LOCUS       NM_002706               2608 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1B (PPM1B),
            transcript variant 1, mRNA.
ACCESSION   NM_002706
VERSION     NM_002706.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2608)
  AUTHORS   Yang,J., Li,X., Zhang,Y., Che,P., Qin,W., Wu,X., Liu,Y. and Hu,B.
  TITLE     Circ_0090231 knockdown protects vascular smooth muscle cells from
            ox-LDL-induced proliferation, migration and invasion via
            miR-942-5p/PPM1B axis during atherosclerosis
  JOURNAL   Mol Cell Biochem 479 (8), 2035-2045 (2024)
   PUBMED   37515673
  REMARK    GeneRIF: Circ_0090231 knockdown protects vascular smooth muscle
            cells from ox-LDL-induced proliferation, migration and invasion via
            miR-942-5p/PPM1B axis during atherosclerosis.
REFERENCE   2  (bases 1 to 2608)
  AUTHORS   Li,Y., Wei,D., Chen,Z., Chen,Y., Deng,Y., Li,M., Zhao,Y. and Niu,K.
  TITLE     RBM10 regulates the tumorigenic potential of human cancer cells by
            modulating PPM1B and YBX1 activities
  JOURNAL   Exp Cell Res 435 (2), 113932 (2024)
   PUBMED   38246397
  REMARK    GeneRIF: RBM10 regulates the tumorigenic potential of human cancer
            cells by modulating PPM1B and YBX1 activities.
REFERENCE   3  (bases 1 to 2608)
  AUTHORS   Du,L., Li,J., Tian,Y. and Feng,R.
  TITLE     Pleckstrin-2-promoted PPM1B degradation plays an important role in
            transforming growth factor-beta-induced breast cancer cell invasion
            and metastasis
  JOURNAL   Cancer Sci 114 (6), 2429-2444 (2023)
   PUBMED   36928924
  REMARK    GeneRIF: Pleckstrin-2-promoted PPM1B degradation plays an important
            role in transforming growth factor-beta-induced breast cancer cell
            invasion and metastasis.
REFERENCE   4  (bases 1 to 2608)
  AUTHORS   Li,R., Dou,J., Bai,T., Cai,B. and Liu,Y.
  TITLE     Protein Phosphatase PPM1B Inhibits Gastric Cancer Progression and
            Serves as a Favorable Prognostic Biomarker
  JOURNAL   Appl Immunohistochem Mol Morphol 30 (5), 366-374 (2022)
   PUBMED   35319516
  REMARK    GeneRIF: Protein Phosphatase PPM1B Inhibits Gastric Cancer
            Progression and Serves as a Favorable Prognostic Biomarker.
REFERENCE   5  (bases 1 to 2608)
  AUTHORS   Parvari,R., Gonen,Y., Alshafee,I., Buriakovsky,S., Regev,K. and
            Hershkovitz,E.
  TITLE     The 2p21 deletion syndrome: characterization of the transcription
            content
  JOURNAL   Genomics 86 (2), 195-211 (2005)
   PUBMED   15913950
REFERENCE   6  (bases 1 to 2608)
  AUTHORS   Seroussi,E., Shani,N., Ben-Meir,D., Chajut,A., Divinski,I.,
            Faier,S., Gery,S., Karby,S., Kariv-Inbal,Z., Sella,O.,
            Smorodinsky,N.I. and Lavi,S.
  TITLE     Uniquely conserved non-translated regions are involved in
            generation of the two major transcripts of protein phosphatase
            2Cbeta
  JOURNAL   J Mol Biol 312 (3), 439-451 (2001)
   PUBMED   11563908
REFERENCE   7  (bases 1 to 2608)
  AUTHORS   Cheng,A., Kaldis,P. and Solomon,M.J.
  TITLE     Dephosphorylation of human cyclin-dependent kinases by protein
            phosphatase type 2C alpha and beta 2 isoforms
  JOURNAL   J Biol Chem 275 (44), 34744-34749 (2000)
   PUBMED   10934208
REFERENCE   8  (bases 1 to 2608)
  AUTHORS   Cheng,A., Ross,K.E., Kaldis,P. and Solomon,M.J.
  TITLE     Dephosphorylation of cyclin-dependent kinases by type 2C protein
            phosphatases
  JOURNAL   Genes Dev 13 (22), 2946-2957 (1999)
   PUBMED   10580002
REFERENCE   9  (bases 1 to 2608)
  AUTHORS   Hishiya,A., Ohnishi,M., Tamura,S. and Nakamura,F.
