LOCUS       NM_015316               5500 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens protein phosphatase 1 regulatory subunit 13B
            (PPP1R13B), mRNA.
ACCESSION   NM_015316
VERSION     NM_015316.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5500)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5500)
  AUTHORS   Patel,K.D., Barasiya,Y.V., Patel,J.B. and Patel,P.S.
  TITLE     Apoptosis stimulating protein of p53 (ASPP) 1 and ASPP2 m-RNA
            expression in oral cancer
  JOURNAL   Arch Oral Biol 119, 104920 (2020)
   PUBMED   32987288
  REMARK    GeneRIF: Apoptosis stimulating protein of p53 (ASPP) 1 and ASPP2
            m-RNA expression in oral cancer.
REFERENCE   3  (bases 1 to 5500)
  AUTHORS   Liu,D., Ertay,A., Hill,C., Zhou,Y., Li,J., Zou,Y., Qiu,H., Yuan,X.,
            Ewing,R.M., Lu,X., Xiong,H. and Wang,Y.
  TITLE     ASPP1 deficiency promotes epithelial-mesenchymal transition,
            invasion and metastasis in colorectal cancer
  JOURNAL   Cell Death Dis 11 (4), 224 (2020)
   PUBMED   32269211
  REMARK    GeneRIF: ASPP1 deficiency promotes epithelial-mesenchymal
            transition, invasion and metastasis in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5500)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5500)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5500)
  AUTHORS   Fogal,V., Kartasheva,N.N., Trigiante,G., Llanos,S., Yap,D.,
            Vousden,K.H. and Lu,X.
  TITLE     ASPP1 and ASPP2 are new transcriptional targets of E2F
  JOURNAL   Cell Death Differ 12 (4), 369-376 (2005)
   PUBMED   15731768
  REMARK    GeneRIF: target of E2F transcription factor
REFERENCE   7  (bases 1 to 5500)
  AUTHORS   Liu,Z.J., Lu,X., Zhang,Y., Zhong,S., Gu,S.Z., Zhang,X.B., Yang,X.
            and Xin,H.M.
  TITLE     Downregulated mRNA expression of ASPP and the hypermethylation of
            the 5'-untranslated region in cancer cell lines retaining wild-type
            p53
  JOURNAL   FEBS Lett 579 (7), 1587-1590 (2005)
   PUBMED   15757645
  REMARK    GeneRIF: ASPP1 CpG island aberrant methylation could be one
            molecular and genetic alteration in wild-type p53 tumours.
REFERENCE   8  (bases 1 to 5500)
  AUTHORS   Bergamaschi,D., Samuels,Y., Jin,B., Duraisingham,S., Crook,T. and
            Lu,X.
  TITLE     ASPP1 and ASPP2: common activators of p53 family members
  JOURNAL   Mol Cell Biol 24 (3), 1341-1350 (2004)
   PUBMED   14729977
REFERENCE   9  (bases 1 to 5500)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
REFERENCE   10 (bases 1 to 5500)
  AUTHORS   Samuels-Lev,Y., O'Connor,D.J., Bergamaschi,D., Trigiante,G.,
            Hsieh,J.K., Zhong,S., Campargue,I., Naumovski,L., Crook,T. and
            Lu,X.
  TITLE     ASPP proteins specifically stimulate the apoptotic function of p53
  JOURNAL   Mol Cell 8 (4), 781-794 (2001)
   PUBMED   11684014
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB461586.2, BC035446.1,
            AJ318887.2, AW295594.1 and AL049840.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_015316.2.
            
            Summary: This gene encodes a member of the ASPP
            (apoptosis-stimulating protein of p53) family of p53 interacting
            proteins. The protein contains four ankyrin repeats and an SH3
            domain involved in protein-protein interactions. ASPP proteins are
            required for the induction of apoptosis by p53-family proteins.
