LOCUS       NM_017607               2997 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory subunit 12C
            (PPP1R12C), transcript variant 1, mRNA.
ACCESSION   NM_017607
VERSION     NM_017607.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2997)
  AUTHORS   Perike,S., Gonzalez-Gonzalez,F.J., Abu-Taha,I., Damen,F.W.,
            Hanft,L.M., Lizama,K.S., Aboonabi,A., Capote,A.E.,
            Aguilar-Sanchez,Y., Levin,B., Han,Z., Sridhar,A., Grand,J.,
            Martin,J., Akar,J.G., Warren,C.M., Solaro,R.J., Ong,S.G.,
            Darbar,D., McDonald,K.S., Goergen,C.J., Wolska,B.M., Dobrev,D.,
            Wehrens,X.H.T. and McCauley,M.D.
  TITLE     PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation
  JOURNAL   Circ Res 133 (9), 758-771 (2023)
   PUBMED   37737016
  REMARK    GeneRIF: PPP1R12C Promotes Atrial Hypocontractility in Atrial
            Fibrillation.
REFERENCE   2  (bases 1 to 2997)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2997)
  AUTHORS   Thiebaut,R., Esmiol,S., Lecine,P., Mahfouz,B., Hermant,A.,
            Nicoletti,C., Parnis,S., Perroy,J., Borg,J.P., Pascoe,L.,
            Hugot,J.P. and Ollendorff,V.
  TITLE     Characterization and Genetic Analyses of New Genes Coding for NOD2
            Interacting Proteins
  JOURNAL   PLoS One 11 (11), e0165420 (2016)
   PUBMED   27812135
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2997)
  AUTHORS   Dutheil,N., Smith,S.C., Agundez,L., Vincent-Mistiaen,Z.I.,
            Escalante,C.R., Linden,R.M. and Henckaerts,E.
  TITLE     Adeno-associated virus Rep represses the human integration site
            promoter by two pathways that are similar to those required for the
            regulation of the viral p5 promoter
  JOURNAL   J Virol 88 (15), 8227-8241 (2014)
   PUBMED   24829354
  REMARK    GeneRIF: Authors demonstrate that Rep proteins of adeno-associated
            virus serotype 2 efficiently repress expression from the target
            site PPP1R12C promoter.
REFERENCE   5  (bases 1 to 2997)
  AUTHORS   Wang,Y., Zhang,W.Y., Hu,S., Lan,F., Lee,A.S., Huber,B.,
            Lisowski,L., Liang,P., Huang,M., de Almeida,P.E., Won,J.H., Sun,N.,
            Robbins,R.C., Kay,M.A., Urnov,F.D. and Wu,J.C.
  TITLE     Genome editing of human embryonic stem cells and induced
            pluripotent stem cells with zinc finger nucleases for cellular
            imaging
  JOURNAL   Circ Res 111 (12), 1494-1503 (2012)
   PUBMED   22967807
REFERENCE   6  (bases 1 to 2997)
  AUTHORS   Mulder,J., Ariaens,A., van den Boomen,D. and Moolenaar,W.H.
  TITLE     p116Rip targets myosin phosphatase to the actin cytoskeleton and is
            essential for RhoA/ROCK-regulated neuritogenesis
  JOURNAL   Mol Biol Cell 15 (12), 5516-5527 (2004)
   PUBMED   15469989
REFERENCE   7  (bases 1 to 2997)
  AUTHORS   Surks,H.K., Richards,C.T. and Mendelsohn,M.E.
  TITLE     Myosin phosphatase-Rho interacting protein. A new member of the
            myosin phosphatase complex that directly binds RhoA
  JOURNAL   J Biol Chem 278 (51), 51484-51493 (2003)
   PUBMED   14506264
  REMARK    GeneRIF: M-RIP can assemble a complex containing both RhoA and
            Myosin phosphatase myosin binding subunit, suggesting that M-RIP
            may play a role in myosin phosphatase regulation by RhoA
REFERENCE   8  (bases 1 to 2997)
  AUTHORS   Bannert,N., Vollhardt,K., Asomuddinov,B., Haag,M., Konig,H.,
            Norley,S. and Kurth,R.
  TITLE     PDZ Domain-mediated interaction of interleukin-16 precursor
            proteins with myosin phosphatase targeting subunits
  JOURNAL   J Biol Chem 278 (43), 42190-42199 (2003)
   PUBMED   12923170
REFERENCE   9  (bases 1 to 2997)
  AUTHORS   Sbodio,J.I. and Chi,N.W.
