LOCUS       NM_001276277           15369 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens diphosphoinositol pentakisphosphate kinase 2
            (PPIP5K2), transcript variant 1, mRNA.
ACCESSION   NM_001276277
VERSION     NM_001276277.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15369)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 15369)
  AUTHORS   Cao,C.H., Ling,H., Han,K., Lu,X.P., Cai,M.Y., Cao,J.H., Zhou,J.,
            Xiang,Z.C., Chen,J.W., Li,S., Lin,J.L., Duan,J.L., Luo,J.,
            Fang,Y.J., Pan,Z.Z., Liang,L., Wang,F., Xie,D. and Wang,F.W.
  TITLE     PPIP5K2 promotes colorectal carcinoma pathogenesis through
            facilitating DNA homologous recombination repair
  JOURNAL   Oncogene 40 (49), 6680-6691 (2021)
   PUBMED   34645979
  REMARK    GeneRIF: PPIP5K2 promotes colorectal carcinoma pathogenesis through
            facilitating DNA homologous recombination repair.
REFERENCE   3  (bases 1 to 15369)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 15369)
  AUTHORS   Khaled,M.L., Bykhovskaya,Y., Gu,C., Liu,A., Drewry,M.D., Chen,Z.,
            Mysona,B.A., Parker,E., McNabb,R.P., Yu,H., Lu,X., Wang,J., Li,X.,
            Al-Muammar,A., Rotter,J.I., Porter,L.F., Estes,A., Watsky,M.A.,
            Smith,S.B., Xu,H., Abu-Amero,K.K., Kuo,A., Shears,S.B.,
            Rabinowitz,Y.S. and Liu,Y.
  TITLE     PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial
            Keratoconus
  JOURNAL   Sci Rep 9 (1), 19406 (2019)
   PUBMED   31852976
  REMARK    GeneRIF: PPIP5K2 and PCSK1 are Candidate Genetic Contributors to
            Familial Keratoconus.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 15369)
  AUTHORS   An,Y., Jessen,H.J., Wang,H., Shears,S.B. and Kireev,D.
  TITLE     Dynamics of Substrate Processing by PPIP5K2, a Versatile Catalytic
            Machine
  JOURNAL   Structure 27 (6), 1022-1028 (2019)
   PUBMED   30956131
  REMARK    GeneRIF: Data suggest that the enzyme-substrate forces are
            predictive of the various diphosphoinositol pentakisphosphate
            kinase 2 (PPIP5K2) catalytic activities.
REFERENCE   6  (bases 1 to 15369)
  AUTHORS   Weaver,J.D., Wang,H. and Shears,S.B.
  TITLE     The kinetic properties of a human PPIP5K reveal that its kinase
            activities are protected against the consequences of a
            deteriorating cellular bioenergetic environment
  JOURNAL   Biosci Rep 33 (2), e00022 (2013)
   PUBMED   23240582
  REMARK    GeneRIF: the specificity constants for PPIP5K2 revise upwards by
            one-to-two orders of magnitude the inherent catalytic activities of
            this enzyme, and we show its equilibrium point favours 80-90%
            depletion of InsP/-InsP.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 15369)
  AUTHORS   Wang,H., Falck,J.R., Hall,T.M. and Shears,S.B.
  TITLE     Structural basis for an inositol pyrophosphate kinase surmounting
            phosphate crowding
  JOURNAL   Nat Chem Biol 8 (1), 111-116 (2011)
   PUBMED   22119861
  REMARK    GeneRIF: describe the PPIP5K2's conformational dynamics, its
            unprecedented topological presentation of nucleotide and inositol
            phosphate, and the charge balance that facilitates partly
            associative in-line phosphoryl transfer
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 15369)
  AUTHORS   Lin,H., Fridy,P.C., Ribeiro,A.A., Choi,J.H., Barma,D.K., Vogel,G.,
            Falck,J.R., Shears,S.B., York,J.D. and Mayr,G.W.
  TITLE     Structural analysis and detection of biological inositol
            pyrophosphates reveal that the family of VIP/diphosphoinositol
            pentakisphosphate kinases are 1/3-kinases
  JOURNAL   J Biol Chem 284 (3), 1863-1872 (2009)
   PUBMED   18981179
REFERENCE   9  (bases 1 to 15369)
  AUTHORS   Choi,J.H., Williams,J., Cho,J., Falck,J.R. and Shears,S.B.
  TITLE     Purification, sequencing, and molecular identification of a
            mammalian PP-InsP5 kinase that is activated when cells are exposed
            to hyperosmotic stress
  JOURNAL   J Biol Chem 282 (42), 30763-30775 (2007)
   PUBMED   17702752
REFERENCE   10 (bases 1 to 15369)
  AUTHORS   Fridy,P.C., Otto,J.C., Dollins,D.E. and York,J.D.
