LOCUS       NM_032192               1815 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1B
            (PPP1R1B), transcript variant 1, mRNA.
ACCESSION   NM_032192
VERSION     NM_032192.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1815)
  AUTHORS   Saidy,B., Vasan,R., Durant,R., Greener,M.R., Immanuel,A.,
            Green,A.R., Rakha,E., Ellis,I., Ball,G., Martin,S.G. and Storr,S.J.
  TITLE     Unravelling transcriptomic complexity in breast cancer through
            modulation of DARPP-32 expression and signalling pathways
  JOURNAL   Sci Rep 13 (1), 21163 (2023)
   PUBMED   38036593
  REMARK    GeneRIF: Unravelling transcriptomic complexity in breast cancer
            through modulation of DARPP-32 expression and signalling pathways.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1815)
  AUTHORS   Cai,J., Litwin,C., Cheng,R., Ma,J.X. and Chen,Y.
  TITLE     DARPP32, a target of hyperactive mTORC1 in the retinal pigment
            epithelium
  JOURNAL   Proc Natl Acad Sci U S A 119 (33), e2207489119 (2022)
   PUBMED   35939707
  REMARK    GeneRIF: DARPP32, a target of hyperactive mTORC1 in the retinal
            pigment epithelium.
REFERENCE   3  (bases 1 to 1815)
  AUTHORS   Khan,A., Molitor,A., Mayeur,S., Zhang,G., Rinaldi,B., Lannes,B.,
            Lhermitte,B., Umair,M., Arold,S.T., Friant,S., Rastegar,S.,
            Anheim,M., Bahram,S. and Carapito,R.
  TITLE     A Homozygous Missense Variant in PPP1R1B/DARPP-32 Is Associated
            With Generalized Complex Dystonia
  JOURNAL   Mov Disord 37 (2), 365-374 (2022)
   PUBMED   34820905
  REMARK    GeneRIF: A Homozygous Missense Variant in PPP1R1B/DARPP-32 Is
            Associated With Generalized Complex Dystonia.
REFERENCE   4  (bases 1 to 1815)
  AUTHORS   Saidy,B., Kotecha,S., Butler,A., Rakha,E.A., Ellis,I.O.,
            Green,A.R., Martin,S.G. and Storr,S.J.
  TITLE     PP1, PKA and DARPP-32 in breast cancer: A retrospective assessment
            of protein and mRNA expression
  JOURNAL   J Cell Mol Med 25 (11), 5015-5024 (2021)
   PUBMED   33991172
  REMARK    GeneRIF: PP1, PKA and DARPP-32 in breast cancer: A retrospective
            assessment of protein and mRNA expression.
REFERENCE   5  (bases 1 to 1815)
  AUTHORS   Zhu,S., Khalafi,S., Chen,Z., Poveda,J., Peng,D., Lu,H., Soutto,M.,
            Que,J., Garcia-Buitrago,M., Zaika,A. and El-Rifai,W.
  TITLE     Silencing of miR490-3p by H. pylori activates DARPP-32 and induces
            resistance to gefitinib
  JOURNAL   Cancer Lett 491, 87-96 (2020)
   PUBMED   32735911
  REMARK    GeneRIF: Silencing of miR490-3p by H. pylori activates DARPP-32 and
            induces resistance to gefitinib.
REFERENCE   6  (bases 1 to 1815)
  AUTHORS   Meister,B., Schultzberg,M., Hemmings,H.C. Jr., Greengard,P.,
            Goldstein,M. and Hokfelt,T.
  TITLE     Dopamine- and adenosine-3',5'-monophosphate (cAMP)-regulated
            phosphoprotein of 32 kDa (DARPP-32) in the adrenal gland:
            immunohistochemical localization
  JOURNAL   J Auton Nerv Syst 36 (1), 75-84 (1991)
   PUBMED   1721636
REFERENCE   7  (bases 1 to 1815)
  AUTHORS   Meister,B., Arvidsson,U., Hemmings,H.C. Jr., Greengard,P. and
            Hokfelt,T.
