LOCUS       NM_002710               2552 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens protein phosphatase 1 catalytic subunit gamma
            (PPP1CC), transcript variant 1, mRNA.
ACCESSION   NM_002710
VERSION     NM_002710.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2552)
  AUTHORS   Feng,P., Wang,Y., Liu,N., Chen,Y., Hu,Y., Huang,Z., Liu,Y.,
            Zheng,S., Jiang,T., Xiao,X., Dai,W., Huang,P. and Xia,Y.
  TITLE     High expression of PPP1CC promotes NHEJ-mediated DNA repair leading
            to radioresistance and poor prognosis in nasopharyngeal carcinoma
  JOURNAL   Cell Death Differ 31 (5), 683-696 (2024)
   PUBMED   38589496
  REMARK    GeneRIF: High expression of PPP1CC promotes NHEJ-mediated DNA
            repair leading to radioresistance and poor prognosis in
            nasopharyngeal carcinoma.
REFERENCE   2  (bases 1 to 2552)
  AUTHORS   Fonodi,M., Thalwieser,Z., Csortos,C. and Boratko,A.
  TITLE     TIMAP, a Regulatory Subunit of Protein Phosphatase 1, Inhibits In
            Vitro Neuronal Differentiation
  JOURNAL   Int J Mol Sci 24 (24), 17360 (2023)
   PUBMED   38139189
  REMARK    GeneRIF: TIMAP, a Regulatory Subunit of Protein Phosphatase 1,
            Inhibits In Vitro Neuronal Differentiation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2552)
  AUTHORS   Yadav,Y., Sharma,M. and Dey,C.S.
  TITLE     PP1gamma regulates neuronal insulin signaling and aggravates
            insulin resistance leading to AD-like phenotypes
  JOURNAL   Cell Commun Signal 21 (1), 82 (2023)
   PUBMED   37085815
  REMARK    GeneRIF: PP1gamma regulates neuronal insulin signaling and
            aggravates insulin resistance leading to AD-like phenotypes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2552)
  AUTHORS   Bonsor,D.A., Alexander,P., Snead,K., Hartig,N., Drew,M.,
            Messing,S., Finci,L.I., Nissley,D.V., McCormick,F., Esposito,D.,
            Rodriguez-Viciana,P., Stephen,A.G. and Simanshu,D.K.
  TITLE     Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF
            activation and Noonan syndrome
  JOURNAL   Nat Struct Mol Biol 29 (10), 966-977 (2022)
   PUBMED   36175670
  REMARK    GeneRIF: Structure of the SHOC2-MRAS-PP1C complex provides insights
            into RAF activation and Noonan syndrome.
REFERENCE   5  (bases 1 to 2552)
  AUTHORS   Kwon,J.J., Hajian,B., Bian,Y., Young,L.C., Amor,A.J., Fuller,J.R.,
            Fraley,C.V., Sykes,A.M., So,J., Pan,J., Baker,L., Lee,S.J.,
            Wheeler,D.B., Mayhew,D.L., Persky,N.S., Yang,X., Root,D.E.,
            Barsotti,A.M., Stamford,A.W., Perry,C.K., Burgin,A., McCormick,F.,
            Lemke,C.T., Hahn,W.C. and Aguirre,A.J.
  TITLE     Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase
            complex
  JOURNAL   Nature 609 (7926), 408-415 (2022)
   PUBMED   35831509
  REMARK    GeneRIF: Structure-function analysis of the SHOC2-MRAS-PP1C
            holophosphatase complex.
REFERENCE   6  (bases 1 to 2552)
  AUTHORS   Egloff,M.P., Cohen,P.T., Reinemer,P. and Barford,D.
  TITLE     Crystal structure of the catalytic subunit of human protein
            phosphatase 1 and its complex with tungstate
  JOURNAL   J Mol Biol 254 (5), 942-959 (1995)
   PUBMED   7500362
REFERENCE   7  (bases 1 to 2552)
  AUTHORS   Van Eynde,A., Wera,S., Beullens,M., Torrekens,S., Van Leuven,F.,
            Stalmans,W. and Bollen,M.
  TITLE     Molecular cloning of NIPP-1, a nuclear inhibitor of protein
            phosphatase-1, reveals homology with polypeptides involved in RNA
            processing
  JOURNAL   J Biol Chem 270 (47), 28068-28074 (1995)
   PUBMED   7499293
REFERENCE   8  (bases 1 to 2552)
  AUTHORS   MacKintosh,R.W., Dalby,K.N., Campbell,D.G., Cohen,P.T., Cohen,P.
            and MacKintosh,C.
  TITLE     The cyanobacterial toxin microcystin binds covalently to
            cysteine-273 on protein phosphatase 1
  JOURNAL   FEBS Lett 371 (3), 236-240 (1995)
   PUBMED   7556599
REFERENCE   9  (bases 1 to 2552)
  AUTHORS   Norman,S.A. and Mott,D.M.