            They promote DNA binding and transactivation of p53-family proteins
            on the promoters of proapoptotic genes. Expression of this gene is
            regulated by the E2F transcription factor. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035446.1, AJ318887.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000202556.14/ ENSP00000202556.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DB461586.2         16-31
            17-2090             BC035446.1         1-2074
            2091-3024           AJ318887.2         1981-2914
            3025-3468           BC035446.1         3009-3452
            3469-4579           BC035446.1         3454-4564
            4580-4944           AW295594.1         18-382              c
            4945-5500           AL049840.8         113055-113610
FEATURES             Location/Qualifiers
     source          1..5500
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..5500
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /note="protein phosphatase 1 regulatory subunit 13B"
                     /db_xref="GeneID:23368"
                     /db_xref="HGNC:HGNC:14950"
                     /db_xref="MIM:606455"
     exon            1..277
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..3541
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /note="apoptosis-stimulating protein of p53, 1; protein
                     phosphatase 1, regulatory (inhibitor) subunit 13B"
                     /codon_start=1
                     /product="apoptosis-stimulating of p53 protein 1"
                     /protein_id="NP_056131.2"
                     /db_xref="CCDS:CCDS41997.1"
                     /db_xref="GeneID:23368"
                     /db_xref="HGNC:HGNC:14950"
                     /db_xref="MIM:606455"
                     /translation="MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGSCH
                     LAEVWRGNERPIPFDHMMYEHLQKWGPRREEVKFFLRHEDSPTENSEQGGRQTQEQRT
                     QRNVINVPGEKRTENGVGNPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLK
                     QQERRQQQSISENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFS
                     AMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQSYNGKLTGPAAVELKRLYQELQ
                     IRNQLNQEQNSKLQQQKELLNKRNMEVAMMDKRISELRERLYGKKIQLNRVNGTSSPQ
                     SPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWPTL
                     KQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPPP
                     IPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGS
                     TPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQS
                     PRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPL
                     PFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPLSPTKLTPIVHSP
                     LRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGT
                     PFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNELPS
                     PEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPA
                     SHPPATSTNKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRIIYEVEDP
                     SKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQ
                     LVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMNKGVAYALWDY
                     EAQNSDELSFHEGDALTILRRKDESETEWWWARLGDREGYVPKNLLGLYPRIKPRQRT
                     LA"
     exon            278..425
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            426..545
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            546..622
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            623..724
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            725..899
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1096
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1237
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1418
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1588
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..2090
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2860
