LOCUS       NM_030949               2219 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14C
            (PPP1R14C), mRNA.
ACCESSION   NM_030949
VERSION     NM_030949.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2219)
  AUTHORS   Liang,Y., Gersch,C.L., Lehman,J., Henry,N.L., Smith,K.L., Rae,J.M.,
            Stearns,V. and Hertz,D.L.
  TITLE     Attempted replication of pharmacogenetic association of variants in
            PPP1R14C and CCDC148 with aromatase inhibitor-induced
            musculoskeletal symptoms
  JOURNAL   Pharmacogenet Genomics 34 (4), 126-129 (2024)
   PUBMED   38359166
  REMARK    GeneRIF: Attempted replication of pharmacogenetic association of
            variants in PPP1R14C and CCDC148 with aromatase inhibitor-induced
            musculoskeletal symptoms.
REFERENCE   2  (bases 1 to 2219)
  AUTHORS   Lee,H.C., Hsieh,C.C. and Tsai,H.J.
  TITLE     KEPI plays a negative role in the repression that accompanies
            translational inhibition guided by the uORF element of human CHOP
            transcript during stress response
  JOURNAL   Gene 817, 146160 (2022)
   PUBMED   35031423
  REMARK    GeneRIF: KEPI plays a negative role in the repression that
            accompanies translational inhibition guided by the uORF element of
            human CHOP transcript during stress response.
REFERENCE   3  (bases 1 to 2219)
  AUTHORS   Hancock,D.B., Soler Artigas,M., Gharib,S.A., Henry,A.,
            Manichaikul,A., Ramasamy,A., Loth,D.W., Imboden,M., Koch,B.,
            McArdle,W.L., Smith,A.V., Smolonska,J., Sood,A., Tang,W.,
            Wilk,J.B., Zhai,G., Zhao,J.H., Aschard,H., Burkart,K.M.,
            Curjuric,I., Eijgelsheim,M., Elliott,P., Gu,X., Harris,T.B.,
            Janson,C., Homuth,G., Hysi,P.G., Liu,J.Z., Loehr,L.R., Lohman,K.,
            Loos,R.J., Manning,A.K., Marciante,K.D., Obeidat,M., Postma,D.S.,
            Aldrich,M.C., Brusselle,G.G., Chen,T.H., Eiriksdottir,G.,
            Franceschini,N., Heinrich,J., Rotter,J.I., Wijmenga,C.,
            Williams,O.D., Bentley,A.R., Hofman,A., Laurie,C.C., Lumley,T.,
            Morrison,A.C., Joubert,B.R., Rivadeneira,F., Couper,D.J.,
            Kritchevsky,S.B., Liu,Y., Wjst,M., Wain,L.V., Vonk,J.M.,
            Uitterlinden,A.G., Rochat,T., Rich,S.S., Psaty,B.M., O'Connor,G.T.,
            North,K.E., Mirel,D.B., Meibohm,B., Launer,L.J., Khaw,K.T.,
            Hartikainen,A.L., Hammond,C.J., Glaser,S., Marchini,J., Kraft,P.,
            Wareham,N.J., Volzke,H., Stricker,B.H., Spector,T.D.,
            Probst-Hensch,N.M., Jarvis,D., Jarvelin,M.R., Heckbert,S.R.,
            Gudnason,V., Boezen,H.M., Barr,R.G., Cassano,P.A., Strachan,D.P.,
            Fornage,M., Hall,I.P., Dupuis,J., Tobin,M.D. and London,S.J.
