LOCUS       NM_006741               1828 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1A
            (PPP1R1A), mRNA.
ACCESSION   NM_006741
VERSION     NM_006741.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1828)
  AUTHORS   Taneera,J., Mohammed,A.K., Khalique,A., Mussa,B.M., Sulaiman,N.,
            Bustanji,Y., Saleh,M.A., Madkour,M., Abu-Gharbieh,E. and
            El-Huneidi,W.
  TITLE     Unraveling the significance of PPP1R1A gene in pancreatic beta-cell
            function: A study in INS-1 cells and human pancreatic islets
  JOURNAL   Life Sci 345, 122608 (2024)
   PUBMED   38574885
  REMARK    GeneRIF: Unraveling the significance of PPP1R1A gene in pancreatic
            beta-cell function: A study in INS-1 cells and human pancreatic
            islets.
REFERENCE   2  (bases 1 to 1828)
  AUTHORS   Wu,X., Wang,Y., Yang,M., Wang,Y., Wang,X., Zhang,L., Liao,L.,
            Li,N., Mao,M., Guan,J. and Ye,F.
  TITLE     Exploring prognostic value and regulation network of PPP1R1A in
            hepatocellular carcinoma
  JOURNAL   Hum Cell 35 (6), 1856-1868 (2022)
   PUBMED   36018458
  REMARK    GeneRIF: Exploring prognostic value and regulation network of
            PPP1R1A in hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 1828)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1828)
  AUTHORS   Cataldo,L.R., Vishnu,N., Singh,T., Bertonnier-Brouty,L.,
            Bsharat,S., Luan,C., Renstrom,E., Prasad,R.B., Fex,M., Mulder,H.
            and Artner,I.
  TITLE     The MafA-target gene PPP1R1A regulates GLP1R-mediated amplification
            of glucose-stimulated insulin secretion in beta-cells
  JOURNAL   Metabolism 118, 154734 (2021)
   PUBMED   33631146
  REMARK    GeneRIF: The MafA-target gene PPP1R1A regulates GLP1R-mediated
            amplification of glucose-stimulated insulin secretion in
            beta-cells.
REFERENCE   5  (bases 1 to 1828)
  AUTHORS   Shi,S.H., Jiang,J., Zhang,W., Sun,L., Li,X.J., Li,C., Ge,Q.D. and
            Zhuang,Z.G.
  TITLE     A Novel lncRNA HOXC-AS3 Acts as a miR-3922-5p Sponge to Promote
            Breast Cancer Metastasis
  JOURNAL   Cancer Invest 38 (1), 1-12 (2020)
   PUBMED   31797701
  REMARK    GeneRIF: HOXC-AS3 is aberrantly overexpressed in breast cancers
            especially the HER2+ type. High expression of HOXC-AS3 has a
            relationship with poor clinical outcomes of breast cancer. HOXC-AS3
            regulates cell invasion and migration both in vitro and in vivo.
            Results demonstrated that miR-3922-5p was a direct target of
            HOXC-AS3, and PPP1R1A was a target of miR-3922-5p in breast cancer.
REFERENCE   6  (bases 1 to 1828)
  AUTHORS   Chen,G., Zhou,X., Nicolaou,P., Rodriguez,P., Song,G., Mitton,B.,
            Pathak,A., Zachariah,A., Fan,G.C., Dorn,G.W. 2nd and Kranias,E.G.
  TITLE     A human polymorphism of protein phosphatase-1 inhibitor-1 is
            associated with attenuated contractile response of cardiomyocytes
            to beta-adrenergic stimulation
  JOURNAL   FASEB J 22 (6), 1790-1796 (2008)
   PUBMED   18192322
  REMARK    GeneRIF: G147D PPI-1 can attenuate responses of cardiomyocytes to
            beta-adrenergic agonists by decreasing PLN phosphorylation and
            therefore may contribute to deteriorated function in heart failure.