  TITLE     Cloning and characterization of two human VIP1-like inositol
            hexakisphosphate and diphosphoinositol pentakisphosphate kinases
  JOURNAL   J Biol Chem 282 (42), 30754-30762 (2007)
   PUBMED   17690096
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB007893.1, AK025159.1,
            DB298507.1 and AC011362.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001276277.2.
            
            Summary: This gene encodes a member of the histidine acid
            phosphatase family of proteins. Despite containing a histidine acid
            phosphatase domain, the encoded protein functions as an inositol
            pyrophosphate kinase, and is thought to lack phosphatase activity.
            This kinase activity is the mechanism by which the encoded protein
            synthesizes high-energy inositol pyrophosphates, which act as
            signaling molecules that regulate cellular homeostasis and other
            processes. This gene may be associated with autism spectrum
            disorder in human patients. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) lacks two in-frame exons in
            the coding region, compared to variant 4. The resulting isoform (1)
            lacks two internal segments, compared to isoform (3).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.40296.1, AB007893.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358359.8/ ENSP00000351126.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3595              AB007893.1         38-3632
            3596-3596           AK025159.1         772-772
            3597-4247           AB007893.1         3634-4284
            4248-5779           AK025159.1         1241-2772
            5780-6093           DB298507.1         1-314               c
            6094-15369          AC011362.2         138651-147926       c
FEATURES             Location/Qualifiers
     source          1..15369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q21.1"
     gene            1..15369
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /note="diphosphoinositol pentakisphosphate kinase 2"
                     /db_xref="GeneID:23262"
                     /db_xref="HGNC:HGNC:29035"
                     /db_xref="MIM:611648"
     exon            1..188
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            189..586
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             473..4204
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /EC_number="2.7.4.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inositol heptaphosphate kinase 2; inositol
                     hexakisphosphate and diphosphoinositol-pentakisphosphate
                     kinase 2; VIP1 homolog 2; insP6 and PP-IP5 kinase 2;
                     histidine acid phosphatase domain-containing protein 1;
                     deafness, autosomal recessive 100"
                     /codon_start=1
                     /product="inositol hexakisphosphate and
                     diphosphoinositol-pentakisphosphate kinase 2 isoform 1"
                     /protein_id="NP_001263206.1"
                     /db_xref="CCDS:CCDS64212.1"
                     /db_xref="GeneID:23262"
                     /db_xref="HGNC:HGNC:29035"
                     /db_xref="MIM:611648"
                     /translation="MSEAPRFFVGPEDTEINPGNYRHFFHHADEDDEEEDDSPPERQI
                     VVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEEVILNEPVENWPLCDCLISFHS
                     KGFPLDKAVAYAKLRNPFVINDLNMQYLIQDRREVYSILQAEGILLPRYAILNRDPNN
                     PKECNLIEGEDHVEVNGEVFQKPFVEKPVSAEDHNVYIYYPTSAGGGSQRLFRKIGSR
                     SSVYSPESNVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSE
                     GKEVRYPVILNAREKLIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKY
                     YDDCAKILGNIVMRELAPQFHIPWSIPLEAEDIPIVPTTSGTMMELRCVIAVIRHGDR
