LOCUS       NM_002708               1421 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens protein phosphatase 1 catalytic subunit alpha
            (PPP1CA), transcript variant 1, mRNA.
ACCESSION   NM_002708
VERSION     NM_002708.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1421)
  AUTHORS   Chen,Z., Li,Y., He,K., Yang,J., Deng,Q., Chen,Y. and Fu,Z.
  TITLE     CircGPRC5A enhances colorectal cancer progress by stabilizing
            PPP1CA and inducing YAP dephosphorylation
  JOURNAL   J Exp Clin Cancer Res 42 (1), 334 (2023)
   PUBMED   38057879
  REMARK    GeneRIF: CircGPRC5A enhances colorectal cancer progress by
            stabilizing PPP1CA and inducing YAP dephosphorylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1421)
  AUTHORS   Mihalic,F., Simonetti,L., Giudice,G., Sander,M.R., Lindqvist,R.,
            Peters,M.B.A., Benz,C., Kassa,E., Badgujar,D., Inturi,R., Ali,M.,
            Krystkowiak,I., Sayadi,A., Andersson,E., Aronsson,H., Soderberg,O.,
            Dobritzsch,D., Petsalaki,E., Overby,A.K., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Large-scale phage-based screening reveals extensive pan-viral
            mimicry of host short linear motifs
  JOURNAL   Nat Commun 14 (1), 2409 (2023)
   PUBMED   37100772
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1421)
  AUTHORS   Bonsor,D.A., Alexander,P., Snead,K., Hartig,N., Drew,M.,
            Messing,S., Finci,L.I., Nissley,D.V., McCormick,F., Esposito,D.,
            Rodriguez-Viciana,P., Stephen,A.G. and Simanshu,D.K.
  TITLE     Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF
            activation and Noonan syndrome
  JOURNAL   Nat Struct Mol Biol 29 (10), 966-977 (2022)
   PUBMED   36175670
REFERENCE   4  (bases 1 to 1421)
  AUTHORS   Kwon,J.J., Hajian,B., Bian,Y., Young,L.C., Amor,A.J., Fuller,J.R.,
            Fraley,C.V., Sykes,A.M., So,J., Pan,J., Baker,L., Lee,S.J.,
            Wheeler,D.B., Mayhew,D.L., Persky,N.S., Yang,X., Root,D.E.,
            Barsotti,A.M., Stamford,A.W., Perry,C.K., Burgin,A., McCormick,F.,
            Lemke,C.T., Hahn,W.C. and Aguirre,A.J.
  TITLE     Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase
            complex
  JOURNAL   Nature 609 (7926), 408-415 (2022)
   PUBMED   35831509
REFERENCE   5  (bases 1 to 1421)
  AUTHORS   Hauseman,Z.J., Fodor,M., Dhembi,A., Viscomi,J., Egli,D., Bleu,M.,
            Katz,S., Park,E., Jang,D.M., Porter,K.A., Meili,F., Guo,H.,
            Kerr,G., Molle,S., Velez-Vega,C., Beyer,K.S., Galli,G.G.,
            Maira,S.M., Stams,T., Clark,K., Eck,M.J., Tordella,L., Thoma,C.R.
            and King,D.A.
  TITLE     Structure of the MRAS-SHOC2-PP1C phosphatase complex
  JOURNAL   Nature 609 (7926), 416-423 (2022)
   PUBMED   35830882
REFERENCE   6  (bases 1 to 1421)
  AUTHORS   Saadat,M., Mizuno,Y., Kikuchi,K. and Yoshida,M.C.
  TITLE     Comparative mapping of the gene encoding the catalytic subunit of
            protein phosphatase type 1 alpha (PPP1CA) to human, rat, and mouse
            chromosomes
  JOURNAL   Cytogenet Cell Genet 70 (1-2), 55-57 (1995)
   PUBMED   7736790
REFERENCE   7  (bases 1 to 1421)
  AUTHORS   Durfee,T., Becherer,K., Chen,P.L., Yeh,S.H., Yang,Y., Kilburn,A.E.,
            Lee,W.H. and Elledge,S.J.
