LOCUS       NM_001080401            1751 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)
            (PPM1N), mRNA.
ACCESSION   NM_001080401 XM_001130135
VERSION     NM_001080401.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1751)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 1751)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat Genet 36 (1), 40-45 (2004)
   PUBMED   14702039
REFERENCE   3  (bases 1 to 1751)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138534.2.
            
            On Oct 21, 2020 this sequence version replaced NM_001080401.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.862344.1,
                                           SRR18074969.627056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000451287.7/ ENSP00000397050.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-969               AC138534.2         31568-32536
            970-1087            AC138534.2         33074-33191
            1088-1193           AC138534.2         33581-33686
            1194-1254           AC138534.2         33775-33835
            1255-1751           AC138534.2         35142-35638
FEATURES             Location/Qualifiers
     source          1..1751
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..1751
                     /gene="PPM1N"
                     /note="protein phosphatase, Mg2+/Mn2+ dependent 1N
                     (putative)"
                     /db_xref="GeneID:147699"
                     /db_xref="HGNC:HGNC:26845"
     exon            1..969
                     /gene="PPM1N"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1323
                     /gene="PPM1N"
                     /EC_number="3.1.3.16"
                     /codon_start=1
                     /product="probable protein phosphatase 1N"
                     /protein_id="NP_001073870.1"
                     /db_xref="CCDS:CCDS46115.1"
                     /db_xref="GeneID:147699"
                     /db_xref="HGNC:HGNC:26845"
                     /translation="MAVLARQLQRLLWTACKKKEREKEGREEEEEEEAGRRAPEGPRS
                     LLTAPRRAQRPHGGAEASGGLRFGASAAQGWRARMEDAHCTWLSLPGLPPGWALFAVL
                     DGHGGARAARFGARHLPGHVLQELGPEPSEPEGVREALRRAFLSADERLRSLWPRVET
                     GGCTAVVLLVSPRFLYLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTI
                     RRRRVEGSLAVSRALGDFTYKEAPGRPPELQLVSAEPEVAALARQAEDEFMLLASDGV
                     WDTVSGAALAGLVASRLRLGLAPELLCAQLLDTCLCKGSLDNMTCILVCFPGAPRPSE
                     EAIRRELALDAALGCRIAELCASAQKPPSLNTVFRTLASEDIPDLPPGGGLDCKATVI
                     AEVYSQICQVSEECGEKGQDGAGKSNPTHLGSALDMEA"
     exon            970..1087
                     /gene="PPM1N"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1193
                     /gene="PPM1N"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1254
                     /gene="PPM1N"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1751
                     /gene="PPM1N"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1699..1704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPM1N"
                     /note="hexamer: ATTAAA"
     polyA_site      1722
                     /gene="PPM1N"
                     /note="major polyA site"
     regulatory      1728..1733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPM1N"
                     /note="hexamer: AATACA"
     polyA_site      1751
                     /gene="PPM1N"
                     /note="major polyA site"
ORIGIN      
        1 gtggagcctt cctgatccca gggctgaagg atggcggtcc tggcccgcca gctgcagcgt
       61 ctcctctgga ccgcttgcaa gaaaaaggag agggagaagg aggggaggga ggaagaggag
      121 gaggaggagg cggggcgcag ggcccccgaa gggcctcggt ctctgttgac agcgccgcgc
      181 cgcgcccagc ggccgcacgg gggtgccgag gcgtctgggg gcctgcgctt cggggcgagc
      241 gcagcgcaag gctggcgcgc gcgcatggag gatgctcact gcacttggct ttcgttacct
      301 ggtctgcccc cgggctgggc cttgtttgcc gtcctcgacg gccacggtgg ggctcgagct
      361 gcccgcttcg gtgcacgcca tttgccaggc catgtgctcc aggagctggg cccggagcct
      421 agcgagcccg agggcgtgcg cgaggcgctg cgccgagcct tcttgagcgc cgacgagcgc
      481 ctgcgctccc tctggccccg cgtggaaacg ggcggctgca cggccgtggt gttgctggtc
      541 tccccgcggt ttctgtacct ggcgcactgc ggtgactccc gcgcggtgct gagccgcgct
      601 ggcgccgtgg ccttcagcac agaggaccac cggccccttc gaccccggga acgcgagcgc
      661 atccacgccg ctggcggcac catccgccgc cgccgcgtcg agggctctct ggccgtgtcg
      721 cgagcgttgg gcgactttac ctacaaggag gctccgggga ggccccccga gctacagctc
      781 gtttctgcgg agccagaggt ggccgcactg gcacgccagg ctgaggacga gttcatgctc
      841 ctggcctctg atggcgtctg ggacactgtg tctggtgctg ccctggcggg actggtggct
      901 tcacgcctcc gcttgggcct ggccccagag cttctctgcg cgcagctgtt ggacacgtgt
      961 ctgtgcaagg gcagcctgga caacatgacc tgcatcctgg tctgcttccc tggggcccct
     1021 aggccttctg aggaggcgat caggagggag ctagcactgg acgcagccct gggctgcaga
     1081 atcgctgaac tgtgtgcctc tgctcagaag ccccccagcc tgaacacagt tttcaggact
     1141 ctggcctcag aggacatccc agatttacct cctgggggag ggctggactg caaggccact
     1201 gtcattgctg aagtttattc tcagatctgc caggtctcag aagagtgcgg agagaagggg
     1261 caggatgggg ctgggaagtc caaccccacg catttgggct cagccttgga catggaggcc
     1321 tgacagctgt tgtcctttgg ggatcctttg cttctctggg gcctcaacag aactaaagaa
     1381 gaaaaccgac cctttcccca actacatgta ccagcggaag gaaggaaggc caatgtagga
     1441 acccaaaatg cttatttctt cttctcttac ttccctctca cagaaaagtc ttacgaatgg
     1501 ggaaattcca ccaacatcca gaccaaaaag aaaaaagccc aaatcgaaaa aaaaaaaaaa
     1561 aaaaaaaaaa aacaaaaaaa cccaaccaaa tgtttttgaa atattcagag ccgaacagat
     1621 tctgagagat aacccagtcc aataacctct ttccttctta ttactcatct gtttttgagg
     1681 ggaagtagag ttttgattat taaactttat ttacataagt gattccaaat acattttctt
     1741 gtaaaaaaca a
//
