LOCUS       NM_001329443            2864 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory subunit 16A
            (PPP1R16A), transcript variant 3, mRNA.
ACCESSION   NM_001329443 XM_005272350
VERSION     NM_001329443.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2864)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2864)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2864)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2864)
  AUTHORS   Yadav,L., Tamene,F., Goos,H., van Drogen,A., Katainen,R.,
            Aebersold,R., Gstaiger,M. and Varjosalo,M.
  TITLE     Systematic Analysis of Human Protein Phosphatase Interactions and
            Dynamics
  JOURNAL   Cell Syst 4 (4), 430-444 (2017)
   PUBMED   28330616
REFERENCE   5  (bases 1 to 2864)
  AUTHORS   Burkhardt,R., Kirsten,H., Beutner,F., Holdt,L.M., Gross,A.,
            Teren,A., Tonjes,A., Becker,S., Krohn,K., Kovacs,P., Stumvoll,M.,
            Teupser,D., Thiery,J., Ceglarek,U. and Scholz,M.
  TITLE     Integration of Genome-Wide SNP Data and Gene-Expression Profiles
            Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids
            and Acylcarnitines in Whole Blood
  JOURNAL   PLoS Genet 11 (9), e1005510 (2015)
   PUBMED   26401656
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2864)
  AUTHORS   Igci,Y.Z., Arslan,A., Akarsu,E., Erkilic,S., Igci,M., Oztuzcu,S.,
            Cengiz,B., Gogebakan,B., Cakmak,E.A. and Demiryurek,A.T.
  TITLE     Differential expression of a set of genes in follicular and classic
            variants of papillary thyroid carcinoma
  JOURNAL   Endocr Pathol 22 (2), 86-96 (2011)
   PUBMED   21509594
  REMARK    GeneRIF: PPP1R16A gene expression is decreased in follicular
            variant of papillary thyroid carcinoma.
REFERENCE   7  (bases 1 to 2864)
  AUTHORS   Yong,J., Tan,I., Lim,L. and Leung,T.
  TITLE     Phosphorylation of myosin phosphatase targeting subunit 3 (MYPT3)
            and regulation of protein phosphatase 1 by protein kinase A
  JOURNAL   J Biol Chem 281 (42), 31202-31211 (2006)
   PUBMED   16920702
  REMARK    GeneRIF: analysis of a novel mechanism for the phosphorylation of
            MYPT3 by PKA and activation of the catalytic activity through
            direct interaction of a central region of MYPT3 with its N-terminal
            region
REFERENCE   8  (bases 1 to 2864)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 2864)
  AUTHORS   Ceulemans,H., Stalmans,W. and Bollen,M.
  TITLE     Regulator-driven functional diversification of protein
            phosphatase-1 in eukaryotic evolution
  JOURNAL   Bioessays 24 (4), 371-381 (2002)
   PUBMED   11948623
  REMARK    Review article
REFERENCE   10 (bases 1 to 2864)
  AUTHORS   Skinner,J.A. and Saltiel,A.R.
  TITLE     Cloning and identification of MYPT3: a prenylatable myosin
            targetting subunit of protein phosphatase 1
  JOURNAL   Biochem J 356 (Pt 1), 257-267 (2001)
   PUBMED   11336659
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB457525.1, CN301973.1,
            HY168641.1 and BC053506.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001329443.1.
            
            Summary: Myosin light chain kinase and phosphatase (MLCP) complexes
            control the phosphorylation states of regulatory myosin light
            chains, which is crucial for muscle and intracellular movement.
            MLCPs typically contain a catalytic protein phosphatase 1 (PP1c)
            subunit, a myosin phosphatase targeting (MYPT) subunit, and another
            smaller subunit. The protein encoded by this gene represents an
            MYPT subunit, which is responsible for directing PP1c to its
            intended targets. However, while the phosphorylation of other MYPT
            members results in PP1c inactivation, phosphorylation of the
            encoded protein by protein kinase A results in PP1c activation.