  TITLE     The retinoblastoma protein associates with the protein phosphatase
            type 1 catalytic subunit
  JOURNAL   Genes Dev 7 (4), 555-569 (1993)
   PUBMED   8384581
REFERENCE   8  (bases 1 to 1421)
  AUTHORS   Barker,H.M., Jones,T.A., da Cruz e Silva,E.F., Spurr,N.K., Sheer,D.
            and Cohen,P.T.
  TITLE     Localization of the gene encoding a type I protein phosphatase
            catalytic subunit to human chromosome band 11q13
  JOURNAL   Genomics 7 (2), 159-166 (1990)
   PUBMED   2161401
REFERENCE   9  (bases 1 to 1421)
  AUTHORS   Carrey,E.A., Campbell,D.G. and Hardie,D.G.
  TITLE     Phosphorylation and activation of hamster carbamyl phosphate
            synthetase II by cAMP-dependent protein kinase. A novel mechanism
            for regulation of pyrimidine nucleotide biosynthesis
  JOURNAL   EMBO J 4 (13B), 3735-3742 (1985)
   PUBMED   4092695
REFERENCE   10 (bases 1 to 1421)
  AUTHORS   Hemmings,H.C. Jr., Greengard,P., Tung,H.Y. and Cohen,P.
  TITLE     DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent
            inhibitor of protein phosphatase-1
  JOURNAL   Nature 310 (5977), 503-505 (1984)
   PUBMED   6087160
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE793459.1, BC008010.1 and
            BC001888.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002708.3.
            
            Summary: The protein encoded by this gene is one of the three
            catalytic subunits of protein phosphatase 1 (PP1). This broadly
            expressed gene encodes the alpha subunit of the PP1 complex that
            associates with over 200 regulatory proteins to form holoenzymes
            which dephosphorylate their biological targets with high
            specificity. PP1 is a serine/threonine specific protein phosphatase
            known to be involved in the regulation of a variety of cellular
            processes, such as cell division, glycogen metabolism, muscle
            contractility, protein synthesis, and HIV-1 viral transcription.
            Increased PP1 activity has been observed in the end stage of heart
            failure. Studies suggest that PP1 is an important regulator of
            cardiac function and that PP1 deregulation is implicated in
            diabetes and multiple types of cancer. Three alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.679370.1,
                                           SRR1163658.40928.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376745.9/ ENSP00000365936.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BE793459.1         49-60
            13-32               BC008010.1         1-20
            33-1421             BC001888.1         1-1389
FEATURES             Location/Qualifiers
     source          1..1421
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..1421
                     /gene="PPP1CA"
                     /gene_synonym="PP-1A; PP1A; PP1alpha; PPP1A"
                     /note="protein phosphatase 1 catalytic subunit alpha"
                     /db_xref="GeneID:5499"
                     /db_xref="HGNC:HGNC:9281"
                     /db_xref="MIM:176875"
     exon            1..131
                     /gene="PPP1CA"
                     /gene_synonym="PP-1A; PP1A; PP1alpha; PPP1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1069
                     /gene="PPP1CA"
                     /gene_synonym="PP-1A; PP1A; PP1alpha; PPP1A"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine protein phosphatase PP1-alpha 1 catalytic
                     subunit; serine/threonine-protein phosphatase PP1-alpha
                     catalytic subunit; protein phosphatase 1, catalytic
                     subunit, alpha isozyme; testicular tissue protein Li 155"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase PP1-alpha
                     catalytic subunit isoform 1"