  TITLE     Protein phosphatase 2C inactivates F-actin binding of human
            platelet moesin
  JOURNAL   J Biol Chem 274 (38), 26705-26712 (1999)
   PUBMED   10480873
REFERENCE   10 (bases 1 to 2608)
  AUTHORS   Marley,A.E., Kline,A., Crabtree,G., Sullivan,J.E. and Beri,R.K.
  TITLE     The cloning expression and tissue distribution of human PP2Cbeta
  JOURNAL   FEBS Lett 431 (1), 121-124 (1998)
   PUBMED   9684878
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA128532.1, AL833035.1 and
            BC064381.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002706.5.
            
            Summary: The protein encoded by this gene is a member of the PP2C
            family of Ser/Thr protein phosphatases. PP2C family members are
            known to be negative regulators of cell stress response pathways.
            This phosphatase has been shown to dephosphorylate cyclin-dependent
            kinases (CDKs), and thus may be involved in cell cycle control.
            Overexpression of this phosphatase is reported to cause cell-growth
            arrest or cell death. Alternative splicing results in multiple
            transcript variants encoding different isoforms. Additional
            transcript variants have been described, but currently do not
            represent full-length sequences. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.6469.1, AK056009.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282412.9/ ENSP00000282412.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               DA128532.1         73-293
            222-278             AL833035.1         99-155
            279-2608            BC064381.1         266-2595
FEATURES             Location/Qualifiers
     source          1..2608
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p21"
     gene            1..2608
                     /gene="PPM1B"
                     /gene_synonym="PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA;
                     PPC2BETAX"
                     /note="protein phosphatase, Mg2+/Mn2+ dependent 1B"
                     /db_xref="GeneID:5495"
                     /db_xref="HGNC:HGNC:9276"
                     /db_xref="MIM:603770"
     exon            1..400
                     /gene="PPM1B"
                     /gene_synonym="PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA;
                     PPC2BETAX"
                     /inference="alignment:Splign:2.1.0"
     exon            401..1260
                     /gene="PPM1B"
                     /gene_synonym="PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA;
                     PPC2BETAX"
                     /inference="alignment:Splign:2.1.0"
     CDS             415..1854
                     /gene="PPM1B"
                     /gene_synonym="PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA;
                     PPC2BETAX"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein phosphatase 2C-like protein; protein phosphatase
                     1B"
                     /codon_start=1
                     /product="protein phosphatase 1B isoform 1"
                     /protein_id="NP_002697.1"
                     /db_xref="CCDS:CCDS1817.1"
                     /db_xref="GeneID:5495"
                     /db_xref="HGNC:HGNC:9276"
                     /db_xref="MIM:603770"
                     /translation="MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVV
                     GIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENV
                     KNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNG
                     QVCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQ
                     LVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVV
                     DTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPD
                     LAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNPHRESDGASDEAEESGSQGKL
                     VEALRQMRINHRGNYRQLLEEMLTSYRLAKVEGEESPAEPAATATSSNSDAGNPVTMQ
                     ESHTESESGLAELDSSNEDAGTKMSGEKI"
     exon            1261..1378
                     /gene="PPM1B"
                     /gene_synonym="PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA;
                     PPC2BETAX"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1490
                     /gene="PPM1B"