                     TPKQKMKMEVRHQKFFDLFEKCDGYKSGKLKLKKPKQLQEVLDIARQLLMELGQNNDS
                     EIEENKPKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDSRREEPSLLLV
                     LKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASD
                     EGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQQRVKARLH
                     EILQKDRDFTAEDYEKLTPSGSISLIKSMHLIKNPVKTCDKVYSLIQSLTSQIRHRME
                     DPKSSDIQLYHSETLELMLRRWSKLEKDFKTKNGRYDISKIPDIYDCIKYDVQHNGSL
                     KLENTMELYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQRTQDDDT
                     VNKLHPVYSRGVLSPERHVRTRLYFTSESHVHSLLSILRYGALCNESKDEQWKRAMDY
                     LNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHFSPGAKGCEEDKNLPSGYGYRP
                     ASRENEGRRPFKIDNDDEPHTSKRDEVDRAVILFKPMVSEPIHIHRKSPLPRSRKTAT
                     NDEESPLSVSSPEGTGTWLHYTSGVGTGRRRRRSGEQITSSPVSPKSLAFTSSIFGSW
                     QQVVSENANYLRTPRTLVEQKQNPTVGSHCAGLFSTSVLGGSSSAPNLQDYARTHRKK
                     LTSSGCIDDATRGSAVKRFSISFARHPTNGFELYSMVPSICPLETLHNALSLKQVDEF
                     LASIASPSSDVPRKTAEISSTALRSSPIMRKKVSLNTYTPAKILPTPPATLKSTKASS
                     KPATSGPSSAVVPNTSSRKKNITSKTETHEHKKNTGKKK"
     exon            587..782
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            783..873
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            874..959
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1114
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1216
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1378
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1500
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1602
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1689
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1765
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1875
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1961
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2087
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2209
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2392
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2534
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2758
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2886
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..3001
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3109
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3226
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3394
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3395..3568
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3569..3641
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3642..3761
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3762..3824
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3825..3965
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3966..4091
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4092..15369
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5757..5762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /note="hexamer: ATTAAA"
     polyA_site      5779
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /note="major polyA site"
     regulatory      6069..6074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /note="hexamer: AATAAA"
     polyA_site      6097
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
     regulatory      13804..13809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /note="hexamer: AATAAA"
     polyA_site      13828
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
     regulatory      15274..15279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /note="hexamer: AATAAA"
     polyA_site      15294
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
     regulatory      15343..15348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
                     /note="hexamer: AGTAAA"
     polyA_site      15369