                     /protein_id="NP_002699.1"
                     /db_xref="CCDS:CCDS8160.1"
                     /db_xref="GeneID:5499"
                     /db_xref="HGNC:HGNC:9281"
                     /db_xref="MIM:176875"
                     /translation="MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSRE
                     IFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLE
                     TICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLP
                     IAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGE
                     NDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEF
                     DNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK"
     exon            132..263
                     /gene="PPP1CA"
                     /gene_synonym="PP-1A; PP1A; PP1alpha; PPP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            264..494
                     /gene="PPP1CA"
                     /gene_synonym="PP-1A; PP1A; PP1alpha; PPP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            495..599
                     /gene="PPP1CA"
                     /gene_synonym="PP-1A; PP1A; PP1alpha; PPP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            600..823
                     /gene="PPP1CA"
                     /gene_synonym="PP-1A; PP1A; PP1alpha; PPP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            824..958
                     /gene="PPP1CA"
                     /gene_synonym="PP-1A; PP1A; PP1alpha; PPP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1421
                     /gene="PPP1CA"
                     /gene_synonym="PP-1A; PP1A; PP1alpha; PPP1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1398..1403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1CA"
                     /gene_synonym="PP-1A; PP1A; PP1alpha; PPP1A"
                     /note="hexamer: AATAAA"
     polyA_site      1421
                     /gene="PPP1CA"
                     /gene_synonym="PP-1A; PP1A; PP1alpha; PPP1A"
                     /note="major polyA site"
ORIGIN      
        1 aggccggaag gaggctgccg gagggcggga ggcaggagcg ggccaggagc tgctgggctg
       61 gagcggcggc gccgccatgt ccgacagcga gaagctcaac ctggactcga tcatcgggcg
      121 cctgctggaa gtgcagggct cgcggcctgg caagaatgta cagctgacag agaacgagat
      181 ccgcggtctg tgcctgaaat cccgggagat ttttctgagc cagcccattc ttctggagct
      241 ggaggcaccc ctcaagatct gcggtgacat acacggccag tactacgacc ttctgcgact
      301 atttgagtat ggcggtttcc ctcccgagag caactacctc tttctggggg actatgtgga
      361 caggggcaag cagtccttgg agaccatctg cctgctgctg gcctataaga tcaagtaccc
      421 cgagaacttc ttcctgctcc gtgggaacca cgagtgtgcc agcatcaacc gcatctatgg
      481 tttctacgat gagtgcaaga gacgctacaa catcaaactg tggaaaacct tcactgactg
      541 cttcaactgc ctgcccatcg cggccatagt ggacgaaaag atcttctgct gccacggagg
      601 cctgtccccg gacctgcagt ctatggagca gattcggcgg atcatgcggc ccacagatgt
      661 gcctgaccag ggcctgctgt gtgacctgct gtggtctgac cctgacaagg acgtgcaggg
      721 ctggggcgag aacgaccgtg gcgtctcttt tacctttgga gccgaggtgg tggccaagtt
      781 cctccacaag cacgacttgg acctcatctg ccgagcacac caggtggtag aagacggcta
      841 cgagttcttt gccaagcggc agctggtgac acttttctca gctcccaact actgtggcga
      901 gtttgacaat gctggcgcca tgatgagtgt ggacgagacc ctcatgtgct ctttccagat
      961 cctcaagccc gccgacaaga acaaggggaa gtacgggcag ttcagtggcc tgaaccctgg
     1021 aggccgaccc atcaccccac cccgcaattc cgccaaagcc aagaaatagc ccccgcacac
     1081 caccctgtgc cccagatgat ggattgattg tacagaaatc atgctgccat gctggggggg
     1141 ggtcaccccg acccctcagg cccacctgtc acggggaaca tggagccttg gtgtattttt
     1201 cttttctttt tttaatgaat caatagcagc gtccagtccc ccagggctgc ttcctgcctg
     1261 cacctgcggt gactgtgagc aggatcctgg ggccgaggct gcagctcagg gcaacggcag
     1321 gccaggtcgt gggtctccag ccgtgcttgg cctcagggct ggcagccgga tcctggggca
     1381 acccatctgg tctcttgaat aaaggtcaaa gctggattct c
//