            [provided by RefSeq, Jan 2020].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.432306.1,
                                           SRR3476690.674163.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000435887.2/ ENSP00000391126.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                DB457525.1         1-93
            94-536              CN301973.1         3-445
            537-590             HY168641.1         455-508
            591-2864            BC053506.1         1-2274
FEATURES             Location/Qualifiers
     source          1..2864
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2864
                     /gene="PPP1R16A"
                     /gene_synonym="MYPT3"
                     /note="protein phosphatase 1 regulatory subunit 16A"
                     /db_xref="GeneID:84988"
                     /db_xref="HGNC:HGNC:14941"
                     /db_xref="MIM:609172"
     exon            1..146
                     /gene="PPP1R16A"
                     /gene_synonym="MYPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            147..325
                     /gene="PPP1R16A"
                     /gene_synonym="MYPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            326..1318
                     /gene="PPP1R16A"
                     /gene_synonym="MYPT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1060..2646
                     /gene="PPP1R16A"
                     /gene_synonym="MYPT3"
                     /note="myosin phosphatase-targeting subunit 3; protein
                     phosphatase 1, regulatory (inhibitor) subunit 16A"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 16A"
                     /protein_id="NP_001316372.1"
                     /db_xref="CCDS:CCDS6429.1"
                     /db_xref="GeneID:84988"
                     /db_xref="HGNC:HGNC:14941"
                     /db_xref="MIM:609172"
                     /translation="MAEHLELLAEMPMVGRMSTQERLKHAQKRRAQQVKMWAQAEKEA
                     QGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANE
                     DGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASG
                     ANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSR
                     LQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWG
                     QVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELKHKHDALLRAQSRQRSL
                     LRRRTSSAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQQPPPTSPEPPEDNDDRQTG
                     AELRPPPPEEDNPEVVRPHNGRVGGSPVRHLYSKRLDRSVSYQLSPLDSTTPHTLVHD
                     KAHHTLADLKRQRAAAKLQRPPPEGPESPETAEPGLPGDTVTPQPDCGFRAGGDPPLL
                     KLTAPAVEAPVERRPCCLLM"
     exon            1319..1389
                     /gene="PPP1R16A"
                     /gene_synonym="MYPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1535
                     /gene="PPP1R16A"
                     /gene_synonym="MYPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1639
                     /gene="PPP1R16A"
                     /gene_synonym="MYPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1764
                     /gene="PPP1R16A"
                     /gene_synonym="MYPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1890
                     /gene="PPP1R16A"
                     /gene_synonym="MYPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..1966
                     /gene="PPP1R16A"
                     /gene_synonym="MYPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2096
                     /gene="PPP1R16A"
                     /gene_synonym="MYPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2262
                     /gene="PPP1R16A"
                     /gene_synonym="MYPT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2864
                     /gene="PPP1R16A"
                     /gene_synonym="MYPT3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2841..2846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R16A"
