LOCUS       NM_001317996            3698 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens peptidylprolyl isomerase like 2 (PPIL2), transcript
            variant 4, mRNA.
ACCESSION   NM_001317996 XM_005261447
VERSION     NM_001317996.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3698)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3698)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   3  (bases 1 to 3698)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3698)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   5  (bases 1 to 3698)
  AUTHORS   Davis,T.L., Walker,J.R., Campagna-Slater,V., Finerty,P.J.,
            Paramanathan,R., Bernstein,G., MacKenzie,F., Tempel,W., Ouyang,H.,
            Lee,W.H., Eisenmesser,E.Z. and Dhe-Paganon,S.
  TITLE     Structural and biochemical characterization of the human
            cyclophilin family of peptidyl-prolyl isomerases
  JOURNAL   PLoS Biol 8 (7), e1000439 (2010)
   PUBMED   20676357
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3698)
  AUTHORS   Carson,R., McKnight,A.J., Todd,S., Liu,W.W., Heggarty,S., Craig,D.,
            McGuinness,B., Irvine,G.B., Passmore,A.P. and Johnston,J.A.
  TITLE     Variation in RTN3 and PPIL2 genes does not influence platelet
            membrane beta-secretase activity or susceptibility to alzheimer's
            disease in the northern Irish population
  JOURNAL   Neuromolecular Med 11 (4), 337-344 (2009)
   PUBMED   19669607
  REMARK    GeneRIF: common genetic variation in the BACE1-interacting
            proteins, RTN3 an PPIL2, does not influence platelet b-secretase
            activity or susceptibility to Alzheimer's disease in this
            population.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3698)
  AUTHORS   Pushkarsky,T., Yurchenko,V., Vanpouille,C., Brichacek,B.,
            Vaisman,I., Hatakeyama,S., Nakayama,K.I., Sherry,B. and
            Bukrinsky,M.I.
  TITLE     Cell surface expression of CD147/EMMPRIN is regulated by
            cyclophilin 60
  JOURNAL   J Biol Chem 280 (30), 27866-27871 (2005)
   PUBMED   15946952
  REMARK    GeneRIF: cyclophilin 60 regulates cell surface expression of
            CD147/EMMPRIN
REFERENCE   8  (bases 1 to 3698)
  AUTHORS   Hatakeyama,S., Yada,M., Matsumoto,M., Ishida,N. and Nakayama,K.I.
  TITLE     U box proteins as a new family of ubiquitin-protein ligases
  JOURNAL   J Biol Chem 276 (35), 33111-33120 (2001)
   PUBMED   11435423
REFERENCE   9  (bases 1 to 3698)
  AUTHORS   Wang,B.B., Hayenga,K.J., Payan,D.G. and Fisher,J.M.
  TITLE     Identification of a nuclear-specific cyclophilin which interacts
            with the proteinase inhibitor eglin c
  JOURNAL   Biochem J 314 (Pt 1) (Pt 1), 313-319 (1996)
   PUBMED   8660300
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000553.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001317996.1.
            
            Summary: This gene is a member of the cyclophilin family of
            peptidylprolyl isomerases. The cyclophilins are a highly conserved
            ubiquitous family, members of which play an important role in
            protein folding, immunosuppression by cyclosporin A, and infection
            of HIV-1 virions. This protein interacts with the proteinase
            inhibitor eglin c and is localized in the nucleus. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (4) lacks a segment in the 3' UTR
            compared to variant 1. Variants 1, 2 and 4 encode the same isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.160995.1,
                                           SRR14038194.682321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AP000553.1         70213-70332
            121-170             AP000553.1         74114-74163
            171-216             AP000553.1         74767-74812
            217-279             AP000553.1         75198-75260
            280-331             AP000553.1         76531-76582
            332-383             AP000553.1         79265-79316
            384-475             AP000553.1         85500-85591
            476-565             AP000553.1         86638-86727
            566-641             AP000553.1         87383-87458
            642-802             AP000553.1         88954-89114
            803-878             AP000553.1         90684-90759
            879-985             AP000553.1         91093-91199
            986-1075            AP000553.1         91844-91933
            1076-1109           AP000553.1         92274-92307