                     /gene="PPIP5K2"
                     /gene_synonym="CFAP160; DFNB100; HISPPD1; IP7K2; VIP2"
ORIGIN      
        1 gtagtagcct gaggttccct tatgtggccc tatagctgtt actgaaggaa gtagcctacg
       61 tccacgccta caactgaagt ctcttgacaa acacctcacc cctgcctccg ggatgaaagg
      121 gggtaaccta gacctgaatg ggcttgacca tctcacaact gctcgcgtga cgaccgcatt
      181 cgtggcaggt aagaagattg ctgtatcaac tcaagaaagc agtaacttca ctgtctttgt
      241 attttgaatt gcaacaacaa ctttgatatc aacaatgaag caatgatatc taagaacaaa
      301 agagtatttg ccaacagtca tcataatatc aagtgattgt ataagcagaa acaagctgtc
      361 acagacctgt gcgtcagcta atatatggag aatgctttct tctgatacta tttacttaga
      421 ggcagtttta atataaatca tttcaattat atctacatca aataaaataa aaatgagtga
      481 agcccccaga ttcttcgttg gaccagaaga tacagaaata aatcctggaa attatcgaca
      541 tttcttccac catgcagatg aagacgatga ggaggaagat gattctccac cagaaaggca
      601 gattgtggtt ggaatatgtt ccatggcaaa gaaatccaaa tccaaaccaa tgaaggaaat
      661 tcttgaacgg atctccttat ttaaatatat cacagtagta gtatttgaag aggaggttat
      721 tttgaatgaa ccagtggaaa actggccttt atgtgattgt cttatttctt tccattctaa
      781 aggatttcca ctggacaaag cggttgccta tgcaaaactc aggaatccat ttgtaatcaa
      841 tgacttgaat atgcagtatc tcatacaaga taggagagaa gtatatagta ttcttcaagc
      901 tgaaggtatt ttacttcctc gttatgctat tttgaaccgt gacccaaata atcccaaaga
      961 atgtaatctg attgaagggg aagatcatgt agaagtaaat ggggaagttt ttcaaaagcc
     1021 atttgtagaa aagccagtca gtgcagaaga tcacaatgtt tacatttatt acccaacttc
     1081 tgctggtggt ggaagtcaaa gactctttag aaagattggc agtagaagta gtgtttattc
     1141 tccagaaagc aatgtacgaa aaacaggctc atatatatat gaagagttta tgcccacaga
     1201 tggtactgat gttaaggttt atacagtggg tccagattat gcccatgctg aagctcgaaa
     1261 atctccagca cttgatggca aggtggaacg agacagtgaa ggaaaagaag taagataccc
     1321 tgttattctc aatgcacgag agaaattaat tgcttggaaa gtctgccttg cttttaagca
     1381 aacagtttgt ggctttgatt tgttacgggc caatggacag tcctatgtct gtgatgtcaa
     1441 tggcttcagt tttgtgaaaa attccatgaa gtattatgat gactgtgcaa aaatacttgg
     1501 aaatattgta atgcgagaac ttgctccaca atttcatatt ccatggtcaa tacccttaga
     1561 agctgaagat atcccaattg taccaactac atctggaact atgatggaac ttagatgtgt
     1621 catagctgtt atacgtcatg gggatcgaac accaaaacaa aaaatgaaaa tggaagtgag
     1681 acatcagaaa ttttttgatc tttttgaaaa gtgtgatgga tataaatcag ggaaattaaa
     1741 actcaaaaaa ccaaaacagt tacaggaagt gctagatatt gcacgacagc ttcttatgga
     1801 gctagggcaa aataatgatt ctgaaattga agaaaacaag ccaaaacttg aacaacttaa
     1861 gactgtatta gagatgtatg gtcatttttc tggaataaat cgtaaggttc agttgaccta
     1921 tctccctcat ggttgtccta aaacatctag tgaagaggag gacagccgaa gagaagaacc
     1981 atctttactt ttggttctaa aatggggagg tgaattaact cctgcaggca gggtccaggc
     2041 tgaagaactt ggaagagcct tcaggtgtat gtatcctgga ggtcaaggag attatgcagg
     2101 atttcctggt tgtggtttac ttagattaca tagcacctac agacatgacc tcaaaatata
     2161 tgcctctgat gaaggacgag tccagatgac tgcagctgct tttgcaaagg ggcttttagc
     2221 tttggaagga gagcttacac ccattcttgt tcaaatggtg aaaagtgcaa atatgaacgg
     2281 tcttttggat agtgatagtg actctctgag cagttgtcag caacgtgtga aggcaaggct
     2341 tcatgaaata cttcagaaag acagagattt tactgctgaa gattatgaaa agcttactcc
     2401 atctggaagc atttctctta tcaaatcaat gcatttaatt aaaaaccctg tgaagacctg
     2461 tgataaagtt tattccttaa ttcagagttt gacttctcaa atcagacatc gaatggaaga
     2521 tcctaaatca tcagatattc agctttacca tagtgaaaca ttggagctta tgctacgtag
     2581 atggtccaag ttagagaaag actttaaaac aaagaatgga agatatgata ttagtaaaat
     2641 ccctgacata tatgactgta taaaatatga tgtccagcat aatggttcct tgaaattaga
     2701 aaacacaatg gaattatata ggctttcgaa ggcattagca gatattgtta tccctcagga
     2761 atatggtata actaaagctg aaaaactgga gattgccaaa ggctactgta ctcctctggt
     2821 tagaaaaatt cgctcagacc ttcagaggac acaagatgat gacactgtaa ataaacttca
     2881 tcctgtgtat tctagaggtg ttctgtctcc tgaacgtcat gttcgtacta gattatattt
     2941 taccagtgaa agtcatgtac attctttgct gtctattctt cgctatggtg ccttatgcaa