                     /gene_synonym="PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA;
                     PPC2BETAX"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1548
                     /gene="PPM1B"
                     /gene_synonym="PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA;
                     PPC2BETAX"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..2608
                     /gene="PPM1B"
                     /gene_synonym="PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA;
                     PPC2BETAX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2581..2586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPM1B"
                     /gene_synonym="PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA;
                     PPC2BETAX"
                     /note="hexamer: AATAAA"
     polyA_site      2608
                     /gene="PPM1B"
                     /gene_synonym="PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA;
                     PPC2BETAX"
                     /note="major polyA site"
ORIGIN      
        1 gcaaaaggag ccgagcggct tctgctcaat ggcggaaaag ccgccggtgc tctgacggcc
       61 tcgttcccct agcagttgcg ggggagtttc ctgccggcgc ggctggagtc tctgattctc
      121 agggttcggt ggttggaaga tgctccagag agacgaggct gcggcggagg aggtggcggc
      181 ggccgaatcg gcaacggcgc tagggtggag agaaggcggc atcggcggcg gcggcggcgt
      241 gaggggccgg gcggtgtaaa cagccccgga ggcggcggtc gagaccccga gggggaagcg
      301 gcggctgagt cagggtcgcg cctccgttgg aaacttgggc tgagtaccgc ggcgggcgcg
      361 agcgaggcgc cctagacatc ttctccctcc cttgcctcag atttattgct aaacatgggt
      421 gcatttttgg ataaacccaa aactgaaaaa cataatgctc atggtgctgg gaatggttta
      481 cgttatggcc tgagcagcat gcaaggatgg agagtggaaa tggaagatgc acacacagct
      541 gttgtaggta ttcctcacgg cttggaagac tggtcatttt ttgcagttta tgatggtcat
      601 gctggatccc gagtggcaaa ttactgctca acacatttat tagaacacat cactactaac
      661 gaagacttta gggcagctgg aaaatcagga tctgctcttg agctttcagt ggaaaatgtt
      721 aagaatggta tcagaactgg atttttgaaa attgatgaat acatgcgtaa cttttcagac
      781 ctcagaaacg ggatggacag gagtggttca actgcagtgg gagttatgat ttcacctaag
      841 catatctact ttatcaactg tggtgattca cgtgctgttc tgtataggaa tggacaagtc
      901 tgcttttcta cccaggatca caaaccttgc aatccaaggg aaaaggagcg aatccaaaat
      961 gcaggaggca gcgtgatgat acaacgtgtt aatggttcat tagcagtatc tcgtgctctg
     1021 ggggactatg attacaagtg tgttgatggc aagggcccaa cagaacaact tgtttctcca
     1081 gagcctgagg tttatgaaat tttaagagca gaagaggatg aatttatcat cttggcttgt
     1141 gatgggatct gggatgttat gagtaatgag gagctctgtg aatatgttaa atctaggctt
     1201 gaggtatctg atgacctgga aaatgtgtgc aattgggtag tggacacttg tttacacaag
     1261 ggaagtcgag ataacatgag tattgtacta gtttgctttt caaatgctcc caaggtctca
     1321 gatgaagcgg tgaaaaaaga ttcagagttg gataagcact tggaatcacg ggttgaagag
     1381 attatggaga agtctggcga ggaaggaatg cctgatcttg cccatgtcat gcgcatcttg
     1441 tctgcagaaa atatcccaaa tttgcctcct gggggaggtc ttgctggcaa gcgtaatgtt
     1501 attgaagctg tttatagtag actgaatcca catagagaaa gtgatggggc ctccgatgaa
     1561 gcagaggaaa gtggatcaca gggaaaattg gtggaagctc tcaggcaaat gagaattaat
     1621 cataggggaa actaccgaca acttctggag gagatgctga ctagttacag gctagctaaa
     1681 gtagagggag aagaaagccc tgctgaacca gctgccacag ctacttcttc gaacagtgat
     1741 gctggaaacc cagtgacaat gcaggaaagc catactgaat cagaaagtgg tcttgctgaa
     1801 ttagacagct ctaatgaaga tgcagggaca aagatgagtg gtgaaaaaat atgactttcc
     1861 tttttggtaa tatttttgtg atctttgatg gtttttaacc taggaagtgt aatgtatgca
     1921 tttatataac tgttttgtta tttgaatctt ggaaaactag ttttattata ttcagatagc
     1981 cttgtttttt aaaaaggcct ttgcatacac ctttatgaga tagtgtaaaa ttgactattt
     2041 atagtactat ggatttaatg aaattatatg tcatttcaca ttgtatgcca gaaattaggc
     2101 taccaattat gaattaaagt cagtagttaa attaatacta gatagaatta gaaattttga
     2161 ttagagagat tatgctatat tatggaaaaa cttgttaatg tagaattata ctgcttcata
     2221 ttattttacc tattagtaca ctcatagtta gctttgtaat aaatttatgt tttctttaat
     2281 aattttagtt cttcaaagaa tggctgatgc tggcctgtaa tttttctttc aaggatgata
     2341 atttgtgtgt tgtttgattt gtttatattt tacatctctg tagttttatt tttagaagtt
     2401 gtgagatatt ggatgtgtgg ctatttttcc tttctctgta ttctttatga aacataactt
     2461 ttgaaaaacc tatgtattat tcatacagct ttggtttgta tattctgtat agcctaacta
     2521 cacacatcaa aatgtatgtc aaccaagtgt ttagaatgaa attataagtg tttaagtcca
     2581 aataaagcat gtgatgtgga ataatcta
//
