LOCUS       NM_002714               4511 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory subunit 10 (PPP1R10),
            transcript variant 1, mRNA.
ACCESSION   NM_002714
VERSION     NM_002714.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4511)
  AUTHORS   Zhao,H., Liu,C., Zhao,C., Che,C., Liu,W. and Mei,Y.
  TITLE     Alternatively-spliced lncRNA-PNUTS promotes HCC cell EMT via
            regulating ZEB1 expression
  JOURNAL   Tumori 109 (1), 28-37 (2023)
   PUBMED   35139713
  REMARK    GeneRIF: Alternatively-spliced lncRNA-PNUTS promotes HCC cell EMT
            via regulating ZEB1 expression.
REFERENCE   2  (bases 1 to 4511)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4511)
  AUTHORS   Marx,A., Luebke,A.M., Clauditz,T.S., Steurer,S., Fraune,C.,
            Hube-Magg,C., Buscheck,F., Hoflmayer,D., Tsourlakis,M.C.,
            Moller-Koop,C., Simon,R., Sauter,G., Gobel,C., Lebok,P., Dum,D.,
            Kind,S., Minner,S., Izbicki,J., Schlomm,T., Huland,H., Heinzer,H.,
            Burandt,E., Haese,A., Graefen,M. and Meiners,J.
  TITLE     Upregulation of Phosphatase 1 Nuclear-Targeting Subunit (PNUTS) Is
            an Independent Predictor of Poor Prognosis in Prostate Cancer
  JOURNAL   Dis Markers 2020, 7050146 (2020)
   PUBMED   32377272
  REMARK    GeneRIF: Upregulation of Phosphatase 1 Nuclear-Targeting Subunit
            (PNUTS) Is an Independent Predictor of Poor Prognosis in Prostate
            Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4511)
  AUTHORS   Cortazar,M.A., Sheridan,R.M., Erickson,B., Fong,N.,
            Glover-Cutter,K., Brannan,K. and Bentley,D.L.
  TITLE     Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation
            Facilitates Termination by a 'Sitting Duck Torpedo' Mechanism
  JOURNAL   Mol Cell 76 (6), 896-908 (2019)
   PUBMED   31677974
  REMARK    GeneRIF: Poly(A) site-dependent deceleration caused by PNUTS-PP1
            and Spt5 dephosphorylation is required to convert Pol II into a
            viable target for the Xrn2 terminator exonuclease, leading to
            transcription termination.
REFERENCE   5  (bases 1 to 4511)
  AUTHORS   Wang,F., Wang,L., Fisher,L.A., Li,C., Wang,W. and Peng,A.
  TITLE     Phosphatase 1 Nuclear Targeting Subunit (PNUTS) Regulates Aurora
            Kinases and Mitotic Progression
  JOURNAL   Mol Cancer Res 17 (1), 10-19 (2019)
   PUBMED   30190438
  REMARK    GeneRIF: PNUTS depletion suppresses the activation of Aurora A/B
            kinases, and disrupts the spatiotemporal regulation of the
            chromosomal passenger complex (CPC). PNUTS dynamically localizes to
            kinetochores, and is required for the activation of the spindle
            assembly checkpoint.
REFERENCE   6  (bases 1 to 4511)
  AUTHORS   Kim,Y.M., Watanabe,T., Allen,P.B., Kim,Y.M., Lee,S.J.,
            Greengard,P., Nairn,A.C. and Kwon,Y.G.
  TITLE     PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit.
            Characterization of its PP1- and RNA-binding domains and regulation
            by phosphorylation
  JOURNAL   J Biol Chem 278 (16), 13819-13828 (2003)
   PUBMED   12574161
  REMARK    GeneRIF: PNUTS has a role in protein kinase A-regulated targeting
            of PP1 to specific RNA-associated complexes in the nucleus
REFERENCE   7  (bases 1 to 4511)
  AUTHORS   Totaro,A., Grifa,A., Carella,M., Rommens,J.M., Valentino,M.A.,
            Roetto,A., Zelante,L. and Gasparini,P.
  TITLE     Cloning of a new gene (FB19) within HLA class I region
  JOURNAL   Biochem Biophys Res Commun 250 (3), 555-557 (1998)
   PUBMED   9784381
REFERENCE   8  (bases 1 to 4511)
  AUTHORS   Allen,P.B., Kwon,Y.G., Nairn,A.C. and Greengard,P.
