LOCUS       NM_006663               3131 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory subunit 13 like
            (PPP1R13L), transcript variant 2, mRNA.
ACCESSION   NM_006663
VERSION     NM_006663.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3131)
  AUTHORS   Tulbah,S., Alruwaili,N., Alhashem,A., Aljohany,A., Alhadeq,F.,
            Brotons,D.C.A., Alwadai,A. and Al-Hassnan,Z.N.
  TITLE     Variable phenotype of a null PPP1R13L allele in children with
            dilated cardiomyopathy
  JOURNAL   Am J Med Genet A 194 (1), 59-63 (2024)
   PUBMED   37698259
  REMARK    GeneRIF: Variable phenotype of a null PPP1R13L allele in children
            with dilated cardiomyopathy.
REFERENCE   2  (bases 1 to 3131)
  AUTHORS   Yin,J., Wang,C., Vogel,U., Ma,Y., Zhang,Y., Wang,H., Sun,Z. and
            Du,S.
  TITLE     Common variants of pro-inflammatory gene IL1B and interactions with
            PPP1R13L and POLR1G in relation to lung cancer among Northeast
            Chinese
  JOURNAL   Sci Rep 13 (1), 7352 (2023)
   PUBMED   37147350
  REMARK    GeneRIF: Common variants of pro-inflammatory gene IL1B and
            interactions with PPP1R13L and POLR1G in relation to lung cancer
            among Northeast Chinese.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3131)
  AUTHORS   Zhou,M., Dong,J., Huang,J., Ye,W., Zheng,Z., Huang,K., Pan,Y.,
            Cen,J., Liang,Y., Shu,G., Ye,S., Lu,X. and Zhang,J.
  TITLE     Chitosan-Gelatin-EGCG Nanoparticle-Meditated LncRNA TMEM44-AS1
            Silencing to Activate the P53 Signaling Pathway for the Synergistic
            Reversal of 5-FU Resistance in Gastric Cancer
  JOURNAL   Adv Sci (Weinh) 9 (22), e2105077 (2022)
   PUBMED   35717675
  REMARK    GeneRIF: Chitosan-Gelatin-EGCG Nanoparticle-Meditated LncRNA
            TMEM44-AS1 Silencing to Activate the P53 Signaling Pathway for the
            Synergistic Reversal of 5-FU Resistance in Gastric Cancer.
REFERENCE   4  (bases 1 to 3131)
  AUTHORS   Zhao,D., Zheng,S., Wang,X., Liu,H., Zhao,K., Li,L. and Hu,Y.
  TITLE     iASPP is essential for HIF-1alpha stabilization to promote
            angiogenesis and glycolysis via attenuating VHL-mediated protein
            degradation
  JOURNAL   Oncogene 41 (13), 1944-1958 (2022)
   PUBMED   35169254
  REMARK    GeneRIF: iASPP is essential for HIF-1alpha stabilization to promote
            angiogenesis and glycolysis via attenuating VHL-mediated protein
            degradation.
REFERENCE   5  (bases 1 to 3131)
  AUTHORS   Yin,J., Hou,W., Vogel,U., Li,X., Ma,Y., Wang,C., Wang,H. and Sun,Z.
  TITLE     TP53 common variants and interaction with PPP1R13L and CD3EAP SNPs
            and lung cancer risk and smoking behavior in a Chinese population
  JOURNAL   Biomed J 45 (1), 169-178 (2022)
   PUBMED   35351459
  REMARK    GeneRIF: TP53 common variants and interaction with PPP1R13L and
            CD3EAP SNPs and lung cancer risk and smoking behavior in a Chinese
            population.
REFERENCE   6  (bases 1 to 3131)
  AUTHORS   Slee,E.A., Gillotin,S., Bergamaschi,D., Royer,C., Llanos,S.,
            Ali,S., Jin,B., Trigiante,G. and Lu,X.
