LOCUS       XM_047431501            9321 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1A
            (PPM1A), transcript variant X3, mRNA.
ACCESSION   XM_047431501
VERSION     XM_047431501.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     gene            1..9321
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /note="protein phosphatase, Mg2+/Mn2+ dependent 1A;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 3 mRNAs, 40 ESTs, 1730 long SRA reads, 13
                     Proteins, and 39% coverage of the annotated genomic
                     feature by RNAseq alignments, including 2 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
     CDS             1490..2716
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /codon_start=1
                     /product="protein phosphatase 1A isoform X1"
                     /protein_id="XP_047287457.1"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
                     /translation="MLIHYIKNQETYEEHQKWQDLEDQDIMGAFLDKPKMEKHNAQGQ
                     GNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLL
                     DHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLI
                     SPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLA
                     VSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEEL
                     CDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAEL
                     DKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNRLN
                     PYKNDDTDSTSTDDMW"
     polyA_site      9321
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 agaggcggcg gcggcggcgg tggcggcgct agggacggga gcgcgcgcgg gagctagaga
       61 gcagtggtct cggcgctcgt ccggcccgca gcttcgggtc ctcaggcggc tgttgctccg
      121 gaacgggtgg ttggggaggg gggggtgggg ggactctaga cagctgaggc gcgaaagcga
      181 tgagtcctcg gctcttcctc ctccttctcc gggacccgct ctctgcctcc ctctccaacg
      241 cccggatgat ctgagccgcg agggcgccga cagccggggg cccggacgca gcccggctcc
      301 tcccctcctc cgccccttcc ccagcctgac ctggcccgcc gctgcagcgg tgacccctcc
      361 cccggctgcc gccgtcgccg ccgcggtgac cccctccccg gctgccgccg ccgccgcctc
      421 ggccgaccag ggacctgccc gcctgcggct gctccggaaa taatttgttg atccatgcgg
      481 tttcattgct actgcggaaa atgtggaact aagaagtggc agtagttgag aagttcattt
      541 tgggccatgc gatttgaggt gtggctattc aagtatagga ggtaggtggt tacacatttt
      601 ttaagctatt aaatagaact ttcacttgaa aaggtttttt tctctctttc ctcagcatct
      661 atctccctac atacacaaaa aaattgcatg tcacaattca tgaactcagt gagtgactct
      721 attttgaaaa atgttagatt atatcaactg aagtctgtta gaggcaaatg cttttggtca
      781 tttttttcag cagggacatt tcatatgtgt aaaatattta gaatccccat gtatttatat
      841 ataaatgaat cttttaccat cttaaatgtt taataagtta tatttttcct ttctttcaac
      901 ttaagtatac aaggttatca gcaaacattt gtagatgctc tatgtgaggt gttttgttta
      961 ttagttttaa ggaagagaaa aaaggatgga ttggatcagg aagtcagtta ttgttttctg
     1021 ggttagtttg agtccaaatc ctcaaatatg cggcgattta taagtagcaa actaggaatt
     1081 taatccactt cagttttgga taacttggat aagacacttt ctgtctatag atctgtctat
     1141 agataacttg gataagacaa gttatccaaa actgataaat ctgaattagt taacagatga
     1201 ggcaaattga gattgtaaat gctaaaagat tattagaaaa ctttataaac taaatagttc
     1261 tatgccatgt ctttttagta ttttgcttgt actataattg tagtgaaaat aggtcagtat
     1321 ctaattttta tagtcactag agctctccaa ctaaatttag cttagatgtt tttctagcaa
