LOCUS       NM_020700               6454 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1H (PPM1H),
            mRNA.
ACCESSION   NM_020700 XM_350880 XM_939302
VERSION     NM_020700.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6454)
  AUTHORS   Yeshaw,W.M., Adhikari,A., Chiang,C.Y., Dhekne,H.S., Wawro,P.S. and
            Pfeffer,S.R.
  TITLE     Localization of PPM1H phosphatase tunes Parkinson's disease-linked
            LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis
  JOURNAL   Proc Natl Acad Sci U S A 120 (44), e2315171120 (2023)
   PUBMED   37889931
  REMARK    GeneRIF: Localization of PPM1H phosphatase tunes Parkinson's
            disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and
            ciliogenesis.
REFERENCE   2  (bases 1 to 6454)
  AUTHORS   Dou,D., Smith,E.M., Evans,C.S., Boecker,C.A. and Holzbaur,E.L.F.
  TITLE     Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and
            ARF6 GTPase disrupts the axonal transport of autophagosomes
  JOURNAL   Cell Rep 42 (5), 112448 (2023)
   PUBMED   37133994
  REMARK    GeneRIF: Regulatory imbalance between LRRK2 kinase, PPM1H
            phosphatase, and ARF6 GTPase disrupts the axonal transport of
            autophagosomes.
REFERENCE   3  (bases 1 to 6454)
  AUTHORS   Zhang,W.Q., Gao,J.N., Chen,X.L. and Yang,X.F.
  TITLE     PPM1H is an independent prognostic biomarker of non-small cell lung
            cancer
  JOURNAL   Neoplasma 68 (5), 917-923 (2021)
   PUBMED   33847131
  REMARK    GeneRIF: PPM1H is an independent prognostic biomarker of non-small
            cell lung cancer.
REFERENCE   4  (bases 1 to 6454)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6454)
  AUTHORS   Berndsen,K., Lis,P., Yeshaw,W.M., Wawro,P.S., Nirujogi,R.S.,
            Wightman,M., Macartney,T., Dorward,M., Knebel,A., Tonelli,F.,
            Pfeffer,S.R. and Alessi,D.R.
  TITLE     PPM1H phosphatase counteracts LRRK2 signaling by selectively
            dephosphorylating Rab proteins
  JOURNAL   Elife 8, e50416 (2019)
   PUBMED   31663853
  REMARK    GeneRIF: PPM1H acts as a key modulator of LRRK2 signaling by
            controlling dephosphorylation of Rab proteins
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6454)
  AUTHORS   Croteau-Chonka,D.C., Marvelle,A.F., Lange,E.M., Lee,N.R.,
            Adair,L.S., Lange,L.A. and Mohlke,K.L.
  TITLE     Genome-wide association study of anthropometric traits and evidence
            of interactions with age and study year in Filipino women
  JOURNAL   Obesity (Silver Spring) 19 (5), 1019-1027 (2011)
   PUBMED   20966902
REFERENCE   7  (bases 1 to 6454)
  AUTHORS   Neale,B.M., Medland,S., Ripke,S., Anney,R.J., Asherson,P.,
            Buitelaar,J., Franke,B., Gill,M., Kent,L., Holmans,P.,
            Middleton,F., Thapar,A., Lesch,K.P., Faraone,S.V., Daly,M.,
            Nguyen,T.T., Schafer,H., Steinhausen,H.C., Reif,A., Renner,T.J.,
            Romanos,M., Romanos,J., Warnke,A., Walitza,S., Freitag,C.,
            Meyer,J., Palmason,H., Rothenberger,A., Hawi,Z., Sergeant,J.,
            Roeyers,H., Mick,E. and Biederman,J.
  CONSRTM   IMAGE II Consortium Group
  TITLE     Case-control genome-wide association study of
            attention-deficit/hyperactivity disorder
  JOURNAL   J Am Acad Child Adolesc Psychiatry 49 (9), 906-920 (2010)
   PUBMED   20732627
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 6454)
  AUTHORS   Kariuki,S.N., Franek,B.S., Kumar,A.A., Arrington,J.,
            Mikolaitis,R.A., Utset,T.O., Jolly,M., Crow,M.K., Skol,A.D. and
            Niewold,T.B.
