LOCUS       NM_177983               2210 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1G (PPM1G),
            mRNA.
ACCESSION   NM_177983 NM_002707
VERSION     NM_177983.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2210)
  AUTHORS   Song,M., Xu,M., Zhang,Q., Fan,T., Xu,J., Hang,C., Cheng,C., Ou,X.,
            Gong,C. and Lu,Q.
  TITLE     PPM1G promotes autophagy and progression of pancreatic cancer via
            upregulating HMGB1
  JOURNAL   Cell Signal 123, 111342 (2024)
   PUBMED   39121976
  REMARK    GeneRIF: PPM1G promotes autophagy and progression of pancreatic
            cancer via upregulating HMGB1.
REFERENCE   2  (bases 1 to 2210)
  AUTHORS   Yin,R., Qu,L., Wang,Z., Tang,J., Gu,H., Wang,X., Yang,D., Du,P. and
            Dong,M.
  TITLE     Prognostic and immunological potential of PPM1G in lung
            adenocarcinoma
  JOURNAL   Mol Med Rep 28 (2) (2023)
   PUBMED   37387407
  REMARK    GeneRIF: Prognostic and immunological potential of PPM1G in lung
            adenocarcinoma.
REFERENCE   3  (bases 1 to 2210)
  AUTHORS   Chen,J., Li,J., Sun,H., Hu,T., Wang,Y., Kang,G., Cao,M. and Li,X.
  TITLE     PPM1G promotes the progression of lung adenocarcinoma by inhibiting
            p38 activation via dephosphorylation of MEK6
  JOURNAL   Carcinogenesis 44 (1), 93-104 (2023)
   PUBMED   36349938
  REMARK    GeneRIF: PPM1G promotes the progression of lung adenocarcinoma by
            inhibiting p38 activation via dephosphorylation of MEK6.
REFERENCE   4  (bases 1 to 2210)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2210)
  AUTHORS   Kim,M., Park,J., Bouhaddou,M., Kim,K., Rojc,A., Modak,M.,
            Soucheray,M., McGregor,M.J., O'Leary,P., Wolf,D., Stevenson,E.,
            Foo,T.K., Mitchell,D., Herrington,K.A., Munoz,D.P., Tutuncuoglu,B.,
            Chen,K.H., Zheng,F., Kreisberg,J.F., Diolaiti,M.E., Gordan,J.D.,
            Coppe,J.P., Swaney,D.L., Xia,B., van 't Veer,L., Ashworth,A.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein interaction landscape of breast cancer
  JOURNAL   Science 374 (6563), eabf3066 (2021)
   PUBMED   34591612
REFERENCE   6  (bases 1 to 2210)
  AUTHORS   Suh,E.J., Kim,T.Y. and Kim,S.H.
  TITLE     PP2Cgamma-mediated S-phase accumulation induced by the
            proteasome-dependent degradation of p21(WAF1/CIP1)
  JOURNAL   FEBS Lett 580 (26), 6100-6104 (2006)
   PUBMED   17054950
  REMARK    GeneRIF: The degradation of p21(WAF1/CIP1) induced by PP2Cgamma was
            mediated in a proteasome-dependent manner.
REFERENCE   7  (bases 1 to 2210)
  AUTHORS   Flajolet,M., Rakhilin,S., Wang,H., Starkova,N., Nuangchamnong,N.,
            Nairn,A.C. and Greengard,P.
  TITLE     Protein phosphatase 2C binds selectively to and dephosphorylates
            metabotropic glutamate receptor 3
  JOURNAL   Proc Natl Acad Sci U S A 100 (26), 16006-16011 (2003)
   PUBMED   14663150
REFERENCE   8  (bases 1 to 2210)
  AUTHORS   Murray,M.V., Kobayashi,R. and Krainer,A.R.
  TITLE     The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing
            factor
  JOURNAL   Genes Dev 13 (1), 87-97 (1999)
   PUBMED   9887102
REFERENCE   9  (bases 1 to 2210)
  AUTHORS   Guthridge,M.A., Bellosta,P., Tavoloni,N. and Basilico,C.
  TITLE     FIN13, a novel growth factor-inducible serine-threonine phosphatase
            which can inhibit cell cycle progression
  JOURNAL   Mol Cell Biol 17 (9), 5485-5498 (1997)
   PUBMED   9271424
  REMARK    GeneRIF: Functional study of the mouse homolog
REFERENCE   10 (bases 1 to 2210)
  AUTHORS   Travis,S.M. and Welsh,M.J.