     3001 tgaatcaaag gatgaacagt ggaaacgagc tatggattat ttaaacgttg tcaatgagct
     3061 caactacatg actcagattg ttatcatgct ttatgaggat cctaataagg atctttcctc
     3121 agaagaacgc tttcatgttg aattacactt tagtccggga gccaaaggtt gtgaagaaga
     3181 caaaaatttg ccatctggct atggatatag accagcttcc agagagaatg aaggcaggag
     3241 accttttaaa attgataatg atgatgaacc acatacttct aaaagagatg aagttgatcg
     3301 agctgtgata ttgtttaaac caatggtatc agagccaatt catatacaca ggaagtctcc
     3361 acttccaaga tctaggaaga cggctacaaa tgatgaagag agccccctga gtgtgtctag
     3421 cccagagggt actggtacct ggctgcatta taccagtggt gtgggtactg ggcgtcgaag
     3481 acgcagatca ggggaacaaa tcacttcttc ccctgtctcc cccaaatcat tggctttcac
     3541 atccagtatt tttggctcat ggcaacaggt tgtatctgaa aatgctaatt acctgagaac
     3601 accaagaact cttgtggaac agaagcagaa tcctactgta gggtctcact gtgcgggcct
     3661 gtttagcacc tcggtgctcg ggggttcttc aagcgcacct aacctacagg attatgctcg
     3721 tactcatcgt aaaaagctga cctcttctgg ctgcatagat gacgccacac gcggttctgc
     3781 tgttaaaagg ttttctatct catttgctcg acacccaacc aatggctttg aattgtattc
     3841 catggtgcca tctatttgtc ctctagaaac tcttcataat gccctatctt taaagcaagt
     3901 ggatgaattt cttgcttcca ttgcttctcc atcatctgac gttccacgga agaccgctga
     3961 aatttcctct acagctttac gttccagtcc aataatgaga aaaaaagtat ctttaaatac
     4021 gtatacacct gcaaagatcc tcccaacacc accagctacc ttaaagagca ctaaagcaag
     4081 cagcaaacca gctacaagtg gaccttctag tgcagttgtt cctaatacct catctcggaa
     4141 aaagaatata actagcaaaa cagaaacgca tgaacacaaa aaaaacactg ggaaaaagaa
     4201 atgaaatctt agcagaagct ggaacttttt atacttataa aaatagtatg ttcttatgtt
     4261 tctccttatg catttatgtg ttcacttaaa aatgttttta aatctaaggt tttctttgtt
     4321 tatgttcagg taaggaactg ttgtcatgat ctggaaatgt ttaaaacaat gtttgttagc
     4381 attctgtgag cagcaaaact tatagtgata aaaatcgatt gttgttaata tgatgtttac
     4441 catgtgcaca tagtaatgaa aaggaacata aaagcccagc aggctcgtac caaagtcaca
     4501 gcagtaatgc tatgtactgc agagtctgat gagctggcct ttgtgcacac ttttattttc
     4561 atgggattgc atcttagctg ttaaaacttc tagattgaaa tttgacagcc agggttacat
     4621 attggggact tttaaagtgt ctttccaaag agatttcatt aaccgtttag attagaatat
     4681 ctttcccaat tgttacagtg acatatatgc tgcaatattt aacaactgga gtattagcca
     4741 catgggttat tttttcaatc tgtgttttga atttttttat tgtgtgttat ttaaaatatt
     4801 acatatgcag ctgggagaac tacacctttg tgcacataga tttatatatt aatttgtaga
     4861 aaatattttc tttatatatt tccttaccat acaaggtgcc ttgttcatca ggaaaacttt
     4921 tgttttgtat tttgacaaga aaggcacctt cagagtttct ttttaagtat agttgacaag
     4981 tgtataaatg ttacacttac tttcagagtt ctttttagat ctaaagaagt cagttcaaaa
     5041 atggaaatca acaatgttag gagaaatctg aattctgtta agttagtaag tattatgtat
     5101 agcatctgtt tttaaccatt tccattctta tccctagtgt atcagttgat cacactaaga
     5161 aagcttaaag attgagcatt tgaaataaat gctctttata aatgattaga tttttgaagg
     5221 gatattgaaa tcattgcgct gtgatttcat ctgtgatgtg aaaaatcaat ttattatcct
     5281 tggtgctttc ccccccacca atgcacaaat aattgtgaac agcttgaaat gacttaaact
     5341 gtaatccaaa tgggacaatc tgataagaat ttcatgcatt ggtagttaaa taacttaaat
     5401 tgctaaagct ttagcttgaa atttatgttt agaaaaacta ttgatttccc atggtatgaa
     5461 tataactatt gtaattcttc aaatgagact cttctcacct taaatagtca tatattaatt
     5521 aacttatagg aaataagcat actatatgtt agctgtttta aaaggtacca gatgtaagag
     5581 tcataaatat atgcaattaa agaagttcat agatttcaca tgaatgtaaa tgtgttatat
     5641 ggagacatgt cttgtaaaca gttgaatgta tgtaagtttt ctgtttgtga aaatgtagtt
     5701 aatgtactca ctgtggaggt cataaggaag ctactttttt tttaaagtgg aacctaatta
     5761 aaatatttcc agaatcaaag agacttaaat ggtaaatttt taaaattttc ttatctctta
     5821 ctttttagtt ttcaaagtag aaaaaatcag gaattttttt attaactagt acttacatat
     5881 taaataaaat ttattattgg ctatatacat agcaatatat tactttccaa actagaaagt
     5941 acagtacaac taactttttc cattgttatg caagaactat tactttcctg tagtcaccaa
     6001 actcagtagt attgctctgt agactagaca ctctatttgt aaaaatctta gaatcacttt