  TITLE     Trait-stratified genome-wide association study identifies novel and
            diverse genetic associations with serologic and cytokine phenotypes
            in systemic lupus erythematosus
  JOURNAL   Arthritis Res Ther 12 (4), R151 (2010)
   PUBMED   20659327
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 6454)
  AUTHORS   Sugiura,T., Noguchi,Y., Sakurai,K. and Hattori,C.
  TITLE     Protein phosphatase 1H, overexpressed in colon adenocarcinoma, is
            associated with CSE1L
  JOURNAL   Cancer Biol Ther 7 (2), 285-292 (2008)
   PUBMED   18059182
  REMARK    GeneRIF: PPM1H, overexpressed in colon adenocarcinoma, is
            associated with CSE1L protein.
REFERENCE   10 (bases 1 to 6454)
  AUTHORS   Labes,M., Roder,J. and Roach,A.
  TITLE     A novel phosphatase regulating neurite extension on CNS inhibitors
  JOURNAL   Mol Cell Neurosci 12 (1-2), 29-47 (1998)
   PUBMED   9770338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC078814.23, DA396561.1, AB032983.1 and AC048341.22.
            
            On Nov 23, 2018 this sequence version replaced NM_020700.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB084258.1, SRR1660805.19399.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228705.7/ ENSP00000228705.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               AC078814.23        154133-154397
            266-672             DA396561.1         1-407
            673-2539            AB032983.1         1-1867
            2540-6454           AC048341.22        43845-47759         c
FEATURES             Location/Qualifiers
     source          1..6454
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.1-q14.2"
     gene            1..6454
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /note="protein phosphatase, Mg2+/Mn2+ dependent 1H"
                     /db_xref="GeneID:57460"
                     /db_xref="HGNC:HGNC:18583"
                     /db_xref="MIM:616016"
     exon            1..659
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             415..1959
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase 1H (PP2C domain containing);
                     ras homolog gene family, member C like 1; neurite
                     extension-related protein phosphatase related to PP2C"
                     /codon_start=1
                     /product="protein phosphatase 1H"
                     /protein_id="NP_065751.1"
                     /db_xref="CCDS:CCDS44934.1"
                     /db_xref="GeneID:57460"
                     /db_xref="HGNC:HGNC:18583"
                     /db_xref="MIM:616016"
                     /translation="MLTRVKSAVANFMGGIMAGSSGSEHGGGSCGGSDLPLRFPYGRP
                     EFLGLSQDEVECSADHIARPILILKETRRLPWATGYAEVINAGKSTHNEDQASCEVLT
                     VKKKAGAVTSTPNRNSSKRRSSLPNGEGLQLKENSESEGVSCHYWSLFDGHAGSGAAV
                     VASRLLQHHITEQLQDIVDILKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGA
                     PGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSSYNISGGCTALIVIC
                     LLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLE
                     FPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGL
                     GDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAE
                     AITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLI
                     HGNKLS"
     exon            660..825
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1170
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1283
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1368
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1487
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1551
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1659
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1811
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..6454
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3138..3143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /note="hexamer: AATAAA"
     polyA_site      3158
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /note="major polyA site"
     polyA_site      6319
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /note="major polyA site"
     regulatory      6424..6429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /note="hexamer: AATAAA"
     polyA_site      6454
                     /gene="PPM1H"
                     /gene_synonym="ARHCL1; NERPP-2C; URCC2"
                     /note="major polyA site"
ORIGIN      
        1 acatgacccg gcggcagtag ccgtggcagc agccgcggcg gctccgcgag ctcgccgggt
       61 gggctcagtt cagcgcacgc cggagccgag cgcagggggc ggggaaggga cctgctgcag
      121 ctgcagccgc ctgggcgctc ctggagcgcg cggtgactcc cccggtcggc ccgctccatg
      181 cagctccgtt gcggaagtgt agcgggggga ggcggcggcc accgcggcac taagcacgag
      241 aggccggggc tcggccccct gcagcactag gctctgggag ccgcgcgcgg cgcgtcccag
      301 tggcccgact cgccgtgcgc ccggcgccca ccgcagcctg catgccccgc gctgcgcctt
      361 gcccggcccc cgccgcctcc tgctcgcacc gctgcagccg ggcgccggag taatatgctc
      421 actcgagtga aatctgccgt ggccaatttc atgggcggca tcatggctgg cagctcaggc
      481 tccgagcacg gcggcggcag ctgcggaggc tcggacctgc ccctgcgttt cccctacggg
      541 cggccagagt tcctggggct gtctcaggac gaggtggagt gcagcgccga ccacatcgcc
      601 cgccccatcc tcatcctcaa ggagactcgg cggctgccct gggccactgg ctacgcagag
      661 gttatcaatg ccgggaagag cacacacaat gaagaccaag ccagctgtga ggtgctcact
      721 gtgaagaaga aggcaggggc cgtgacctca accccaaaca ggaactcatc caagagacgg
      781 tcctcccttc ccaatgggga agggctgcag ctgaaggaga actcggaatc cgagggtgtt
      841 tcctgccact attggtcgct gtttgacggg cacgcggggt ccggggccgc ggtggtggcg
      901 tcacgcctgc tgcagcacca catcacggag cagctgcagg acatcgtgga catcctgaag
      961 aactccgccg tcctgccccc tacctgcctg ggggaggagc ctgagaacac gcccgccaac
     1021 agccggactc tgacccgggc agcctccctg cgcggagggg tgggggcccc gggctccccc
     1081 agcacgcccc ccacacgctt ctttaccgag aagaagattc cccatgagtg cctggtcatc
     1141 ggagcgcttg aaagtgcatt caaggaaatg gacctacaga tagaacgaga gaggagttca
     1201 tataatatat ctggtggctg cacggccctc attgtgattt gccttttggg gaagctgtat
     1261 gttgcaaatg ctggggatag cagggccata atcatcagaa atggagaaat tatccccatg
     1321 tcttcagaat ttacccccga gacggagcgc cagcgacttc agtacctggc attcatgcag
     1381 cctcacttgc tgggaaatga gttcacacat ttggagtttc caaggagagt acagagaaag