  TITLE     The N-terminus of a novel isoform of human iASPP is required for
            its cytoplasmic localization
  JOURNAL   Oncogene 23 (56), 9007-9016 (2004)
   PUBMED   15489900
REFERENCE   7  (bases 1 to 3131)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   8  (bases 1 to 3131)
  AUTHORS   Bergamaschi,D., Samuels,Y., O'Neil,N.J., Trigiante,G., Crook,T.,
            Hsieh,J.K., O'Connor,D.J., Zhong,S., Campargue,I., Tomlinson,M.L.,
            Kuwabara,P.E. and Lu,X.
  TITLE     iASPP oncoprotein is a key inhibitor of p53 conserved from worm to
            human
  JOURNAL   Nat Genet 33 (2), 162-167 (2003)
   PUBMED   12524540
REFERENCE   9  (bases 1 to 3131)
  AUTHORS   Takada,N., Sanda,T., Okamoto,H., Yang,J.P., Asamitsu,K., Sarol,L.,
            Kimura,G., Uranishi,H., Tetsuka,T. and Okamoto,T.
  TITLE     RelA-associated inhibitor blocks transcription of human
            immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1
            actions
  JOURNAL   J Virol 76 (16), 8019-8030 (2002)
   PUBMED   12134007
  REMARK    GeneRIF: Effect of RAI on transcription and replication of human
            immunodeficiency virus type 1 (HIV-1).
REFERENCE   10 (bases 1 to 3131)
  AUTHORS   Yang,J.P., Hori,M., Sanda,T. and Okamoto,T.
  TITLE     Identification of a novel inhibitor of nuclear factor-kappaB,
            RelA-associated inhibitor
  JOURNAL   J Biol Chem 274 (22), 15662-15670 (1999)
   PUBMED   10336463
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092309.3 and BC032298.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006663.3.
            
            Summary: IASPP is one of the most evolutionarily conserved
            inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455)
            and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar
            2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032298.1, SRR7346977.1137704.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360957.10/ ENSP00000354218.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC092309.3         38676-38690         c
            16-38               AC092309.3         38653-38675         c
            39-3064             BC032298.1         13-3038
            3065-3131           AC092309.3         13259-13325         c
FEATURES             Location/Qualifiers
     source          1..3131
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..3131
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /note="protein phosphatase 1 regulatory subunit 13 like"
                     /db_xref="GeneID:10848"
                     /db_xref="HGNC:HGNC:18838"
                     /db_xref="MIM:607463"
     exon            1..71
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /inference="alignment:Splign:2.1.0"
     exon            72..147
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2579
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /note="retinoic acid induced 4; NFkB interacting protein
                     1; inhibitor of apoptosis stimulating protein of p53;
                     protein iASPP; PPP1R13B-like protein; inhibitor of ASPP
                     protein; protein phosphatase 1, regulatory (inhibitor)
                     subunit 13 like"
                     /codon_start=1