  TITLE     Genome-wide joint meta-analysis of SNP and SNP-by-smoking
            interaction identifies novel loci for pulmonary function
  JOURNAL   PLoS Genet 8 (12), e1003098 (2012)
   PUBMED   23284291
REFERENCE   4  (bases 1 to 2219)
  AUTHORS   Soler Artigas,M., Loth,D.W., Wain,L.V., Gharib,S.A., Obeidat,M.,
            Tang,W., Zhai,G., Zhao,J.H., Smith,A.V., Huffman,J.E., Albrecht,E.,
            Jackson,C.M., Evans,D.M., Cadby,G., Fornage,M., Manichaikul,A.,
            Lopez,L.M., Johnson,T., Aldrich,M.C., Aspelund,T., Barroso,I.,
            Campbell,H., Cassano,P.A., Couper,D.J., Eiriksdottir,G.,
            Franceschini,N., Garcia,M., Gieger,C., Gislason,G.K., Grkovic,I.,
            Hammond,C.J., Hancock,D.B., Harris,T.B., Ramasamy,A.,
            Heckbert,S.R., Heliovaara,M., Homuth,G., Hysi,P.G., James,A.L.,
            Jankovic,S., Joubert,B.R., Karrasch,S., Klopp,N., Koch,B.,
            Kritchevsky,S.B., Launer,L.J., Liu,Y., Loehr,L.R., Lohman,K.,
            Loos,R.J., Lumley,T., Al Balushi,K.A., Ang,W.Q., Barr,R.G.,
            Beilby,J., Blakey,J.D., Boban,M., Boraska,V., Brisman,J.,
            Britton,J.R., Brusselle,G.G., Cooper,C., Curjuric,I., Dahgam,S.,
            Deary,I.J., Ebrahim,S., Eijgelsheim,M., Francks,C., Gaysina,D.,
            Granell,R., Gu,X., Hankinson,J.L., Hardy,R., Harris,S.E.,
            Henderson,J., Henry,A., Hingorani,A.D., Hofman,A., Holt,P.G.,
            Hui,J., Hunter,M.L., Imboden,M., Jameson,K.A., Kerr,S.M.,
            Kolcic,I., Kronenberg,F., Liu,J.Z., Marchini,J., McKeever,T.,
            Morris,A.D., Olin,A.C., Porteous,D.J., Postma,D.S., Rich,S.S.,
            Ring,S.M., Rivadeneira,F., Rochat,T., Sayer,A.A., Sayers,I.,
            Sly,P.D., Smith,G.D., Sood,A., Starr,J.M., Uitterlinden,A.G.,
            Vonk,J.M., Wannamethee,S.G., Whincup,P.H., Wijmenga,C.,
            Williams,O.D., Wong,A., Mangino,M., Marciante,K.D., McArdle,W.L.,
            Meibohm,B., Morrison,A.C., North,K.E., Omenaas,E., Palmer,L.J.,
            Pietilainen,K.H., Pin,I., Pola Sbreve Ek,O., Pouta,A., Psaty,B.M.,
            Hartikainen,A.L., Rantanen,T., Ripatti,S., Rotter,J.I., Rudan,I.,
            Rudnicka,A.R., Schulz,H., Shin,S.Y., Spector,T.D., Surakka,I.,
            Vitart,V., Volzke,H., Wareham,N.J., Warrington,N.M., Wichmann,H.E.,
            Wild,S.H., Wilk,J.B., Wjst,M., Wright,A.F., Zgaga,L., Zemunik,T.,
            Pennell,C.E., Nyberg,F., Kuh,D., Holloway,J.W., Boezen,H.M.,
            Lawlor,D.A., Morris,R.W., Probst-Hensch,N., Kaprio,J., Wilson,J.F.,
            Hayward,C., Kahonen,M., Heinrich,J., Musk,A.W., Jarvis,D.L.,
            Glaser,S., Jarvelin,M.R., Ch Stricker,B.H., Elliott,P.,
            O'Connor,G.T., Strachan,D.P., London,S.J., Hall,I.P., Gudnason,V.
            and Tobin,M.D.
  CONSRTM   International Lung Cancer Consortium; GIANT consortium
  TITLE     Genome-wide association and large-scale follow up identifies 16 new
            loci influencing lung function
  JOURNAL   Nat Genet 43 (11), 1082-1090 (2011)
   PUBMED   21946350
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2219)
  AUTHORS   Daskalow,K., Boisguerin,P., Jandrig,B., Van Landeghem,F.K.,
            Volkmer,R., Micheel,B. and Schenk,J.A.
  TITLE     Generation of an antibody against the protein phosphatase 1
            inhibitor KEPI and characterization of the epitope
  JOURNAL   Anticancer Res 30 (5), 1573-1578 (2010)
   PUBMED   20592344
  REMARK    GeneRIF: analysis of antibodies generated against the protein
            phosphatase 1 inhibitor KEPI and characterization of the epitope
REFERENCE   6  (bases 1 to 2219)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 2219)
  AUTHORS   Liu,Q.R., Zhang,P.W., Zhen,Q., Walther,D., Wang,X.B. and Uhl,G.R.
  TITLE     KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by
            morphine
  JOURNAL   J Biol Chem 277 (15), 13312-13320 (2002)
   PUBMED   11812771
  REMARK    GeneRIF: regulation by morphine
            GeneRIF: PPP1R14C gene encodes a PKC-potentiated inhibitory
            protein, KEPI, for type-1 Ser/Thr protein phosphatase (PP1). KEPI
            mRNA and protein were enriched in brain, heart and skeletal muscle.