     1441 gagcttggaa agaagatgct ctacagggac tttaatatga caggctgggc atacaaaacc
     1501 attgaggatg aggacttgaa gttccccctt atatatggag aaggcaagaa ggcccgggta
     1561 atggcaacta ttggagtgac caggggactt ggggaccatg acctgaaggt gcatgactcc
     1621 aacatctaca ttaaaccatt cctgtcttca gctccagagg taagaatcta cgatctttca
     1681 aaatatgatc atggatcaga tgatgtgctg atcttggcca ctgatggact ctgggacgtt
     1741 ttatcaaatg aagaagtagc agaagcaatc actcagtttc ttcctaactg tgatccagat
     1801 gatcctcaca ggtacacact ggcagctcag gacctggtga tgcgtgcccg gggtgtgctg
     1861 aaggacagag gatggcggat atctaatgac cgactgggct caggagacga catttctgta
     1921 tatgtcattc ctttaataca tggaaacaag ctgtcatgaa aatggcccag gggattggga
     1981 ggacagaggg gaagaaagct gggatgcctc ttggcaggac ggaactggga agtgccccag
     2041 ctgagttcca agtgatgcag tctcttccca gcccaagcgg ggagttcatg gccaaaagac
     2101 tatgcttcaa gatgaccctt tggtttccat ttcttcttta gtaacaggtc aactcaacaa
     2161 gagcaaaaca caaaggctgc taccaagtgt tgttgtattt cagttccttt cataggcctc
     2221 cgaggtggcc attgactatt tggggtatat atgtcatatt tattttatct agagtagctg
     2281 gggcagccat tttcaggtgt aaatggcaga ggactcttca gcctgtcaag ctgccagctt
     2341 atctacgggt taaaaagtgc tgcattggaa agtagggggt catgcctcaa aatgtaagta
     2401 agtgcccacc ttctaggaag cctgaggttt atttcaggga ttgccgtctg ccccccgccc
     2461 cccttctctt tttttcttct ctgtttctat tcttttatgg cagtggtgga gtgaggcagg
     2521 gatttttttt tttttttttc gtgtttttga cattccttga atctgttttt tattcccctt
     2581 ccacagaaca ggcctgggac tttccaacac cctgctaagg aagttctgtg tccaagtccc
     2641 acccaggctg ggttgtcccc acctcctcca gcccacacag cccaggcagc atccgggcca
     2701 gtgccctgca tgacagaggg tctttgttgt gtaatgtttg ttcccaagtt gcattttcta
     2761 accgaatcag tgtgttttca tgaaactgag tgtttctgtg gaccagtagt tcctctgttg
     2821 tcttcagtgg tcttcctgtg tggctcaagg gttctctgtg agagtctgga ttttcatttc
     2881 tggaatggct ggccccatcc cacttttctg tatcatgggg acacatataa agcagtgttt
     2941 aatagagcag tttaagaagt tgcttgcatc tgttggttca ccatggctca tctggggacc
     3001 attttggatt catgtttcat ggcttgtgac tgtccccaag cccactccaa acaaagtgta
     3061 aggatcagag ttctgtcaag gagcagcagt tctgctctcc ccatcatctt tgtgcaaggc
     3121 ccctcggggg gcactttaat aaaagaattt gaaatgggtt gactggccat tctcatgctg
     3181 tgctccctgt ctcttctctt ctctaaagaa tcatgtccca gctcctcaag gtccctctat
     3241 ggttccacat ctgagtgttc gccacaagag cagcagcagc aggcacagtg catgccatat
     3301 ctacctgctg cttctctgct gggaggaatg gccaagtaga ttataaaact cacttctgtc
     3361 tcttaggcag acttgtacgg ccacaaaatt acctagtctt cttcctgctg agctactgag
     3421 gtattgccac cattttgaca actttgagta attaaaacac tcttctgacc caaaaaggaa
     3481 aaaaggtcac tgacgtgacc cccccagcat gctagagagc taattccagt tctcatattt
     3541 gtttgaattt cttcccagag gagaggatag gaacctctcc tccagggcag taaatcacct
     3601 gcatttctgg agttgtcggt attgtattcg aaaaggcctg gagcccctcc tgctcaggaa
     3661 agaactcatt ccagggtgtg gagacagtgc cgtctggcag gtgaaatact gtgggaattc
     3721 acgccaccag gtgtttgtgc aagtgttggc ctgggaagaa tgggacttcg gccttgtcag
     3781 gagttgtctt catctgcagc acgtttcttc ctcctgcagt agatcttagc taccccagat
     3841 atctctatgg agagaagttt gtggaaaatg ctttgcttcg tggcagagtc tgatgctgta
     3901 ggaaaacctt cgggcatgtg acagcagtgt ggtccactcc ctgttctgcc ctggcactca
