LOCUS       NM_005167               1714 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1J (PPM1J),
            mRNA.
ACCESSION   NM_005167 XM_352931
VERSION     NM_005167.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1714)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1714)
  AUTHORS   Komaki,K., Katsura,K., Ohnishi,M., Guang Li,M., Sasaki,M.,
            Watanabe,M., Kobayashi,T. and Tamura,S.
  TITLE     Molecular cloning of PP2Ceta, a novel member of the protein
            phosphatase 2C family
  JOURNAL   Biochim Biophys Acta 1630 (2-3), 130-137 (2003)
   PUBMED   14654243
REFERENCE   3  (bases 1 to 1714)
  AUTHORS   Kashiwaba,M., Katsura,K., Ohnishi,M., Sasaki,M., Tanaka,H.,
            Nishimune,Y., Kobayashi,T. and Tamura,S.
  TITLE     A novel protein phosphatase 2C family member (PP2Czeta) is able to
            associate with ubiquitin conjugating enzyme 9
  JOURNAL   FEBS Lett 538 (1-3), 197-202 (2003)
   PUBMED   12633878
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL603832.28.
            
            On Apr 8, 2021 this sequence version replaced NM_005167.6.
            
            Summary: This gene encodes the serine/threonine protein
            phosphatase. The mouse homolog of this gene apparently belongs to
            the protein phosphatase 2C family of genes. The exact function of
            this gene is not yet known. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC073828.1, AK093270.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309276.11/ ENSP00000308926.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               AL603832.28        67534-67890         c
            358-472             AL603832.28        66055-66169         c
            473-760             AL603832.28        65302-65589         c
            761-873             AL603832.28        64903-65015         c
            874-958             AL603832.28        64529-64613         c
            959-1077            AL603832.28        63824-63942         c
            1078-1141           AL603832.28        63566-63629         c
            1142-1249           AL603832.28        63302-63409         c
            1250-1401           AL603832.28        63018-63169         c
            1402-1714           AL603832.28        62556-62868         c
FEATURES             Location/Qualifiers
     source          1..1714
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..1714
                     /gene="PPM1J"
                     /gene_synonym="PP2C-zeta; PP2CZ; PP2Czeta; PPP2CZ"
                     /note="protein phosphatase, Mg2+/Mn2+ dependent 1J"
                     /db_xref="GeneID:333926"
                     /db_xref="HGNC:HGNC:20785"
                     /db_xref="MIM:609957"
     exon            1..357
                     /gene="PPM1J"
                     /gene_synonym="PP2C-zeta; PP2CZ; PP2Czeta; PPP2CZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1549
                     /gene="PPM1J"
                     /gene_synonym="PP2C-zeta; PP2CZ; PP2Czeta; PPP2CZ"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase 1J (PP2C domain containing);
                     protein phosphatase 2C zeta"
                     /codon_start=1
                     /product="protein phosphatase 1J"
                     /protein_id="NP_005158.5"
                     /db_xref="CCDS:CCDS855.2"
                     /db_xref="GeneID:333926"
                     /db_xref="HGNC:HGNC:20785"
                     /db_xref="MIM:609957"
                     /translation="MLNRVRSAVAHLVSSGGAPPPRPKSPDLPNAASAPPAAAPEAPR
                     SPPAKAGSGSATPAKAVEARASFSRPTFLQLSPGGLRRADDHAGRAVQSPPDTGRRLP
                     WSTGYAEVINAGKSRHNEDQACCEVVYVEGRRSVTGVPREPSRGQGLCFYYWGLFDGH
                     AGGGAAEMASRLLHRHIREQLKDLVEILQDPSPPPLCLPTTPGTPDSSDPSHLLGPQS
                     CWSSQKEVSHESLVVGAVENAFQLMDEQMARERRGHQVEGGCCALVVIYLLGKVYVAN
                     AGDSRAIIVRNGEIIPMSREFTPETERQRLQLLGFLKPELLGSEFTHLEFPRRVLPKE
                     LGQRMLYRDQNMTGWAYKKIELEDLRFPLVCGEGKKARVMATIGVTRGLGDHSLKVCS
                     STLPIKPFLSCFPEVRVYDLTQYEHCPDDVLVLGTDGLWDVTTDCEVAATVDRVLSAY