  TITLE     PP2C gamma: a human protein phosphatase with a unique acidic domain
  JOURNAL   FEBS Lett 412 (3), 415-419 (1997)
   PUBMED   9276438
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA520893.1 and BC000057.2.
            
            On Nov 23, 2018 this sequence version replaced NM_177983.2.
            
            Summary: The protein encoded by this gene is a member of the PP2C
            family of Ser/Thr protein phosphatases. PP2C family members are
            known to be negative regulators of cell stress response pathways.
            This phosphatase is found to be responsible for the
            dephosphorylation of Pre-mRNA splicing factors, which is important
            for the formation of functional spliceosome. Studies of a similar
            gene in mice suggested a role of this phosphatase in regulating
            cell cycle progression. [provided by RefSeq, Apr 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.55608.1,
                                           SRR1803614.275238.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344034.5/ ENSP00000342778.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                DA520893.1         93-151
            60-2210             BC000057.2         1-2151
FEATURES             Location/Qualifiers
     source          1..2210
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..2210
                     /gene="PPM1G"
                     /gene_synonym="PP2CG; PP2CGAMMA; PPP2CG"
                     /note="protein phosphatase, Mg2+/Mn2+ dependent 1G"
                     /db_xref="GeneID:5496"
                     /db_xref="HGNC:HGNC:9278"
                     /db_xref="MIM:605119"
     exon            1..289
                     /gene="PPM1G"
                     /gene_synonym="PP2CG; PP2CGAMMA; PPP2CG"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1810
                     /gene="PPM1G"
                     /gene_synonym="PP2CG; PP2CGAMMA; PPP2CG"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase magnesium-dependent 1 gamma;
                     protein phosphatase 1C; PP2C-gamma"
                     /codon_start=1
                     /product="protein phosphatase 1G"
                     /protein_id="NP_817092.1"
                     /db_xref="CCDS:CCDS1752.1"
                     /db_xref="GeneID:5496"
                     /db_xref="HGNC:HGNC:9278"
                     /db_xref="MIM:605119"
                     /translation="MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHN
                     CIPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAID
                     AKLTTEEVIKELAQIAGRPTEDEDEKEKVADEDDVDNEEAALLHEEATMTIEELLTRY
                     GQNCHKGPPHSKSGGGTGEEPGSQGLNGEAGPEDSTRETPSQENGPTAKAYTGFSSNS
                     ERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEE
                     CSEEEDGYSSEEAENEEDEDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDSGTTAVVA
                     LIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDGRVNG
                     GLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQ
                     EVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICFKPR
                     NTAELQPESGKRKLEEVLSTEGAEENGNSDKKKKAKRD"
     exon            290..359
                     /gene="PPM1G"
                     /gene_synonym="PP2CG; PP2CGAMMA; PPP2CG"
                     /inference="alignment:Splign:2.1.0"
     exon            360..445
                     /gene="PPM1G"
                     /gene_synonym="PP2CG; PP2CGAMMA; PPP2CG"
                     /inference="alignment:Splign:2.1.0"
     exon            446..578
                     /gene="PPM1G"
                     /gene_synonym="PP2CG; PP2CGAMMA; PPP2CG"
                     /inference="alignment:Splign:2.1.0"
     exon            579..994
                     /gene="PPM1G"
                     /gene_synonym="PP2CG; PP2CGAMMA; PPP2CG"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1135