     3961 gagtcatgtg taagtaggaa acctgagcaa gtcttccgtg gaggaccctg agctgccgtc
     4021 tttgggatcc ttcctgtgtc cccaccgtct ttcatttatt tgctttcctg ggcctctatc
     4081 tgggccctac cttgagcttc tccagtttta ttcaagccac cagagtaaga atttgggtgt
     4141 agatgtcaca actaccttct actcaattca ccaattcatt tactgctatg gcacgtctca
     4201 ggaataactc tagaaacctc taaatcgaaa tattataaaa tcttgagcac ttagtcctgc
     4261 tggttttagt tagaaaggca tccaggaatt gttttcctac gcccccttga gtggaaagat
     4321 cttagttaga agataaagtc aagtttgtgt tcaggggatg ggaggaagac tataaataag
     4381 atgaagaaat caaaagtagg aaacatgatg taaacgaagc atggcagatc tgtccagcac
     4441 tgatattgct ctataaattg agcttactca gttttggcct tattttttta cccaggcccc
     4501 atgtcaccca gtcctaaaac agtaaccgtg tctacataac gggttggccc ctggtgcatc
     4561 cctggaaaag tcaaaggacg cacacttcga aattctgcag aacgtattta tacatggttc
     4621 agaaatcttg cgtatctgac ttatagccaa atctgcttgc tcgaatagcc tcagaggaag
     4681 tcttgtttaa taaaaacctt ttgatttcct agtcaagtct ttatggttgt ctcgaggggt
     4741 gtgtggctac tttaatgaaa ggctttcctg ctctaaatct ctttgctggg ctgggcctct
     4801 tcagactatc tggtgaaact cctttcctta gaacaaactc agtccgtcca tgctctgtgg
     4861 cattttgcta gatgataacc aaagccttat tcctgtagcc agtgtcagca gtcagagagg
     4921 tggagggtgt gttctgctgt ggttatgcat acctatctgc tgttcttgag gtgtaaaagg
     4981 aaaggtgaaa atcgggccag gccaagtact cagctgtctt aataggatga agccttaagc
     5041 agtggaaatt tcagttattt tccacagtat tccattttgg aggatttggg gtgtttactt
     5101 tttaaattct tgaacaactt aacctccatg aggctttgtg aagtcagctg tgaccaccct
     5161 cctcttactg tgttctcagt attcattcac ttccagggaa gaatgacagc cacagggaga
     5221 tggtggtggg caagaatgag agtcccagga tccagattta gcctcagatc ttccccattc
     5281 aggaagggtt ttccatttaa caagagcact agtatgaaaa cattagggac aaatctccca
     5341 tgtctttgaa attcggattc tcctcttgag atccccttcc tcacctgcca atcaacttta
     5401 taaggccaca agtggtcact ggttttcctt ccacaggttt gaggttctca gctttcctta
     5461 agcgacccag cagctccgct gttttcagag tgaatatgtt aagctttgat gagattctat
     5521 tttcagtaag ttagtgcttc tgggacactt ggagaaagct gtgagagtca ttgtctacgc
     5581 aaagaacaac gaagctgatc ctaaaagtga tccaatctaa gaaaatggta aaacgagctc
     5641 tggccacagc acagaatttt atgtgaggaa ctcagatttt tgaagactta acaattgcag
     5701 agaaaggttg cagcctgcac accatagccc acctctctga gcagactttg gttttgtgtg
     5761 gtgacgtggc acatgtttgt acactgggat ttttcaaagg acgctacgcg agcagactga
     5821 cttgcctctt ctgtgagcac tgtggctttt gtcagatgga gtgccggtct gcagaggact
     5881 gctctttcga atccacagtg ttatctgtgt aaatagcttt aatttttctt ctgtgtctta
     5941 ggtgaagttt tgttcatgta gcaaccaggt agacagtgac caaataaggc tgtaaatgtg
     6001 ctgtagtttt ctactgtgat gtacttgaag gagaacctgt gtcctctact tttctgatct
     6061 cccacaagta ttttgtgttt gtttcctgag tcctgaggtt attattttac tcctgttttg
     6121 cccccagttt tctttgtttt ttttctggag acccagggag gcccatggtg gagatcattt
     6181 gtaaggaatg gatcatggtc tgggtttcca aaactaccct agtacagtga atgagagaaa
     6241 tctgcctgga aattgtttca gaaccatgta cctttatgct ttgtgattgt gaaacattga
     6301 cttttttgta accccaaaat gaaaactgtt tagtaaaggg gatctatttt gtgtgttttg
     6361 aaacttaggt gcaatgtccc ctggaaaaag ctaaagaaat gtatatgttc aatgacattt
     6421 taaaataaaa tattatatat atgtatatac gaca
//