     6061 ccaaaacaaa taaaaagtct actgtatcag agcaaaatgt tatagttatc actgtttagt
     6121 ggcagtttga ctgaagcatc tgtttctcac ttgattctgt cctgagaaga tgtgggattt
     6181 tttggtttta aatactagaa gatatttctt cttagagccc agtcctccat cccaaagagg
     6241 tgaactagcc cagcatgaag aattgtctag tcaccctgag atattaatct tcataatgta
     6301 ttattcagtt ccttcaccct taaaagccat ataataggct cagacctaac ttagcccttg
     6361 aagtctagtg ctggcagatt ctgctgccct ggtttaaatg agttacgtag tccattctca
     6421 aatactagca aatttggggg gcgtggtaca gcaattttgg gtgaagaaaa gtgtgctgaa
     6481 caccttatgt cagtgataga caagatatag aggctgaagg gaatacagta aagtaacaaa
     6541 aacatgtggc agtgtgctta gcataaacat agagcacaaa ggcaatagat ggaaattatg
     6601 agagaaaagt taaagttctt caagaaatat ccaattaaaa ctcactagcc aaggaaaaag
     6661 tttctgtttt cacccggatt tctttttggg ttgactctgt ctgacctaaa tgtccactgt
     6721 taactagtgc catgccagtt tgaaccaaga tttcacattt ttgttttgta ttcatacttt
     6781 ggtagaaatt tctcagtctt tgtgtattta taagaatttg ctttacacat agtgtacagt
     6841 gtttattaac tttacatcat tttatccttg ccttactatc tggacagtgt agactgccta
     6901 tattcttagt tggggttggg atctcttctc ttagagtggc ccagcagttt tagcccctct
     6961 ctaattctct tttcctgtgt tgggagatat caaaacaaca gaattcttgc cagtgggaac
     7021 atttttcttt tttagacaag gtctcattct gtcaccccag ctggagtgca gtggcacagt
     7081 cttaattcac tacagccttg aactcctggg ctcaagaaat ctttctgctt cagcctccta
     7141 aatagctggt actataggtg cgtgccacca cacccagctc atgggaataa tttttacact
     7201 ccttcagaag gagtcatttg tgattggagt ccacatagaa acaggtttcc ctctgtacat
     7261 aatcgtaggt accaaaatat tactgtgtaa agtgttgttt atataggtca atttttgtgg
     7321 aagatctaat ttctattttc agagaacaga gcacattaaa aaatctattt agtattgtgt
     7381 actatataat ctatgtgaat tatagctcct taactaaata tattactgag tttttttttt
     7441 aatactgtaa gttctagggt acatgtgcac aatgtgcagg tttgttacat aggtatacat
     7501 gtgccatgtt ggtttgctgc acccatgaac tcatcattta cattaggtat ttctcctaat
     7561 gctatccctc ccccagcccc ccacccactg acaggcccag tgtgtgatgt tccccgccct
     7621 gtgtccaagt actgttctca ttgttcagtt ccctcttatg agtgagaaca tgcggtgttt
     7681 ggttttctgt ccttgtgata gtttgctgag aatgatggtt tccagcttca tccatgtcct
     7741 tgtcatcctt ttttttggct gcatagtatt ccatggtgta tatgtgccac attttcttaa
     7801 tccagtctat cattgatgga catctgggtt ggtcccaagt ctttgctatt gtgaatagtg
     7861 ccacaataaa catacgtgtg catgtgtctt tatagtggca tgatttataa tcctttgggt
     7921 atatacccag taatgggatg gctgggtcaa atggtatttc tagttctaga tccttgagga
     7981 atcgccacac tgtcttccac aatggttgaa ctaatttaca ctcccaccaa gtgttcctat
     8041 ttctccacat cctctccagc atctgttgtt tcctgacttt tcaatgatcg ccattctaac
     8101 tggcgtgaga tggtatctca tttgtaagat gatatctcat tgagattttt ataaactgct
     8161 tttcttttgg ttcatgtgct ttgtcatgga ttgtgagaaa aacatctttt cgcttaggga
     8221 tcactgtcaa tttctccttt tattatcaat ggtttttact ttacttttta tatagtatgt
     8281 gggtatgttt tctggtgcat ataaattcat gaatgctaga ttttcattat aggttttacc
     8341 ttatcattat taaaatgtcc tttttgtcca ttggatactt tttgttctat aaattgtcag
     8401 atattaagat tatgacctat gctttatttt ggcttgcatt tgcctgatat tcatcttttt
     8461 actttttggt atttgtgtca ctttgtttta ggttatttaa tatagtatat attgggtttt
     8521 gctttgtgat tcaattttaa gatccctttt acttaataga ttagtgtagt ctgttttatg
     8581 taatgtatct ttgcttttag attgtgcttg ctttttttat tgctttaaaa ttcttttgtc
     8641 tttctgtaac aatactttcc actgcaagta ggaaaattcc aattgaaact ggtttaaatc
     8701 atcagaaaat gtattattac acatttctga aggtccaaag gtggggttgg cttcagccac
     8761 agttgcatta gccatattgt catcaaaagc ccaagtgacc tcccttgtca cctctggcat
     8821 agtataaact ttatcccaaa gttgttttct ctcgtgttaa caataattgc tgtcggtttc
     8881 agtgaggact acatattttt tttgttcatg tccaacacaa taaaaattga gggaagttct
     8941 gtcccaatcc tggaatatta atattaagcc atctacttca gtgtgattga gccaacttct
     9001 ttgatcatct actcacccct agataaatag aatactccag gagattccca tgaccttact
     9061 gaccctagag cagatgatgg agtcagtttt tccgaaaagc ctcagcactg ttgacatttt
     9121 ggaccataaa attctacatc ataggaagct gttccatgca tagcagcatg tctagtagga
