LOCUS       NM_144641               2231 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1M (PPM1M),
            transcript variant 1, mRNA.
ACCESSION   NM_144641
VERSION     NM_144641.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2231)
  AUTHORS   Zeng,R., Wang,L., Zhang,Y., Yang,Y., Yang,J. and Qin,Y.
  TITLE     Exploring the immunological role and prognostic potential of PPM1M
            in pan-cancer
  JOURNAL   Medicine (Baltimore) 102 (12), e32758 (2023)
   PUBMED   36961170
  REMARK    GeneRIF: Exploring the immunological role and prognostic potential
            of PPM1M in pan-cancer.
REFERENCE   2  (bases 1 to 2231)
  AUTHORS   Kamada,R., Kudoh,F., Ito,S., Tani,I., Janairo,J.I.B.,
            Omichinski,J.G. and Sakaguchi,K.
  TITLE     Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution,
            structures, diseases and inhibitors
  JOURNAL   Pharmacol Ther 215, 107622 (2020)
   PUBMED   32650009
  REMARK    Review article
REFERENCE   3  (bases 1 to 2231)
  AUTHORS   Velasco,H.M., Ullah,E., Martin,A.M., Hufnagel,R.B. and Prada,C.E.
  TITLE     Novel progressive acrodysostosis-like skeletal dysplasia,
            cerebellar atrophy, and ichthyosis
  JOURNAL   Am J Med Genet A 182 (10), 2214-2221 (2020)
   PUBMED   32783359
  REMARK    GeneRIF: Novel progressive acrodysostosis-like skeletal dysplasia,
            cerebellar atrophy, and ichthyosis.
REFERENCE   4  (bases 1 to 2231)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   5  (bases 1 to 2231)
  AUTHORS   Chen,D.T., Jiang,X., Akula,N., Shugart,Y.Y., Wendland,J.R.,
            Steele,C.J., Kassem,L., Park,J.H., Chatterjee,N., Jamain,S.,
            Cheng,A., Leboyer,M., Muglia,P., Schulze,T.G., Cichon,S.,
            Nothen,M.M., Rietschel,M., McMahon,F.J., Farmer,A., McGuffin,P.,
            Craig,I., Lewis,C., Hosang,G., Cohen-Woods,S., Vincent,J.B.,
            Kennedy,J.L. and Strauss,J.
  CONSRTM   BiGS
  TITLE     Genome-wide association study meta-analysis of European and
            Asian-ancestry samples identifies three novel loci associated with
            bipolar disorder
  JOURNAL   Mol Psychiatry 18 (2), 195-205 (2013)
   PUBMED   22182935
  REMARK    Erratum:[Mol Psychiatry. 2013 Feb;18(2):264-6. Farmer, A [added];
            McGuffin, P [added]; Craig, I [added]; Lewis, C [added]; Hosang, G
            [added]; Cohen-Woods, S [added]; Vincent, J B [added]; Kennedy, J L
            [added]; Strauss, J [added]]
REFERENCE   6  (bases 1 to 2231)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2231)
  AUTHORS   Henmi,T., Amano,K., Nagaura,Y., Matsumoto,K., Echigo,S., Tamura,S.
            and Kobayashi,T.
  TITLE     A mechanism for the suppression of interleukin-1-induced nuclear
            factor kappaB activation by protein phosphatase 2Ceta-2
  JOURNAL   Biochem J 423 (1), 71-78 (2009)
   PUBMED   19594441
  REMARK    GeneRIF: PP2Ceta-2 inhibits the IL-1-NF-kappaB signalling pathway
            by selectively dephosphorylating IKKbeta.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2231)
  AUTHORS   Komaki,K., Katsura,K., Ohnishi,M., Guang Li,M., Sasaki,M.,
            Watanabe,M., Kobayashi,T. and Tamura,S.
  TITLE     Molecular cloning of PP2Ceta, a novel member of the protein
            phosphatase 2C family
  JOURNAL   Biochim Biophys Acta 1630 (2-3), 130-137 (2003)
   PUBMED   14654243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006252.4, DB479638.1, BF516133.1, AB474372.1, BC009644.1 and
            AA829740.1.