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..2998
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            2999..3132
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3299
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3499
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            3500..5500
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3782..3787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /note="hexamer: AATAAA"
     polyA_site      3804
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
     regulatory      4699..4704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /note="hexamer: ATTAAA"
     polyA_site      4731
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /note="major polyA site"
     regulatory      4923..4928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /note="hexamer: AATAAA"
     polyA_site      4943
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /note="major polyA site"
     polyA_site      5057
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
     regulatory      5090..5095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /note="hexamer: AATAAA"
     polyA_site      5128
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
ORIGIN      
        1 aggctgtcgg gctggggctg aggctgaggc tgaggttgag gcggcggcgg cggcggccgg
       61 gtgcccggga cagcgacgca gcgcgccggc ggccgcgaca gggccagcga gagccccgca
      121 gcccgccgca gctgccgcct cgccgcggcc gggccggaga gcacggcggc gggagcgcgg
      181 ccttaggagg cggccggagc ggtgggcaca gctcggcgcg gagcgtcctg tcaggcggcg
      241 gccgagggcg tcgcggactc tccccgcgat gatgccgatg atattaactg ttttcttgag
      301 caacaatgaa cagattttaa cagaagttcc tataacaccg gaaacaacct gtcgagatgt
      361 tgtagaattt tgcaaggaac ctggagaagg cagctgccat ttagctgaag tgtggagggg
      421 aaatgaacgt cccataccct ttgatcatat gatgtacgaa catcttcaga aatggggtcc
      481 acggagggaa gaagtgaaat ttttccttcg acacgaggac tccccaactg agaacagtga
      541 acaaggtggc cgtcagaccc aagagcaacg aactcagaga aatgtaataa atgtacctgg
      601 agaaaaacgt actgaaaatg gggttgggaa tccacgtgtt gaacttaccc tctcagagct
      661 ccaagatatg gcagctaggc aacagcagca gattgaaaat cagcagcaga tgttggttgc
      721 caaggaacag cgtttacatt ttctaaagca acaggagcgc cgtcagcagc agtctatttc
      781 tgaaaatgaa aagcttcaga aattgaaaga acgagttgaa gcccaggaga acaagctgaa
      841 gaaaattcgt gcaatgagag gacaagtcga ctacagcaaa atcatgaacg gcaatctgtc
      901 tgctgaaata gaaaggttca gtgccatgtt ccaggaaaag aagcaggaag tacagactgc
      961 aattttaagg gttgatcagc ttagtcagca attggaagat ttaaagaaag gaaaactgaa
     1021 tgggttccag tcttacaatg gcaaattgac gggaccagcg gcggtggagt taaaaagact
     1081 gtaccaagaa ctacagattc gtaaccaact taaccaggaa caaaattcaa aacttcagca
     1141 gcagaaggaa ctcttaaata agcgcaacat ggaggtggcc atgatggaca agcgaatcag
     1201 tgaactgcgt gaacgtctct atgggaaaaa aattcagctg aaccgtgtga atggcacgtc
     1261 atcaccacag tcccctctga gcacatcggg cagggtcgct gctgtggggc cttatatcca
     1321 ggttcccagt gccggaagct ttcctgtgct gggggaccct ataaagcccc agtctctcag
     1381 tattgcctca aatgctgctc atggaagatc caaatccgct aatgatggaa actggccaac
     1441 attaaaacag aattctagct cttccgtgaa accagtgcag gtggccggtg cagactggaa
     1501 ggatccgagc gtggaggggt ctgtcaagca gggcactgtc tccagccagc ctgtgccctt
     1561 ctcagcactg ggacccacgg agaagccggg catcgagatt ggtaaagtgc cacctcccat
     1621 cccgggtgta ggcaagcagc tgcctccaag ctatgggaca tacccaagtc ctacacctct
     1681 gggtcctggg tcgacaagct ccctggaaag gaggaaggaa ggcagcttgc ccaggcccag
     1741 tgcaggcctg ccaagtcgac agaggcccac cctgctgccc gccacaggca gcacccccca
     1801 gccaggctcc tcacaacaga ttcagcagag gatttccgta ccgccaagtc ccacgtaccc
     1861 gccagcggga ccacctgcat ttccagctgg ggacagcaag cctgaactcc cactgacagt
     1921 ggccattagg cctttcctgg ctgataaagg gtcaaggcca cagtctccca ggaaaggacc
     1981 ccagacagtg aattcaagtt ccatatactc catgtacctc cagcaagcca caccacctaa
     2041 gaattaccag ccggcagcac acagcgcctt aaataagtca gttaaagcag tgtatggtaa
     2101 gcccgtttta ccttcgggtt caacctctcc atcgccgctg ccgtttcttc acgggtcact
     2161 gtccacgggc acaccacagc ctcagccacc ttcagaaagt actgagaaag agcctgagca
     2221 ggatggcccc gccgcccccg cagatggcag caccgtggag agcctgccac ggccactcag
