LOCUS       NM_016059               1516 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens peptidylprolyl isomerase like 1 (PPIL1), mRNA.
ACCESSION   NM_016059
VERSION     NM_016059.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1516)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1516)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1516)
  AUTHORS   Chai,G., Webb,A., Li,C., Antaki,D., Lee,S., Breuss,M.W., Lang,N.,
            Stanley,V., Anzenberg,P., Yang,X., Marshall,T., Gaffney,P.,
            Wierenga,K.J., Chung,B.H., Tsang,M.H., Pais,L.S., Lovgren,A.K.,
            VanNoy,G.E., Rehm,H.L., Mirzaa,G., Leon,E., Diaz,J., Neumann,A.,
            Kalverda,A.P., Manfield,I.W., Parry,D.A., Logan,C.V., Johnson,C.A.,
            Bonthron,D.T., Valleley,E.M.A., Issa,M.Y., Abdel-Ghafar,S.F.,
            Abdel-Hamid,M.S., Jennings,P., Zaki,M.S., Sheridan,E. and
            Gleeson,J.G.
  TITLE     Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause
            Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly
  JOURNAL   Neuron 109 (2), 241-256 (2021)
   PUBMED   33220177
REFERENCE   4  (bases 1 to 1516)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1516)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 1516)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 1516)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   8  (bases 1 to 1516)
  AUTHORS   Tripodis,N., Mason,R., Humphray,S.J., Davies,A.F., Herberg,J.A.,
            Trowsdale,J., Nizetic,D., Senger,G. and Ragoussis,J.
  TITLE     Physical map of human 6p21.2-6p21.3: region flanking the
            centromeric end of the major histocompatibility complex
  JOURNAL   Genome Res 8 (6), 631-643 (1998)
   PUBMED   9647638
REFERENCE   9  (bases 1 to 1516)
  AUTHORS   Mann,S.S., Pettenati,M.J., von Kap-herr,C. and Hart,T.C.
  TITLE     Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to
            human chromosome region 6p21.1 by radiation hybrid mapping and
            fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 228-229 (1998)
   PUBMED   10072585
REFERENCE   10 (bases 1 to 1516)
  AUTHORS   Ozaki,K., Fujiwara,T., Kawai,A., Shimizu,F., Takami,S., Okuno,S.,
            Takeda,S., Shimada,Y., Nagata,M., Watanabe,T., Takaichi,A.,
            Takahashi,E., Nakamura,Y. and Shin,S.
  TITLE     Cloning, expression and chromosomal mapping of a novel
            cyclophilin-related gene (PPIL1) from human fetal brain
  JOURNAL   Cytogenet Cell Genet 72 (2-3), 242-245 (1996)
   PUBMED   8978786
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK026636.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016059.4.
            
            Summary: This gene is a member of the cyclophilin family of
            peptidylprolyl isomerases (PPIases). The cyclophilins are a highly
            conserved, ubiquitous family, members of which play an important
            role in protein folding, immunosuppression by cyclosporin A, and
            infection of HIV-1 virions. Based on similarity to other PPIases,
            this protein could accelerate the folding of proteins and might
            catalyze the cis-trans isomerization of proline imidic peptide
            bonds in oligopeptides. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003048.1, AK026636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373699.6/ ENSP00000362803.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1516              AK026636.1         24-1539
FEATURES             Location/Qualifiers
     source          1..1516
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..1516
                     /gene="PPIL1"
                     /gene_synonym="CGI-124; CYPL1; hCyPX; PCH14; PPIase"
                     /note="peptidylprolyl isomerase like 1"
                     /db_xref="GeneID:51645"
                     /db_xref="HGNC:HGNC:9260"
                     /db_xref="MIM:601301"
     exon            1..87
