LOCUS       NM_139126               2475 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens peptidylprolyl isomerase like 4 (PPIL4), mRNA.
ACCESSION   NM_139126
VERSION     NM_139126.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2475)
  AUTHORS   Barak,T., Ristori,E., Ercan-Sencicek,A.G., Miyagishima,D.F.,
            Nelson-Williams,C., Dong,W., Jin,S.C., Prendergast,A., Armero,W.,
            Henegariu,O., Erson-Omay,E.Z., Harmanci,A.S., Guy,M., Gultekin,B.,
            Kilic,D., Rai,D.K., Goc,N., Aguilera,S.M., Gulez,B., Altinok,S.,
            Ozcan,K., Yarman,Y., Coskun,S., Sempou,E., Deniz,E., Hintzen,J.,
            Cox,A., Fomchenko,E., Jung,S.W., Ozturk,A.K., Louvi,A.,
            Bilguvar,K., Connolly,E.S. Jr., Khokha,M.K., Kahle,K.T., Yasuno,K.,
            Lifton,R.P., Mishra-Gorur,K., Nicoli,S. and Gunel,M.
  TITLE     PPIL4 is essential for brain angiogenesis and implicated in
            intracranial aneurysms in humans
  JOURNAL   Nat Med 27 (12), 2165-2175 (2021)
   PUBMED   34887573
  REMARK    GeneRIF: PPIL4 is essential for brain angiogenesis and implicated
            in intracranial aneurysms in humans.
REFERENCE   2  (bases 1 to 2475)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2475)
  AUTHORS   Okada,Y., Wu,D., Trynka,G., Raj,T., Terao,C., Ikari,K., Kochi,Y.,
            Ohmura,K., Suzuki,A., Yoshida,S., Graham,R.R., Manoharan,A.,
            Ortmann,W., Bhangale,T., Denny,J.C., Carroll,R.J., Eyler,A.E.,
            Greenberg,J.D., Kremer,J.M., Pappas,D.A., Jiang,L., Yin,J., Ye,L.,
            Su,D.F., Yang,J., Xie,G., Keystone,E., Westra,H.J., Esko,T.,
            Metspalu,A., Zhou,X., Gupta,N., Mirel,D., Stahl,E.A., Diogo,D.,
            Cui,J., Liao,K., Guo,M.H., Myouzen,K., Kawaguchi,T., Coenen,M.J.,
            van Riel,P.L., van de Laar,M.A., Guchelaar,H.J., Huizinga,T.W.,
            Dieude,P., Mariette,X., Bridges,S.L. Jr., Zhernakova,A., Toes,R.E.,
            Tak,P.P., Miceli-Richard,C., Bang,S.Y., Lee,H.S., Martin,J.,
            Gonzalez-Gay,M.A., Rodriguez-Rodriguez,L., Rantapaa-Dahlqvist,S.,
            Arlestig,L., Choi,H.K., Kamatani,Y., Galan,P., Lathrop,M., Eyre,S.,
            Bowes,J., Barton,A., de Vries,N., Moreland,L.W., Criswell,L.A.,
            Karlson,E.W., Taniguchi,A., Yamada,R., Kubo,M., Liu,J.S., Bae,S.C.,
            Worthington,J., Padyukov,L., Klareskog,L., Gregersen,P.K.,
            Raychaudhuri,S., Stranger,B.E., De Jager,P.L., Franke,L.,
            Visscher,P.M., Brown,M.A., Yamanaka,H., Mimori,T., Takahashi,A.,
            Xu,H., Behrens,T.W., Siminovitch,K.A., Momohara,S., Matsuda,F.,
            Yamamoto,K. and Plenge,R.M.
  CONSRTM   RACI consortium; GARNET consortium
  TITLE     Genetics of rheumatoid arthritis contributes to biology and drug
            discovery
  JOURNAL   Nature 506 (7488), 376-381 (2014)
   PUBMED   24390342
REFERENCE   4  (bases 1 to 2475)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 2475)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 2475)
  AUTHORS   Scanlan,M.J., Gout,I., Gordon,C.M., Williamson,B., Stockert,E.,
            Gure,A.O., Jager,D., Chen,Y.T., Mackay,A., O'Hare,M.J. and Old,L.J.
  TITLE     Humoral immunity to human breast cancer: antigen definition and
            quantitative analysis of mRNA expression
  JOURNAL   Cancer Immun 1, 4 (2001)
   PUBMED   12747765
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2475)
  AUTHORS   Zeng,L., Zhou,Z., Xu,J., Zhao,W., Wang,W., Huang,Y., Cheng,C.,
            Xu,M., Xie,Y. and Mao,Y.