  TITLE     Molecular cloning and chromosomal localization of a human skeletal
            muscle PP-1 gamma 1 cDNA
  JOURNAL   Mamm Genome 5 (1), 41-45 (1994)
   PUBMED   8111128
REFERENCE   10 (bases 1 to 2552)
  AUTHORS   Barker,H.M., Craig,S.P., Spurr,N.K. and Cohen,P.T.
  TITLE     Sequence of human protein serine/threonine phosphatase 1 gamma and
            localization of the gene (PPP1CC) encoding it to chromosome bands
            12q24.1-q24.2
  JOURNAL   Biochim Biophys Acta 1178 (2), 228-233 (1993)
   PUBMED   8394140
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA514523.1, BC014073.2,
            X74008.1, AW575661.1 and AC144522.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002710.3.
            
            Summary: The protein encoded by this gene belongs to the protein
            phosphatase family, PP1 subfamily. PP1 is an ubiquitous
            serine/threonine phosphatase that regulates many cellular
            processes, including cell division. It is expressed in mammalian
            cells as three closely related isoforms, alpha, beta/delta and
            gamma, which have distinct localization patterns. This gene encodes
            the gamma isozyme. Alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.115674.1,
                                           SRR1803616.104681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150385, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335007.10/ ENSP00000335084.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DA514523.1         89-108
            21-1181             BC014073.2         1-1161
            1182-2011           X74008.1           1152-1981
            2012-2424           AW575661.1         16-428              c
            2425-2552           AC144522.12        105878-106005       c
FEATURES             Location/Qualifiers
     source          1..2552
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..2552
                     /gene="PPP1CC"
                     /gene_synonym="PP-1G; PP1C; PPP1G"
                     /note="protein phosphatase 1 catalytic subunit gamma"
                     /db_xref="GeneID:5501"
                     /db_xref="HGNC:HGNC:9283"
                     /db_xref="MIM:176914"
     exon            1..239
                     /gene="PPP1CC"
                     /gene_synonym="PP-1G; PP1C; PPP1G"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1156
                     /gene="PPP1CC"
                     /gene_synonym="PP-1G; PP1C; PPP1G"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein phosphatase PP1-gamma catalytic
                     subunit; serine/threonine phosphatase 1 gamma; protein
                     phosphatase 1C catalytic subunit; protein phosphatase 1,
                     catalytic subunit, gamma isozyme"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase PP1-gamma
                     catalytic subunit isoform 1"
                     /protein_id="NP_002701.1"
                     /db_xref="CCDS:CCDS9150.1"
                     /db_xref="GeneID:5501"
                     /db_xref="HGNC:HGNC:9283"
                     /db_xref="MIM:176914"
                     /translation="MADLDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSRE
                     IFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLE
                     TICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLP
                     IAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGE
                     NDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEF
                     DNAGAMMSVDETLMCSFQILKPAEKKKPNATRPVTPPRGMITKQAKK"
     exon            240..371
                     /gene="PPP1CC"
                     /gene_synonym="PP-1G; PP1C; PPP1G"
                     /inference="alignment:Splign:2.1.0"
     exon            372..602
                     /gene="PPP1CC"
                     /gene_synonym="PP-1G; PP1C; PPP1G"
                     /inference="alignment:Splign:2.1.0"
     exon            603..707
                     /gene="PPP1CC"
                     /gene_synonym="PP-1G; PP1C; PPP1G"
                     /inference="alignment:Splign:2.1.0"
     exon            708..931
                     /gene="PPP1CC"
                     /gene_synonym="PP-1G; PP1C; PPP1G"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1066
                     /gene="PPP1CC"
