LOCUS       NM_173672               3585 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens peptidylprolyl isomerase like 6 (PPIL6), transcript
            variant 1, mRNA.
ACCESSION   NM_173672
VERSION     NM_173672.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3585)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3585)
  AUTHORS   Davis,T.L., Walker,J.R., Campagna-Slater,V., Finerty,P.J.,
            Paramanathan,R., Bernstein,G., MacKenzie,F., Tempel,W., Ouyang,H.,
            Lee,W.H., Eisenmesser,E.Z. and Dhe-Paganon,S.
  TITLE     Structural and biochemical characterization of the human
            cyclophilin family of peptidyl-prolyl isomerases
  JOURNAL   PLoS Biol 8 (7), e1000439 (2010)
   PUBMED   20676357
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3585)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL109947.19 and AL359711.18.
            
            On Jul 26, 2019 this sequence version replaced NM_173672.4.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ363562.1, BC038716.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000521072.7/ ENSP00000427929.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AL109947.19        39611-39783         c
            174-269             AL109947.19        35259-35354         c
            270-458             AL109947.19        30312-30500         c
            459-521             AL109947.19        26249-26311         c
            522-669             AL109947.19        26002-26149         c
            670-726             AL109947.19        18342-18398         c
            727-862             AL359711.18        122475-122610       c
            863-3585            AL359711.18        112655-115377       c
FEATURES             Location/Qualifiers
     source          1..3585
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..3585
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
                     /note="peptidylprolyl isomerase like 6"
                     /db_xref="GeneID:285755"
                     /db_xref="HGNC:HGNC:21557"
     exon            1..173
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..974
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     radial spoke 12 homolog; peptidyl-prolyl cis-trans
                     isomerase-like 6; cyclophilin-like protein PPIL6; rotamase
                     PPIL6; peptidylprolyl isomerase (cyclophilin)-like 6;
                     problable inactive peptidyl-prolyl cis-trans
                     isomerase-like 6; probable inactive peptidyl-prolyl
                     cis-trans isomerase-like 6"
                     /codon_start=1
                     /product="probable inactive peptidyl-prolyl cis-trans
                     isomerase-like 6 isoform 1"
                     /protein_id="NP_775943.1"
                     /db_xref="CCDS:CCDS5074.1"
                     /db_xref="GeneID:285755"
                     /db_xref="HGNC:HGNC:21557"
                     /translation="MARPQPCGPPHARCGSPSLPERPLQVKVVGLFSCPNFQIAKSAA
                     ENLKNNHPSKFEDPILVPLQEFAWHQYLQEKKRELKNETWEYSSSVISFVNGQFLGDA
                     LDLQKWAHEVWDIVDIKPSALYDALTEDFSAKFLRDTKHDFVFLDICIDSSPIGRLIF
                     ELYCDVCPKTCKNFQVLCTGKAGFSQRGIRLHYKNSIFHRIVQNGWIQGGDIVYGKGD
                     NGESIYGPTFEDENFSVPHNKRGVLGMANKGRHSNGSQFYITLQATPYLDRKFVAFGQ
                     LIEGTEVLKQLELVPTQNERPIHMCRITDSGDPYA"
     exon            174..269
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
                     /inference="alignment:Splign:2.1.0"
     exon            270..458
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
                     /inference="alignment:Splign:2.1.0"
     exon            459..521
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
                     /inference="alignment:Splign:2.1.0"
     exon            522..669
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
                     /inference="alignment:Splign:2.1.0"
     exon            670..726
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
                     /inference="alignment:Splign:2.1.0"
     exon            727..862
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
                     /inference="alignment:Splign:2.1.0"
     exon            863..3585
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1040..1045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
                     /note="hexamer: ATTAAA"
     regulatory      1054..1059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
                     /note="hexamer: GATAAA"
     polyA_site      1065
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
                     /note="major polyA site"
     polyA_site      1072
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
     polyA_site      1914
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
