LOCUS       NM_014337               4068 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens peptidylprolyl isomerase like 2 (PPIL2), transcript
            variant 1, mRNA.
ACCESSION   NM_014337
VERSION     NM_014337.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4068)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4068)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   3  (bases 1 to 4068)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4068)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   5  (bases 1 to 4068)
  AUTHORS   Davis,T.L., Walker,J.R., Campagna-Slater,V., Finerty,P.J.,
            Paramanathan,R., Bernstein,G., MacKenzie,F., Tempel,W., Ouyang,H.,
            Lee,W.H., Eisenmesser,E.Z. and Dhe-Paganon,S.
  TITLE     Structural and biochemical characterization of the human
            cyclophilin family of peptidyl-prolyl isomerases
  JOURNAL   PLoS Biol 8 (7), e1000439 (2010)
   PUBMED   20676357
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4068)
  AUTHORS   Carson,R., McKnight,A.J., Todd,S., Liu,W.W., Heggarty,S., Craig,D.,
            McGuinness,B., Irvine,G.B., Passmore,A.P. and Johnston,J.A.
  TITLE     Variation in RTN3 and PPIL2 genes does not influence platelet
            membrane beta-secretase activity or susceptibility to alzheimer's
            disease in the northern Irish population
  JOURNAL   Neuromolecular Med 11 (4), 337-344 (2009)
   PUBMED   19669607
  REMARK    GeneRIF: common genetic variation in the BACE1-interacting
            proteins, RTN3 an PPIL2, does not influence platelet b-secretase
            activity or susceptibility to Alzheimer's disease in this
            population.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4068)
  AUTHORS   Pushkarsky,T., Yurchenko,V., Vanpouille,C., Brichacek,B.,
            Vaisman,I., Hatakeyama,S., Nakayama,K.I., Sherry,B. and
            Bukrinsky,M.I.
  TITLE     Cell surface expression of CD147/EMMPRIN is regulated by
            cyclophilin 60
  JOURNAL   J Biol Chem 280 (30), 27866-27871 (2005)
   PUBMED   15946952
  REMARK    GeneRIF: cyclophilin 60 regulates cell surface expression of
            CD147/EMMPRIN
REFERENCE   8  (bases 1 to 4068)
  AUTHORS   Hatakeyama,S., Yada,M., Matsumoto,M., Ishida,N. and Nakayama,K.I.
  TITLE     U box proteins as a new family of ubiquitin-protein ligases
  JOURNAL   J Biol Chem 276 (35), 33111-33120 (2001)
   PUBMED   11435423
REFERENCE   9  (bases 1 to 4068)
  AUTHORS   Wang,B.B., Hayenga,K.J., Payan,D.G. and Fisher,J.M.
  TITLE     Identification of a nuclear-specific cyclophilin which interacts
            with the proteinase inhibitor eglin c
  JOURNAL   Biochem J 314 (Pt 1) (Pt 1), 313-319 (1996)
   PUBMED   8660300
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000553.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014337.3.
            
            Summary: This gene is a member of the cyclophilin family of
            peptidylprolyl isomerases. The cyclophilins are a highly conserved
            ubiquitous family, members of which play an important role in
            protein folding, immunosuppression by cyclosporin A, and infection
            of HIV-1 virions. This protein interacts with the proteinase
            inhibitor eglin c and is localized in the nucleus. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 4 encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.157620.1,
                                           SRR1803613.189868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398831.8/ ENSP00000381812.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AP000553.1         70213-70332
            121-170             AP000553.1         74114-74163
            171-216             AP000553.1         74767-74812
            217-279             AP000553.1         75198-75260
            280-331             AP000553.1         76531-76582
            332-383             AP000553.1         79265-79316
            384-475             AP000553.1         85500-85591
            476-565             AP000553.1         86638-86727
            566-641             AP000553.1         87383-87458
            642-802             AP000553.1         88954-89114
            803-878             AP000553.1         90684-90759
            879-985             AP000553.1         91093-91199
            986-1075            AP000553.1         91844-91933
            1076-1109           AP000553.1         92274-92307
            1110-1227           AP000553.1         92933-93050
            1228-1284           AP000553.1         98017-98073