  TITLE     Identification of a tankyrase-binding motif shared by IRAP, TAB182,
            and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif
            and is a novel tankyrase partner
  JOURNAL   J Biol Chem 277 (35), 31887-31892 (2002)
   PUBMED   12080061
REFERENCE   10 (bases 1 to 2997)
  AUTHORS   Tan,I., Ng,C.H., Lim,L. and Leung,T.
  TITLE     Phosphorylation of a novel myosin binding subunit of protein
            phosphatase 1 reveals a conserved mechanism in the regulation of
            actin cytoskeleton
  JOURNAL   J Biol Chem 276 (24), 21209-21216 (2001)
   PUBMED   11399775
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010327.8, HY013088.1 and
            AF312028.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017607.3.
            
            Summary: The gene encodes a subunit of myosin phosphatase. The
            encoded protein regulates the catalytic activity of protein
            phosphatase 1 delta and assembly of the actin cytoskeleton.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Oct
            2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF312028.1, BC010628.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263433.8/ ENSP00000263433.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC010327.8         11047-11083         c
            38-78               HY013088.1         1-41
            79-2997             AF312028.1         3-2921
FEATURES             Location/Qualifiers
     source          1..2997
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..2997
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /note="protein phosphatase 1 regulatory subunit 12C"
                     /db_xref="GeneID:54776"
                     /db_xref="HGNC:HGNC:14947"
                     /db_xref="MIM:613245"
     exon            1..415
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..2443
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /note="isoform a is encoded by transcript variant 1;
                     leukocyte receptor cluster (LRC) encoded novel gene 3;
                     leukocyte receptor cluster (LRC) member 3; myosin-binding
                     subunit 85; protein phosphatase 1 myosin-binding subunit
                     p85; protein phosphatase 1 myosin-binding subunit of 85
                     kDa; protein phosphatase 1, regulatory (inhibitor) subunit
                     12C"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 12C
                     isoform a"
                     /protein_id="NP_060077.1"
                     /db_xref="CCDS:CCDS12916.1"
                     /db_xref="GeneID:54776"
                     /db_xref="HGNC:HGNC:14947"
                     /db_xref="MIM:613245"
                     /translation="MSGEDGPAAGPGAAAAAARERRREQLRQWGARAGAEPGPGERRA
                     RTVRFERAAEFLAACAGGDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGI
                     SALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANI
                     AAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAM
                     PEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDAC
                     RLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEASQSRGQEPQA
                     PSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPR
                     TLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRS
                     ASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPPPCLENSSPPSRIPEPE
                     SPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLT
                     DLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPDGQGPGPQAARE
                     HRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGG
                     FRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERR
                     ALERKAAELEEELKALSDLRADNQRLKDENAALIRVISKLSK"
     exon            416..546
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            547..665
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            666..825
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            826..970
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1045
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1119
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1247
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1321
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1480
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1548
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1686
