LOCUS       NM_138689                989 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14B
            (PPP1R14B), mRNA.
ACCESSION   NM_138689 XM_370630
VERSION     NM_138689.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 989)
  AUTHORS   Zhou,N., Guo,C., Du,J., Xu,Q., Li,J., Huang,D., Zheng,X. and Tu,L.
  TITLE     PPP1R14B-mediated phosphorylation enhances protein stability of
            RPS6KA1 to promote hepatocellular carcinoma tumorigenesis
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119840 (2024)
   PUBMED   39216602
  REMARK    GeneRIF: PPP1R14B-mediated phosphorylation enhances protein
            stability of RPS6KA1 to promote hepatocellular carcinoma
            tumorigenesis.
REFERENCE   2  (bases 1 to 989)
  AUTHORS   Cheng,L., Mi,J., Zhang,J., Huang,H. and Mo,Z.
  TITLE     Upregulated PPP1R14B is connected to cancer progression and immune
            infiltration in kidney renal clear cell carcinoma
  JOURNAL   Clin Transl Oncol 26 (1), 119-135 (2024)
   PUBMED   37261660
  REMARK    GeneRIF: Upregulated PPP1R14B is connected to cancer progression
            and immune infiltration in kidney renal clear cell carcinoma.
REFERENCE   3  (bases 1 to 989)
  AUTHORS   Kirkbride,J.A., Nilsson,G.Y., Kim,J.I., Takeya,K., Tanaka,Y.,
            Tokumitsu,H., Suizu,F. and Eto,M.
  TITLE     PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1
            and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis
  JOURNAL   Biomolecules 13 (12), 1741 (2023)
   PUBMED   38136612
  REMARK    GeneRIF: PHI-1, an Endogenous Inhibitor Protein for Protein
            Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1
            Proteostasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 989)
  AUTHORS   Liao,L., Zhang,Y.L., Deng,L., Chen,C., Ma,X.Y., Andriani,L.,
            Yang,S.Y., Hu,S.Y., Zhang,F.L., Shao,Z.M. and Li,D.Q.
  TITLE     Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote
            Progression and Paclitaxel Resistance in Triple-Negative Breast
            Cancer
  JOURNAL   Cancer Res 83 (3), 471-484 (2023)
   PUBMED   36484700
  REMARK    GeneRIF: Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to
            Promote Progression and Paclitaxel Resistance in Triple-Negative
            Breast Cancer.
REFERENCE   5  (bases 1 to 989)
  AUTHORS   Xiang,N., Chen,T., Zhao,X. and Zhao,M.
  TITLE     In vitro assessment of roles of PPP1R14B in cervical and
            endometrial cancer
  JOURNAL   Tissue Cell 77, 101845 (2022)
   PUBMED   35679681
  REMARK    GeneRIF: In vitro assessment of roles of PPP1R14B in cervical and
            endometrial cancer.
REFERENCE   6  (bases 1 to 989)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 989)
  AUTHORS   Tountas,N.A. and Brautigan,D.L.
  TITLE     Migration and retraction of endothelial and epithelial cells
            require PHI-1, a specific protein-phosphatase-1 inhibitor protein
  JOURNAL   J Cell Sci 117 (Pt 24), 5905-5912 (2004)
   PUBMED   15522888
  REMARK    GeneRIF: PHI-1 participates in regulatory events at the trailing
            edge of migrating cells and modulates retraction of endothelial and
            epithelial cells
REFERENCE   8  (bases 1 to 989)
  AUTHORS   Tountas,N.A., Mandell,J.W., Everett,A.D. and Brautigan,D.L.
  TITLE     Juxtamembrane localization of the protein phosphatase-1 inhibitor
            protein PHI-1 in smooth muscle cells
  JOURNAL   Histochem Cell Biol 121 (4), 343-350 (2004)
   PUBMED   15083373
  REMARK    GeneRIF: Whereas CPI-17 staining was diffuse, PHI-1 was
            concentrated along the cell membrane in distinct foci. The common
            tissue distribution but different cellular localization of PHI-1
            and CPI-17 suggest distinctive physiological roles for these PP1
            inhibitors.
REFERENCE   9  (bases 1 to 989)
  AUTHORS   Eto,M., Karginov,A. and Brautigan,D.L.
  TITLE     A novel phosphoprotein inhibitor of protein type-1 phosphatase
            holoenzymes
  JOURNAL   Biochemistry 38 (51), 16952-16957 (1999)
   PUBMED   10606530
  REMARK    GeneRIF: An inhibitory phosphoprotein that inhibits the myosin- and
            glycogen-associated holoenzyme versions of protein type-1
            phosphatase (PP1) as well as the monomeric catalytic subunit of PP1
            in multiple tissues.
REFERENCE   10 (bases 1 to 989)
  AUTHORS   Lagercrantz,J., Carson,E., Larsson,C., Nordenskjold,M. and Weber,G.