            1285-1357           AP000553.1         98794-98866
            1358-1420           AP000553.1         98956-99018
            1421-1554           AP000553.1         99138-99271
            1555-4068           AP000553.1         99595-102108
FEATURES             Location/Qualifiers
     source          1..4068
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21-q11.22"
     gene            1..4068
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /note="peptidylprolyl isomerase like 2"
                     /db_xref="GeneID:23759"
                     /db_xref="HGNC:HGNC:9261"
                     /db_xref="MIM:607588"
     exon            1..120
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1651
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant 1;
                     peptidylprolyl cis-trans isomerase; cyclophilin-like
                     protein CyP-60; peptidyl-prolyl cis-trans isomerase-like
                     2; cyclophilin, 60kDa; PPIase; cyclophilin-60; rotamase
                     PPIL2; U-box domain containing 7; peptidylprolyl isomerase
                     (cyclophilin)-like 2; RING-type E3 ubiquitin transferase
                     isomerase-like 2; probable inactive peptidyl-prolyl
                     cis-trans isomerase-like 2; RING-type E3 ubiquitin-protein
                     ligase PPIL2"
                     /codon_start=1
                     /product="RING-type E3 ubiquitin-protein ligase PPIL2
                     isoform a"
                     /protein_id="NP_055152.1"
                     /db_xref="CCDS:CCDS13793.1"
                     /db_xref="GeneID:23759"
                     /db_xref="HGNC:HGNC:9261"
                     /db_xref="MIM:607588"
                     /translation="MGKRQHQKDKMYITCAEYTHFYGGKKPDLPQTNFRRLPFDHCSL
                     SLQPFVYPVCTPDGIVFDLLNIVPWLKKYGTNPSNGEKLDGRSLIKLNFSKNSEGKYH
                     CPVLFTVFTNNTHIVAVRTTGNVYAYEAVEQLNIKAKNFRDLLTDEPFSRQDIITLQD
                     PTNLDKFNVSNFYHVKNNMKIIDPDEEKAKQDPSYYLKNTNAETRETLQELYKEFKGD
                     EILAATMKAPEKKKVDKLNAAHYSTGKVSASFTSTAMVPETTHEAAAIDEDVLRYQFV
                     KKKGYVRLHTNKGDLNLELHCDLTPKTCENFIRLCKKHYYDGTIFHRSIRNFVIQGGD
                     PTGTGTGGESYWGKPFKDEFRPNLSHTGRGILSMANSGPNSNRSQFFITFRSCAYLDK
                     KHTIFGRVVGGFDVLTAMENVESDPKTDRPKEEIRIDATTVFVDPYEEADAQIAQERK
                     TQLKVAPETKVKSSQPQAGSQGPQTFRQGVGKYINPAATKRAAEEEPSTSATVPMSKK
                     KPSRGFGDFSSW"
     exon            121..170
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            171..216
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            217..279
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            280..331
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            332..383
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            384..475
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            476..565
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            566..641
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            642..802
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            803..878
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            879..985
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1075
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1109
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1227
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1284
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1357
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1420
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1554
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..4068
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4049..4054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /note="hexamer: ATTAAA"
     polyA_site      4057
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
     polyA_site      4068
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /note="major polyA site"
ORIGIN      
        1 agtggtcacg gaactcggct gcggctccat ggtctgagtt gtcagccgtt gttttttcgt
       61 gctcgctagt cgccgccgcc gctccgccat ggggaagcga cagcaccaaa aggacaaaat
      121 gtacattacc tgtgctgaat acactcactt ttatggtggc aagaagccag atctcccaca
      181 aacaaatttt cgtcgtttac cttttgacca ctgcagtctc tctctgcagc cctttgtcta
      241 cccagtctgc actcccgatg gcatcgtctt tgacttactg aacattgttc catggcttaa
      301 gaagtacggg accaacccca gcaatggaga gaagctggac gggaggtccc tgatcaagct
      361 gaacttttcc aagaacagtg aggggaagta ccactgccca gtgctgttta ccgtgttcac