                     /gene_synonym="MYPT3"
                     /note="hexamer: GATAAA"
     polyA_site      2864
                     /gene="PPP1R16A"
                     /gene_synonym="MYPT3"
                     /note="major polyA site"
ORIGIN      
        1 atgggtaccg cgggccggaa gtgtagcgtt gccatggcga gggccgggtg cggggcccgc
       61 ccccgcagcg cctcagggag cgcggggccc actgacccgc ggaagccagc ggacccactt
      121 gtgcggcggt cggcgcgggg cgcgaggtac tggcacacgg atgaggagtc gtagaagagg
      181 ggcctgcaga ttgtgctctc agcaagcctg tcgtctagtg gaagacactg gccgggacac
      241 agagcccacg tgtggacacc gctgtgggtt ggtggcaggg gtcgagcagg tgccatcagg
      301 cacatgaacg gtggagtctt caaaggtgtg agcagctgct ggaagaggag gtgctcctga
      361 agacactgcg gccggcccgc ctgtgccctt ggtgccctgg ctgcctagag agcctcaccc
      421 ctgggccctg gggccaggac tccaggactc tgactacctg ccctccccca gcctcagcgg
      481 ctgcacctcc tcgttagtac tgatgcactg acctcggcac acagctggga ggggttgggg
      541 gctgggtcat ggctgctccc aggccccacc caggctcctg agcctagaag gtgaaaagag
      601 gactctcagg ggctcacagg ggctctcact gctggttggc cctgccctcc cttccccctc
      661 agcagggtgc ccggaagctg gaaccttgtt atctgggtaa ttagtttcag accctgcact
      721 gaggccggcc aggtctcggg gctgcctccc ataggttgtg caccctgacc ccgagaggga
      781 ggcgaggcgc tgcttgtcga cagctagagg ctggcctggg gagcaggttt ggggtgccct
      841 cccacactgc cctccctgcc ccggcccatg ccccccaggg ctgcctgggc ctggttattg
      901 tgtggggcct cctgacccag ccaagggcac gaagctctgg gaaggggatg cccccgaggg
      961 tgccagtcca gctagctgcc ccacccctca ggcccagcct ggcccccaag ctccccactc
     1021 tggtgccccg agcagccctg tgggcaagca gccgccgcca tggccgagca cctggagctg
     1081 ctggcagaga tgcccatggt gggcaggatg agcacacagg agcggctgaa gcatgcccag
     1141 aagcggcgcg cccagcaggt gaagatgtgg gcccaggctg agaaggaggc ccagggcaag
     1201 aagggtcctg gggagcgtcc ccggaaggag gcagccagcc aagggctcct gaagcaggtc
     1261 ctcttccctc ccagtgttgt ccttctggag gccgctgccc gaaatgacct ggaagaagtc
     1321 cgccagttcc ttgggagtgg ggtcagccct gacttggcca acgaggacgg cctgacggcc
     1381 ctgcaccagt gctgcattga tgatttccga gagatggtgc agcagctcct ggaggctggg
     1441 gccaacatca atgcctgtga cagtgagtgc tggacgcctc tgcatgctgc ggccacctgc
     1501 ggccacctgc acctggtgga gctgctcatc gccagtggcg ccaatctcct ggcggtcaac
     1561 accgacggga acatgcccta tgacctgtgt gatgatgagc agacgctgga ctgcctggag
     1621 actgccatgg ccgaccgtgg catcacccag gacagcatcg aggccgcccg ggccgtgcca
     1681 gaactgcgca tgctggacga catccggagc cggctgcagg ccggggcaga cctccatgcc
     1741 cccctggacc acggggccac gctgctgcac gtcgcagccg ccaacgggtt cagcgaggcg
     1801 gctgccctgc tgctggaaca ccgagccagc ctgagcgcta aggaccaaga cggctgggag
     1861 ccgctgcacg ccgcggccta ctggggccag gtgcccctgg tggagctgct cgtggcgcac
     1921 ggggccgacc tgaacgcaaa gtccctgatg gacgagacgc cccttgatgt gtgcggggac
     1981 gaggaggtgc gggccaagct gctggagctg aagcacaagc acgacgccct cctgcgcgcc
     2041 cagagccgcc agcgctcctt gctgcgccgc cgcacctcca gcgccggcag ccgcgggaag
     2101 gtggtgaggc gggtgagcct aacccagcgc accgacctgt accgcaagca gcacgcccag
     2161 gaggccatcg tgtggcaaca gccgccgccc accagcccgg agccgcccga ggacaacgat
     2221 gaccgccaga caggcgcaga gctcaggccg ccgcccccgg aggaggacaa ccccgaagtg
     2281 gtcaggccgc acaatggccg agtagggggc tccccagtgc ggcatctata ctccaagcga
     2341 ctagaccgga gtgtctccta ccagctgagc cccctggaca gcaccacccc ccacaccctg
     2401 gtccacgaca aggcccacca caccctggct gacctgaagc gccagcgagc tgctgccaag
     2461 ctgcagcgac ccccacctga ggggcccgag agccctgaga cagctgagcc tggcctgcct
     2521 ggtgacacgg tgacccccca gcctgactgt ggcttcaggg caggcgggga cccacccctg
     2581 ctcaagctca cagccccggc ggtggaggct cccgtggaga ggaggccgtg ctgcctgctc
     2641 atgtgaggct gttgctcagc atgcaggggc cctgtcgcgg gcacagccca aggctgcctc
     2701 cccacggtgc gtgccctggt gctgcgggtg cagcacggaa accccggctt ctactgtaca
     2761 ggacactggc ccctctcagg tcagaagaca tgcctggagg gatgtctggc tgcaaagact
     2821 atttttatcc tgcaactctt gataaagggc tgttttgcca tgga
//