                     /product="relA-associated inhibitor"
                     /protein_id="NP_006654.2"
                     /db_xref="CCDS:CCDS33050.1"
                     /db_xref="GeneID:10848"
                     /db_xref="HGNC:HGNC:18838"
                     /db_xref="MIM:607463"
                     /translation="MDSEAFQSARDFLDMNFQSLAMKHMDLKQMELDTAAAKVDELTK
                     QLESLWSDSPAPPGPQAGPPSRPPRYSSSSIPEPFGSRGSPRKAATDGADTPFGRSES
                     APTLHPYSPLSPKGRPSSPRTPLYLQPDAYGSLDRATSPRPRAFDGAGSSLGRAPSPR
                     PGPGPLRQQGPPTPFDFLGRAGSPRGSPLAEGPQAFFPERGPSPRPPATAYDAPASAF
                     GSSLLGSGGSAFAPPLRAQDDLTLRRRPPKAWNESDLDVAYEKKPSQTASYERLDVFA
                     RPASPSLQLLPWRESSLDGLGGTGKDNLTSATLPRNYKVSPLASDRRSDAGSYRRSLG
                     SAGPSGTLPRSWQPVSRIPMPPSSPQPRGAPRQRPIPLSMIFKLQNAFWEHGASRAML
                     PGSPLFTRAPPPKLQPQPQPQPQPQSQPQPQLPPQPQTQPQTPTPAPQHPQQTWPPVN
                     EGPPKPPTELEPEPEIEGLLTPVLEAGDVDEGPVARPLSPTRLQPALPPEAQSVPELE
                     EVARVLAEIPRPLKRRGSMEQAPAVALPPTHKKQYQQIISRLFHRHGGPGPGGPEPEL
                     SPITEGSEARAGPPAPAPPAPIPPPAPSQSSPPEQPQSMEMRSVLRKAGSPRKARRAR
                     LNPLVLLLDAALTGELEVVQQAVKEMNDPSQPNEEGITALHNAICGANYSIVDFLITA
                     GANVNSPDSHGWTPLHCAASCNDTVICMALVQHGAAIFATTLSDGATAFEKCDPYREG
                     YADCATYLADVEQSMGLMNSGAVYALWDYSAEFGDELSFREGESVTVLRRDGPEETDW
                     WWAALHGQEGYVPRNYFGLFPRVKPQRSKV"
     exon            148..290
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /inference="alignment:Splign:2.1.0"
     exon            291..804
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /inference="alignment:Splign:2.1.0"
     exon            805..903
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /inference="alignment:Splign:2.1.0"
     exon            904..995
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1446
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1907
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2039
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2173
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2340
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2540
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..3131
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3109..3114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /note="hexamer: AATAAA"
     polyA_site      3131
                     /gene="PPP1R13L"
                     /gene_synonym="ARCME; CMAEA; IASPP; NKIP1; RAI; RAI4"
                     /note="major polyA site"
ORIGIN      
        1 cccgttctcc gctccccaag ccggagcccg agctggagga agcccccagg tgccaggatc
       61 tgcccggatc cgcgcccgct ccggccggca ccatggacag cgaggcattc cagagcgcgc
      121 gggactttct ggacatgaac ttccagtcgc tggccatgaa acacatggat ctgaagcaga
      181 tggagctgga cacggcggcg gccaaggtgg atgaactgac caagcagctg gagtcgctgt
      241 ggtcagactc tcccgcgcct cctggcccgc aggccggacc cccttctagg ccgccccggt
      301 acagctccag ctcgatccct gagcccttcg gcagccgagg gtccccccgg aaggcggcca
      361 ccgacggcgc agacaccccg ttcggacgat cagagagtgc cccaacccta cacccctaca
      421 gcccgctgtc ccccaaggga cggccgtcgt cgccgcgcac cccgctctac ctgcagccgg
      481 acgcctacgg cagcctggac cgcgcgacct cgccccggcc ccgcgccttc gatggcgcag