                     EPNDHSRYTALAQALVLGARGTPRDRGWRLPNNKLGSGDDISVFVIPLGGPGSYS"
     exon            358..472
                     /gene="PPM1J"
                     /gene_synonym="PP2C-zeta; PP2CZ; PP2Czeta; PPP2CZ"
                     /inference="alignment:Splign:2.1.0"
     exon            473..760
                     /gene="PPM1J"
                     /gene_synonym="PP2C-zeta; PP2CZ; PP2Czeta; PPP2CZ"
                     /inference="alignment:Splign:2.1.0"
     exon            761..873
                     /gene="PPM1J"
                     /gene_synonym="PP2C-zeta; PP2CZ; PP2Czeta; PPP2CZ"
                     /inference="alignment:Splign:2.1.0"
     exon            874..958
                     /gene="PPM1J"
                     /gene_synonym="PP2C-zeta; PP2CZ; PP2Czeta; PPP2CZ"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1077
                     /gene="PPM1J"
                     /gene_synonym="PP2C-zeta; PP2CZ; PP2Czeta; PPP2CZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1141
                     /gene="PPM1J"
                     /gene_synonym="PP2C-zeta; PP2CZ; PP2Czeta; PPP2CZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1249
                     /gene="PPM1J"
                     /gene_synonym="PP2C-zeta; PP2CZ; PP2Czeta; PPP2CZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1401
                     /gene="PPM1J"
                     /gene_synonym="PP2C-zeta; PP2CZ; PP2Czeta; PPP2CZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1714
                     /gene="PPM1J"
                     /gene_synonym="PP2C-zeta; PP2CZ; PP2Czeta; PPP2CZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1696..1701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPM1J"
                     /gene_synonym="PP2C-zeta; PP2CZ; PP2Czeta; PPP2CZ"
                     /note="hexamer: AATAAA"
     polyA_site      1714
                     /gene="PPM1J"
                     /gene_synonym="PP2C-zeta; PP2CZ; PP2Czeta; PPP2CZ"
                     /note="major polyA site"
ORIGIN      
        1 gccgcggccg agggcggggc agggaggcag catgctaaac cgggtgcgct cggccgtggc
       61 gcacctggtg agctccgggg gcgctccgcc tccgcgcccc aaatccccgg acctgcccaa
      121 cgccgcctcg gcgccgcccg ccgccgctcc agaagcgccc aggagccctc ccgcgaaggc
      181 tgggagcggg agcgcgacgc ccgcgaaggc tgttgaggct cgagcgagct tctccagacc
      241 gacctttctg cagctgagcc ccggggggct gcgacgcgcc gatgaccacg cgggccgggc
      301 tgtgcaaagc cccccggaca cgggccgccg cctgccctgg agcacaggct acgccgaggt
      361 catcaatgct ggcaagagtc ggcacaatga ggaccaggct tgctgtgaag tggtgtatgt
      421 ggaaggtcgg aggagtgtta caggagtacc tagggagcct agccgaggcc agggactctg
      481 cttctactac tggggcctat ttgatgggca tgcagggggc ggagctgctg aaatggcctc
      541 acggctcctg catcgccata tccgagagca gctaaaggac ctggtagaga tacttcagga
      601 cccttcgcca ccacccctct gcctcccaac cactccgggg accccagatt cctccgatcc
      661 ctctcacttg cttggccctc agtcctgctg gtcttcacag aaggaagtga gccacgagag
      721 cctggtagtg ggggccgttg agaatgcctt ccagctcatg gatgagcaga tggcccggga
      781 gcggcgtggc caccaagtgg aggggggctg ctgtgcactg gttgtgatct acctgctagg
      841 caaggtgtac gtggccaatg caggcgatag cagggccatc attgtccgga atggtgaaat
      901 cattccaatg tcccgggagt ttaccccgga gactgagcgc cagcgtcttc agctgcttgg
      961 cttcctgaaa ccagagctgc taggcagtga attcacccac cttgagttcc cccgcagagt
     1021 tctgcccaag gagctggggc agaggatgtt gtaccgggac cagaacatga ccggctgggc
     1081 ctacaaaaag atcgagctgg aggatctcag gtttcctctg gtctgtgggg agggcaaaaa
     1141 ggctcgggtg atggccacca ttggggtgac ccgaggcttg ggagaccaca gccttaaggt
     1201 ctgcagttcc accctgccca tcaagccctt tctctcctgc ttccctgagg tacgagtgta
     1261 tgacctgaca caatatgagc actgcccaga tgatgtgcta gtcctgggaa cagatggcct
     1321 gtgggatgtc actactgact gtgaggtagc tgccactgtg gacagggtgc tgtcggccta
     1381 tgagcctaat gaccacagca ggtatacagc tctggcccaa gctctggtcc tgggggcccg
     1441 gggtaccccc cgagaccgtg gctggcgtct ccccaacaac aagctgggtt ccggggatga
     1501 catctctgtc ttcgtcatcc ccctgggagg gccaggcagt tactcctgag gggctgaaca
     1561 ccatccctcc cactagcctc tccatactta ctcctctcac agcccaaatt ctgaagttgt
     1621 ctccctgacc cttctttagt ggcaacttaa ctgaagaagg gatgtccgct atatccaaaa
     1681 ttacagctat tggcaaataa acgagatgga taaa
//
