LOCUS       NM_002709               4916 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens protein phosphatase 1 catalytic subunit beta (PPP1CB),
            transcript variant 1, mRNA.
ACCESSION   NM_002709
VERSION     NM_002709.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4916)
  AUTHORS   Zhou,Y., Peng,X., Fang,C., Peng,X., Tang,J., Wang,Z., Long,Y.,
            Chen,J., Peng,Y., Zhang,Z., Zhou,Y., Tang,J., Liao,J., Xiao,D.,
            Tao,Y., Shi,Y. and Liu,S.
  TITLE     Histones Methyltransferase NSD3 Inhibits Lung Adenocarcinoma
            Glycolysis Through Interacting with PPP1CB to Decrease STAT3
            Signaling Pathway
  JOURNAL   Adv Sci (Weinh) 11 (38), e2400381 (2024)
   PUBMED   39119928
  REMARK    GeneRIF: Histones Methyltransferase NSD3 Inhibits Lung
            Adenocarcinoma Glycolysis Through Interacting with PPP1CB to
            Decrease STAT3 Signaling Pathway.
REFERENCE   2  (bases 1 to 4916)
  AUTHORS   Bonsor,D.A., Alexander,P., Snead,K., Hartig,N., Drew,M.,
            Messing,S., Finci,L.I., Nissley,D.V., McCormick,F., Esposito,D.,
            Rodriguez-Viciana,P., Stephen,A.G. and Simanshu,D.K.
  TITLE     Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF
            activation and Noonan syndrome
  JOURNAL   Nat Struct Mol Biol 29 (10), 966-977 (2022)
   PUBMED   36175670
REFERENCE   3  (bases 1 to 4916)
  AUTHORS   Kwon,J.J., Hajian,B., Bian,Y., Young,L.C., Amor,A.J., Fuller,J.R.,
            Fraley,C.V., Sykes,A.M., So,J., Pan,J., Baker,L., Lee,S.J.,
            Wheeler,D.B., Mayhew,D.L., Persky,N.S., Yang,X., Root,D.E.,
            Barsotti,A.M., Stamford,A.W., Perry,C.K., Burgin,A., McCormick,F.,
            Lemke,C.T., Hahn,W.C. and Aguirre,A.J.
  TITLE     Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase
            complex
  JOURNAL   Nature 609 (7926), 408-415 (2022)
   PUBMED   35831509
REFERENCE   4  (bases 1 to 4916)
  AUTHORS   Liau,N.P.D., Johnson,M.C., Izadi,S., Gerosa,L., Hammel,M.,
            Bruning,J.M., Wendorff,T.J., Phung,W., Hymowitz,S.G. and
            Sudhamsu,J.
  TITLE     Structural basis for SHOC2 modulation of RAS signalling
  JOURNAL   Nature 609 (7926), 400-407 (2022)
   PUBMED   35768504
REFERENCE   5  (bases 1 to 4916)
  AUTHORS   Wang,L., Zhang,L., Gong,X.D., Fu,J.L., Gan,Y.W., Hou,M., Nie,Q.,
            Xiang,J.W., Xiao,Y., Wang,Y., Zheng,S.Y., Yang,L., Chen,H.,
            Xiang,M.Q., Liu,Y. and Li,D.W.
  TITLE     PP-1beta and PP-2Aalpha modulate cAMP response element-binding
            protein (CREB) functions in aging control and stress response
            through de-regulation of alphaB-crystallin gene and p300-p53
            signaling axis
  JOURNAL   Aging Cell 20 (9), e13458 (2021)
   PUBMED   34425033
  REMARK    GeneRIF: PP-1beta and PP-2Aalpha modulate cAMP response
            element-binding protein (CREB) functions in aging control and
            stress response through de-regulation of alphaB-crystallin gene and
            p300-p53 signaling axis.
REFERENCE   6  (bases 1 to 4916)
  AUTHORS   Fujioka,M., Takahashi,N., Odai,H., Araki,S., Ichikawa,K., Feng,J.,
            Nakamura,M., Kaibuchi,K., Hartshorne,D.J., Nakano,T. and Ito,M.
  TITLE     A new isoform of human myosin phosphatase targeting/regulatory
            subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal
            mapping
  JOURNAL   Genomics 49 (1), 59-68 (1998)
   PUBMED   9570949
REFERENCE   7  (bases 1 to 4916)
  AUTHORS   Kawabe,T., Muslin,A.J. and Korsmeyer,S.J.
  TITLE     HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts
            a G2/M cell-cycle checkpoint
  JOURNAL   Nature 385 (6615), 454-458 (1997)
   PUBMED   9009195
REFERENCE   8  (bases 1 to 4916)
  AUTHORS   Prochazka,M., Mochizuki,H., Baier,L.J., Cohen,P.T. and Bogardus,C.