            
            On Nov 23, 2018 this sequence version replaced NM_144641.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.482776.1, AB474372.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323588.9/ ENSP00000319894.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC006252.4         5395-5428           c
            35-51               DB479638.1         1-17
            52-66               BF516133.1         64-78               c
            67-1446             AB474372.1         1-1380
            1447-1870           BC009644.1         1008-1431
            1871-2231           AA829740.1         39-399              c
FEATURES             Location/Qualifiers
     source          1..2231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..2231
                     /gene="PPM1M"
                     /gene_synonym="PP2C-eta; PP2CE; PP2Ceta"
                     /note="protein phosphatase, Mg2+/Mn2+ dependent 1M"
                     /db_xref="GeneID:132160"
                     /db_xref="HGNC:HGNC:26506"
                     /db_xref="MIM:608979"
     exon            1..290
                     /gene="PPM1M"
                     /gene_synonym="PP2C-eta; PP2CE; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1446
                     /gene="PPM1M"
                     /gene_synonym="PP2C-eta; PP2CE; PP2Ceta"
                     /EC_number="3.1.3.16"
                     /note="isoform a is encoded by transcript variant 1;
                     protein phosphatase 1M (PP2C domain containing); protein
                     phosphatase 2C eta-2"
                     /codon_start=1
                     /product="protein phosphatase 1M isoform a"
                     /protein_id="NP_653242.3"
                     /db_xref="CCDS:CCDS93282.1"
                     /db_xref="GeneID:132160"
                     /db_xref="HGNC:HGNC:26506"
                     /db_xref="MIM:608979"
                     /translation="MSAGWFRRRFLPGEPLPAPRPPGPHASPVPYRRPRFLRGSSSSP
                     GAADASRRPDSRPVRSPARGRTLPWNAGYAEIINAEKSEFNEDQAACGKLCIRRCEFG
                     AEEEWLTLCPEEFLTGHYWALFDGHGGPAAAILAANTLHSCLRRQLEAVVEGLVATQP
                     PMHLNGRCICPSDPQFVEEKGIRAEDLVIGALESAFQECDEVIGRELEASGQMGGCTA
                     LVAVSLQGKLYMANAGDSRAILVRRDEIRPLSFEFTPETERQRIQQLAFVYPELLAGE
                     FTRLEFPRRLKGDDLGQKVLFRDHHMSGWSYKRVEKSDLKYPLIHGQGRQARLLGTLA
                     VSRGLGDHQLRVLDTNIQLKPFLLSVPQVTVLDVDQLELQEDDVVVMATDGLWDVLSN
                     EQVAWLVRSFLPGNQEDPHRFSKLAQMLIHSTQGKEDSLTEEGQVSYDDVSVFVIPLH
                     SQGQESSDH"
     exon            291..408
                     /gene="PPM1M"
                     /gene_synonym="PP2C-eta; PP2CE; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     exon            409..663
                     /gene="PPM1M"
                     /gene_synonym="PP2C-eta; PP2CE; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     exon            664..776
                     /gene="PPM1M"
                     /gene_synonym="PP2C-eta; PP2CE; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     exon            777..861
                     /gene="PPM1M"
                     /gene_synonym="PP2C-eta; PP2CE; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     exon            862..980
                     /gene="PPM1M"
                     /gene_synonym="PP2C-eta; PP2CE; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1044
                     /gene="PPM1M"
                     /gene_synonym="PP2C-eta; PP2CE; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1152