REFERENCE   8  (bases 1 to 2219)
  AUTHORS   Ceulemans,H., Stalmans,W. and Bollen,M.
  TITLE     Regulator-driven functional diversification of protein
            phosphatase-1 in eukaryotic evolution
  JOURNAL   Bioessays 24 (4), 371-381 (2002)
   PUBMED   11948623
  REMARK    Review article
REFERENCE   9  (bases 1 to 2219)
  AUTHORS   Connor,J.H., Weiser,D.C., Li,S., Hallenbeck,J.M. and Shenolikar,S.
  TITLE     Growth arrest and DNA damage-inducible protein GADD34 assembles a
            novel signaling complex containing protein phosphatase 1 and
            inhibitor 1
  JOURNAL   Mol Cell Biol 21 (20), 6841-6850 (2001)
   PUBMED   11564868
REFERENCE   10 (bases 1 to 2219)
  AUTHORS   Scanlan,M.J., Gout,I., Gordon,C.M., Williamson,B., Stockert,E.,
            Gure,A.O., Jager,D., Chen,Y.T., Mackay,A., O'Hare,M.J. and Old,L.J.
  TITLE     Humoral immunity to human breast cancer: antigen definition and
            quantitative analysis of mRNA expression
  JOURNAL   Cancer Immun 1, 4 (2001)
   PUBMED   12747765
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355497.14, CB994599.1, AK096272.1, AF308297.1 and AL096708.34.
            
            On Nov 22, 2018 this sequence version replaced NM_030949.2.
            
            Summary: The degree of protein phosphorylation is regulated by a
            balance of protein kinase and phosphatase activities. Protein
            phosphatase-1 (PP1; see MIM 176875) is a signal-transducing
            phosphatase that influences neuronal activity, protein synthesis,
            metabolism, muscle contraction, and cell division. PPP1R14C is an
            inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by
            OMIM, Feb 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF407165.2, ERR279847.3594.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361131.5/ ENSP00000355260.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL355497.14        189158-189165
            9-539               CB994599.1         29-559
            540-993             AK096272.1         168-621
            994-2129            AF308297.1         858-1993
            2130-2219           AL096708.34        73398-73487
FEATURES             Location/Qualifiers
     source          1..2219
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..2219
                     /gene="PPP1R14C"
                     /gene_synonym="CPI17-like; KEPI; NY-BR-81"
                     /note="protein phosphatase 1 regulatory inhibitor subunit
                     14C"
                     /db_xref="GeneID:81706"
                     /db_xref="HGNC:HGNC:14952"
                     /db_xref="MIM:613242"
     exon            1..455
                     /gene="PPP1R14C"
                     /gene_synonym="CPI17-like; KEPI; NY-BR-81"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..647
                     /gene="PPP1R14C"
                     /gene_synonym="CPI17-like; KEPI; NY-BR-81"
                     /note="kinase C-enhanced PP1 inhibitor; serologically
                     defined breast cancer antigen NY-BR-81; PKC-potentiated
                     PP1 inhibitory protein; kinase-enhanced PP1 inhibitor"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 14C"
                     /protein_id="NP_112211.1"
                     /db_xref="CCDS:CCDS5226.1"
                     /db_xref="GeneID:81706"
                     /db_xref="HGNC:HGNC:14952"
                     /db_xref="MIM:613242"
                     /translation="MSVATGSSETAGGASGGGARVFFQSPRGGAGGSPGSSSGSGSSR
                     EDSAPVATAAAAGQVQQQQQRRHQQGKVTVKYDRKELRKRLVLEEWIVEQLGQLYGCE
                     EEEMPEVEIDIDDLLDADSDEERASKLQEALVDCYKPTEEFIKELLSRIRGMRKLSPP
                     QKKSV"
     exon            456..539
                     /gene="PPP1R14C"