REFERENCE   7  (bases 1 to 1828)
  AUTHORS   Weiser,D.C., Sikes,S., Li,S. and Shenolikar,S.
  TITLE     The inhibitor-1 C terminus facilitates hormonal regulation of
            cellular protein phosphatase-1: functional implications for
            inhibitor-1 isoforms
  JOURNAL   J Biol Chem 279 (47), 48904-48914 (2004)
   PUBMED   15345721
  REMARK    GeneRIF: multiple domains in I-1 target cellular PP1 complexes, and
            I-1 has a role as a cellular regulator of eIF2alpha phosphorylation
REFERENCE   8  (bases 1 to 1828)
  AUTHORS   Connor,J.H., Weiser,D.C., Li,S., Hallenbeck,J.M. and Shenolikar,S.
  TITLE     Growth arrest and DNA damage-inducible protein GADD34 assembles a
            novel signaling complex containing protein phosphatase 1 and
            inhibitor 1
  JOURNAL   Mol Cell Biol 21 (20), 6841-6850 (2001)
   PUBMED   11564868
REFERENCE   9  (bases 1 to 1828)
  AUTHORS   Mayerhofer,A., Hemmings,H.C. Jr., Snyder,G.L., Greengard,P.,
            Boddien,S., Berg,U. and Brucker,C.
  TITLE     Functional dopamine-1 receptors and DARPP-32 are expressed in human
            ovary and granulosa luteal cells in vitro
  JOURNAL   J Clin Endocrinol Metab 84 (1), 257-264 (1999)
   PUBMED   9920093
REFERENCE   10 (bases 1 to 1828)
  AUTHORS   Endo,S., Zhou,X., Connor,J., Wang,B. and Shenolikar,S.
  TITLE     Multiple structural elements define the specificity of recombinant
            human inhibitor-1 as a protein phosphatase-1 inhibitor
  JOURNAL   Biochemistry 35 (16), 5220-5228 (1996)
   PUBMED   8611507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP211831.1, U48707.1, AC079310.20 and BM876308.1.
            
            On Nov 24, 2018 this sequence version replaced NM_006741.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022470.1, SRR1660807.97540.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2154125
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257905.13/ ENSP00000257905.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-581               BP211831.1         1-581
            582-815             U48707.1           419-652
            816-1736            AC079310.20        17331-18251         c
            1737-1828           BM876308.1         22-113              c
FEATURES             Location/Qualifiers
     source          1..1828
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..1828
                     /gene="PPP1R1A"
                     /gene_synonym="I1; IPP1"
                     /note="protein phosphatase 1 regulatory inhibitor subunit
                     1A"
                     /db_xref="GeneID:5502"
                     /db_xref="HGNC:HGNC:9286"
                     /db_xref="MIM:613246"
     exon            1..255
                     /gene="PPP1R1A"
                     /gene_synonym="I1; IPP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..687
                     /gene="PPP1R1A"
                     /gene_synonym="I1; IPP1"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase inhibitor-1; I-1; IPP-1"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 1A"
                     /protein_id="NP_006732.3"
                     /db_xref="CCDS:CCDS44912.1"
                     /db_xref="GeneID:5502"
                     /db_xref="HGNC:HGNC:9286"
                     /db_xref="MIM:613246"
                     /translation="MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSD
                     QSSPEIDEDRIPNPHLKSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPE
                     GAAESTGTQESRPPGIPDTEVESRLGTSGTAKKTAECIPKTHERGSKEPSTKEPSTHI
                     PPLDSKGANSV"
     exon            256..316