            1110-1227           AP000553.1         92933-93050
            1228-1284           AP000553.1         98017-98073
            1285-1357           AP000553.1         98794-98866
            1358-1420           AP000553.1         98956-99018
            1421-1554           AP000553.1         99138-99271
            1555-1657           AP000553.1         99595-99697
            1658-3698           AP000553.1         100068-102108
FEATURES             Location/Qualifiers
     source          1..3698
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21-q11.22"
     gene            1..3698
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /note="peptidylprolyl isomerase like 2"
                     /db_xref="GeneID:23759"
                     /db_xref="HGNC:HGNC:9261"
                     /db_xref="MIM:607588"
     exon            1..120
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1651
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant 4;
                     peptidylprolyl cis-trans isomerase; cyclophilin-like
                     protein CyP-60; peptidyl-prolyl cis-trans isomerase-like
                     2; cyclophilin, 60kDa; PPIase; cyclophilin-60; rotamase
                     PPIL2; U-box domain containing 7; peptidylprolyl isomerase
                     (cyclophilin)-like 2; RING-type E3 ubiquitin transferase
                     isomerase-like 2; probable inactive peptidyl-prolyl
                     cis-trans isomerase-like 2; RING-type E3 ubiquitin-protein
                     ligase PPIL2"
                     /codon_start=1
                     /product="RING-type E3 ubiquitin-protein ligase PPIL2
                     isoform a"
                     /protein_id="NP_001304925.1"
                     /db_xref="CCDS:CCDS13793.1"
                     /db_xref="GeneID:23759"
                     /db_xref="HGNC:HGNC:9261"
                     /db_xref="MIM:607588"
                     /translation="MGKRQHQKDKMYITCAEYTHFYGGKKPDLPQTNFRRLPFDHCSL
                     SLQPFVYPVCTPDGIVFDLLNIVPWLKKYGTNPSNGEKLDGRSLIKLNFSKNSEGKYH
                     CPVLFTVFTNNTHIVAVRTTGNVYAYEAVEQLNIKAKNFRDLLTDEPFSRQDIITLQD
                     PTNLDKFNVSNFYHVKNNMKIIDPDEEKAKQDPSYYLKNTNAETRETLQELYKEFKGD
                     EILAATMKAPEKKKVDKLNAAHYSTGKVSASFTSTAMVPETTHEAAAIDEDVLRYQFV
                     KKKGYVRLHTNKGDLNLELHCDLTPKTCENFIRLCKKHYYDGTIFHRSIRNFVIQGGD
                     PTGTGTGGESYWGKPFKDEFRPNLSHTGRGILSMANSGPNSNRSQFFITFRSCAYLDK
                     KHTIFGRVVGGFDVLTAMENVESDPKTDRPKEEIRIDATTVFVDPYEEADAQIAQERK
                     TQLKVAPETKVKSSQPQAGSQGPQTFRQGVGKYINPAATKRAAEEEPSTSATVPMSKK
                     KPSRGFGDFSSW"
     exon            121..170
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            171..216
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            217..279
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            280..331
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            332..383
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            384..475
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            476..565
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            566..641
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            642..802
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            803..878
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            879..985
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1075
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1109
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1227
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1284
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1357
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1420
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1554
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1657
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..3698
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3679..3684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /note="hexamer: ATTAAA"
     polyA_site      3687
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
     polyA_site      3698
                     /gene="PPIL2"
                     /gene_synonym="CYC4; Cyp-60; CYP60; hCyP-60; UBOX7"
                     /note="major polyA site"
ORIGIN      
        1 agtggtcacg gaactcggct gcggctccat ggtctgagtt gtcagccgtt gttttttcgt
       61 gctcgctagt cgccgccgcc gctccgccat ggggaagcga cagcaccaaa aggacaaaat