                     /gene_synonym="PP-1G; PP1C; PPP1G"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..2552
                     /gene="PPP1CC"
                     /gene_synonym="PP-1G; PP1C; PPP1G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2306..2311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1CC"
                     /gene_synonym="PP-1G; PP1C; PPP1G"
                     /note="hexamer: ATTAAA"
     polyA_site      2327
                     /gene="PPP1CC"
                     /gene_synonym="PP-1G; PP1C; PPP1G"
                     /note="major polyA site"
     regulatory      2401..2406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1CC"
                     /gene_synonym="PP-1G; PP1C; PPP1G"
                     /note="hexamer: AATAAA"
     polyA_site      2421
                     /gene="PPP1CC"
                     /gene_synonym="PP-1G; PP1C; PPP1G"
                     /note="major polyA site"
     regulatory      2480..2485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1CC"
                     /gene_synonym="PP-1G; PP1C; PPP1G"
                     /note="hexamer: AATACA"
     polyA_site      2510
                     /gene="PPP1CC"
                     /gene_synonym="PP-1G; PP1C; PPP1G"
ORIGIN      
        1 cttctcgtgg ttccagtggg gagagaagga ggaagtaggg agcggggtgg cagggggggg
       61 acccgccgcg gctgctgcca ccgccgccac caccgcctct gctcgtggcg tgggaaagga
      121 ggtgtgagtc ccgggcgcga gccggcggcg gcgccgctgc gggagggtcg gcggtgggaa
      181 ggcgatggcg gatttagata aactcaacat cgacagcatt atccaacggc tgctggaagt
      241 gagagggtcc aagcctggta agaatgtcca gcttcaggag aatgaaatca gaggactgtg
      301 cttaaagtct cgtgaaatct ttctcagtca gcctatccta ctagaacttg aagcaccact
      361 caaaatatgt ggtgacatcc atggacaata ctatgatttg ctgcgacttt ttgagtacgg
      421 tggtttccca ccagaaagca actacctgtt tcttggggac tatgtggaca ggggaaagca
      481 gtcattggag acgatctgcc tcttactggc ctacaaaata aaatatcctg agaatttttt
      541 tcttctcaga gggaaccatg aatgtgccag catcaacaga atttatggat tttatgatga
      601 atgtaaaaga agatacaaca ttaaactatg gaaaactttc acagactgtt ttaactgttt
      661 accgatagca gccatcgtgg atgagaagat attctgctgt catggaggtt tatcaccaga
      721 tcttcaatct atggagcaga ttcggcgaat tatgcgacca actgatgtac cagatcaagg
      781 tcttctttgt gatcttttgt ggtctgaccc cgataaagat gtcttaggct ggggtgaaaa
      841 tgacagagga gtgtccttca catttggtgc agaagtggtt gcaaaatttc tccataagca
      901 tgatttggat cttatatgta gagcccatca ggtggttgaa gatggatatg aattttttgc
      961 aaagaggcag ttggtcactc tgttttctgc gcccaattat tgcggagagt ttgacaatgc
     1021 aggtgccatg atgagtgtgg atgaaacact aatgtgttct tttcagattt taaagcctgc
     1081 agagaaaaag aagccaaatg ccacgagacc tgtaacgcct ccaaggggta tgatcacaaa
     1141 gcaagcaaag aaatagatgt cgttttgaca ctgcctagtc gggacttgta acatagagta
     1201 tataaccttc atttttaaga ctgtaatgtg tactggtcag cttgctcaga tagatctgtg
     1261 tttgtggggg cccttccttc catttttgat ttagtgaatg gcatttgctg gttataacag
     1321 caaatgaaag actcttcact ccaaaaagaa aagtgttttg ttttttaatt ctctgttcct
     1381 tttgcaaaca attttaatga tggtgttaaa gctgtacacc ccaggacagt ttatcctgtc
     1441 tgaggagtaa gtgtacaatt gatctttttt aattcagtac aacccataat catgtaaatg
     1501 ctcattttct ttaggacata aagagagccc tagggtgctc tgaatctgta catgttcttg
     1561 tcataaaatg catactgttg atacaaacca ctgtgaacat tttttatttg agaattttgt
     1621 ttcaaaggga ttgctttttc ctctcattgt cttgttatgt acaaactagt ttttatagct
     1681 atcaacatta ggagtaactt tcaaccttgc cagcatcact ggtatgatgt atatttaatt
     1741 aaagcacact tttccccgac cgtatactta aaatgacaaa gccattcttt taaatatttg
     1801 tgactctttc ctaaagccaa agtttctgtt gaattatgtt ttgacacacc cctaagtaca
     1861 aggtggtatg gttgtataca catgctgcct tcttggggat tcaaaaacag gtttttgatt
     1921 ttgaatagca attagtgata tagtgctgtt taagctacta acgataaaag gtaataacat
     1981 tttatacaat ttccatatag tctattcatt aagtaatctt tttacagttg catcaggcct
     2041 gaacccgtcc attcagaaag cttcaaatta tagaaacaat actgttctat acgagtgacc
     2101 gattatgctt tctttggcct acattcttta ttctgcggtg aagttgaggc ttataagtta
     2161 aaacaaagga actaacttac tgtccaccag tttatacaga actcacagta cctatgactt
     2221 ttttaaacta agatctgtta aaaaagaaat ctgtttcaac agatgaccgt gtacaatacc
     2281 gtgtggtgaa aatgaattca gacttattaa atgatgaact tgttaaatct tctcagtgtc
     2341 tatttatcag cacaatacac acaggagaac tgttgatggc atattgaata gattttcctg
     2401 aataaattgc tctggaaacc acacggttgc attttggttt tgcttctttc aaatagtctg
     2461 ttttccaaag atggattata atacagatac taatactctt tgagttgtaa cctggagaca
     2521 tctatttgtg taatagagtg atgaggtgga ac
//