     1381 ttatatactt acaaagttta cttttaaaaa ttgtgtaata catgccttta tagaaattta
     1441 agaaaacgac ttatggatta tgtacttcag atcacagcac aactagaaga tgttgataca
     1501 ttacataaaa aatcaggaaa cctatgaaga acatcaaaag tggcaagacc tagaggatca
     1561 agacataatg ggagcatttt tagacaagcc aaagatggaa aagcataatg cccaggggca
     1621 gggtaatggg ttgcgatatg ggctaagcag catgcaaggc tggcgtgttg aaatggagga
     1681 tgcacatacg gctgtgatcg gtttgccaag tggacttgaa tcgtggtcat tctttgctgt
     1741 gtatgatggg catgctggtt ctcaggttgc caaatactgc tgtgagcatt tgttagatca
     1801 catcaccaat aaccaggatt ttaaagggtc tgcaggagca ccttctgtgg aaaatgtaaa
     1861 gaatggaatc agaacaggtt ttctggagat tgatgaacac atgagagtta tgtcagagaa
     1921 gaaacatggt gcagatagaa gtgggtcaac agctgtaggt gtcttaattt ctccccaaca
     1981 tacttatttc attaactgtg gagactcaag aggtttactt tgtaggaaca ggaaagttca
     2041 tttcttcaca caagatcaca aaccaagtaa tccgctggag aaagaacgaa ttcagaatgc
     2101 aggtggctct gtaatgattc agcgtgtgaa tggctctctg gctgtatcga gggcccttgg
     2161 ggattttgat tacaaatgtg tccatggaaa aggtcctact gagcagcttg tctcaccaga
     2221 gcctgaagtc catgatattg aaagatctga agaagatgat cagttcatta tccttgcatg
     2281 tgatggtatc tgggatgtta tgggaaatga agagctctgt gattttgtaa gatccagact
     2341 tgaagtcact gatgaccttg agaaagtttg caatgaagta gtcgacacct gtttgtataa
     2401 gggaagtcga gacaacatga gtgtgatttt gatctgtttt ccaaatgcac ccaaagtatc
     2461 gccagaagca gtgaagaagg aggcagagtt ggacaagtac ctggaatgca gagtagaaga
     2521 aatcataaag aagcaggggg aaggcgtccc cgacttagtc catgtgatgc gcacattagc
     2581 gagtgagaac atccccagcc tcccaccagg gggtgaattg gcaagcaaga ggaatgttat
     2641 tgaagccgtt tacaatagac tgaatcctta caaaaatgac gacactgact ctacatcaac
     2701 agatgatatg tggtaaaact gctcatctag ccatggagtt taccttcacc tccaaaggag
     2761 agtacagctc aactttgttg aaacttttaa catccatcct caactttaag gaaggggata
     2821 tgacatgggt gagaatgatt acatcagaga acttcagcag tacaacagct agcccagaac
     2881 tgattttttt tttttttttt gtaaatttga gacttatgta agcgtgattt caaaccataa
     2941 ttcgtgttgt aaatcagact ccagcaattt ttgttgtatg attttgtttt tttgtaaagt
     3001 gtaattgtcc ttgtacaaaa tgctcatatt taattatgaa ctgctttaaa tcactatcaa
     3061 agttacaaga aatgtttggc ttattgtgtg atgcaacaga tatatagccc tttcaagtca
     3121 tgttgtgttt ggacttgggg ttggaacagg gagagcagca gccatgtcag ctacacgctc
     3181 aaatgtgcag atgattatgg aaaataacct caaaatctta caaagctgaa catccaagga
     3241 gttattgaaa actatcttaa atgttcttgg taggggagtt ggcattgttg ataaagccag
     3301 tcccttcatt taactgtctt tcaggatgtt ccttcgttgt ttccatgagt attgcaggta
     3361 ataatacagt gtattcataa gaatctcaat cttggggcta aatgccttgt ttctttgcac
     3421 ctcttttcaa gtccttacat ttaattacta attgataagc agcagcttcc tacatatagt
     3481 aggaaactgc cacatttttg ctatcatgat tggctgggcc tgctgctgtt cctagtaaga
     3541 tattctgaat tccattttat caataaagct tgatttaaca aacaagaaac ttaatcatgt
     3601 atgtgtaatt cctcttttac cctggccttt taaaacactg tgccgttgta atgagacgtt
     3661 tctcataggg aaagatgtta gtctctttta attggacaac actgtcactc aaggcataga
     3721 tgaaactttc cttccattag aaagactaaa agatttaatt cttggttgta ccttaatcta
     3781 ttttttaaat aggtttcttt caggctgctt atttttcatt aagatgtgta tcagcttgga
     3841 tttgcctact gtttaattaa aatatttatt gtcaaagttt gacaatctaa cactctatgg
     3901 taggggtgtg tgtgtgtgtg tttgtgagtg tgtgtttgcc tgtgattttt aattggccca
     3961 tgtctttaga atccaagtgg ttaagatgta tttgtgattt gaaatatagc atgttgataa