  TITLE     Molecular cloning, structure and expression of a novel nuclear
            RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain
  JOURNAL   Cytogenet Cell Genet 95 (1-2), 43-47 (2001)
   PUBMED   11978968
  REMARK    GeneRIF: Molecular cloning, structure and expression of a novel
            nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal
            brain
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315388.1, AF357880.1 and
            AL357619.15.
            
            On May 17, 2019 this sequence version replaced NM_139126.3.
            
            Summary: This gene is a member of the cyclophilin family of
            peptidylprolyl isomerases. The cyclophilins are a highly conserved
            family, members of which play an important role in protein folding,
            immunosuppression by cyclosporin A, and infection of HIV-1 virions.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF357880.1, SRR1803612.259629.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253329.3/ ENSP00000253329.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AK315388.1         60-67
            9-2075              AF357880.1         1-2067
            2076-2076           AL357619.15        10210-10210         c
            2077-2475           AF357880.1         2069-2467
FEATURES             Location/Qualifiers
     source          1..2475
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..2475
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /note="peptidylprolyl isomerase like 4"
                     /db_xref="GeneID:85313"
                     /db_xref="HGNC:HGNC:15702"
                     /db_xref="MIM:607609"
     exon            1..108
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1517
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /EC_number="5.2.1.8"
                     /note="serologically defined breast cancer antigen
                     NY-BR-18; PPIase; cyclophilin-type peptidyl-prolyl
                     cis-trans isomerase; cyclophilin-like protein PPIL4;
                     rotamase PPIL4; peptidylprolyl isomerase
                     (cyclophilin)-like 4"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase-like 4"
                     /protein_id="NP_624311.1"
                     /db_xref="CCDS:CCDS34550.1"
                     /db_xref="GeneID:85313"
                     /db_xref="HGNC:HGNC:15702"
                     /db_xref="MIM:607609"
                     /translation="MAVLLETTLGDVVIDLYTEERPRACLNFLKLCKIKYYNYCLIHN
                     VQRDFIIQTGDPTGTGRGGESIFGQLYGDQASFFEAEKVPRIKHKKKGTVSMVNNGSD
                     QHGSQFLITTGENLDYLDGVHTVFGEVTEGMDIIKKINETFVDKDFVPYQDIRINHTV
                     ILDDPFDDPPDLLIPDRSPEPTREQLDSGRIGADEEIDDFKGRSAEEVEEIKAEKEAK
                     TQAILLEMVGDLPDADIKPPENVLFVCKLNPVTTDEDLEIIFSRFGPIRSCEVIRDWK
                     TGESLCYAFIEFEKEEDCEKAFFKMDNVLIDDRRIHVDFSQSVAKVKWKGKGGKYTKS
                     DFKEYEKEQDKPPNLVLKDKVKPKQDTKYDLILDEQAEDSKSSHSHTSKKHKKKTHHC
                     SEEKEDEDYMPIKNTNQDIYREMGFGHYEEEESCWEKQKSEKRDRTQNRSRSRSRERD
                     GHYSNSHKSKYQTDLYERERSKKRDRSRSPKKSKDKEKSKYR"
     exon            109..176
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /inference="alignment:Splign:2.1.0"
     exon            177..241
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /inference="alignment:Splign:2.1.0"
     exon            242..359
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /inference="alignment:Splign:2.1.0"
     exon            360..502
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /inference="alignment:Splign:2.1.0"
     exon            503..599
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /inference="alignment:Splign:2.1.0"
     exon            600..716
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /inference="alignment:Splign:2.1.0"
     exon            717..841
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /inference="alignment:Splign:2.1.0"
     exon            842..908
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1020
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1117
