LOCUS       NM_014634               5149 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1F (PPM1F),
            transcript variant 1, mRNA.
ACCESSION   NM_014634
VERSION     NM_014634.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5149)
  AUTHORS   Asanoma,K., Yagi,H., Onoyama,I., Cui,L., Hori,E., Kawakami,M.,
            Maenohara,S., Hachisuga,K., Tomonobe,H., Kodama,K., Yasunaga,M.,
            Ohgami,T., Okugawa,K., Yahata,H., Kitao,H. and Kato,K.
  TITLE     The BHLHE40-PPM1F-AMPK pathway regulates energy metabolism and is
            associated with the aggressiveness of endometrial cancer
  JOURNAL   J Biol Chem 300 (3), 105695 (2024)
   PUBMED   38301894
  REMARK    GeneRIF: The BHLHE40-PPM1F-AMPK pathway regulates energy metabolism
            and is associated with the aggressiveness of endometrial cancer.
REFERENCE   2  (bases 1 to 5149)
  AUTHORS   Grimm,T.M., Dierdorf,N.I., Betz,K., Paone,C. and Hauck,C.R.
  TITLE     PPM1F controls integrin activity via a conserved phospho-switch
  JOURNAL   J Cell Biol 219 (12) (2020)
   PUBMED   33119040
  REMARK    GeneRIF: PPM1F controls integrin activity via a conserved
            phospho-switch.
REFERENCE   3  (bases 1 to 5149)
  AUTHORS   Zhang,C., Han,X., Yang,L., Fu,J., Sun,C., Huang,S., Xiao,W.,
            Gao,Y., Liang,Q., Wang,X., Luo,F., Lu,W. and Zhou,Y.
  TITLE     Circular RNA circPPM1F modulates M1 macrophage activation and
            pancreatic islet inflammation in type 1 diabetes mellitus
  JOURNAL   Theranostics 10 (24), 10908-10924 (2020)
   PUBMED   33042261
  REMARK    GeneRIF: Circular RNA circPPM1F modulates M1 macrophage activation
            and pancreatic islet inflammation in type 1 diabetes mellitus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5149)
  AUTHORS   Singh,P., Gan,C.S., Guo,T., Phang,H.Q., Sze,S.K. and Koh,C.G.
  TITLE     Investigation of POPX2 phosphatase functions by comparative
            phosphoproteomic analysis
  JOURNAL   Proteomics 11 (14), 2891-2900 (2011)
   PUBMED   21656682
  REMARK    GeneRIF: Data identify a biochemical pathway through which POPX2
            exerts its apparent cellular function: the regulation of activity
            of glycogen synthase kinase-3, which in turn modulates
            extracellular signal-regulated kinase and cell motility.
REFERENCE   5  (bases 1 to 5149)
  AUTHORS   Voss,M., Paterson,J., Kelsall,I.R., Martin-Granados,C.,
            Hastie,C.J., Peggie,M.W. and Cohen,P.T.
  TITLE     Ppm1E is an in cellulo AMP-activated protein kinase phosphatase
  JOURNAL   Cell Signal 23 (1), 114-124 (2011)
   PUBMED   20801214
  REMARK    Erratum:[Cell Signal. 2011 May;23(5):947]
REFERENCE   6  (bases 1 to 5149)
  AUTHORS   Xie,Y., Tan,E.J., Wee,S., Manser,E., Lim,L. and Koh,C.G.
  TITLE     Functional interactions between phosphatase POPX2 and mDia modulate
            RhoA pathways
  JOURNAL   J Cell Sci 121 (Pt 4), 514-521 (2008)
   PUBMED   18230650
REFERENCE   7  (bases 1 to 5149)
  AUTHORS   Harvey,B.P., Banga,S.S. and Ozer,H.L.
  TITLE     Regulation of the multifunctional Ca2+/calmodulin-dependent protein
            kinase II by the PP2C phosphatase PPM1F in fibroblasts
  JOURNAL   J Biol Chem 279 (23), 24889-24898 (2004)
   PUBMED   15140879
  REMARK    GeneRIF: PPM1F plays a key role in the regulation of CaMKII
            intracellularly
REFERENCE   8  (bases 1 to 5149)
  AUTHORS   Koh,C.G., Tan,E.J., Manser,E. and Lim,L.
  TITLE     The p21-activated kinase PAK is negatively regulated by POPX1 and
            POPX2, a pair of serine/threonine phosphatases of the PP2C family
  JOURNAL   Curr Biol 12 (4), 317-321 (2002)
   PUBMED   11864573
  REMARK    GeneRIF: The p21-activated kinase PAK is negatively regulated by
            POPX1 and POPX2, a pair of serine/threonine phosphatases of the
            PP2C family. (POPX1; POPX2)
REFERENCE   9  (bases 1 to 5149)
  AUTHORS   Tan,K.M., Chan,S.L., Tan,K.O. and Yu,V.C.