     4021 tatttagctg ttggccttta caaataactt tcaaagctta aggaattgta gatataaaaa
     4081 taacctaatt taatttaggc ttaaattcct ctgattaagc atgtgaaagt aagttttaaa
     4141 atctgtcgca ttgaaaagat tactgttccg tgcccttctg tatttttgtc tctttaggtt
     4201 gaatattgta tttatcacca tgtaatcatt cagtaggcag attcccacta gaaaactgtt
     4261 gaaatgtaag actaaaatac aacattgaat acaaaatcaa aattttgtgt ataaaaacca
     4321 gtatagtcca ttttgttata tttgtttttt ccctaacttg gaaatataca tatttgtata
     4381 tatagcctta aaattaatgt aaagttaggg gagtagtggg gaaagtaatg tgaaatgtct
     4441 cagatttaag tagttaaata ccagcaaaat cttttcatta tccctcttat tttgtgaggt
     4501 gattaaatgt aacttaattg tatttaattt atatcttatt ccagcatgaa tgaggaaaaa
     4561 ctgaagtact atttatattt agaaattcat atcagttgaa attacagaac caattccata
     4621 cttacaataa atacttaatg tctaaatctg tggtagagtg cgaagtatga taatgttcta
     4681 agttatggct ttgcaagcat ctaaatgtgc atttaatgaa taccagtgct tctagtatag
     4741 actaattacc agacatactg gtactgaaag ctaaatccct attataacaa accagttcct
     4801 taatatttta agtagactga caactttagt tccagaaatt gcaaaacttt gaactggact
     4861 gtgtaatctt ttgagatgca aaacttaagt cacaagtaga gtatgtgatg gaaagctgta
     4921 tttcaaacca taacagcata tttagagcct tttttttttg agtctttaaa caagagaaaa
     4981 ttaaaatatt cctgtcaaaa ttattagtat tgaaattagg cttggacacg agagagaacc
     5041 gtatttgagt gatgtgagaa gactaaatct tttccacatg agtcagcact gccatactaa
     5101 taattttttt actataaaaa tacaggaagg aagtatacat tataacagca gactgtgtgt
     5161 gttcctgatt cctggaggta atagtggggg gaaaccaacc atacttttta aaggcacttt
     5221 tgcacctcta ttgtgcactt cattcttgta ccacttaaat tcttcacccc catccccttt
     5281 ttttgtgcta attagcatct cagggcaatg cctcaaaaat gtttgatgtg ttctgttctt
     5341 tggagggaaa aagttcttat gtgatgataa tatagtactc aaaatatact tttatcattt
     5401 aaatgtctta tttgctgcta tgaataggaa ataacatttt gtatagcagg ctctgtttta
     5461 ccctaacatt aaaaaatttc actgatcttt ctttcattaa cagggtagaa tctcctaatt
     5521 tccactttct tgggaatata cttttataga caatagaagc agttctcaat attagcatat
     5581 actttaaaaa atcaaagtga taacttaatt cagctttgga agtatctcaa acatattttt
     5641 actttatagt gcattaactt gcttctagag tacttaatgc aactgctcta gccacttaat
     5701 tttttatact aatctcaaca ttaagaaatt tggattaagt aataaattag ttatgtaatt
     5761 caagtaatct gaattacagc agtactttta gtgatcattc ataggactat atattaaccc
     5821 agctaataac tcagtttttt tacaaaatgt ttcgagtatt attggtaaaa cactgttcta
     5881 ggctaagcac attgggactg taaagaaatg agtagatcct tggcttcaag tttacatctg
     5941 gacaatttat aatctagtgt atgttagtat tataactgga tcactcatca aaaaatatat
     6001 atatatatct attgcccacc tgctatctac caggtactta gctgatcaag gcaggcccct
     6061 gccctaaaga ccttgtttat acttccttta ctcacctgaa aactgttctc cagtttattt
     6121 tcttctctct aaagttaaag agtaattcag aagaaaattt tgcttagcat aagaataaaa
     6181 ttggactgaa gaggcttaag cccattcagt atccttgatt gcatttatcc aacggccttt
     6241 attcttcctg ctgacagcag taactcagag gaataggtag tagatttctg aaaattatcc
     6301 agccatggaa atgtaggtgg ggtttgagtt taaggcattt aaaaatgtaa atatctctag
     6361 ctaaatttat cttaagtaga actctgtgtt tttgtaacac actgccagtg ttaatatcaa
     6421 attttagcca aattattact atgtgtttta atattttaaa ataatttcac tgcccatctt
     6481 tactggacaa actcatttgg agttcaactt gtgatttctg aaagaactga tgaaattggg
     6541 tactgctttt tttctccatt tttcgttttg ttttaatttt gaatttcatg gtatatactt
     6601 ttagttcaaa ctcagctgtt tgtacagtat tgtattagga tttggtatta gaaaagatgt