                     /gene_synonym="CPI17-like; KEPI; NY-BR-81"
                     /inference="alignment:Splign:2.1.0"
     exon            540..572
                     /gene="PPP1R14C"
                     /gene_synonym="CPI17-like; KEPI; NY-BR-81"
                     /inference="alignment:Splign:2.1.0"
     exon            573..2219
                     /gene="PPP1R14C"
                     /gene_synonym="CPI17-like; KEPI; NY-BR-81"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2164..2169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R14C"
                     /gene_synonym="CPI17-like; KEPI; NY-BR-81"
                     /note="hexamer: AATAAA"
     polyA_site      2184
                     /gene="PPP1R14C"
                     /gene_synonym="CPI17-like; KEPI; NY-BR-81"
                     /note="major polyA site"
     polyA_site      2219
                     /gene="PPP1R14C"
                     /gene_synonym="CPI17-like; KEPI; NY-BR-81"
ORIGIN      
        1 agagcagccg ggcggctggg cgcgcgcggc gcagagcagg tgccggggag cccttcgcat
       61 gcggctgccg ggccggaggt ggtagcggcg ccgggcgcgc tccgcccgcc cctcctccgg
      121 gccgcactga ggctcgggcg cgcggggaca tgtcggtggc gacgggcagc agcgagacgg
      181 ccggcggggc cagcggcggc ggcgcacggg ttttcttcca aagcccccgg ggtggcgccg
      241 gtggcagccc cggctccagc agcggctcag gctcctcccg ggaggactcg gcgcccgtgg
      301 ccacggcggc cgctgcaggg caggttcagc agcaacagca gcggcgacac cagcagggaa
      361 aagtgacagt gaaatacgat cgtaaggagc ttcggaagcg gctggtgctg gaggaatgga
      421 tcgtggagca gctgggtcag ctctacggct gcgaggaaga agaaatgcca gaggtagaaa
      481 ttgacattga tgatcttctt gatgcagaca gtgatgaaga gagagcttca aaattacagg
      541 aagctcttgt agactgctac aaaccaacag aggaatttat caaagagctg ctttctcgga
      601 taagaggcat gaggaaactg agccctccgc agaagaagag tgtatgattc tggaacaggg
      661 tgaaactctc ccagagacga agaaagagtc ctgggatttg tacttcatga agacttttgt
      721 gaaagaatag gtgtccttat gaacaacgtt tttgtttttt tttttttctt ttttggtgtg
      781 aaggtggggg ggtctattag acatttattc aagagcgttc tttttttggt tttaaaggtt
      841 tttgttaatg taatatttta atagcaaaga tatcatgact ctagccacag cctaaccaag
      901 gattatcaaa ggaggtggac actcaaggaa gggccacgcc aggctgcgtt tcctgcaagg
      961 actcagatgt tcagtacctt atgatacagg gaagatagtt ttcttacaag tagtttggta
     1021 atattttttt tcttaagttg tacatttgac tcagctgtca aatttctcac acttgtatat
     1081 atctacacac aactaagtta aaatgttgat gtgagtttta tttcacatgg atggaataaa
     1141 cttgtggttg tcctttaact ggaggtccca gcacatgtgt tttcaagagg ccactaggca
     1201 ttcttcactg agtgctgctg acttcaacgt tcactttatg caccaaagtg aaagaattca
     1261 gtgtatccgt tattttaatg cactacacca cagaaatgtt aagttggtca agggcttaat
     1321 ttatggaatt tctattattt cattggttgg gatgctttgc caggtcatgt gcttattgtc
     1381 tcattttgta gtcttttaaa gttgtatgaa cccttaattt gaagaactaa cttgatttct
     1441 agagaaatat ccacactatc tcagtggtat tttgcattgg aaaaaggaag cactgtgtag
     1501 cagtgaattg tctgctttcc accgagtact gtgtttattc tctctccagg aaagcagatc
     1561 aaaagaaagt tagcagatcg agtgtcttct tccttagaaa taggttctgg tagcttctgt
     1621 gcctgggtag tatcagacca gtgggagtaa accgagtgtt aagtgtcaag gtgagaaagc
     1681 ctcacattct ctcaagacag ttgctctagg agctgagttg ctggtttgga agtgtggaga
     1741 ttgcatttct ggcttctctc aatggcttgt gttgaggact ctgggtgctc ctggccctaa
     1801 ttgtgcaccc tgatccccgt gcttggagct aggcctggtg gcgtgctcta gccctctcag
     1861 ttaccagctc tttggagaag gatcaaaatt cagatggaat gtgggatggg taataggtga
     1921 gagtagaaac ccttccctcc aggaggcccc cgctgactcc cacagaaacc cacctaccat
     1981 aagatgtctt caggtggcct tgtccaagga tgggggtcag gcattttata tcaagggtgc
     2041 tctgaacata ttttattttt taaaaaaact atgtttgtga attttgcgta tactggcaag
     2101 cttttgaaaa tgtatttaat tttgtattgt ttaccaatga tttatttaca agatatttac
     2161 tcaaataaat ggagctgctt acaagcctgt tgacatgtgt ggcttgcaca acacgttaa
//