      121 gtacattacc tgtgctgaat acactcactt ttatggtggc aagaagccag atctcccaca
      181 aacaaatttt cgtcgtttac cttttgacca ctgcagtctc tctctgcagc cctttgtcta
      241 cccagtctgc actcccgatg gcatcgtctt tgacttactg aacattgttc catggcttaa
      301 gaagtacggg accaacccca gcaatggaga gaagctggac gggaggtccc tgatcaagct
      361 gaacttttcc aagaacagtg aggggaagta ccactgccca gtgctgttta ccgtgttcac
      421 caacaacacc cacatcgtgg ctgtgaggac gaccggcaac gtctacgcct atgaggcagt
      481 ggaacagcta aatatcaagg ccaagaactt ccgggacctg ctgaccgacg agcccttctc
      541 ccggcaggac atcatcaccc tccaggaccc caccaatttg gacaagttca atgtctctaa
      601 cttctatcat gtgaagaata acatgaaaat aatagaccca gatgaagaga aggccaaaca
      661 ggacccgtct tattatctga aaaatacaaa tgccgagacc cgagagaccc tgcaggagct
      721 ctacaaggag ttcaaagggg acgagattct ggcagccacc atgaaggccc cggagaagaa
      781 gaaagtggac aagctgaacg ctgcccacta ttccacaggg aaggtcagcg cttccttcac
      841 ctccaccgcg atggtcccgg agaccacaca tgaagcagct gccatcgacg aggatgtgct
      901 gcgctaccag tttgtgaaga agaagggcta cgtgcggctg cacaccaaca agggcgacct
      961 caacctggag ctgcactgcg acctgacacc aaaaacctgc gaaaacttca tcaggctttg
     1021 caagaagcat tattacgatg gcaccatctt ccacagatcc atccggaact ttgtgatcca
     1081 agggggcgac cccacaggca caggcacggg tggggagtca tactggggga agcccttcaa
     1141 agacgagttc cggcccaacc tctcgcacac gggccgcggc atcctcagca tggccaactc
     1201 cgggcccaac agcaacaggt ctcaattctt catcacgttt cgctcctgtg cctacctgga
     1261 caagaagcat accatctttg gacgggttgt tgggggcttt gacgtactga cagccatgga
     1321 gaatgtggag agtgacccca aaactgaccg ccctaaggag gagatccgca ttgatgccac
     1381 tacagtgttc gtggacccct atgaggaggc cgatgcccag attgcgcagg agcggaagac
     1441 acagctcaag gtagccccgg agaccaaagt gaagagcagc cagccccagg cagggagcca
     1501 gggcccccag accttccgcc agggcgtggg caagtacatc aacccagcag ccacgaagcg
     1561 agcagcagag gaagagccct caaccagtgc cactgtcccc atgtccaaga agaagcccag
     1621 tcggggtttt ggggacttca gctcctggta gcagcaggct ccagtgcagt ggtgtgatca
     1681 tggctcactg cagcctcgac ctcctgggct caagcaatcc tcctgcctca gcctcgcaag
     1741 tagctgggac tacagccgtg caccactaca tccagctgta tatgtctggt tttcttaccc
     1801 ctacttctgt catcttctca gggacagcct atttatacaa ccagtgtggt cccctgacca
     1861 acgccattac ctgggacaag ttttcagacc ccagacttac tgagcctaag cctctgcagg
     1921 gtgggcttct cggtctgttt tgacaaaact tcaggggctt ctgaaggctg gtgttggacg
     1981 gcagcattga gtttcctgcc gtgccctgcc tgagctctca gggccctgct cacctgctct
     2041 ggctgtgaac cacctgggct tcatctcaag cctgcctggc gtctctgtgc ccctgtgaga
     2101 atcttgaggg gacccacact gggttgaggc cagtgtctcc tgctgtgaga acaagtggat
     2161 gtccctctcc ccgccctcct gctgaagtgg ccttgctgct ctcaggcccg gccactgggc
     2221 tccaagactc tgctcctcct gtcagtcact gactctgatg gccttgggcc agctgcatca
     2281 gcagccctta aagaaagacc cctccctcaa cccccatttt tctgttaaat gtgcccctgg
     2341 ctggcttttt cttcgtcttc agcccaggcc agtggtcagt gttctcatgt catggactct
     2401 ccttgcctga cacttgcctc ttgggctccc tgttgccctc aggccacccc ccacttctag
     2461 ttcttcacac taagccctaa cttaggcctt gttcttggtt ttctcatttt tgttgcccca
     2521 aatcttgaac ctgtcagcaa cttgcaggct gtacctctgc ccttcctttt ctcatcaatc
     2581 actgatgctg aagctgcagg cctgagccct ttgtctccct ggatgctggg tggcgcctca
     2641 tctgcatctc tgcctcaccc catccactgc cacaggctgc ctgatgacca ctagaggtat
     2701 gtctgcccct cgtcaccctg ctgcacacca atctgtggcc cttcatcatg ctaagaacaa
     2761 gaactgcgcc atggctggct ccttctcttc tccagcccat ccctctgcag cctgtcatcc
     2821 ctgtctgtga ccattggtcg ggcccctggg ctctagagtg acttttgacg ccctccatcc
     2881 ctcccgccag gcactgtcct ccgcaaggcc tggtgcagcc ctggcagtaa ctggcttgta
     2941 agaggctcag acaccaagct gggcctgcag aggaggggca cagtaggaca cagtgactgc
     3001 ccaggtgtcc acacacctgt aggcctctga gccagcgtcc agggtacagg tgcgggtggt
     3061 ggggatgaag gcctgaccag ggagggagaa gcaggtttgg agaggaccct gtgcccaccc
     3121 tgacagacac cctggctggc cctgactgac tgtattctct ggccacattc aagtccccca
     3181 ttggtggggg cagagaagta ggaccaggcc atccttggct ccagagctcg aagaccccaa
     3241 gacagccctc tgctctcagc ggcgccacag agagcctggg ctcagccttc tgcatcagga
     3301 catggcctcg tccactgagg gcacgattta aacatttgac atcagaagct ttatttgtaa
     3361 acctcacaca gataaggacc aagggctggc ggtgtggcca gaggacaggg gaagctgaag
     3421 gccccgtgct tgagctcggc agtcctgctc cttgcagtga agccaccatg ggtgaccgtc
     3481 cagcctcacc cggtggcctg cacagtgagg gaagggcttc agggccatct gctcccaggg
     3541 caggggacag gccaccaagg acctttggca aatgaaggtt tacatttctg tagtttgttt
     3601 gttttagagc ttaatttgta gttttttagc tattaaaacc atttgaattt ttaacgacct
     3661 gatgagggca tcaggtaaat taaaggattt tgggaaga
//