  TITLE     Dopamine- and adenosine-3':5'-monophosphate (cAMP)-regulated
            phosphoprotein of Mr 32,000 (DARPP-32) in the retina of cat, monkey
            and human
  JOURNAL   Neurosci Lett 131 (1), 66-70 (1991)
   PUBMED   1791981
REFERENCE   8  (bases 1 to 1815)
  AUTHORS   Meister,B., Askergren,J., Tunevall,G., Hemmings,H.C. Jr. and
            Greengard,P.
  TITLE     Identification of a dopamine- and 3'5'-cyclic adenosine
            monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in
            parathyroid hormone-producing cells of the human parathyroid gland
  JOURNAL   J Endocrinol Invest 14 (8), 655-661 (1991)
   PUBMED   1663529
REFERENCE   9  (bases 1 to 1815)
  AUTHORS   Ouimet,C.C. and Greengard,P.
  TITLE     Distribution of DARPP-32 in the basal ganglia: an electron
            microscopic study
  JOURNAL   J Neurocytol 19 (1), 39-52 (1990)
   PUBMED   2191086
REFERENCE   10 (bases 1 to 1815)
  AUTHORS   Halpain,S., Girault,J.A. and Greengard,P.
  TITLE     Activation of NMDA receptors induces dephosphorylation of DARPP-32
            in rat striatal slices
  JOURNAL   Nature 343 (6256), 369-372 (1990)
   PUBMED   2153935
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF464196.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_032192.3.
            
            Summary: This gene encodes a bifunctional signal transduction
            molecule. Dopaminergic and glutamatergic receptor stimulation
            regulates its phosphorylation and function as a kinase or
            phosphatase inhibitor. As a target for dopamine, this gene may
            serve as a therapeutic target for neurologic and psychiatric
            disorders. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF464196.1, SRR3476690.132327.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254079.9/ ENSP00000254079.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1815              AF464196.1         27-1841
FEATURES             Location/Qualifiers
     source          1..1815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..1815
                     /gene="PPP1R1B"
                     /gene_synonym="DARPP-32; DARPP32"
                     /note="protein phosphatase 1 regulatory inhibitor subunit
                     1B"
                     /db_xref="GeneID:84152"
                     /db_xref="HGNC:HGNC:9287"
                     /db_xref="MIM:604399"
     exon            1..522
                     /gene="PPP1R1B"
                     /gene_synonym="DARPP-32; DARPP32"
                     /inference="alignment:Splign:2.1.0"
     CDS             442..1056
                     /gene="PPP1R1B"
                     /gene_synonym="DARPP-32; DARPP32"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dopamine and cAMP-regulated neuronal phosphoprotein 32"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 1B
                     isoform 1"
                     /protein_id="NP_115568.2"
                     /db_xref="CCDS:CCDS11339.1"
                     /db_xref="GeneID:84152"
                     /db_xref="HGNC:HGNC:9287"
                     /db_xref="MIM:604399"
                     /translation="MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEH
                     SSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQAS
                     EEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSAGQKTTCGQGLE
                     GPWERPPPLDESERDGGSEDQVEDPALSEPGEEPQRPSPSEPGT"
     exon            523..583
                     /gene="PPP1R1B"