                     /gene="PPP1R1A"
                     /gene_synonym="I1; IPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            317..354
                     /gene="PPP1R1A"
                     /gene_synonym="I1; IPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            355..418
                     /gene="PPP1R1A"
                     /gene_synonym="I1; IPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            419..574
                     /gene="PPP1R1A"
                     /gene_synonym="I1; IPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..681
                     /gene="PPP1R1A"
                     /gene_synonym="I1; IPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..1828
                     /gene="PPP1R1A"
                     /gene_synonym="I1; IPP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      796..801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R1A"
                     /gene_synonym="I1; IPP1"
                     /note="hexamer: GATAAA"
     polyA_site      815
                     /gene="PPP1R1A"
                     /gene_synonym="I1; IPP1"
                     /note="major polyA site"
     polyA_site      1828
                     /gene="PPP1R1A"
                     /gene_synonym="I1; IPP1"
ORIGIN      
        1 agagtccccg gagccgcgag ctgggagcgc tgtgccggga gccgggagcc gagcgcgccg
       61 ggctggggcc ggggccggag cggagcggag agggagcgcg cccgccccag ccccgagtcc
      121 cgccgccttc cctcccgccg cagcgcgggc ccaccggccg ccgccccagc catggagcaa
      181 gacaacagcc cccgaaagat ccagttcacg gtcccgctgc tggagccgca ccttgacccc
      241 gaggcggcgg agcagattcg gaggcgccgc cccacccctg ccaccctcgt gctgaccagt
      301 gaccagtcat ccccagagat agatgaagac cggatcccca acccacatct caagtccact
      361 ttggcaatgt ctccacggca acggaagaag atgacaagga tcacacccac aatgaaagag
      421 ctccagatga tggttgaaca tcacctgggg caacagcagc aaggagagga acctgagggg
      481 gccgctgaga gcacaggaac ccaggagtcc cgcccacctg ggatcccaga cacagaagtg
      541 gagtcaaggc tgggcacctc tgggacagca aaaaaaactg cagaatgcat ccctaaaact
      601 cacgagagag gcagtaagga acccagcaca aaagaaccct caacccatat accaccactg
      661 gattccaagg gagccaactc ggtctgagag aggaggaggt atcttgggat caagactgca
      721 gtttgggaat gcatggacac cggatttgtt tcttattcct tcacttttgg ggaaaatctc
      781 ttgtttttaa aaagtgataa atttggtgtt aggtccttgg cactttcctt cttttccaac
      841 tgggagaatc ctttctccct gccttcttgc cctgccctct ctgtagcccc caccctcctg
      901 ccaagctgcc tctgggaagg aagaaacagg agctaggcag aagccttgag cagggaagag
      961 ttcttccctt agccctgact ttacttgctg tgggaagaga gatgagggtc agataggtgg
     1021 gaggactaac ttccagggtg ccaagaagga agaaaagccc caggttctct tttcttattg
     1081 aggaacgatc cgaccacctc acaggcctgc cctgcagctg gaagactcgg cgctctaagg
     1141 cctgtgccgt gtccagctgt gactgtgcgg tgggctccat ctgctggaca aaaggggaac
     1201 tgcaccatgg cacttggccc atgggaaaga gggtatggtg gtgtgccgat acctcctcgc
     1261 ctgccctcca agccccagct gccttccttt tggattccca agcttcagga tgtgttccct
     1321 cttccagctg tgggaccgct gtcccttatt tcaacccgtt agcaacaatg gatagagaac
     1381 acagtggcta ttaatgaaga ggcccatgct ggagactgga agggttccct tgtcctagac
     1441 attgaggggc ccagataaga ccaaaaccaa gcataagaga agaaactgtc tcagatctca
     1501 cggccaggcc tctctcctgc tgctgttttt gattttccca ggtagtggga gagaggaaag
     1561 gagggaaggc aagattcttt ccccctccct gctgaagcat gtggtacaga ggcaagagca
     1621 gagcctgaga agcgtcaggt cccacttctg ccatgcagct actatgagcc ctcggggcct
     1681 cctcctgggc ctcagcttgc ccagatacat acctaaatat atatatatat atatatgagg
     1741 gagaacgcct cacccagatt ttatcatgct ggaaagagtg tatgtatgtg aagatgcttg
     1801 gtcaacttgt acccagtgaa cacacaca
//