                     /gene="PPM1M"
                     /gene_synonym="PP2C-eta; PP2CE; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1301
                     /gene="PPM1M"
                     /gene_synonym="PP2C-eta; PP2CE; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..2231
                     /gene="PPM1M"
                     /gene_synonym="PP2C-eta; PP2CE; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2210..2215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPM1M"
                     /gene_synonym="PP2C-eta; PP2CE; PP2Ceta"
                     /note="hexamer: ATTAAA"
     polyA_site      2231
                     /gene="PPM1M"
                     /gene_synonym="PP2C-eta; PP2CE; PP2Ceta"
                     /note="major polyA site"
ORIGIN      
        1 cttcctcccg cgggcggccc agccctagcg ccccgcgctc cgcgggcagc cccctgccgc
       61 cgcgccatgt ccgccggctg gttccggcgc cgcttcctgc ctggggagcc gctccccgcg
      121 ccgcggccgc ctgggccgca tgccagcccc gtgccctacc gacggccccg cttccttcgc
      181 ggctccagct ccagccccgg ggcggccgac gcctcgcgcc gcccagactc ccggcccgtg
      241 cgcagccccg cacgaggacg cacgctaccc tggaatgcag gctacgccga gattatcaat
      301 gcagagaaat ctgaattcaa tgaggatcaa gccgcctgtg ggaagctgtg catccggaga
      361 tgtgagtttg gggctgaaga agagtggctg accctgtgcc cagaggagtt cctgacaggc
      421 cattactggg cactgttcga tgggcacggc ggtcctgcag cagccatctt ggctgccaac
      481 accctgcact cctgcttgcg ccggcagctg gaggccgtgg tggaaggctt ggtggccact
      541 cagcccccca tgcacctcaa tggccgctgc atctgcccca gtgaccctca gtttgtggag
      601 gaaaagggca tcagggcaga agacttggtg atcggggcat tggagagtgc ctttcaggaa
      661 tgtgatgagg tgatcgggcg ggagctggag gcctcaggcc agatgggcgg ctgcacagcc
      721 ctggtggctg tgtccctgca gggaaagctg tacatggcca atgctgggga tagcagggcc
      781 atcttggtgc ggagagatga gatacggcca ctgagcttcg agttcacccc agagactgag
      841 cggcagcgga tccagcagct ggcctttgtc tatcctgagc ttctggctgg tgagttcacc
      901 cgactggagt tccctcggcg gctgaagggg gatgacttgg gacagaaggt tttgttcagg
      961 gatcaccaca tgagtggctg gagctacaaa cgtgtggaga aatcggatct caagtaccca
     1021 ctgatccatg gacagggtag gcaggctcgg ttactaggaa cactggctgt ctcccggggc
     1081 ctgggagacc atcagctcag agtcctggac acaaacatcc agctcaagcc cttcttgctc
     1141 tctgtgccac aggtgactgt gctggatgtg gaccagctgg agctacagga ggatgatgtg
     1201 gttgtcatgg caactgatgg actctgggat gtactgtcca acgagcaggt ggcatggctg
     1261 gtgcggagct tcctccctgg gaaccaagag gacccacaca ggttctcaaa gctggcccag
     1321 atgctgatac acagcacaca gggaaaggaa gacagtctca cagaggaagg gcaggtgtcc
     1381 tacgatgacg tctctgtgtt cgtgattccc ttgcacagtc agggccaaga gagcagtgac
     1441 cactgaggat tcagacactg tatcccagaa ctgctctagt gcccgggtgt ggtctgggca
     1501 tccctccagt gtgaccaaga gcaaatcctg cctgccctat ccctagccac cgcccagtgc
     1561 tctcactatc cacctcaaca cacatccatc tcaagaggaa catttatacc aggcagtcag
     1621 agctggaagt gtatggagag cccagcccac caggtcctgc cttttgcggt gataaccttc
     1681 tctggcagag tgactttaca acttaactag gaaacccatg tgaggctcct cagacaggat
     1741 cttgaacagc ccaaagtatc attctcagat aggggcaccc aagctaaggg tattagccaa
     1801 agatgccagg atgggtagct agcccatgtt tagatccagg tctccaattc atggttatca
     1861 gggcatgtgt tcaacaaccc ccaaagtcca cgcaggtggc ttgtagaaac ctttgggcag
     1921 cctcatgtct gctaaaacag ccatcttcaa gacagcccct gaaaagagac cagttcaggt
     1981 cctgccctgc tgttctttgc tggagatgag gaacaggtgc tggggctaaa gtttggggta
     2041 gagcacaagg gacaagagga actcttggag ttggctgggt gagagggctc tccatttgct
     2101 acctgtagta gcctgcctct taactggttg cttctcccta gttccagccc tgccctggtc
     2161 tgatgcccca acactgccct tgctttgttt tccctgtcac ctccctatta ttaaatgttt
     2221 tctacagaag a
//