      541 gcagctccct cggccgtgcg ccctccccgc ggcccgggcc aggcccgctc cgccagcagg
      601 gtccccccac gcctttcgac ttcctgggcc gcgcaggctc cccccgcggc agccccctgg
      661 cggaggggcc ccaggccttc ttccccgagc gtgggccgtc accgcgcccc cctgccacag
      721 cctacgacgc gccagcgtcc gccttcggga gctccctgct aggctccggc ggcagcgcat
      781 tcgccccgcc tctgcgcgcg caagacgacc tgacgctgcg ccggcggcct ccgaaagcct
      841 ggaacgagtc tgacctggac gtggcgtacg agaagaagcc ttcgcagaca gcgagctatg
      901 aacgcctgga cgtcttcgca aggcctgcct cgccgagcct gcagctgttg ccttggaggg
      961 agagcagcct ggatggactg gggggcaccg gcaaggacaa cctcactagc gccaccctgc
     1021 cgcgcaatta caaggtctct cctctggcca gcgaccggcg ttcagacgcg ggcagctacc
     1081 ggcgctcgct gggctccgcg gggccgtcgg gcactttgcc tcgcagctgg cagcccgtca
     1141 gccgcatccc catgcccccc tccagccccc agccccgcgg ggccccgcgc cagcgtccca
     1201 tccccctcag catgatcttc aagctgcaga acgccttctg ggagcacggg gccagccgcg
     1261 ccatgctccc tgggtccccc ctcttcaccc gagcaccccc gcctaagctg cagccccaac
     1321 cacaaccaca gccccagcca caatcacaac cacagcccca gctgccccca cagccccaga
     1381 cccaacccca aacccctacc ccagcccccc agcatcccca acagacatgg ccccctgtga
     1441 acgaaggacc ccccaaaccc cccaccgagc tggagcctga gccggagata gaggggctgc
     1501 tgacaccagt gctggaggct ggcgatgtgg atgaaggccc tgtagcaagg cctctcagcc
     1561 ccacgaggct gcagccagca ctgccaccgg aggcacagtc ggtgcccgag ctggaggagg
     1621 tggcacgggt gttggcggaa attccccggc ccctcaaacg caggggctcc atggagcagg
     1681 cccctgctgt ggccctgccc cctacccaca agaaacagta ccagcagatc atcagccgcc
     1741 tcttccatcg tcatgggggg ccagggcccg gggggccgga gccagagctg tcccccatca
     1801 ctgagggatc tgaggccagg gcagggcccc ctgctcctgc cccaccagct cccattccac
     1861 ccccggcccc gtcccagagc agcccaccag agcagccgca gagcatggag atgcgctctg
     1921 tgctgcggaa ggcgggctcc ccgcgcaagg cccgccgcgc gcgcctcaac cctctggtgc
     1981 tcctcctgga cgcggcgctg accggggagc tggaggtggt gcagcaggcg gtgaaggaga
     2041 tgaacgaccc gagccagccc aacgaggagg gcatcactgc cttgcacaac gccatctgcg
     2101 gcgccaacta ctctatcgtg gatttcctca tcaccgcggg tgccaatgtc aactcccccg
     2161 acagccacgg ctggacaccc ttgcactgcg cggcgtcgtg caacgacaca gtcatctgca
     2221 tggcgctggt gcagcacggc gctgcaatct tcgccaccac gctcagcgac ggcgccaccg
     2281 ccttcgagaa gtgcgaccct taccgcgagg gttatgctga ctgcgccacc tacctggcag
     2341 acgtcgagca gagtatgggg ctgatgaaca gcggggcagt gtacgctctc tgggactaca
     2401 gcgccgagtt cggggacgag ctgtccttcc gcgagggcga gtcggtcacc gtgctgcgga
     2461 gggacgggcc ggaggagacc gactggtggt gggccgcgct gcacggccag gagggctacg
     2521 tgccgcggaa ctacttcggg ctgttcccca gggtgaagcc tcaaaggagt aaagtctagc
     2581 aggatagaag gaggtttctg aggctgacag aaacaagcat tcctgccttc cctccagacc
     2641 tctccctctg ttttttgctg cctttatctg cacccctcac cctgctggtg gtggtccttg
     2701 ccaccggttc tctgttctcc tggaagtcca gggaagaagg agggccccag ccttaaattt
     2761 agtaatctgc cttagccttg ggaggtctgg gaagggctgg aaatcactgg ggacaggaaa
     2821 ccacttcctt ttgccaaatc agatcccgtc caaagtgcct cccatgccta ccaccatcat
     2881 cacatccccc agcaagccag ccacctgccc agccgggcct gggatgggcc accacaccac
     2941 tggatattcc tgggagtcac tgctgacacc atctctccca gcagtcttgg ggtctgggtg
     3001 ggaaacattg gtctctacca ggatccctgc cccacctctc cccaattaag tgccttcaca
     3061 cagcactggt ttaatgttta taaacaaaat agagaaactt tccttataaa taaaagtagt
     3121 ttgcacagaa a
//