  TITLE     Isolation and characterization of PNUTS, a putative protein
            phosphatase 1 nuclear targeting subunit
  JOURNAL   J Biol Chem 273 (7), 4089-4095 (1998)
   PUBMED   9461602
REFERENCE   9  (bases 1 to 4511)
  AUTHORS   Kreivi,J.P., Trinkle-Mulcahy,L., Lyon,C.E., Morrice,N.A., Cohen,P.
            and Lamond,A.I.
  TITLE     Purification and characterisation of p99, a nuclear modulator of
            protein phosphatase 1 activity
  JOURNAL   FEBS Lett 420 (1), 57-62 (1997)
   PUBMED   9450550
REFERENCE   10 (bases 1 to 4511)
  AUTHORS   Totaro,A., Rommens,J.M., Grifa,A., Lunardi,C., Carella,M.,
            Huizenga,J.J., Roetto,A., Camaschella,C., De Sandre,G. and
            Gasparini,P.
  TITLE     Hereditary hemochromatosis: generation of a transcription map
            within a refined and extended map of the HLA class I region
  JOURNAL   Genomics 31 (3), 319-326 (1996)
   PUBMED   8838313
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC150310.1 and AJ544537.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002714.3.
            
            Summary: This gene encodes a protein phosphatase 1 binding protein.
            The encoded protein plays a role in many cellular processes
            including cell cycle progression, DNA repair and apoptosis by
            regulating the activity of protein phosphatase 1. This gene lies
            within the major histocompatibility complex class I region on
            chromosome 6, and alternatively spliced transcript variants have
            been observed for this gene. [provided by RefSeq, Jul 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005690.1, AJ544537.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376511.7/ ENSP00000365694.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BC150310.1         65-67
            4-4511              AJ544537.1         1-4508
FEATURES             Location/Qualifiers
     source          1..4511
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..4511
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /note="protein phosphatase 1 regulatory subunit 10"
                     /db_xref="GeneID:5514"
                     /db_xref="HGNC:HGNC:9284"
                     /db_xref="MIM:603771"
     exon            1..20
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            21..541
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            542..659
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     CDS             553..3375
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /note="PP1-binding protein of 114 kDa; phosphatase 1
                     nuclear targeting subunit; MHC class I region proline-rich
                     protein CAT53; HLA-C associated transcript 53; protein
                     phosphatase 1, regulatory (inhibitor) subunit 10; testis
                     tissue sperm-binding protein Li 67n"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 1
                     regulatory subunit 10"
                     /protein_id="NP_002705.2"
                     /db_xref="CCDS:CCDS4681.1"
                     /db_xref="GeneID:5514"
                     /db_xref="HGNC:HGNC:9284"
                     /db_xref="MIM:603771"
                     /translation="MGSGPIDPKELLKGLDSFLNRDGEVKSVDGISKIFSLMKEARKM
                     VSRCTYLNILLQTRSPEILVKFIDVGGYKLLNNWLTYSKTTNNIPLLQQILLTLQHLP
                     LTVDHLKQNNTAKLVKQLSKSSEDEELRKLASVLVSDWMAVIRSQSSTQPAEKDKKKR
                     KDEGKSRTTLPERPLTEVKAETRAEEAPEKKREKPKSLRTTAPSHAKFRSTGLELETP
                     SLVPVKKNASTVVVSDKYNLKPIPLKRQSNVAAPGDATPPAEKKYKPLNTTPNATKEI
                     KVKIIPPQPMEGLGFLDALNSAPVPGIKIKKKKKVLSPTAAKPSPFEGKTSTEPSTAK
                     PSSPEPAPPSEAMDADRPGTPVPPVEVPELMDTASLEPGALDAKPVESPGDPNQLTRK
                     GRKRKSVTWPEEGKLREYFYFELDETERVNVNKIKDFGEAAKREILSDRHAFETARRL