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1265
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..2475
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2027..2032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /note="hexamer: TATAAA"
     polyA_site      2046
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /note="major polyA site"
     regulatory      2092..2097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /note="hexamer: AATATA"
     polyA_site      2122
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
     regulatory      2213..2218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /note="hexamer: AATAAT"
     polyA_site      2237
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
                     /note="major polyA site"
     polyA_site      2393
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
     polyA_site      2475
                     /gene="PPIL4"
                     /gene_synonym="HDCME13P"
ORIGIN      
        1 ctcctcccgg ggtttgtagc ggaggaggag cgggcgccat ggcggttcta ctggagacca
       61 ctttaggcga cgtcgtcatc gacttgtaca ccgaagaacg gccgcgtgcc tgcttgaatt
      121 tcttgaaact gtgcaaaata aaatattaca attattgcct tattcacaat gtacagaggg
      181 attttatcat acaaactggc gatcctacag ggactggccg tggaggagag tctatctttg
      241 gccaactgta tggtgatcaa gcaagctttt ttgaggcaga aaaagtccca agaattaagc
      301 acaagaagaa aggcacagtg tccatggtga ataatggcag tgatcaacat ggatctcagt
      361 ttcttatcac cacaggagaa aatctagatt atcttgatgg tgtccatacg gtgtttggtg
      421 aggtgacaga aggcatggac ataattaaga aaattaatga gacctttgtt gacaaggact
      481 ttgtaccata tcaggatatc aggataaatc atacggtgat tttagatgat ccatttgatg
      541 accctcctga tttattaatc cctgatcgat caccagaacc tacaagggaa caattagata
      601 gtggtcgaat aggagcagat gaagaaattg atgatttcaa aggaagatca gctgaggaag
      661 tagaagaaat aaaggcagaa aaagaggcta aaactcaggc tatacttttg gagatggtgg
      721 gagacctacc tgatgcagat attaaacctc cagaaaatgt actgtttgtg tgtaaattga
      781 acccagtgac cacagatgag gatctggaaa taatattctc tagatttggg ccaataagaa
      841 gttgtgaagt tatccgagac tggaagacag gagagtccct ctgttacgct tttattgaat
      901 ttgaaaagga agaagattgt gagaaagcat tcttcaaaat ggacaatgtg cttatagatg
      961 acagaagaat acatgtggat tttagccagt cggttgcaaa ggttaaatgg aaaggaaaag
     1021 gtgggaaata caccaagagt gatttcaagg agtatgaaaa agaacaggat aaaccaccta
     1081 atttggttct gaaagataaa gtaaagccca aacaggatac aaaatacgat cttatattag
     1141 atgagcaggc cgaagactca aaatcaagtc actcacacac aagtaaaaaa cacaagaaga
     1201 aaacccatca ctgttctgaa gagaaagaag atgaggacta catgccaatc aaaaatacta
     1261 atcaggatat ctatagagaa atggggtttg gtcactatga agaagaagaa agctgttggg
     1321 agaaacaaaa gagtgaaaag agagaccgaa ctcagaaccg aagtcgtagc cgatctcgag
     1381 agagggatgg ccattatagt aatagtcata aatcaaaata ccaaacagat ctttatgaaa
     1441 gagaaaggag taaaaagaga gaccgaagca gaagtccaaa gaagtccaaa gataaagaaa
     1501 aatctaagta tagatgaaag atgaagaggc agaattgaga ggctaacata tttactcttg
     1561 tctaacttaa gagtgccagg aaagcagatg cttagatttt gtgtcaaagc ttgttatttt
     1621 tttcatacta ggattatggt ctttagatta atactgatta tatagagcac ggaaagataa
     1681 agaattgaac attttctttg tatacttttt tacactaatt ttattgttat acataaatgg
     1741 tagtcttcat ttttgaagtc ttacattttc actctttttt taatgaagta tttcatacta
     1801 caaaaataca taaacgtata tataaaggga taataaatgt aaatatctgt gtactcatca
     1861 gccagcttaa gatacagatg ttgtcgacat tttagaagtt ccctaaggcc ctctccctct
     1921 caaataatta tttggaattt tgtgtttgtc atttgtctat tatagtttta caacatacgt
     1981 atgtatctgt aagtgaaatg ttaattttgt atgtttctga attttatata aatggcaaaa
     2041 tgtttacttc tgtgactttc tttcattttt attgctatat agtattatat aaatatacta
     2101 caacttattc attcttgatg gacatttgag ttttgtttat ttgtttttgc tgttgaaaca
     2161 atgctgctgt gaacattgta tctagcagtt atattgcttg atatattgat aaaataatgc
     2221 caaatttgtg ttctgaagtg actgtactag tttatacctc tcttggcact gtgagttacc
     2281 tttgtttcat agcatctcca acacttaagt tcagacttaa aaatttgcca acctagtgga
     2341 tgttaagtgg tatctacctg tgatttccag caagattact gttatctctg ctcttccatg
     2401 tgtaagatgt catttttttc ctggctgctt ttaaggtttt ctgtcactgg ttgtaagaag
     2461 tttgattatg atgtg
//