      421 caacaacacc cacatcgtgg ctgtgaggac gaccggcaac gtctacgcct atgaggcagt
      481 ggaacagcta aatatcaagg ccaagaactt ccgggacctg ctgaccgacg agcccttctc
      541 ccggcaggac atcatcaccc tccaggaccc caccaatttg gacaagttca atgtctctaa
      601 cttctatcat gtgaagaata acatgaaaat aatagaccca gatgaagaga aggccaaaca
      661 ggacccgtct tattatctga aaaatacaaa tgccgagacc cgagagaccc tgcaggagct
      721 ctacaaggag ttcaaagggg acgagattct ggcagccacc atgaaggccc cggagaagaa
      781 gaaagtggac aagctgaacg ctgcccacta ttccacaggg aaggtcagcg cttccttcac
      841 ctccaccgcg atggtcccgg agaccacaca tgaagcagct gccatcgacg aggatgtgct
      901 gcgctaccag tttgtgaaga agaagggcta cgtgcggctg cacaccaaca agggcgacct
      961 caacctggag ctgcactgcg acctgacacc aaaaacctgc gaaaacttca tcaggctttg
     1021 caagaagcat tattacgatg gcaccatctt ccacagatcc atccggaact ttgtgatcca
     1081 agggggcgac cccacaggca caggcacggg tggggagtca tactggggga agcccttcaa
     1141 agacgagttc cggcccaacc tctcgcacac gggccgcggc atcctcagca tggccaactc
     1201 cgggcccaac agcaacaggt ctcaattctt catcacgttt cgctcctgtg cctacctgga
     1261 caagaagcat accatctttg gacgggttgt tgggggcttt gacgtactga cagccatgga
     1321 gaatgtggag agtgacccca aaactgaccg ccctaaggag gagatccgca ttgatgccac
     1381 tacagtgttc gtggacccct atgaggaggc cgatgcccag attgcgcagg agcggaagac
     1441 acagctcaag gtagccccgg agaccaaagt gaagagcagc cagccccagg cagggagcca
     1501 gggcccccag accttccgcc agggcgtggg caagtacatc aacccagcag ccacgaagcg
     1561 agcagcagag gaagagccct caaccagtgc cactgtcccc atgtccaaga agaagcccag
     1621 tcggggtttt ggggacttca gctcctggta gcagcaggtt ggccgctgtg gaccttggtg
     1681 gggttgcagg gctgggggcc catgtccaca tctccatttc cagcctttct agcctgccct
     1741 ctgctgccag ccaataaatt gcttgcctgc tgcctgcatc ccctttcctg gcccctggga
     1801 gcccacagcc ttcccatccc ttaacctgtt gccaagggcc ttggccctgt ttccaggacc
     1861 tggcccagcc agagcccact gctgggacct tcaagcacaa ggcctgccct acacccaggc
     1921 tggtgcctca ggcctcccct ctagtaggca ggccaggtta gtgaggaagg actgtgtctc
     1981 cagattgtgg tttcctcttt aagacagggt cttgctctgt tgcccaggct ccagtgcagt
     2041 ggtgtgatca tggctcactg cagcctcgac ctcctgggct caagcaatcc tcctgcctca
     2101 gcctcgcaag tagctgggac tacagccgtg caccactaca tccagctgta tatgtctggt
     2161 tttcttaccc ctacttctgt catcttctca gggacagcct atttatacaa ccagtgtggt
     2221 cccctgacca acgccattac ctgggacaag ttttcagacc ccagacttac tgagcctaag
     2281 cctctgcagg gtgggcttct cggtctgttt tgacaaaact tcaggggctt ctgaaggctg
     2341 gtgttggacg gcagcattga gtttcctgcc gtgccctgcc tgagctctca gggccctgct
     2401 cacctgctct ggctgtgaac cacctgggct tcatctcaag cctgcctggc gtctctgtgc
     2461 ccctgtgaga atcttgaggg gacccacact gggttgaggc cagtgtctcc tgctgtgaga
     2521 acaagtggat gtccctctcc ccgccctcct gctgaagtgg ccttgctgct ctcaggcccg
     2581 gccactgggc tccaagactc tgctcctcct gtcagtcact gactctgatg gccttgggcc
     2641 agctgcatca gcagccctta aagaaagacc cctccctcaa cccccatttt tctgttaaat
     2701 gtgcccctgg ctggcttttt cttcgtcttc agcccaggcc agtggtcagt gttctcatgt
     2761 catggactct ccttgcctga cacttgcctc ttgggctccc tgttgccctc aggccacccc
     2821 ccacttctag ttcttcacac taagccctaa cttaggcctt gttcttggtt ttctcatttt
     2881 tgttgcccca aatcttgaac ctgtcagcaa cttgcaggct gtacctctgc ccttcctttt
     2941 ctcatcaatc actgatgctg aagctgcagg cctgagccct ttgtctccct ggatgctggg
     3001 tggcgcctca tctgcatctc tgcctcaccc catccactgc cacaggctgc ctgatgacca
     3061 ctagaggtat gtctgcccct cgtcaccctg ctgcacacca atctgtggcc cttcatcatg
     3121 ctaagaacaa gaactgcgcc atggctggct ccttctcttc tccagcccat ccctctgcag
     3181 cctgtcatcc ctgtctgtga ccattggtcg ggcccctggg ctctagagtg acttttgacg
     3241 ccctccatcc ctcccgccag gcactgtcct ccgcaaggcc tggtgcagcc ctggcagtaa
     3301 ctggcttgta agaggctcag acaccaagct gggcctgcag aggaggggca cagtaggaca
     3361 cagtgactgc ccaggtgtcc acacacctgt aggcctctga gccagcgtcc agggtacagg
     3421 tgcgggtggt ggggatgaag gcctgaccag ggagggagaa gcaggtttgg agaggaccct
     3481 gtgcccaccc tgacagacac cctggctggc cctgactgac tgtattctct ggccacattc
     3541 aagtccccca ttggtggggg cagagaagta ggaccaggcc atccttggct ccagagctcg
     3601 aagaccccaa gacagccctc tgctctcagc ggcgccacag agagcctggg ctcagccttc
     3661 tgcatcagga catggcctcg tccactgagg gcacgattta aacatttgac atcagaagct
     3721 ttatttgtaa acctcacaca gataaggacc aagggctggc ggtgtggcca gaggacaggg
     3781 gaagctgaag gccccgtgct tgagctcggc agtcctgctc cttgcagtga agccaccatg
     3841 ggtgaccgtc cagcctcacc cggtggcctg cacagtgagg gaagggcttc agggccatct
     3901 gctcccaggg caggggacag gccaccaagg acctttggca aatgaaggtt tacatttctg
     3961 tagtttgttt gttttagagc ttaatttgta gttttttagc tattaaaacc atttgaattt
     4021 ttaacgacct gatgagggca tcaggtaaat taaaggattt tgggaaga
//