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1777
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1858
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1919
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2005
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2046
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2149
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2254
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2305
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2356
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2997
                     /gene="PPP1R12C"
                     /gene_synonym="AAVS1; LENG3; MBS85; p84; p85"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttcccggc ggcccccggg gcgggcgggc gggcgggtgg tggcggcggt tggggctcgg
       61 cgctcgctcg ctcgctgggc gggcgggcgg tgcgatgtcc ggagaggatg gcccggcggc
      121 tggcccgggg gcggcggcgg cggctgcccg ggagcggcga cgggagcagc tgcggcagtg
      181 gggggcgcgg gcgggcgccg agcctggccc cggagagcgc cgcgcccgca ccgtccgctt
      241 cgagcgcgcc gccgagttcc tggcggcctg tgcgggcggc gacctggacg aggcgcgtct
      301 gatgctgcgc gccgccgacc ctggccccgg cgccgagctc gaccccgccg cgccgccgcc
      361 cgcccgcgcc gtgctggact ccaccaacgc cgacggtatc agcgccctgc accaggcctg
      421 cattgatgag aacctggagg tggtgcgctt cttggtggag cagggcgcca ctgtgaacca
      481 ggcagacaac gagggctgga cgccactgca cgtggccgcc tcctgtggct acctagatat
      541 cgccaggtac ctcctgagcc acggggccaa catcgccgcc gtcaacagtg acggggacct
      601 gcccctggac ctggccgagt cggacgccat ggaggggctg ctgaaggcgg agatcgcccg
      661 ccgaggtgtg gatgtggaag cagccaagcg ggcagaagag gaattgctcc ttcatgacac
      721 gaggtgctgg ctgaatgggg gcgccatgcc agaggcccgg cacccccgca caggcgcctc
      781 tgccctgcac gtggctgctg ccaagggcta cattgaggtg atgaggttgc tccttcaggc
      841 tggctacgac ccagagctcc gggacgggga cggctggact cccctgcacg cagcggcaca
      901 ctggggcgtg gaggatgcct gccgcctgct ggccgagcat ggcgggggca tggactcact
      961 gacccatgcg gggcagcgtc cctgtgacct ggccgatgag gaagtactga gcctgttgga
     1021 ggaactggcc cggaaacagg aggaccttcg gaaccaaaaa gaagcttccc agagccgggg
     1081 ccaggagccc caagcgccct ctagcagcaa acacagaagg agctctgtgt gtcgtctgag
     1141 cagtcgcgag aagatttccc tccaggactt gtccaaggag cgccggcctg gtggggctgg
     1201 ggggcccccc atccaggacg aggatgaggg ggaagaaggt cccaccgaac caccccctgc
     1261 agaacccaga accctcaatg gcgtctcctc cccgccgcac cccagcccta agagtcccgt
     1321 gcagcttgaa gaggccccct tctccaggcg ctttggcctc ctgaagacag ggagttctgg
     1381 tgccctgggt ccccctgaaa ggcggacagc ggagggagcc cctggggctg ggctgcagcg
     1441 ctcggcttcc tcctcctggc tggaagggac ctccactcag gccaaggagc tccgtcttgc
     1501 cagaattacc ccgaccccct ccccgaagct gccggagccc tctgtcctgt ctgaggtcac
     1561 caagcctcct ccttgcttgg agaactcctc gcctccctcc aggattccgg agcctgaatc
     1621 cccagcgaag ccaaacgtcc ccacagcctc cacggcgccc ccagcggact cccgggaccg
     1681 acggaggtcc taccagatgc ctgtgcggga tgaggagtcg gaatcccaga gaaaagctcg
     1741 ctcccgtctc atgcgccagt ctcggaggtc cacacagggt gtgactctta cagacctgaa
     1801 ggaggcagag aaggctgcag ggaaggcccc agagtcagag aagccggcgc agagcctgga
     1861 cccttcccga aggccccgcg tccctggagt ggagaactct gacagccctg cccagagagc
     1921 agaggcgccc gacgggcagg gtccgggacc gcaggcggcc agggagcacc gcaaggtcgg
     1981 aaaggagtgg agggggcctg cggaggggga ggaggcggag ccggctgacc gcagccagga
     2041 gtccagcacc ctggagggcg gcccctcggc ccgcaggcag cggtggcagc gggacctcaa
     2101 cccagaacct gagccagaat cggaagagcc agacggaggc tttaggacgc tgtatgcaga
     2161 gctgcgcagg gagaacgagc ggcttcgcga ggccctgacc gagaccacgc tgcggctggc
     2221 gcagctcaag gtggagctgg agcgggccac gcagaggcaa gaacgcttcg ctgagaggcc
     2281 agccctcctg gaactggaga gattcgagcg cagggccctg gaacgcaagg ccgcagagct
     2341 ggaggaggag ctgaaggccc tgtctgacct ccgcgctgac aaccagcgcc tcaaggatga
     2401 gaatgcagcg ttgatccgcg tcatcagcaa actctccaag tgacccggag ggactttccc
     2461 gcacccgtat ttatacagct gcttctgcca cacgcacccc ttcccccgtg tgaacacgag
     2521 tgacagggct ccgggggaag tctcagagaa gccatagccc ccctgggacc tccggactgg
     2581 gaggggagca gagtccccag gagccgaggg ggccacccga ggccaggatg gaggtgggag
     2641 gccgagccaa gcagggggac gttgccagag gggaccaggg ccagagacgg gaccaggaag
     2701 gaactgagga ccaagaagtg caaggatcag tagccaggac cagagtggcc gcctggaggt
     2761 ccccatctca cgtgtgatgc caccccgtca cccctcccct cctgagcagg gatccaagaa
     2821 tgtgccaaga gtcccgccag cctcagccag gtgggcctgt atatagggtc catgtgcaat
     2881 agggagggac gtcttctatt ttttgctgcc ccctccccgc ccactgtctg gggcaggggg
     2941 agaaggtatt ttcgagataa agcacaggca ccacaaataa aagtcgtgaa gttgcca
//