     6661 gtaaatatct tagtatataa ttgtttctca tttgaggttt ttcttctaag ggaccttaaa
     6721 gagttttata tacttttgct cacagaaact gctggtgaga ttaccatttt ttgagtatct
     6781 agtcttctag tttttctttt aggcattagg aagccttctt tagagttcaa aattttagaa
     6841 gcctaatttg ctcttacttc cttcaattat gtgccatgtg ttttggtttg tatatgtttt
     6901 aaattgtata tttccttgga atatgcttga aatatttaag aatacatttt caaaatgtat
     6961 aatactgtat tgttttgttg atcagaataa taagtctcag ttaaatgttt gttattactg
     7021 atagtcaaaa tgctcaatag aaatgatgag aggcattggt tccaattcat tgtcaaatga
     7081 acgttttcta attttgttca cagattcttt ccctttcgat tgttctgtat gttaagatag
     7141 tggcttctgc tctcactgtt ttcctattta tattactagc aggtaggagt gctaattaga
     7201 aaaacttaga tggtattgaa attacagttg acaacttata tttttatgag atggagaaaa
     7261 aagattaagt tgatataaca acaaagtgga ctttttttct tccttatcct gcacgaaata
     7321 ttgcccttgt ttcctctact ttcctcttgg tgttttctct ttttttcaaa cagaaacagg
     7381 ccaattccat tttcttgagc aagaaagctt agtgtgttac ttcatcaagg ccagctaata
     7441 ctgtgttaaa ccgggctgaa aatgagaaaa cttgggagat ggaggaatgg ggaaatggca
     7501 gtgggatagg tagggaagga ttactcttaa ttgttttaaa agccatagga aagtcttcct
     7561 tgtacgtggc tgtaaattta taagaactat tgtgtcacat aaaccaacaa gaatgaacct
     7621 ttgctgcttc agataatttg atttttccag caaggaaatt aataagttac tgattcttca
     7681 gcatagaaac aactgagaag aattaatgca atgtttcttc actagaaaac ccaacccttc
     7741 atttcttttc attgctccaa aacccagttt tcaactaatg gttttctcat taaactaaat
     7801 gtttagaaaa gttgtttaga gtttttcttt ttcttttaca tagtcctcct gatccagtat
     7861 aagactattt agtaacgtgc atttgtatgg tactatctaa agtaagttag attgatgtaa
     7921 gagatcgggt agctgcggaa caaaattagt tatatcctaa ttaggtacag tgaatgacac
     7981 aaaatcattt tagcaatgct tcttaacctt ttggggtcac aggcgttttg agactgatga
     8041 atcctaggga cttatttacc caggaaaatg cgtatataac atacatatct ccctaaagtt
     8101 tacaatattg tagtggttca tgggccccct ggttaagagc ccattctaaa gtacaatagg
     8161 gcatcatccc ttttcctgca aagcccaaaa gtatatttct agggcatgaa aataacttga
     8221 gtctatttta aggaattgtt tcactctaga ggtagatagg ggacctggct agaatctgac
     8281 attaaaatat actttttaaa aaatattata tttggggtgg ggaaagtgat taaaaggtga
     8341 aaaaaaaaca tagtattcag aagttttgga ggttaatgtc tttctctaag atttgccact
     8401 ttagaaattc aacagaaaag aggtaaaaca gaaatggaat gtatctggaa catttttggc
     8461 ctccatagtg cagatatact atattaacaa gtaatacatt tatttacctg tcagatctcc
     8521 aggttttaag attttgagct ttctagtatt aggattcatt aaatgttcaa ttcatttcat
     8581 attctaagga attaggttat ttacttacta attcaggatg ttaaaataac atccaagtcg
     8641 gacaaccacc accaatgcac acagttaatg agatttctaa aatataataa gtacaatgta
     8701 acaaacgtat agaattttgc atttgttgcc aaaattagat gtttaatgac agcttattta
     8761 attcccattt gtgggacttc tggaacatag aaaccattat cttacctggt tatcccttga
     8821 ctaaatagca tatctgcagg aaaatatctt gtttgtagtg atatgcccca atagtgattg
     8881 atttcactct tgaaatgagt tatatcactt aatttgtata aatgttatga gtggagagac
     8941 atgtacatgt taaaagcatg ttgcattata tattcatttt ttaaactcta taaatgttaa
     9001 gaataatata attgcagaaa tatttttctt aaatacaatg tgtaacaaaa ttctccgtag
     9061 caactcaccc actttgcagt ttatgtgatc cacactttta aagaaattcc ataaatgtat
     9121 attttgtatt atgtattatt tcctggtcca aagaaaatat gtgaattcag ttctaacttt
     9181 aagaatgtac tgtttgtttt caagttcatt gaaaaattgc attcagcctg cgaatggttg
     9241 cagattgtat gttagatgaa aagtagaaat aatttctagt ttggaaaact ggtgccacta
     9301 aataaacagg caattacata a
//