     9181 tctctgtacc tagctgtgaa gtgttgagag tcagttaagg taagtagctg aaatgaaaat
     9241 aacaatcaca tctttattca cttactatga taaaattata agcaagagac caaaaaggaa
     9301 agtagggcca gctccttgtt gttccatttt tcccctacca tggactagca ctggacatgc
     9361 gtcaatcaga cgacatgcag tccaggcaga ggaaattgtt tcactgctaa ggagcaatga
     9421 acaaaaggtt cctgccatct tatggacctc aaggactgcg gacagggagc agggaagggt
     9481 tagaagtaga aaacaactga gtcagagtgg agatgagtgt ctcagtcaag gcccaccaat
     9541 agcgaggtct ctgtggaggc acctgaaaag tgtctcaacc aaggccccct gataaggaag
     9601 actcagcatg gaggtacctg gtctaggaat gcagctaggt ttatagacat ggccagccca
     9661 gggggtcctg agcaccagat acaactccct ccagagactg gctgtgttta aatctcatgt
     9721 gggaagggca cctttcccct acaaagcctg tcaggcaaag cctttgtaat tgcttatggt
     9781 caggcctgaa agatcacaca tcagactttg gcctggaaca tatctcctca ccctaaatgc
     9841 cagcagcatc gcctccaaac tgtggcagtc aaaaatgtct ccagacatta gtaaatgtct
     9901 tttgtgaggg aagaattgac cctagttaag aaccactgcc ctaaagcaca tgattctgtg
     9961 gaaaagaagg atatatgacc aaaatcatca ttttggatag tgagggcatg gataatggat
    10021 acataatcag caatgtatgc tgtatactac acttgcatta tgttattcac atttgctata
    10081 gttcacttgt tgtgctaatg gttttttcct tcactatgat tttgaattat atttaatttt
    10141 aaagtctata tatatatata tatagatcct atctgttgac tccttgctgt gaacaatatc
    10201 caattagtgt attttttcct ctactgcaca gttttggttg attatttttt ccttttcatt
    10261 tcttttctga actttgttag cttatgttgc atttcctttg gttgttttgc tatggtgttt
    10321 ctgatcaact acatttcttt atgaactcta tttccttaag ttctttgagt tatgacagta
    10381 tatttggtca catttttcat gtgctcagct gattcattct ttcctgttga gtggttttta
    10441 tctgctaatt gtttctgctt gttccatttc tccttttctt gaagtgtttg tgcatgaaca
    10501 ctgtgcaggt ttattttcaa gtattactta cctttatatg agataaattt ctttctggct
    10561 catctatttg atacaatttc ttttttgttt gtttttgttt tgtttttgtt gttttttaaa
    10621 atgcaatttc atatgttagg taggttggct tttctttttc tttttctttt tttttttgag
    10681 atggagtttt actcttgttg cctaggctgg agtgcagtgg catgatctca gctcactgca
    10741 acctccacct tccagtttca aatgattctc ctccctcagc ctccagagta gctgggatta
    10801 caggcgcccg ccaccacgcc tggctaattt ttgcattttt agtagagact gggtttcacc
    10861 atgttggcca ggctggtctc gaactcctga cctcatgatc ttcctgcctc agcctcccaa
    10921 aatgctggaa ttacaggcat gagccatcat gcccggccgt aggttggcat tttaagctca
    10981 cacaatccta ccaaggtgac agtgaatctc cttatgacag gattgtgggt ctgagagagc
    11041 tgttgtagcc ttttactctc tccagtcaac aaagattggc aactacaggg ttaccacctt
    11101 tggagtctct ttcctcctgt ctgccacgtc tacagactac tgcttgtcaa tgtgatatgc
    11161 atgtattttc ttcttcagct ttgcccctcc tgccactgta ccagacaata tccaggaaat
    11221 cccctactac tgacactcat cccatttcca ttgttttaga gaaggaacta gttgttgttg
    11281 tttttttttc cctgtctcag attatgtcat ctattttgga gtattttggt ctaatgactt
    11341 tggctgcgat atggagctat ctgaccttta ctgcacctgg cagctctatc tcctattttg
    11401 gggttgaggt taaagtgtct tctagttttg ttgaagatag tttatgtttc tcttcatatt
    11461 tgatgataat tttttaaatt aagacctaat ttctccttca ttttcaaact ggatatcatt
    11521 tcttttgtgg ttaatattct ttgacaagaa ggaagaggag gaggaagaag aacaaaagaa
    11581 gcctgcctct ctttagactg cccatctcaa ttatatttta aaaatgaagt taatatctgt
    11641 cctgctaaca gtagtgttgt cagaatcaaa tgaaataata tttggtaaac tataaagtga
    11701 agaccaaatt tgaaggacta tttgtttttg ttgtaataga gttgtatata gtccagatgt
    11761 caaccaggcc tcttcagcat ttttatagtc aaagatgtac aagatagctc ctaatgctct
    11821 tttatggctg ctcctgttgc cagggcaaca gcctgcctag taacaatcta acagacaccc
    11881 cccaaaaacc aaaaaataaa ggttattcta gcatcttctc cttttaaaaa tctttaaaat
    11941 aagagaattc agttcttccc aaagcagtgt ttaaaaaaaa aaagtattta aataaaatca
    12001 aggataccat cccacccacc tatcttacat tttgtgtggt atgagtggca ccattgtgtg
    12061 acccaggtag gatagtggat gtacagttta gatacccatt ttaaagcagt tagaaagatg
    12121 taacttgaca aggaaagcag tctcttttgt cattctacat ttagtgcttc aggagtactt
    12181 gatatatgga aggatttttt taaaaaaaag gaaaaatgaa tatgccttca gaaagttttt
    12241 tgctgctttt aaaagccata gatttgtctt aagttagtca atgctgaata gaaagcttga