                     /gene="PPIL1"
                     /gene_synonym="CGI-124; CYPL1; hCyPX; PCH14; PPIase"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..532
                     /gene="PPIL1"
                     /gene_synonym="CGI-124; CYPL1; hCyPX; PCH14; PPIase"
                     /EC_number="5.2.1.8"
                     /note="cyclophilin-related gene 1; peptidyl-prolyl
                     cis-trans isomerase; rotamase PPIL1; peptidylprolyl
                     isomerase (cyclophilin)-like 1; cyclophilin like 1"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase-like 1"
                     /protein_id="NP_057143.1"
                     /db_xref="CCDS:CCDS4826.1"
                     /db_xref="GeneID:51645"
                     /db_xref="HGNC:HGNC:9260"
                     /db_xref="MIM:601301"
                     /translation="MAAIPPDSWQPPNVYLETSMGIIVLELYWKHAPKTCKNFAELAR
                     RGYYNGTKFHRIIKDFMIQGGDPTGTGRGGASIYGKQFEDELHPDLKFTGAGILAMAN
                     AGPDTNGSQFFVTLAPTQWLDGKHTIFGRVCQGIGMVNRVGMVETNSQDRPVDDVKII
                     KAYPSG"
     exon            88..242
                     /gene="PPIL1"
                     /gene_synonym="CGI-124; CYPL1; hCyPX; PCH14; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            243..311
                     /gene="PPIL1"
                     /gene_synonym="CGI-124; CYPL1; hCyPX; PCH14; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            312..1516
                     /gene="PPIL1"
                     /gene_synonym="CGI-124; CYPL1; hCyPX; PCH14; PPIase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1492..1497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIL1"
                     /gene_synonym="CGI-124; CYPL1; hCyPX; PCH14; PPIase"
                     /note="hexamer: AATAAA"
     polyA_site      1516
                     /gene="PPIL1"
                     /gene_synonym="CGI-124; CYPL1; hCyPX; PCH14; PPIase"
                     /note="major polyA site"
ORIGIN      
        1 actagacaag cattccgccg ccggcttcgc tatggcggca attcccccag attcctggca
       61 gccacccaac gtttacttgg agaccagcat gggaatcatt gtgctggagc tgtactggaa
      121 gcatgctcca aagacctgta agaactttgc tgagttggct cgtcgaggtt actacaatgg
      181 cacaaaattc cacagaatta tcaaagactt catgatccaa ggaggtgacc caacagggac
      241 aggtcgaggt ggtgcatcta tctatggcaa acagtttgaa gatgaacttc atccagactt
      301 gaaattcacg ggggctggaa ttctcgcaat ggccaatgcg gggccagata ccaatggcag
      361 ccagttcttt gtgaccctcg cccccaccca gtggcttgac ggcaaacaca ccatttttgg
      421 ccgagtgtgt cagggcatag gaatggtgaa tcgcgtggga atggtagaaa caaactccca
      481 ggaccgccct gtggacgacg tgaagatcat taaggcatac ccttctgggt agacttgcta
      541 ccctcttgag cagctcttct gagatggccc cagtgaacca gcttctagat gacatagaat
      601 gacatgtaat gctaaattca ttttggcttt gcaagtcatg aagcttagga ggcctggcat
      661 cttgggtgag ttagagatgg aagtacattt taataggatg cttcttttct cttcccccag
      721 tgcctaggtt gccagagcat ttgcacaaat gcccctgttt atcaataggt gactacttac
      781 tacacatgaa ccataatgct gcttcttgtg catgtctgct ctgatatacg tcgaacaatg
      841 tagcagccac tgtcatttct cagtggtttt gcctaaccaa acttcttcct aaggagattt
      901 atattctggc ctacacagca gtccttgatg gctgacagcc acagaattcc aaaccaagta
      961 gtgtctgtca gccctcttaa ctctgtgcac gccctatttc agtcttttac atttgttctt
     1021 ctagggaatg tatgcatctc tatatatatt ttccctctca aaaccagaac atcaacagtg
     1081 ctgtttctga cacttcagac atcccacgca aagccacatt gaatttttgc caaatgaaaa
     1141 acacatccaa caatcaagtt tctaagaagg tgtcaagtgg ggaataataa taatgtataa
     1201 taatcaagaa attagtttat taaaaggaag cagaagcatt gaccattttt tcccagagaa
     1261 gaggagaaat ctgtagtgag caaaggacag accatgaatc ctccttgaga agtagtactc
     1321 tcagaaagga gaagcgccac tcaagttctt ttaacccaag actttagaga aattaggtcc
     1381 aagattttta tatgttcagt tgtttatgta taaaaataac tttctggatt ttgtggggag
     1441 gagcaggaga ggaaggaagt taatacctat gtaatacata gaaacttcca caataaaatg
     1501 ccattgatgg ttgaaa
//