                     SHDNMEEKVPWVCPRPLVLPSPLVTPGSNSQERYIQAEREKGILQELFLNKESPHEPD
                     PEPYEPIPPKLIPLDEECSMDETPYVETLEPGGSGGSPDGAGGSKLPPVLANLMGSMG
                     AGKGPQGPGGGGINVQEILTSIMGSPNSHPSEELLKQPDYSDKIKQMLVPHGLLGPGP
                     IANGFPPGGPGGPKGMQHFPPGPGGPMPGPHGGPGGPVGPRLLGPPPPPRGGDPFWDG
                     PGDPMRGGPMRGGPGPGPGPYHRGRGGRGGNEPPPPPPPFRGARGGRSGGGPPNGRGG
                     PGGGMVGGGGHRPHEGPGGGMGNSSGHRPHEGPGGGMGSGHRPHEGPGGSMGGGGGHR
                     PHEGPGGGISGGSGHRPHEGPGGGMGAGGGHRPHEGPGGSMGGSGGHRPHEGPGHGGP
                     HGHRPHDVPGHRGHDHRGPPPHEHRGHDGPGHGGGGHRGHDGGHSHGGDMSNRPVCRH
                     FMMKGNCRYENNCAFYHPGVNGPPLP"
     exon            660..746
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            747..882
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            883..934
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1012
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1186
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1292
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1405
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1506
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1654
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1813
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..2060
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2124
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2319
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2395
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2509
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..3265
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..4511
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4492..4497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /note="hexamer: AATAAA"
     polyA_site      4511
                     /gene="PPP1R10"
                     /gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
                     /note="major polyA site"
ORIGIN      
        1 attctggggt tcgtttagag gtttgaattt tctcggagaa agacaggccg gccacgagga
       61 aaacagaaac aagccgcagc aacatctaag cccttgaaag gatcctgaga gaggggggaa
      121 agggaaaaca gcagccacca gcccaaccac ttgtgtcttc tgccccttcc cacctatctt
      181 gcccacccca ccagcccacg ctgcttggga cttgaaatct gtggccgaag gaccgtcact
      241 acataacttc aaaaataatc aaccaccctc ccttcccaaa ccacccaaat tcactcatcc
      301 agcgtttact tttttgaatc cactcagaac ttttttctgc gacccccctc cctaaatgga
      361 gttgggtggg ggggaaatga atactgagtt ggcctttatt ttttaaaaga ctttttgatc
      421 caatgaggcc ccctaaataa ttgagttttg ggtcctggtt ggttgtttta ttttttttcc
      481 tccaaaattt taccccctcc cccctgagcc cgaggtgctg acgtcgcaaa aaaattggat
      541 aaaaccacca tcatgggttc gggtcccata gaccccaaag aacttctcaa gggcctggac
      601 agcttcctta accgagatgg ggaagtcaaa agtgtggatg ggatttccaa gatcttcagt
      661 ttgatgaagg aagcacgaaa gatggtgagt cgatgcactt acttgaacat tctcctgcag
      721 acccgttcac cagaaatatt ggtcaaattt attgacgttg gcggctacaa acttcttaac
      781 aattggctga cgtattcaaa gacaaccaac aacattcccc tcctccagca aattctactg
      841 accctgcagc atctaccgct cactgtagac catctcaagc agaacaacac agctaaactg
      901 gtgaagcagc tgagcaagtc aagtgaggat gaagagctcc ggaaattggc ctcagtcctt
      961 gtcagcgact ggatggctgt catccgctct cagagcagta cccagcctgc tgagaaagat
     1021 aagaagaaac gtaaagatga aggaaaaagt cgaactaccc ttcctgagcg acctttgaca
     1081 gaggtgaagg ctgagacccg ggctgaggag gccccagaga agaagaggga gaagcccaag
     1141 tctcttcgca ccacagcacc cagtcatgcc aagttccgtt ccactggact agagctggag
     1201 acaccatcct tggtgcctgt gaagaagaat gccagcacag tggtggtttc tgacaagtac
     1261 aaccttaaac ccatccccct caaacgtcag agcaacgtag ctgctccagg agatgccact
     1321 ccccctgcag agaagaaata caagccactc aacacaacac ctaatgccac caaagagatc
     1381 aaagtgaaga tcatcccgcc acagcctatg gagggcctgg gctttctgga tgctcttaat