  TITLE     Molecular and linkage analysis of type-1 protein phosphatase
            catalytic beta-subunit gene: lack of evidence for its major role in
            insulin resistance in Pima Indians
  JOURNAL   Diabetologia 38 (4), 461-466 (1995)
   PUBMED   7796987
REFERENCE   9  (bases 1 to 4916)
  AUTHORS   Saadat,M., Kakinoki,Y., Mizuno,Y., Kikuchi,K. and Yoshida,M.C.
  TITLE     Chromosomal localization of human, rat, and mouse protein
            phosphatase type 1 beta catalytic subunit genes (PPP1CB) by
            fluorescence in situ hybridization
  JOURNAL   Jpn J Genet 69 (6), 697-700 (1994)
   PUBMED   7857673
REFERENCE   10 (bases 1 to 4916)
  AUTHORS   Barker,H.M., Brewis,N.D., Street,A.J., Spurr,N.K. and Cohen,P.T.
  TITLE     Three genes for protein phosphatase 1 map to different human
            chromosomes: sequence, expression and gene localisation of protein
            serine/threonine phosphatase 1 beta (PPP1CB)
  JOURNAL   Biochim Biophys Acta 1220 (2), 212-218 (1994)
   PUBMED   8312365
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX477003.1, BC002697.2,
            X80910.1, BX647295.1, BM835970.1, CD722576.1 and BE047402.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002709.2.
            
            Summary: The protein encoded by this gene is one of the three
            catalytic subunits of protein phosphatase 1 (PP1). PP1 is a
            serine/threonine specific protein phosphatase known to be involved
            in the regulation of a variety of cellular processes, such as cell
            division, glycogen metabolism, muscle contractility, protein
            synthesis, and HIV-1 viral transcription. Mouse studies suggest
            that PP1 functions as a suppressor of learning and memory. Two
            alternatively spliced transcript variants encoding distinct
            isoforms have been observed. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. It encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.191333.1,
                                           SRR1660809.235384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395366.3/ ENSP00000378769.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               BX477003.1         15-228
            215-495             BC002697.2         1-281
            496-3408            X80910.1           459-3371
            3409-3632           BX647295.1         2670-2893
            3633-3929           BM835970.1         111-407
            3930-4488           CD722576.1         47-605
            4489-4916           BE047402.1         6-433               c
FEATURES             Location/Qualifiers
     source          1..4916
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.2"
     gene            1..4916
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
                     /note="protein phosphatase 1 catalytic subunit beta"
                     /db_xref="GeneID:5500"
                     /db_xref="HGNC:HGNC:9282"
                     /db_xref="MIM:600590"
     exon            1..347
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1279
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.53"
                     /note="isoform 1 is encoded by transcript variant 1;
                     epididymis secretory sperm binding protein Li 80p; protein
                     phosphatase 1-delta; protein phosphatase 1-beta;
                     serine/threonine-protein phosphatase PP1-beta catalytic
                     subunit; protein phosphatase 1, catalytic subunit, beta
                     isozyme; myosin phosphatase"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase PP1-beta
                     catalytic subunit isoform 1"
                     /protein_id="NP_002700.1"
                     /db_xref="CCDS:CCDS33169.1"
                     /db_xref="GeneID:5500"
                     /db_xref="HGNC:HGNC:9282"
                     /db_xref="MIM:600590"
                     /translation="MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREI
                     FLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLET
