LOCUS       NM_021959               1621 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 11
            (PPP1R11), mRNA.
ACCESSION   NM_021959
VERSION     NM_021959.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1621)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1621)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1621)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1621)
  AUTHORS   Yadav,L., Tamene,F., Goos,H., van Drogen,A., Katainen,R.,
            Aebersold,R., Gstaiger,M. and Varjosalo,M.
  TITLE     Systematic Analysis of Human Protein Phosphatase Interactions and
            Dynamics
  JOURNAL   Cell Syst 4 (4), 430-444 (2017)
   PUBMED   28330616
REFERENCE   5  (bases 1 to 1621)
  AUTHORS   St-Denis,N., Gupta,G.D., Lin,Z.Y., Gonzalez-Badillo,B., Veri,A.O.,
            Knight,J.D.R., Rajendran,D., Couzens,A.L., Currie,K.W., Tkach,J.M.,
            Cheung,S.W.T., Pelletier,L. and Gingras,A.C.
  TITLE     Phenotypic and Interaction Profiling of the Human Phosphatases
            Identifies Diverse Mitotic Regulators
  JOURNAL   Cell Rep 17 (9), 2488-2501 (2016)
   PUBMED   27880917
REFERENCE   6  (bases 1 to 1621)
  AUTHORS   Zhang,J., Zhang,L., Zhao,S. and Lee,E.Y.
  TITLE     Identification and characterization of the human HCG V gene product
            as a novel inhibitor of protein phosphatase-1
  JOURNAL   Biochemistry 37 (47), 16728-16734 (1998)
   PUBMED   9843442
REFERENCE   7  (bases 1 to 1621)
  AUTHORS   Lepourcelet,M., Andrieux,N., Giffon,T., Pichon,L., Hampe,A.,
            Galibert,F. and Mosser,J.
  TITLE     Systematic sequencing of the human HLA-A/HLA-F region:
            establishment of a cosmid contig and identification of a new gene
            cluster within 37 kb of sequence
  JOURNAL   Genomics 37 (3), 316-326 (1996)
   PUBMED   8938444
REFERENCE   8  (bases 1 to 1621)
  AUTHORS   Giffon,T., Lepourcelet,M., Pichon,L., Jezequel,P., Bouric,P.,
            Carn,G., Pontarotti,P., Gall,J.Y. and David,V.
  TITLE     Cloning of a human homologue of the mouse Tctex-5 gene within the
            MHC class I region
  JOURNAL   Immunogenetics 44 (5), 331-339 (1996)
   PUBMED   8781118
REFERENCE   9  (bases 1 to 1621)
  AUTHORS   Amadou,C., Ribouchon,M.T., Mattei,M.G., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G., Avoustin,P. and Pontarotti,P.
  TITLE     Localization of new genes and markers to the distal part of the
            human major histocompatibility complex (MHC) region and comparison
            with the mouse: new insights into the evolution of mammalian
            genomes
  JOURNAL   Genomics 26 (1), 9-20 (1995)
   PUBMED   7782091
REFERENCE   10 (bases 1 to 1621)
  AUTHORS   el Kahloun,A., Chauvel,B., Mauvieux,V., Dorval,I., Jouanolle,A.M.,
            Gicquel,I., Le Gall,J.Y. and David,V.
  TITLE     Localization of seven new genes around the HLA-A locus
  JOURNAL   Hum Mol Genet 2 (1), 55-60 (1993)
   PUBMED   8490624
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB126242.1 and AL669914.2.
            
            On Nov 23, 2018 this sequence version replaced NM_021959.2.