     1441 tcagcccctg ttccaggcat caaaattaag aagaaaaaaa aagtactgtc acctacggct
     1501 gccaagccaa gcccctttga agggaaaacg agcacagaac caagcacagc caaaccttct
     1561 tccccagaac cagcaccacc ttctgaggca atggacgcag accgtccagg caccccggtt
     1621 ccccctgttg aagtcccgga gctcatggat acagcctctt tggagccagg agctctggat
     1681 gccaagccag tggagagtcc tggagatcct aaccaactga cccggaaagg caggaagagg
     1741 aaaagtgtga catggcctga ggaaggcaaa ctgagagaat atttctattt tgaattggat
     1801 gaaactgaac gagtaaatgt gaataagatc aaggactttg gtgaggcggc taagcgagag
     1861 atactgtcag accgacatgc atttgagaca gcgcggcgtc tgagccatga taacatggag
     1921 gagaaggtgc cctgggtgtg cccccggccc ctggttctgc cctcacctct tgtcacccct
     1981 ggaagcaata gtcaggagcg atatatccag gctgagcggg agaagggaat ccttcaggag
     2041 ctcttcctga acaaggagag tcctcatgag cctgatcctg agccctacga gcccataccc
     2101 cctaaactca tccccctaga tgaggagtgt tccatggatg agactccgta tgttgagact
     2161 ctggaacctg gggggtcagg tggctcacct gatggggcag gaggctccaa gttgcctcca
     2221 gttctggcca atcttatggg aagcatgggt gctggaaagg gcccccaagg ccctggagga
     2281 ggaggcatta atgtccaaga gatcctcacc tccatcatgg gtagcccaaa cagtcatcct
     2341 tcagaggaac tactgaaaca accagactat tcggacaaga tcaagcagat gctggtgcca
     2401 catggactcc taggccctgg cccaatagcc aatggtttcc caccaggggg tcctgggggc
     2461 cccaagggca tgcagcactt tccccctgga cctgggggac ctatgccagg tccccatgga
     2521 ggccctggtg ggccagtggg tccacgtctt ctgggtcctc caccccctcc ccggggaggt
     2581 gatcccttct gggatggccc gggcgaccct atgcggggtg gcccaatgcg ggggggtcca
     2641 ggaccaggtc ctggaccata ccatagaggc cgaggtggcc gaggaggaaa cgaacctcct
     2701 cctcctcctc ctccattccg aggcgccaga ggaggtcgct ctggaggagg acccccaaat
     2761 ggacgagggg gccctggtgg gggcatggtt ggaggtggtg ggcatcgtcc tcacgaaggc
     2821 cctggtgggg gcatgggcaa cagcagtgga catcgtcccc acgaaggccc tggcggtggc
     2881 atgggaagtg ggcatcgccc ccatgaaggc cctggtggta gcatgggtgg gggtggagga
     2941 catcgtcccc acgaaggccc tggcggtggc atcagtggtg gcagtggcca tcgtccccat
     3001 gaaggccctg gcggaggaat gggtgccggt ggtggacatc gcccccacga aggccctggc
     3061 ggaagcatgg gtggaagtgg tggacatcgt ccccatgaag gccctggaca cggggggccc
     3121 catggccacc ggcctcatga tgtccctggt caccgaggcc atgaccatcg agggccgcca
     3181 cctcatgagc accgtggcca tgatggtcct ggccacgggg gagggggcca ccgagggcac
     3241 gatggaggcc acagccatgg aggagacatg tcaaaccgcc ctgtctgccg acatttcatg
     3301 atgaagggca actgccgcta tgagaacaac tgtgccttct accacccggg tgtcaatggg
     3361 ccccccctgc cctagggacc atttgcctgc cctgttcaca caacccctgt ggactgcagc
     3421 ctcgctcttt ccaccctgtt atggcttctg tgaggcccat tttccctttt ccccagctga
     3481 tgaggagccg gccccctcag ttcccacttg cttgggttcc tgggggtttt ctgatcactg
     3541 gtgcgcattg atgtacatat tttcctccag tctggggagg agagagactg gaaacgttcc
     3601 tggactgctg aagaggagac ccagttggct tcactttttg agaagattcg ccctgtaccc
     3661 caaacccctt tccagtatta cccttaatgc ttgagaacct aaagctggtt atcctggcga
     3721 acacccctac ccttctattg cgggtcccca catgcacaca gaactctgac acaggatcag
     3781 ctgcacttaa gaaatcatcc cagctaagtt cattattcct catggggtgg ggagatgctg
     3841 aaaggggtat tgtatatccc actgcactga gagggctcaa tcagctggat ttgagttctg
     3901 gaacacacat catccccacc cctcccccag cgtgggctca ccattcttag tcctttctca
     3961 agtgggacct tcaactttct gtgaacaccc agtctgcgtc ctgggtctgc taggttcgat
     4021 gatggcgaac tcgtatctgc atccggtgca agttttagct ggcagaggtg agaccggtgg
     4081 tgctggtctg cctttgccaa ctatagccag tctggagact tgataaaata cttcagtgag
     4141 accagcttct catcaacttg ggcccggcgt gctgggcctg aaagtcacac tacatgcact
     4201 gcctttggga gtcagctcac tccctgctcc cacctggaac cttgccagcg tgaaggaggc
     4261 ttccaggtac ttcaccctgt caaccacctc tgaatcccca ccaggcgcct tcctgggtgg
     4321 attcaacaag atgattttgc cctttcccag ttctctcctt cactttggca tcagttgttt
     4381 tctatgaaaa cagtggattg gttgggtttt gtgcagggtc ttgggttaga gccaaaatgg
     4441 atttgaggat gagtattttt ttttttggtt ttgtatattt tgtacattaa taataaacag
     4501 tggaaagaga a
//