     regulatory      3560..3565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
                     /note="hexamer: AATAAA"
     polyA_site      3585
                     /gene="PPIL6"
                     /gene_synonym="bA425D10.6; dJ919F19.1; PPIase; RSPH12"
ORIGIN      
        1 gcagtgtttg gggtcaccgg gcgtccccgg gcgcggccat ggcaaggccg cagccgtgcg
       61 ggcccccgca cgctaggtgc ggctcgccgt cgctgccgga gcggccgctg caggtgaagg
      121 tggtggggct cttcagctgc cccaactttc agattgcgaa gagcgccgct gagaatctga
      181 agaataatca tccatccaaa tttgaagatc ctatattagt tcctcttcaa gaatttgcat
      241 ggcatcaata tctacaggag aaaaaaaggg aactcaaaaa tgaaacctgg gaatattctt
      301 cctctgtgat ttcttttgtt aatggtcagt ttctgggtga tgcattggat ctgcagaaat
      361 gggcccacga ggtgtgggat atagttgaca ttaaaccctc tgcactttat gacgcactca
      421 ctgaggattt ttccgctaag ttcttaagag acaccaagca tgatttcgtg tttttggaca
      481 tttgtattga ttcttctcca attggaagat tgatttttga gctatactgt gatgtgtgtc
      541 ccaaaacatg taaaaatttt caggtcttgt gcacaggaaa agcagggttt tctcaacgtg
      601 gcataagact acattacaaa aattccattt ttcatcgaat agtacagaat ggctggatac
      661 aaggagggga tatagtgtat ggaaaaggag ataatggaga gtcgatttat ggtccaacat
      721 ttgaagatga aaacttttca gttcctcata ataaaagagg agtacttgga atggccaaca
      781 aaggccgtca cagcaacggg tcacaattct atatcacact gcaagcaact ccttatctag
      841 atagaaaatt tgtggctttt gggcaactga ttgaaggaac agaagtgctt aaacaactag
      901 aattagttcc aacacagaat gaaagaccaa tacatatgtg tagaattact gacagtggag
      961 atccttatgc ttgattttca tatcaatatt ttctgtgata atttattact ttgtatctga
     1021 tcagctgttt gtggatttaa ttaaaaagta cttgataaat tgtaatttga aagccgtggc
     1081 agacactgta ggttgcctca tctacaccca atccctcccc atcttccttt cctgtctctg
     1141 tcatagagac tgtgaaaggg tggtactcaa tttcctagac tcctttgcag ccacgggtgg
     1201 ccatgagaga tggttctggc cagtgggaca ggaatagaac gccagtggtc ctgccccttc
     1261 cccttcatcc agtctggaat gtggagaggc tggagctaca gctgtcatct tgtggccata
     1321 aagaaaaggc tgaggccagg tgtggtagct cacgcctgta atcccagcac ttgggaggcc
     1381 gaggcaggtg gatcacaaga tcaagagatt gagaccatcc tggccaacat ggtgaaaccc
     1441 tgtctctact aaaactacag aaattagctg ggcatggtgg catgcacttg tagtcccagc
     1501 tacttgggaa gctgaggcag aagaatctct tgaacccggg aggcggaggt tgcagtgagc
     1561 cgagatgccg ccactgcact ccagcctggc gacagagaga gactgtctca aaaaaaaaga
     1621 aaggccaagt actgcagaga tgtcagcccc agtctcttga gctgcgggac caataccagc
     1681 aaccacctac tctggacttc ttattatagg agactaacag agccctgtgt tgtgttgttt
     1741 atgttactgt tggttgagaa ttttgttact tgtggacaaa aaattcttaa tttagcaaca
     1801 cacctgatag cctaagacat ttgtaataga attatgttct tgtttgtaac tacatgtact
     1861 cctaggagaa acttggtaag taaccaaata ggaatgatgc agaagaaaaa gcaattcatt
     1921 gtaatatttc attgtttata ccagcattca gaaagagtat ctacactttg gatgttttca
     1981 tatatgacat gaacatcatc cttatctctc tgagccatac caaccctatg aaaaccaagg
     2041 gcttgtttta cagtgtccgt ggtggctgac tcatgtgatg ttattggaga ttcagcttta
     2101 tcactactct gtaatctaaa gttctcaagc tcatatcacc tggggagctt ttaaaatgta
     2161 acctaacaga ccttgtcctt gacctactga ggcagagttc ccaggcgtgg ggcagagatt
     2221 ctgtgttcat ttggttcttt ccccagggtt cccaggcgtg gggcacagat tctgtgttca
     2281 tttagctctt tccccagggt tcccatttag acagctgggc actagtcatc tgggaatcac
     2341 tgcaagacat aaggaactgg ttccagtccc catggtgtaa tgtagtcagc agagtgcttg
     2401 actctgctat tggtgacctt gctcagctcc tgttaccacc actaccctgt gcccctgctc
     2461 tgcccagact aagagtgctt ttcttttttt tttttttttt tttttttttt ttgagacgga
     2521 atctcactct gtcgcccagg ctggagtgca gtggcacaat ctcggctcac tgcaagctct
     2581 gcctccctga ttcatgccat tctcctgcct cagcctcccg agtagctggg actacaggcg
     2641 cctgccacca cgcctggcta attttttgta tttttagtag agatgggatt tcaccatgtt
     2701 agccaggatg gtcccgatct tgtgacctcg tgatccgccc gcctcggcct cccaaagtgc
     2761 tgagattaca aaggcgtgag ccaccgcacc cggctgagag tgcttttctt accctaagca
     2821 gaatgaggtt tgtcttccaa gaacaatctc tatttacatc agtcttaaag aggcaggctt
     2881 ctaatggata tgaggcttgc caaaagtagg cgtaggcttt tttaactttt tattttgaaa
     2941 tatagattca caggaagttg caaaaatagt acagagcagt cctgtgtacc tttcacccat
     3001 tttccccagt ggctacgctt acaaaacggt agtacaatat caaaccaggc agctgacatt
     3061 ggtacaatgt gtgtgatgcc attttatcat gagtatattc atgtaaccaa cactatagag
     3121 aaaatataga acctttccag cacctcaaag acccccttcc agtacccctt tacagtcaac
     3181 ccactcccct gccctctgcc atccctaact cctgacaact ggcatttgct tttcctttta
     3241 atgacagctt tattgctata tgacatatgc tttatgctaa gacctgaggt ggatgggagg
     3301 aagcagaccg cctatgttac attctcaact gacccagagc aacatagtgt taagaatgtg
     3361 tgttctaggg ccagaatcct ggctctgcca ttccctagct gcacaaactc aggcaagaac
     3421 ttttctgtgc ctcaattcct tcatctgaga aacagtggta cctaccacat aagattgctg
     3481 tgagggttcc atgaatcaat aatttctata aagaacctat aagagacctg gtctgctgta
     3541 agcactcgat aaatttaata ataaattact aatgtgtaac cttca
//