            
            Summary: This gene encodes a specific inhibitor of protein
            phosphatase-1 (PP1) with a differential sensitivity toward the
            metal-independent and metal-dependent forms of PP1. The gene is
            located within the major histocompatibility complex class I region
            on chromosome 6. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1144568.1,
                                           SRR3476690.458544.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376772.8/ ENSP00000365963.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-500               CB126242.1         111-610
            501-1621            AL669914.2         63846-64966
FEATURES             Location/Qualifiers
     source          1..1621
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..1621
                     /gene="PPP1R11"
                     /gene_synonym="CFAP255; HCG-V; HCGV; IPP3; TCTE5; TCTEX5"
                     /note="protein phosphatase 1 regulatory inhibitor subunit
                     11"
                     /db_xref="GeneID:6992"
                     /db_xref="HGNC:HGNC:9285"
                     /db_xref="MIM:606670"
     exon            1..282
                     /gene="PPP1R11"
                     /gene_synonym="CFAP255; HCG-V; HCGV; IPP3; TCTE5; TCTEX5"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..594
                     /gene="PPP1R11"
                     /gene_synonym="CFAP255; HCG-V; HCGV; IPP3; TCTE5; TCTEX5"
                     /EC_number="2.3.2.27"
                     /note="t-complex-associated-testis-expressed 5;
                     inhibitor-3; protein phosphatase 1 regulatory subunit 11;
                     HCG V; protein phosphatase inhibitor 3; hemochromatosis
                     candidate gene V protein"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase PPP1R11"
                     /protein_id="NP_068778.1"
                     /db_xref="CCDS:CCDS4671.1"
                     /db_xref="GeneID:6992"
                     /db_xref="HGNC:HGNC:9285"
                     /db_xref="MIM:606670"
                     /translation="MAEAGAGLSETVTETTVTVTTEPENRSLTIKLRKRKPEKKVEWT
                     SDTVDNEHMGRRSSKCCCIYEKPRAFGESSTESDEEEEEGCGHTHCVRGHRKGRRRAT
                     LGPTPTTPPQPPDPSQPPPGPMQH"
     exon            283..391
                     /gene="PPP1R11"
                     /gene_synonym="CFAP255; HCG-V; HCGV; IPP3; TCTE5; TCTEX5"
                     /inference="alignment:Splign:2.1.0"
     exon            392..1621
                     /gene="PPP1R11"
                     /gene_synonym="CFAP255; HCG-V; HCGV; IPP3; TCTE5; TCTEX5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1598..1603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R11"
                     /gene_synonym="CFAP255; HCG-V; HCGV; IPP3; TCTE5; TCTEX5"
                     /note="hexamer: AATAAA"
     polyA_site      1621
                     /gene="PPP1R11"
                     /gene_synonym="CFAP255; HCG-V; HCGV; IPP3; TCTE5; TCTEX5"
                     /note="major polyA site"
ORIGIN      
        1 gtcacacccg gaagcggcga gccggaagtg gggttagcca ggttatcccc aggggtggag
       61 aagcggaggc ccaggaggag ggggaataaa gaaggtggag gatcctggct accactctga
      121 atccgatacc gcttctctta gacctcagcg acagaaaaag ggaagggtgt ctcatccccc
      181 ttcctcctct cctccctgtc ctgagcctta gccatggccg aggcaggggc tgggctgagc
      241 gagaccgtca ctgagacaac ggttaccgtg acaaccgagc ccgagaaccg gagccttacc
      301 atcaaacttc ggaaacggaa gccagagaaa aaggtagaat ggacaagtga cactgtggac
      361 aatgaacaca tgggccgccg ctcatccaaa tgctgctgta tttatgagaa acctcgggcc
      421 tttggcgaga gctccacgga aagtgatgag gaggaagaag agggctgtgg tcatacacac
      481 tgtgtacgtg gccaccgcaa aggacggcgt cgtgcaaccc taggaccgac ccccaccacc
      541 cctccccagc ctcctgaccc ttcccagccc cctccagggc caatgcagca ctaaatccct
      601 ctctcctcca gcattcctgt gtctgtctgg ccctaaatgt atccatgtgg ctacttctcc
      661 agccccctcc ttccctctct tctgcctgat agagggaaga ggaagaggag gacgaacaga
      721 gatcctgaaa ttctgacttg ctgctattcc agaacccagc ctcctgggtt tccccagtcc
      781 tcatttttcc tcccaatacc cacccttctc tctcgaggga tctaggcacc ttggtcccag
      841 tgtcttcctt ttgttctcac tgccaaactg cctgtcctgg gatctagtta tcttggccct
      901 gcactctcaa catgagtagc gaacacttaa attgggtttt caacagtccc agctttcact
      961 gccagggtcc cagtcagatt ccaggaattt gcgccctaac tttgcttgct aatcctggtt
     1021 tagagctatc ccactaaaat atttaatcct aattcttagt ccttgcctgt gagatatgag
     1081 gtcttacagg agacctcaga gctcccagcc cttctcctcc tgctaaccct tctcacaccc
     1141 tcaagaggag ttagaaaaga ggtccttgtc attctcacct cttatggaaa atggaataag
     1201 aaataatcat atcctttctt cccacccttc tcctgttatt taggatttct gacaaagctg
     1261 gcttgagatt ggtcacttag agccgactgt ctcctctgcc ttttgttttt cagcttcaga
     1321 gacagatcca atatagtccc agggacctgg gtctctggga gaggaaggaa gagggaggga
     1381 gcaaagagat tggggtatgt cccctgtagt acactcttac ctcttacttc ctagactttg
     1441 atttctccgg cagcccagat gttcagttct cttggcccct ctctacccct tactgggatc
     1501 cggttttcat tttccggtcc ttttgccata cacagttaca gagatcagtc aaatccatac
     1561 caccactgag atctcattta ttgccacaga tgcacaaaat aaataaccca aaatcacaaa
     1621 a
//
