LOCUS       NM_017726                750 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14D
            (PPP1R14D), transcript variant 1, mRNA.
ACCESSION   NM_017726
VERSION     NM_017726.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 750)
  AUTHORS   Cao,H., Wang,Z., Wang,Y., Ye,L., Li,R., Xue,Y., Li,K., Di,T.,
            Li,T., Fan,Z., Liu,Y., Guo,J., Yao,H. and Ge,C.
  TITLE     PPP1R14D promotes the proliferation, migration and invasion of lung
            adenocarcinoma via the PKCalpha/BRAF/MEK/ERK signaling pathway
  JOURNAL   Int J Oncol 61 (6) (2022)
   PUBMED   36263632
  REMARK    GeneRIF: PPP1R14D promotes the proliferation, migration and
            invasion of lung adenocarcinoma via the PKCalpha/BRAF/MEK/ERK
            signaling pathway.
REFERENCE   2  (bases 1 to 750)
  AUTHORS   Liu,Q.R., Zhang,P.W., Lin,Z., Li,Q.F., Woods,A.S., Troncoso,J. and
            Uhl,G.R.
  TITLE     GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory
            protein, is activated by PKC and inactivated by PKA
  JOURNAL   Biochem J 377 (Pt 1), 171-181 (2004)
   PUBMED   12974676
  REMARK    GeneRIF: A gastrointestinal- and brain-specific PP1 inhibitory
            protein (GBPI-1)is activated by PKC phosphorylation. A longer
            GBPI-2 splice variant mRNA is found in testes.
REFERENCE   3  (bases 1 to 750)
  AUTHORS   Ceulemans,H., Stalmans,W. and Bollen,M.
  TITLE     Regulator-driven functional diversification of protein
            phosphatase-1 in eukaryotic evolution
  JOURNAL   Bioessays 24 (4), 371-381 (2002)
   PUBMED   11948623
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY050671.1 and AI963626.1.
            
            On Jun 2, 2019 this sequence version replaced NM_017726.7.
            
            Summary: Protein phosphatase-1 (PP1; see MIM 176875) is a major
            cellular phosphatase that reverses serine/threonine protein
            phosphorylation. PPP1R14D is a PP1 inhibitor that itself is
            regulated by phosphorylation (Liu et al., 2004 [PubMed
            12974676]).[supplied by OMIM, Feb 2010].
            
            Transcript Variant: This variant (1) lacks an exon in the coding
            region, compared to variant 2, resulting in a frameshift and a
            protein (isoform 1) with a truncated C-terminus, compared to
            isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000258.1, AA516447.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299174.10/ ENSP00000299174.6
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-748               AY050671.1         30-777
            749-750             AI963626.1         14-15               c
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..750
                     /gene="PPP1R14D"
                     /gene_synonym="CPI17-like; GBPI-1; GBPI1"
                     /note="protein phosphatase 1 regulatory inhibitor subunit
                     14D"
                     /db_xref="GeneID:54866"
                     /db_xref="HGNC:HGNC:14953"
                     /db_xref="MIM:613256"
     exon            1..322
                     /gene="PPP1R14D"
                     /gene_synonym="CPI17-like; GBPI-1; GBPI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..505
                     /gene="PPP1R14D"
                     /gene_synonym="CPI17-like; GBPI-1; GBPI1"
                     /note="isoform 1 is encoded by transcript variant 1; gut
                     and brain phosphatase inhibitor 1; protein phosphatase 1
                     regulatory subunit 14D; PKC-dependent PP1 inhibitory
                     protein; gastrointestinal and brain-specific
                     PP1-inhibitory protein 1"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 14D
                     isoform 1"
                     /protein_id="NP_060196.1"
                     /db_xref="CCDS:CCDS10066.1"
                     /db_xref="GeneID:54866"
                     /db_xref="HGNC:HGNC:14953"
                     /db_xref="MIM:613256"
                     /translation="MLSSSPASCTSPSPDGENPCKKVHWASGRRRTSSTDSESKSHPD
                     SSKIPRSRRPSRLTVKYDRGQLQRWLEMEQWVDAQVQELFQDQATPSEPEIDLEALMD
                     LSTEEQKTQLEAILGNCPRPTEAFISELLSQLKKLRRLSRPQK"
     exon            323..406
                     /gene="PPP1R14D"
                     /gene_synonym="CPI17-like; GBPI-1; GBPI1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..439
                     /gene="PPP1R14D"
                     /gene_synonym="CPI17-like; GBPI-1; GBPI1"
                     /inference="alignment:Splign:2.1.0"
     exon            440..750
                     /gene="PPP1R14D"
                     /gene_synonym="CPI17-like; GBPI-1; GBPI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      729..734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R14D"
                     /gene_synonym="CPI17-like; GBPI-1; GBPI1"
                     /note="hexamer: GATAAA"
     polyA_site      750
                     /gene="PPP1R14D"
                     /gene_synonym="CPI17-like; GBPI-1; GBPI1"
                     /note="major polyA site"
ORIGIN      
        1 acttccctct gtggctctgc tcagaactgg cggtttttcc cagctccttg cccagaccaa
       61 tacttccatg ctgtcttcaa gccctgcttc ctgcacatct cccagcccag atggggagaa
      121 cccatgtaag aaggtccact gggcttctgg gaggagaagg acatcatcca cagactcaga
      181 gtccaagtcc cacccggact cctccaagat acccaggtcc cggagaccca gccgcctgac
      241 agtgaagtat gaccggggcc agctccagcg ctggctggag atggagcaat gggtggatgc
      301 tcaagttcag gagctcttcc aggatcaagc aaccccttct gagcctgaga ttgacctgga
      361 agctctcatg gatctatcca cagaggagca gaagactcag ctggaggcca ttcttgggaa
      421 ctgcccccgc cccacagagg cttttatctc tgagctgctc agtcaactca agaaactccg
      481 gagactcagc cggcctcaga aataagcctg agagaccatc tttagcagcc tcagcactgc
      541 caggcctgcc ctgaaactcc agatcctggc taagagggaa atagctcctt gggacacaaa
      601 caagaaatgt ggacaaggag ggacatttgc atactcctac tgtctgtgtg gtcacagcta
      661 gtttctgtca gctgggctct ctgggagaaa gctggctgtt gtccaatgcc ttccttggca
      721 gccaagtgga taaaaccttt aggagcccca
//