     2281 ccccaccaag ctcacgccca tcgtgcattc gccactgcgc taccagagtg atgcagacct
     2341 ggaggccctc cgcaggaagc tggccaacgc gccccggccc ctgaaaaagc gcagctccat
     2401 cacagagccc gagggccccg gcgggcccaa catccagaag ctgctgtacc agcgcttcaa
     2461 caccctggcc ggtggcatgg agggcacccc tttctaccag cccagcccct cccaggactt
     2521 catgggcacc ttggccgatg tggacaatgg aaacaccaat gccaatggaa acctggaaga
     2581 gctcccccct gcccagccca cagccccact ccccgctgag cctgccccgt catcagatgc
     2641 caatgataat gagttacctt cccccgaacc agaggagctc atctgtcccc aaaccaccca
     2701 ccaaactgcc gagccggcag aggacaataa caacaacgtg gccacggtcc ccaccacgga
     2761 gcagatcccg agtcctgtgg ctgaggcccc atctccaggg gaagagcagg tccctccagc
     2821 acctcttccc cctgccagcc accctcctgc cacctccacg aacaagcgga ccaacttgaa
     2881 gaagcccaac tcggagcgga cggggcacgg gctgagagtc cggtttaacc ccctggcact
     2941 gctcctagac gcgtctctgg aaggagagtt cgatctggtg cagaggatca tctatgaggt
     3001 ggaagatccc agcaagccca acgacgaagg gatcacccca ctgcacaacg ccgtctgcgc
     3061 cggccaccat cacatcgtga agttcctgct ggattttggt gtcaacgtga atgctgctga
     3121 tagtgatgga tggacgccgc tgcactgcgc tgcctcttgt aacagcgttc acctctgcaa
     3181 acagctggtg gagagtggtg ccgccatttt tgcctcaacc ataagcgaca ttgaaactgc
     3241 tgcagacaag tgtgaggaga tggaggaagg ctacatccag tgctcccagt ttctatatgg
     3301 ggtgcaggaa aagctgggtg tgatgaacaa aggtgtggcg tatgctctgt gggactacga
     3361 ggcccagaac agtgacgagc tgtccttcca cgaaggggac gccctcacca tcctgaggcg
     3421 caaggacgaa agcgagactg agtggtggtg ggctcgcctt ggagaccggg agggctatgt
     3481 gcccaaaaac ctgctggggc tgtatccacg gatcaaaccc cgacagcgaa cactcgcctg
     3541 aacttccttt tggagcaccg catggtcttg ccagctacca ggagccactt aagagattat
     3601 tgtgctgttt tccaggaaag ctgcagctag aaaatggtct taatggtgct cactttagca
     3661 gacagcgtcc acaatgtgaa tcctacagtt tccaggtgag gccctttctc cagtttgccc
     3721 attaactggg agaggtactt tcgcctccaa ggactgaatt ttgccaatta ctataaatcc
     3781 aaataaatac ccactttcaa aacacccacc cctcttgcca ttaagaagtc ccataacccc
     3841 cggttggttg ccagtgaaga cagaagctct tactgacttg gccccgaggc catcaccccc
     3901 tccagcagtg aacactgtcc gccgctgtga ggcctgctcc cctgcgaccg ccctgccccc
     3961 cgtcaccgaa tcggacactc atcctttctc acacttccca cacatgatcc ttcttccctt
     4021 catcaccaaa ggagcctctg tatggaaaca tgtccagtgt tgctgcccag tgtgtatgcc
     4081 tcccagtacc cactctgctc ggccgccttg ggggttccgc ttcctgttcc agttcaccta
     4141 aaggctgatt gtgcaggccc agcactgtgg ctggactgcc gcgccacggg caccaggacc
     4201 cctaagacca agtgacaact gggagagcct cagcatatac tcttctcctc cgatctcaca
     4261 gcctgtcatg ctgctcagtg tggttctcac ccctgcaagc tcaaattcag ttccctgaat
     4321 ggagtcaggt gctggaggcc gtggcagcgg agggtggttg gggttggggc tgggggtgga
     4381 ctggtgtgag ggcagaccag ggccaggtag acggggctgt ttggtgcctg aaggatggca
     4441 gacgcctggt gtcaggaggg gccgccacca aggagcagca gctggggcag aggagctggg
     4501 gtcaggggcc acccctctct gccgatctcc ctgcctgggc tggctgtgag gccacctttg
     4561 tcccaggccc agcctcaagg caaggagggc gcttcactga ggtgtgaatt gtacgtacag
     4621 gctttttata taccaaaagt attttttgac tagaccattc aaagctaccc gaactatgtt
     4681 ggaaattttt tttttctcat taaaatacag gcccttaggc tctatttttc atgtatgagt
     4741 cgtgtgtaat ttatgtaaaa atgtgtgtac agactcactg atgcagcact gtagcccatc
     4801 accttggagc actgactgta catagtgtgg tgaagaaaag tgaacgccct tgtagagcag
     4861 cccgaccaca ggagcatggc cgctgccagc ccagacgctg ctgacgctgt gtaaatgtgc
     4921 acaataaacc cgtctcaccc cggcggctgt gagtcttctt tctggaccca gactgcgctg
     4981 tggcacgagg gttcaggtga tctggacaca ggaaggcgag gccttgtccg tatgttcaaa
     5041 atagttttta atcataagct ttatatacaa attgctgtac agtcatctta ataaagtgaa
     5101 atagtgagtg aaaagtacaa aacacaaagc ccccacgttc cccttggtga agtatcaaag
     5161 gatcactcac agcccagaag ccccaaatta gtgacaaggt aagtggacaa gtctgtgaaa
     5221 caggctaagg caagtgctgt aaactggcta ttagaggcga acaggctcca ctgcagacca
     5281 gaagcctgag ttcctactgc ccaaactggt tctgtggaag aattaaatga aatgaatatt
     5341 gatgggccag aaccttctag tagacctgcg aactcataaa aatggtatat attatgctaa
     5401 aaatagttta gcagtagtgt agctcagtct ctcccacccc caattaagta ttgacaatac
     5461 acaaattcta aaacatgaag ctgtttaaag cattaataaa
//