  TITLE     Isolation and characterization of a novel gene close to the human
            phosphoinositide-specific phospholipase C beta 3 gene on
            chromosomal region 11q13
  JOURNAL   Genomics 31 (3), 380-384 (1996)
   PUBMED   8838322
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001453.6, BM847221.1, BC014522.2, BF155230.1 and BC071884.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138689.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.215150.1,
                                           SRR1163658.87582.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309318.8/ ENSP00000310117.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AP001453.6         19124-19125         c
            3-150               BM847221.1         1-148
            151-714             BC014522.2         1-564
            715-715             BF155230.1         3-3                 c
            716-983             BC014522.2         566-833
            984-989             BC071884.1         737-742
FEATURES             Location/Qualifiers
     source          1..989
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..989
                     /gene="PPP1R14B"
                     /gene_synonym="PHI-1; PLCB3N; PNG; SOM172"
                     /note="protein phosphatase 1 regulatory inhibitor subunit
                     14B"
                     /db_xref="GeneID:26472"
                     /db_xref="HGNC:HGNC:9057"
                     /db_xref="MIM:601140"
     exon            1..528
                     /gene="PPP1R14B"
                     /gene_synonym="PHI-1; PLCB3N; PNG; SOM172"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..714
                     /gene="PPP1R14B"
                     /gene_synonym="PHI-1; PLCB3N; PNG; SOM172"
                     /note="phospholipase C beta-3 neighboring gene protein;
                     phospholipase C-beta-3 neighbouring gene protein"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 14B"
                     /protein_id="NP_619634.1"
                     /db_xref="CCDS:CCDS31596.1"
                     /db_xref="GeneID:26472"
                     /db_xref="HGNC:HGNC:9057"
                     /db_xref="MIM:601140"
                     /translation="MADSGTAGGAALAAPAPGPGSGGPGPRVYFQSPPGAAGEGPGGA
                     DDEGPVRRQGKVTVKYDRKELRKRLNLEEWILEQLTRLYDCQEEEIPELEIDVDELLD
                     MESDDARAARVKELLVDCYKPTEAFISGLLDKIRGMQKLSTPQKK"
     exon            529..612
                     /gene="PPP1R14B"
                     /gene_synonym="PHI-1; PLCB3N; PNG; SOM172"
                     /inference="alignment:Splign:2.1.0"
     exon            613..645
                     /gene="PPP1R14B"
                     /gene_synonym="PHI-1; PLCB3N; PNG; SOM172"
                     /inference="alignment:Splign:2.1.0"
     exon            646..989
                     /gene="PPP1R14B"
                     /gene_synonym="PHI-1; PLCB3N; PNG; SOM172"
                     /inference="alignment:Splign:2.1.0"
     regulatory      957..962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R14B"
                     /gene_synonym="PHI-1; PLCB3N; PNG; SOM172"
                     /note="hexamer: AATAAA"
     polyA_site      989
                     /gene="PPP1R14B"
                     /gene_synonym="PHI-1; PLCB3N; PNG; SOM172"
                     /note="major polyA site"
ORIGIN      
        1 gagacagaga aagcgcttcg gcggctgcag ctcgggcggc ggccgcgggg gacaaagggc
       61 gggcggatcg gcggggaggg ggcggggcgc ggccaggcca agcccggggg ctccgcatgc
      121 tgcagctgcc cccgggcgcc cccgccgccg ccctcgccgc ggagccgcgc ggagcggagc
      181 cggcgagcta acccgagcca gccggcgggc gtcccggagg cggtggcgca gggaggggcc
      241 cgacgctcgc acgtggcccc ggcggccgcc atggcggaca gcggcaccgc ggggggcgcg
      301 gcgttggcgg ccccggcccc cgggccgggc agtggcggcc caggaccacg cgtctacttt
      361 cagagccccc ccggggccgc aggagagggc ccgggcgggg cggacgatga gggcccagtg
      421 aggcgccaag ggaaggtcac cgtcaagtat gaccgcaagg agctacggaa gcgcctcaac
      481 ctagaggagt ggatcctgga gcagctcacg cgcctctacg actgccagga agaggagatc
      541 ccagaactgg agattgacgt ggatgagctc ctggacatgg agagtgacga tgcccgggct
      601 gccagggtca aggagctgct ggttgactgt tacaaaccca cagaggcctt catttctggc
      661 ctgctggaca agatccgggg catgcagaag ctgagcacac cccagaagaa gtgacggtcc
      721 ccgacccagg agaacggtgg ctcccacagg acaatcgctg ccccccaacc tcgtagcaac
      781 agcaataccg ggggaccctg cggccaggcc tggtgccatg agcagggctc ctcgtgcccc
      841 tggcccaggg gtctcttccc ctgccccctc agttttccac ttttggggtt ttttattgtt
      901 attaaactga tgggactttt tgtgttttta tattgactct gcggcgcggg ccctttaata
      961 aagctaggat acgcctttgg tgcagctaa
//