                     ICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPI
                     AAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGEN
                     DRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFD
                     NAGGMMSVDETLMCSFQILKPSEKKAKYQYGGLNSGRPVTPPRTANPPKKR"
     exon            348..479
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
                     /inference="alignment:Splign:2.1.0"
     exon            480..710
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
                     /inference="alignment:Splign:2.1.0"
     exon            711..815
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
                     /inference="alignment:Splign:2.1.0"
     exon            816..887
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1039
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1174
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..4916
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2994..2999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
                     /note="hexamer: AGTAAA"
     polyA_site      3013
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
                     /note="major polyA site"
     regulatory      3603..3608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
                     /note="hexamer: AATAAA"
     polyA_site      3632
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
     regulatory      4751..4756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
                     /note="hexamer: AATAAA"
     polyA_site      4780
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
     regulatory      4891..4896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
                     /note="hexamer: ATTAAA"
     polyA_site      4916
                     /gene="PPP1CB"
                     /gene_synonym="HEL-S-80p; MP; NSLH2; PP-1B; PP1B; PP1beta;
                     PP1c; PPP1beta; PPP1CD"
ORIGIN      
        1 gcggagctgg gcggtgccga ggaggaggag gtggcggcct gggtctgacg cggccctgtt
       61 cgagggggcc tctcttgttt atttatttat tttccgtggg tgcctccgag tgtgcgcgcg
      121 ctctcgctac ccggcgggga gggggtgggg ggagggcccg ggaaaagggg gagttggagc
      181 cggggtcgaa acgccgcgtg acttgtaggt gagagaacgc cgagccgtcg ccgcagcctc
      241 cgccgccgag aagcccttgt tcccgctgct gggaaggaga gtctgtgccg acaagatggc
      301 ggacggggag ctgaacgtgg acagcctcat cacccggctg ctggaggtac gaggatgtcg
      361 tccaggaaag attgtgcaga tgactgaagc agaagttcga ggcttatgta tcaagtctcg
      421 ggagatcttt ctcagccagc ctattctttt ggaattggaa gcaccgctga aaatttgtgg
      481 agatattcat ggacaatata cagatttact gagattattt gaatatggag gtttcccacc
      541 agaagccaac tatcttttct taggagatta tgtggacaga ggaaagcagt ctttggaaac
      601 catttgtttg ctattggctt ataaaatcaa atatccagag aacttctttc tcttaagagg
      661 aaaccatgag tgtgctagca tcaatcgcat ttatggattc tatgatgaat gcaaacgaag
      721 atttaatatt aaattgtgga agaccttcac tgattgtttt aactgtctgc ctatagcagc
      781 cattgtggat gagaagatct tctgttgtca tggaggattg tcaccagacc tgcaatctat
      841 ggagcagatt cggagaatta tgagacctac tgatgtccct gatacaggtt tgctctgtga
      901 tttgctatgg tctgatccag ataaggatgt gcaaggctgg ggagaaaatg atcgtggtgt
      961 ttcctttact tttggagctg atgtagtcag taaatttctg aatcgtcatg atttagattt
     1021 gatttgtcga gctcatcagg tggtggaaga tggatatgaa ttttttgcta aacgacagtt
     1081 ggtaacctta ttttcagccc caaattactg tggcgagttt gataatgctg gtggaatgat
     1141 gagtgtggat gaaactttga tgtgttcatt tcagatattg aaaccatctg aaaagaaagc
     1201 taaataccag tatggtggac tgaattctgg acgtcctgtc actccacctc gaacagctaa
     1261 tccgccgaag aaaaggtgaa gaaaggaatt ctgtaaagaa accatcagat ttgttaagga
     1321 catacttcat aatatataag tgtgcactgt aaaaccatcc agccatttga caccctttat
     1381 gatgtcacac ctttaactta aggagacggg taaaggatct taaatttttt tctaatagaa
     1441 agatgtgcta cactgtattg taataagtat actctgttat agtcaacaaa gttaaatcca
     1501 aattcaaaat tatccattaa agttacatct tcatgtatca caatttttaa agttgaaaag
     1561 catcccagtt aaactagatg tgatagttaa accagatgaa agcatgatga tccatctgtg
     1621 taatgtggtt ttagtgttgc ttggttgttt aattattttg agcttgtttt gtttttgttt