                     /gene_synonym="DARPP-32; DARPP32"
                     /inference="alignment:Splign:2.1.0"
     exon            584..606
                     /gene="PPP1R1B"
                     /gene_synonym="DARPP-32; DARPP32"
                     /inference="alignment:Splign:2.1.0"
     exon            607..682
                     /gene="PPP1R1B"
                     /gene_synonym="DARPP-32; DARPP32"
                     /inference="alignment:Splign:2.1.0"
     exon            683..886
                     /gene="PPP1R1B"
                     /gene_synonym="DARPP-32; DARPP32"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1006
                     /gene="PPP1R1B"
                     /gene_synonym="DARPP-32; DARPP32"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1815
                     /gene="PPP1R1B"
                     /gene_synonym="DARPP-32; DARPP32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1797..1802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R1B"
                     /gene_synonym="DARPP-32; DARPP32"
                     /note="hexamer: AATAAA"
     polyA_site      1815
                     /gene="PPP1R1B"
                     /gene_synonym="DARPP-32; DARPP32"
                     /note="major polyA site"
ORIGIN      
        1 agaggcagag acacacgcgg agaggaggag aggctgaggg agggaggtgg agaaggacgg
       61 gagaggcaga gagaggagac acgcagagac actcaggagg ggagagacac cgagacgcag
      121 agacactcag gaggggagag acaccgagac gcagagacac ccaggccggg gagcgcgagg
      181 gagcgaggca cagacctggc tcagcgagcg cggggggcga gccccgagtc ccgagagcct
      241 gggggcgcgc ccagcccggg cgccgaccct cctcccgctc ccgcgccctc ccctcggcgg
      301 gcacggtatt tttatccgtg cgcgaacagc cctcctcctc ctctcgccgc acagcccgcc
      361 gcctgcgcgg gggagcccag cacagaccgc cgccgggacc ccgagtcgcg caccccagcc
      421 ccaccgccca ccccgcgcgc catggacccc aaggaccgca agaagatcca gttctcggtg
      481 cccgcgcccc ctagccagct cgacccccgc caggtggaga tgatccggcg caggagacca
      541 acgcctgcca tgctgttccg gctctcagag cactcctcac cagaggagga agcctccccc
      601 caccagagag cctcaggaga ggggcaccat ctcaagtcga agagacccaa cccctgtgcc
      661 tacacaccac cttcgctgaa agctgtgcag cgcattgctg agtctcacct gcagtctatc
      721 agcaatttga atgagaacca ggcctcagag gaggaggatg agctggggga gcttcgggag
      781 ctgggttatc caagagagga agatgaggag gaagaggagg atgatgaaga agaggaagaa
      841 gaagaggaca gccaggctga agtcctgaag gtcatcaggc agtctgctgg gcaaaagaca
      901 acctgtggcc agggtctgga agggccctgg gagcgcccac cccctctgga tgagtccgag
      961 agagatggag gctctgagga ccaagtggaa gacccagcac taagtgagcc tggggaggaa
     1021 cctcagcgcc cttccccctc tgagcctggc acataggcac ccagcctgca tctcccagga
     1081 ggaagtggag gggacatcgc tgttccccag aaacccactc tatcctcacc ctgttttgtg
     1141 ctcttcccct cgcctgctag ggctgcggct tctgacttct agaagactaa ggctggtctg
     1201 tgtttgcttg tttgcccacc tttggctgat acccagagaa cctgggcact tgctgcctga
     1261 tgcccacccc tgccagtcat tcctccattc acccagcggg aggtgggatg tgagacagcc
     1321 cacattggaa aatccagaaa accgggaaca gggatttgcc cttcacaatt ctactcccca
     1381 gatcctctcc cctggacaca ggagacccac agggcaggac cctaagatct ggggaaagga
     1441 ggtcctgaga accttgaggt acccttagat ccttttctac ccactttcct atggaggatt
     1501 ccaagtcacc acttctctca ccggcttcta ccagggtcca ggactaaggc gtttttctcc
     1561 atagcctcaa cattttggga atcttccctt aatcaccctt gctcctcctg ggtgcctgga
     1621 agatggactg gcagagacct ctttgttgcg ttttgtgctt tgatgccagg aatgccgcct
     1681 agtttatgtc cccggtgggg cacacagcgg ggggcgccag gttttccttg tcccccagct
     1741 gctctgcccc tttccccttc ttccctgact ccaggcctga acccctcccg tgctgtaata
     1801 aatctttgta aataa
//