    12301 tgataaaggt gggtgggtgg atggatggat ggatgaatga aggaaaaatt aggagaaaag
    12361 agaaagcaga ggaggggtga gacagagaac aaaagaacac aggctctact gttaacaaaa
    12421 agcagcatcg ctgatgtgtg gggaataaat tggaagtcat atcattacga cttttttttc
    12481 atgccacata gatatgctga tttgtccaac aatgcctgta ctcaaaagtc atgacaataa
    12541 aatgagacct gggagtccca aatgttatta actaccacaa ttttatataa ctgattcttc
    12601 actggtcatc cagaagcctt tttgaaagtc ccactgccat acctgcctcc tcggtgaaat
    12661 agatgtaaaa gccacaaaga gagaatcaat gagccacact catattggaa gcgaatggag
    12721 ttgacttcac cagtgggaaa agcaattact tttcaaagtg aaaactgatc aattcacaac
    12781 tcaaggaaag catggagtaa tttcagaact ccagtaagaa gtgataaatg tctagtttgg
    12841 aatcatgtgg ctgaaaatct taccatatgc tttccacagg ctgagcaaga ggatagatca
    12901 ttgaatagat gctttaattc catttttgac aatgaacctt gtgcttctga aaatatttat
    12961 atttaaccat gaggttatga tgattttttc tctacacttt ttgagaagcc tcttcagaaa
    13021 agagcaaagt tgtctgctct aatggataga ataaggagct gggagaaagg agacctgggt
    13081 attaatctca gctctaccac tacatggtag agctatgtag tggtagacta tctgggagac
    13141 tctagaatct ttaccattcc ctctactatt cctagctccc ttttctttca tagtcaacaa
    13201 gtgctttttg aacaattatt gaggtaaata acatacccta aaagttagta ctgattccca
    13261 ttatcatgct ctgttgttcc ctggatgctc ttttgaggaa tttacttggt taatacagtt
    13321 aatagtataa tacttataat aacaattttg agaattatca gcatgagaca atttatttgc
    13381 ataatagctt tttgttatta tccagaatac atttagttct ggattttgtt tgatattgtg
    13441 aatgcaaact atttttttgt gttagcctaa ataaaatgaa atacagttat ggaaatattt
    13501 ctgctgcaag aaaagaatta catacaacta gtatacatat ttagaggtgc tgtagtcttc
    13561 tagactgtaa aggcagatgg ccgtgagtgg aaatctgagt gtataggatg tgtttcgtgt
    13621 tcccactgca tatgcattat tacccttgtc tgagtggttg tttaaactga catctgtaaa
    13681 actaatctgt aaagtgagat ctgggttctg acctatctct tacagtccat aatgttgtga
    13741 ttctaagaat atttcattcc ttactgcttt ctgccctcca ttctgaccaa tgctgcaacc
    13801 acaaataaaa acattactta ccctatgaga aagactagac cttatactca ttttatctta
    13861 acagtttatt ataactcatt ttgaccactc ctccctcaaa aaaaattgtc cctagaaaac
    13921 tagagtgatc atagggatca gatgacatgt tactgggtga agccaggaag ctaccatata
    13981 catagaaaag ttagttgcca aatatggtgt gggaatttgg gaggaattta tctgctcaaa
    14041 aactctcacc tacttactag atatagtgtt tgtaatgtta gccttggaga ttctacctta
    14101 aaaatatcat tgagaaagct cagagaactc ccaggtaaac acacaggtag ccccttctaa
    14161 aatgcaaatg ccctttgaag gccagcttta ttaatcttgc cattaacccc atagttaatc
    14221 atatgcattt ctcacagtga cctgaaaaca ggcattcctt ctctaaatgt gtgctgaatg
    14281 ctggttataa accagttact acactaagcc ctgatgatac aaatatgaaa agtcctgttt
    14341 ccagggaatt tactttctaa tgaggaacca agtgctcaaa agcagtcata aagttcatgg
    14401 caaaataacc cacataatta actgctttgt tacaaaaact tggaaatata gataaaatat
    14461 ttattttgga aatatatgtt acaggtgaaa agcaagaatt aaaactagtt atctgaatgt
    14521 aaaaggaatc aacggctaaa tcaagcttaa agtcttcctg tccaagggat atgaaaggta
    14581 cctcaacctt tggttttggt tttggttttg gttttgtttt tttggtcaac atgaattata
    14641 gctaggggaa gagataaaca gggggttagg ttgtagatta tatgcatgac agattgctgg
    14701 aattgggctc cattcacaaa ggagggagca ggaaagggtt tctcttgact ggaccacaaa
    14761 tataaaatct catgccctct cattatcttg ataagcccta taggtccata aaagaaataa
    14821 aatgccaaaa cataccatga ggacactttc acaatccagg gcacacacat gactcccgca
    14881 ataggaaacc acactgaaga cattctcaca atttaaaaca agttgtaaac tacaggaaac
    14941 agttggcatc ccaggagagt tgttgcctga ggaactagat ggtggtatgt tattctggca
    15001 tatagggaac agaataagac atgagggtag gaagaggttt ttaaaagcaa agttaggcat
    15061 tcaatgatga cttcataaat gtgcctgggc tggcctttaa tggaaggctt taatttaggg
    15121 aacttaaaga atttcataat attggagtat aaactgctgg aaataaggat gctatttaat
    15181 agactctctt agatttttca taaaatgcta atagaatccc aaaggaagtg tgtattctaa
    15241 aatgttattg tgtatgttat aaaagctttg taaaataaag tgatgttaag ctactattgt
    15301 aaagttaaaa attttttcag tcatctgtaa tctcattacc caagtaaaac tgttttcatt
    15361 tttccatta
//