  TITLE     The Caenorhabditis elegans sex-determining protein FEM-2 and its
            human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein
            kinase phosphatases that promote apoptosis
  JOURNAL   J Biol Chem 276 (47), 44193-44202 (2001)
   PUBMED   11559703
REFERENCE   10 (bases 1 to 5149)
  AUTHORS   Kitani,T., Ishida,A., Okuno,S., Takeuchi,M., Kameshita,I. and
            Fujisawa,H.
  TITLE     Molecular cloning of Ca2+/calmodulin-dependent protein kinase
            phosphatase
  JOURNAL   J Biochem 125 (6), 1022-1028 (1999)
   PUBMED   10348902
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291628.1, AC245452.3 and
            N34773.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014634.3.
            
            Summary: The protein encoded by this gene is a member of the PP2C
            family of Ser/Thr protein phosphatases. PP2C family members are
            known to be negative regulators of cell stress response pathways.
            This phosphatase can interact with Rho guanine nucleotide exchange
            factors (PIX), and thus block the effects of p21-activated kinase 1
            (PAK), a protein kinase mediating biological effects downstream of
            Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma
            (CAMK2G/CAMK-II) is found to be one of the substrates of this
            phosphatase. The overexpression of this phosphatase or CAMK2G has
            been shown to mediate caspase-dependent apoptosis. An alternatively
            spliced transcript variant has been identified, but its full-length
            nature has not been determined. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291628.1, D13640.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263212.10/ ENSP00000263212.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1375              AK291628.1         1-1375
            1376-5133           AC245452.3         64230-67987         c
            5134-5149           N34773.1           21-36               c
FEATURES             Location/Qualifiers
     source          1..5149
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.22"
     gene            1..5149
                     /gene="PPM1F"
                     /gene_synonym="CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2"
                     /note="protein phosphatase, Mg2+/Mn2+ dependent 1F"
                     /db_xref="GeneID:9647"
                     /db_xref="HGNC:HGNC:19388"
                     /db_xref="MIM:619309"
     exon            1..57
                     /gene="PPM1F"
                     /gene_synonym="CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            58..323
                     /gene="PPM1F"
                     /gene_synonym="CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1482
                     /gene="PPM1F"
                     /gene_synonym="CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     partner of PIX 2; protein phosphatase 1F (PP2C domain
                     containing); Ca(2+)/calmodulin-dependent protein kinase
                     phosphatase; CaM-kinase phosphatase; PP2C phosphatase;
                     protein fem-2 homolog"
                     /codon_start=1
                     /product="protein phosphatase 1F isoform 1"
                     /protein_id="NP_055449.1"
                     /db_xref="CCDS:CCDS13796.1"
                     /db_xref="GeneID:9647"
                     /db_xref="HGNC:HGNC:19388"
                     /db_xref="MIM:619309"
                     /translation="MSSGAPQKSSPMASGAEETPGFLDTLLQDFPALLNPEDPLPWKA
                     PGTVLSQEEVEGELAELAMGFLGSRKAPPPLAAALAHEAVSQLLQTDLSEFRKLPREE
                     EEEEEDDDEEEKAPVTLLDAQSLAQSFFNRLWEVAGQWQKQVPLAARASQRQWLVSIH
                     AIRNTRRKMEDRHVSLPSFNQLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAA
                     RQPELPTDPEGALREAFRRTDQMFLRKAKRERLQSGTTGVCALIAGATLHVAWLGDSQ