     1681 gttttcacta gaataatggc aaatacttct aatttttttc cctaaacatt tttaaaagtg
     1741 aaatatggga agagctttac agacattcac caactattat tttcccttgt ttatctactt
     1801 agatatctgt ttaatcttac taagaaaact ttcgcctcat tacattaaaa aggaatttta
     1861 gagattgatt gttttaaaaa aaaatacgca cattgtccaa tccagtgatt ttaatcatac
     1921 agtttgactg ggcaaacttt acagctgata gtgaatattt tgctttatac aggaattgac
     1981 actgatttgg atttgtgcac tctaattttt aacttattga tgctctattg tgcagtagca
     2041 tttcatttaa gataaggctc atatagtatt acccaactag ttggtaatgt gattatgtgg
     2101 taccttggct ttaggttttc attcgcacgg aacacctttt ggcatgctta acttcctggt
     2161 aacaccttca cctgcattgg ttttcttttt cttttttctt tctttttttt tttttttttt
     2221 tttttgagtt gttgtttgtt tttagatcca cagtacatga gaatcctttt ttgacaagcc
     2281 ttggaaagct gacactgtct ctttttcctc cctctatacg aaggatgtat ttaaatgaat
     2341 gctggtcagt gggacatttt gtcaactatg ggtattgggt gcttaactgt ctaatattgc
     2401 catgtgaatg ttgtatacga ttgtaaggct tatgtcacta aagattttta ttctgatttt
     2461 ttcataatca aaggtcatat gatactgtat agacaagctt tgtagtgaag tatagtagca
     2521 ataatttctg tacctgatca agtttattgc agcctttctt ttcctatttc ttttttttaa
     2581 gggttagtat taacaaatgg caatgagtag aaaagttaac atgaagattt tagaaggaga
     2641 gaacttacag gacacagatt tgtgattctt tgactgtgac actattggat gtgattctaa
     2701 aagcttttat tgagcattgt caaatttgta agcttcatag ggatggacat catatctata
     2761 atgcccttct atatgtgcta ccatagatgt gacatttttg accttaatat cgtctttgaa
     2821 aatgttaaat tgagaaacct gttaacttac attttatgaa ttggcacatt gtattactta
     2881 ctgcaagaga tatttcattt tcagcacagt gcaaaagttc tttaaaatgc atatgtcttt
     2941 ttttctaatt ccgttttgtt ttaaagcaca ttttaaatgt agttttctca tttagtaaaa
     3001 gttgtctaat tgatatgaag cctgactgat tttttttttc cttacagtga gacatttaag
     3061 cacacatttt attcacatag atactatgtc cttgacatat tgaaatgatt cttttctgaa
     3121 agtattcatg atctgcatat gatgtattag gttaggtcac aaaggtttta tctgaggtga
     3181 tttaaataac ttcctgattg gagtgtgtaa gctgagcgat ttctaataaa attttagttg
     3241 tacactttta gtagtcatag tgaagcaggt ctagaaaata agcctttggc agggaaaaag
     3301 ggcaatgttg attaatctca gtattaaacc acattaatct gtatcccatt gtctggcttt
     3361 tgtaaattca tccaggtcaa gactaagtat gttggttaat aggaatcctt tttttttttt
     3421 ttaaagacta aatgtgaaaa aataatcact acttaagcta attaatattg gtcattaaat
     3481 ttaaaggatg gaaatttatc atgtttaaaa attattcaag cactcttaaa accacttaaa
     3541 cagcctccag tcataaaaat gtgttcttta caaatatttg cttggcaaca cgacttgaaa
     3601 taaataaaac tttgtttctt aggagaaaat gattctgtaa ttccagtgtc actaatttat
     3661 attgttcttt cctctgattt ttttcaggtt agtgattttt ttgtatacaa tttaatccaa
     3721 atgttatgac attcagaaat catgaaacac agtagatatc tgttataatg tggtgtatca
     3781 catggattat aaagcaaagt tatggtcgat ttctattctt gaaagaatca actacagtga
     3841 atcctttgca tttgaagcct taacatgcat tgctttaatt ttgcccaggg acaaatttta
     3901 ataatcagca agactggttt gtgcaaagcg ttgagtcatc aggtatttag agcctagcca
     3961 gctacccagt atccatgctg ccatatccct tcattgtaaa aagtacctaa acattcgtga
     4021 aatgattttt tttagctgaa aaatgctggc aagaagaatt ttaaagctta aaataggtgg
     4081 taaatttgaa gtatgagtgt gttcacgaga aacataggct tttcaaaaaa atttttattc
     4141 aaggcaaagc aaggaacatc ttgagatatg tctcaagaat ataaagatgt attattttaa
     4201 gccaaggagc tgaaatatat ctcagtttat aaattcaggt atattctttt tgtctccatg
     4261 gcaaccataa cttttgaacc aaaaaaaatt gtttttacat ctttatgctg aaaatgtgtt
     4321 tagattagga atatggtcgg gctgaatttg ctgttgctcc ctaaccaaat ccacctcttg
     4381 ttttccttgt gagtccatgg ctaaatcaaa gctgcccctg agaagagact taatccaagc
     4441 ctgattgtac tagtggcatc acttagaagt aggctttccc tcttcctagt agatctcaat
     4501 gttttataat tccttaaaac agctgaaaat tgggacaaca tactttacgc aatgaacagt
     4561 agttaaatag gaaataaact agttccatat aagtatacac ctagagtttt aattaccttt
     4621 ataatgtttc ttaaaagtga aacttagata caattgtgat tggatactta gatactaagt
     4681 gaaacttagt gtaacaattt tgatctgtta aattggattt tacatgtaca tttgaatgcc
     4741 agaatttcta aataaatccc ctggttagga aattttaaaa gtcaaagctt gttttcttca
     4801 accactacct tctacattgg ttgacttaga ccgtaagctt tttaagtttc tcattgtaat
     4861 ttaccttctc atgcagattg ctgatgtttt attaaacctt atttttacaa aaatga
//
