa gcactctgtg tggcttagtg gagtgtgtct
      181 gaggaaacac atcccggaca ccacttaggg ttagtctttc tgagctcttc acatctctga
      241 ctaattatca tcattaccat ggagcccaac agtcccaaaa agatacagtt tgccgtgcct
      301 gtattccaga gtcagattgc acctgaagca gcagagcaga tcaggaaaag aagacctaca
      361 ccagcatcac ttgtgattct caatgagcat aaccccccag aaatagatga caagaggggg
      421 cccaacacac aaggggaatt acagaatgca tcccctaagc aaaggaagca gagtgtgtac
      481 acaccaccca ccataaaagg ggttaagcat ctgaaaggcc agaatgaatc agcattccct
      541 gaagaagaag aaggcaccaa tgaaagagag gagcagcggg accattaatt actggtctgc
      601 agcaagaagg cttcttggaa ataactgaac tattaacttt tctgagtata ccatggaatt
      661 ccactgcttg acttccagaa gcatcctcca tctctgcacc ccacactcat acagtagcta
      721 tgcacatcct ggaagtctcc ttgactgaac tttagaacta agtacacatt gttccacatc
      781 acttataatt aaagaataag catttatttt acagtgattc ttctttttaa ctatgtaaaa
      841 atttgcatac atgtgactgt tctaacttta atactgccag agcttaatcc ttgatgtcct
      901 actgataagg tttgcattct aacaacacat gtaaataaca tcactttaag agtaaaaaat
      961 aaatagtaaa cacatttaga catgagtgtg tgtgtgtgtg tgtgtgggtt tagcttaaag
     1021 agaaatatct aataaagctt ttagcttga
//