                     VILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGDVFQK
                     PYVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSGLRVAEE
                     LVAAARERGSHDNITVMVVFLRDPQELLEGGNQGEGDPQAEGRRQDLPSSLPEPETQA
                     PPRS"
     exon            324..472
                     /gene="PPM1F"
                     /gene_synonym="CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            473..675
                     /gene="PPM1F"
                     /gene_synonym="CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..864
                     /gene="PPM1F"
                     /gene_synonym="CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1008
                     /gene="PPM1F"
                     /gene_synonym="CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1102
                     /gene="PPM1F"
                     /gene_synonym="CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..5149
                     /gene="PPM1F"
                     /gene_synonym="CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5130..5135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPM1F"
                     /gene_synonym="CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2"
                     /note="hexamer: AATAAA"
     polyA_site      5149
                     /gene="PPM1F"
                     /gene_synonym="CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2"
                     /note="major polyA site"
ORIGIN      
        1 agcagcttgc gggacacgga gccgcgagga gacagctgag gcccgcggag accagggggt
       61 gaagcctgga gaccctcttg ccctggccta gctgcaggcc cccgggatgc tttgggcatg
      121 tcctctggag ccccacagaa gagcagccca atggccagtg gagctgagga gaccccaggc
      181 ttcctggaca cgctcctgca agacttccca gccctgctga acccagagga ccctctgcca
      241 tggaaggccc cagggacggt gctcagccag gaggaggtgg agggcgagct ggctgagctg
      301 gccatgggct ttctgggcag caggaaggcc ccgccaccac ttgctgctgc tctggcccac
      361 gaagcagttt cacagctgct acagacagac ctttccgaat tcaggaagtt gcccagggag
      421 gaagaagaag aggaggagga cgatgacgag gaggaaaagg cccctgtgac cttgctggat
      481 gcccaaagcc tggcacagag tttctttaac cgcctttggg aagtcgccgg ccagtggcag
      541 aagcaggtgc cattggctgc ccgggcctca cagcggcagt ggctggtctc catccacgcc
      601 atccggaaca ctcgccgcaa gatggaggac cggcacgtgt ccctcccttc cttcaaccag
      661 ctcttcggct tgtctgaccc tgtgaaccgc gcctactttg ctgtgtttga tggtcacgga
      721 ggcgtggatg ctgcgaggta cgccgctgtc cacgtgcaca ccaacgctgc ccgccagcca
      781 gagctgccca cagaccctga gggagccctc agagaagcct tccggcgcac cgaccagatg
      841 tttctcagga aagccaagcg agagcggctg cagagcggca ccacaggtgt gtgtgcgctc
      901 attgcaggag cgaccctgca cgtcgcctgg ctcggggatt cccaggtcat tttggtacag
      961 cagggacagg tggtgaagct gatggagcca cacagaccag aacggcagga tgagaaggcg
     1021 cgcattgaag cattgggtgg ctttgtgtct cacatggact gctggagagt caacgggacc
     1081 ctggccgtct ccagagccat cggggatgtc ttccagaagc cctacgtgtc tggggaggcc
     1141 gatgcagctt cccgggcgct gacgggctcc gaggactacc tgctgcttgc ctgtgatggc
     1201 ttctttgacg tcgtacccca ccaggaagtt gttggcctgg tccagagcca cctgaccagg
     1261 cagcagggca gcgggctccg tgtcgccgag gagctggtgg ctgcggcccg ggagcggggc
     1321 tcccacgaca acatcacggt catggtggtc ttcctcaggg acccccaaga gctgctggag
     1381 ggcgggaacc agggagaagg ggacccccag gcagaaggga ggaggcagga cttgccctcc
     1441 agccttccag aacctgagac ccaggctcca ccaagaagct aggtggtttc caggcccctg
     1501 ccctcccctt cctcccatcc ttgtccttct ctccctcaga agcctcagga cccaacaggt
     1561 ggcaggcagt ggacagggtg cccgccccac agtgctttcc ccagcacccc agagccagtc
     1621 gggacacccc ccgcagcccg tcctggtggc tgtggaactg cactgggtgg cgggcagatg
     1681 gtggaaggca gcttaggaga cctcaccaaa gagaagatgg accggctctt gctcccagct
     1741 cctattaggc ccggggtggg accagaggtc ataggtgccc aacggcagcc aaaccaaaga
     1801 cactggtgtg catggggcag catggttgtg cacgtgggac cctggggcgg acccaggagc
     1861 caaactcttg aagcaccccc tgggtcaggc ccagcagcgg agtggccagc cccagtttcc
     1921 cattgctcct ctctgcggcc agggccaggt gggttcatat ttacagatat gcccagccag