                     /gene="PPM1G"
                     /gene_synonym="PP2CG; PP2CGAMMA; PPP2CG"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1370
                     /gene="PPM1G"
                     /gene_synonym="PP2CG; PP2CGAMMA; PPP2CG"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1500
                     /gene="PPM1G"
                     /gene_synonym="PP2CG; PP2CGAMMA; PPP2CG"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1603
                     /gene="PPM1G"
                     /gene_synonym="PP2CG; PP2CGAMMA; PPP2CG"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..2210
                     /gene="PPM1G"
                     /gene_synonym="PP2CG; PP2CGAMMA; PPP2CG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2192..2197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPM1G"
                     /gene_synonym="PP2CG; PP2CGAMMA; PPP2CG"
                     /note="hexamer: ACTAAA"
     polyA_site      2210
                     /gene="PPM1G"
                     /gene_synonym="PP2CG; PP2CGAMMA; PPP2CG"
                     /note="major polyA site"
ORIGIN      
        1 acagctcccg tcccgttacc gcctcctggc cggcctcgcg cctttcaccg gcaccttgcg
       61 tcggtcgcgc cgcggggcct gctcctgccg cgcgcacccc cggggcttcg gctccggcac
      121 gggtcgcgcc cagctttcct gcacctgagg ccgccggcca gccgccgcca tgggtgccta
      181 cctctcccag cccaacacgg tgaagtgctc cggggacggg gtcggcgccc cgcgcctgcc
      241 gctgccctac ggcttctccg ccatgcaagg ctggcgcgtc tccatggagg atgctcacaa
      301 ctgtattcct gagctggaca gtgagacagc catgttttct gtctacgatg gacatggagg
      361 ggaggaagtt gccttgtact gtgccaaata tcttcctgat atcatcaaag atcagaaggc
      421 ctacaaggaa ggcaagctac agaaggcttt agaagatgcc ttcttggcta ttgacgccaa
      481 attgaccact gaagaagtca ttaaagagct ggcacagatt gcagggcgac ccactgagga
      541 tgaagatgaa aaagaaaaag tagctgatga agatgatgtg gacaatgagg aggctgcact
      601 gctgcatgaa gaggctacca tgactattga agagctgctg acacgctacg ggcagaactg
      661 tcacaagggc cctccccaca gcaaatctgg aggtgggaca ggcgaggaac cagggtccca
      721 gggcctcaat ggggaggcag gacctgagga ctcaactagg gaaactcctt cacaagaaaa
      781 tggccccaca gccaaggcct acacaggctt ttcctccaac tcggaacgtg ggactgaggc
      841 aggccaagtt ggtgagcctg gcattcccac tggtgaggct gggccttcct gctcttcagc
      901 ctctgacaag ctgcctcgag ttgctaagtc caagttcttt gaggacagtg aggatgagtc
      961 agatgaggcg gaggaagaag aggaagacag tgaggaatgc agcgaggaag aggatggcta
     1021 cagcagtgag gaggcagaga atgaggaaga tgaggatgac accgaggagg ctgaagagga
     1081 cgatgaagaa gaagaagaag agatgatggt gccagggatg gaaggcaaag aggagcctgg
     1141 ctctgacagt ggtacaacag cggtggtggc cctgatacga gggaagcagt tgattgtagc
     1201 caacgcagga gactctcgct gtgtggtatc tgaggctggc aaagctttag acatgtccta
     1261 tgatcacaaa ccagaggatg aagtagaact agcacgcatc aagaatgctg gtggcaaggt
     1321 caccatggat gggcgagtca acgggggcct caacctctcc agagccattg gggaccactt
     1381 ctataagaga aacaagaacc tgccacctga ggaacagatg atttcagccc ttcctgacat
     1441 caaggtgctg actctcactg acgaccatga attcatggtc attgcctgtg atggcatctg
     1501 gaatgtgatg agcagccagg aagttgtaga tttcattcaa tcaaagatca gccagcgtga
     1561 tgaaaatggg gagcttcggt tattgtcatc cattgtggaa gagctgctgg atcagtgcct
     1621 ggcaccagac acttctgggg atggtacagg gtgtgacaac atgacctgca tcatcatttg
     1681 cttcaagccc cgaaacacag cagagctcca gccagagagt ggcaagcgaa aactagagga
     1741 ggtgctctct actgaggggg ctgaagaaaa tggcaacagc gacaagaaga agaaggccaa
     1801 gcgagactag cagtcatcca gacccctgcc cacctagact gttttctgag ccctccggac
     1861 ctgagactga gttttgtctt tttcctttag ccttagcagt gggtatgagg tgtgcagggg
     1921 gagctgggtg gcttcactcc gcccattcca aagagggctc tccctccaca ctgcagccgg
     1981 gagcctctgc tgtccttccc agccgcctct gctcctcggg ctcatcaccg gttctgtgcc
     2041 tgtgctctgt tgtgttggag ggaaggactg gcggttctgg tttttactct gtgaacttta
     2101 tttaaggaca ttctttttta ttggcggctc catggccctc ggccgcttgc acccgctctc
     2161 tgttgtacac tttcaatcaa cactttttca gactaaaggc caaaacctaa
//