     1981 tcctggtcgg ccacaccagt gtcccaaaga ggagagcgca gcagagccag gggtctgttc
     2041 tgtagcagcc acccccctgc ccccactcca gggcagccat gatgtgcttg ggcccaccag
     2101 ggccttccgg gctgctctct tccctgagcc cggaaccggc gacgcacatg tgtcttttgt
     2161 tggtgtgttt gtttttttcc agggaggtct aattccgaag cagtattcca ggttttctct
     2221 ttgttttatc agtgccaaga tgacctgttg tgtcatataa tttaagcaga gcttagcatt
     2281 tattttattc tttagaaaac ttaagtattt acttttttaa agctattttt caaggaacct
     2341 ttttttgcag tattattgaa tttattttct aaatcaggat tgaaacagga acttttccag
     2401 gtggtgttaa taagccattc aagtgcctta cacagctttg aagaaactag gactgcagtg
     2461 ggctcggata ggcccattga ggtttttaga aaagcaggat ttgttttgtt agggaggcat
     2521 gattttggtg agatctttct ggaagagttt tccgcctctt tgtgatgctg aacaccccca
     2581 aggttctccc ctccccccgc tgcccaggtg actggcagga gctgcgactg ccacgtagtg
     2641 gtgcctgggc ccgacagcgg ggctctgggc atcccgggtg accttggccc atctgcctgc
     2701 attcccaccc ccttgggcct ggctggatcc caggcagagg gaccttgctg ctgtgtgatt
     2761 ggaacattcc caaatatctt gtgaatttgt aatcaaattg gtctcattgg gaaagactct
     2821 taattaagag gctcaggcaa gcacagaggc agcccgtggg tctctgtctc agtctggagg
     2881 cagcagggat gctgctggga gtccatggca caggccacag cccctcacct tgccgcggtg
     2941 gctggcagca cgcctgcctt gctctgcccc atgccctgaa caggcatgag agctccacgt
     3001 cccctagtgc accctgagag ggggctcaca agtgaccgat cctgggtgcc tcagggagct
     3061 cactgagggc gtgcaaagtt gaaagtggca aggctggggg agggtgtcgg gtagagggaa
     3121 gagggcaggg ggctagggga ggactcagag gccatctgca gggccaagcc acaggaaggg
     3181 ctgagctgga ggtgggcagg gctgctccag gcaggtcaga gcagtgcagg gggaggagag
     3241 gagaaaggga ggaagctggg ctgtgtggtc cccatgaagg cattcagagt ccacctgcag
     3301 acagcgagag ccccaggaag gtttgcacag ctgtgcccca agcaccttgg cctcctctca
     3361 gctcgccgag gaggcacgct agagccgcct tcccggtggg agccctctgt cccacaggga
     3421 gcggggagcc agctttgctg gggccctacc tgcatgccca gccttacccc tcattctcac
     3481 agcacagatg aggttgagac catgcagtca atgcattgct taaggtctct tatttacaaa
     3541 aaaaaacctt aaacatagtc gctgtcattc agacattcag agaatggttg gccacaaaca
     3601 atgaccaagt attgcttggc ttaacttgaa ggcctgctgt ctccttctgg gggtcaggga
     3661 cgcagctcca ccctcaccac tagcccaccc tgcccgtggg cataaccttg acgaagagag
     3721 agaatgattg gcatctgctt ttctcttttc tttgctaata attctgttcc tggctgccga
     3781 gagtgaagtt tcaccatgtg gaggtttggc tcctatcacc tggtggtctg attcataccc
     3841 tagcctgagg ctccactgga agatctcgca gcctcagtgt atgggaaacc ctttccccag
     3901 gcttgtccca gcactgccgc tccccacccc tgagccagga ccccagagga tggccatgcc
     3961 ccgtgcctgg cagaggtctg gtgccagcac tgggagctgc tccgcccttg ccttggggcc
     4021 gagggagccc tcgtccaccc ctgcacagca gctgggcaca gaggagcgct cttccatctt
     4081 gaccaggact gcaccaagaa gcaccaggtg tcttcagcct ccaacctccg gggcgacctt
     4141 ctcttccagc cacagtccca tgagggcccc tagccaggga cactggtctg taaattgtaa
     4201 tcctttctcc agcccagctc tccacttgtt ccttgtgtga gctgagcagg cagtgcacct
     4261 ctgagtgtcc cttttgtaag gcccaggggt tgcactgagt ctgcagaggc cgcgacctcc
     4321 tagaacgctg tgggtgcagg tgagccggcg tgtcctgggg agatgctgcc agcacacagg
     4381 ggccctcctg ctgccagcag gttggggtgg ttaagtctta ttagtgtcta ttcttaaaat
     4441 taagtgggct ggagaagaat ggagctccac atgccagcac cgtatatgga atacaaaagc
     4501 tggggaagca gggcctgcct tacaggtgtg gctgactctg agcccaggcc tgcaggggtg
     4561 gagggcagtc cctcagaatc ccagaggcag tcccagcctc agaacccagg ataggaaatg
     4621 ggtgtgttta gtggggaaag ggacggggtg cagacggcag ggccagtatg gggccccctc
     4681 cctctcctct cctctcctat ggtgagccca gcgtgggcac cgggccgtct cagccgtgtt
     4741 cccagggctg ggaggacagc tctggccctt cttaggccta gcctcgtccc aagctaaatg
     4801 taagccagtt gggctgtgtt aaaggaagca gtgtttttgg ttcgattctg cctctgtagc
     4861 tcaagggggg cagcccccag agtcctgtgc attctgccaa ggctccatag ctttgccaaa
     4921 tgcacggagc tctgccattc cggtgcagtg caggccttgc gaagggttta tctgcgttcg
     4981 tctcggtggg cttctcctgc atgggagttg tgttcctgtg caagggggag ctttgctcca
     5041 ggacaggatg actgtcttcc ctattcttag ggacaagtcc caagatgcca gaaaggcagt
     5101 ctcccaagga cccaccatgc agaagtgtca ataaaccaca agttctgaa
//
