LOCUS       NM_006347                754 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens peptidylprolyl isomerase H (PPIH), transcript variant
            1, mRNA.
ACCESSION   NM_006347
VERSION     NM_006347.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 754)
  AUTHORS   Ye,J., Pang,Y., Yang,X., Zhang,C., Shi,L., Chen,Z., Huang,G.,
            Wang,X. and Lu,F.
  TITLE     PPIH gene regulation system and its prognostic significance in
            hepatocellular carcinoma: a comprehensive analysis
  JOURNAL   Aging (Albany NY) 15 (20), 11448-11470 (2023)
   PUBMED   37874737
  REMARK    GeneRIF: PPIH gene regulation system and its prognostic
            significance in hepatocellular carcinoma: a comprehensive analysis.
REFERENCE   2  (bases 1 to 754)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 754)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 754)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 754)
  AUTHORS   Trepte,P., Kruse,S., Kostova,S., Hoffmann,S., Buntru,A.,
            Tempelmeier,A., Secker,C., Diez,L., Schulz,A., Klockmeier,K.,
            Zenkner,M., Golusik,S., Rau,K., Schnoegl,S., Garner,C.C. and
            Wanker,E.E.
  TITLE     LuTHy: a double-readout bioluminescence-based two-hybrid technology
            for quantitative mapping of protein-protein interactions in
            mammalian cells
  JOURNAL   Mol Syst Biol 14 (7), e8071 (2018)
   PUBMED   29997244
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 754)
  AUTHORS   Reidt,U., Wahl,M.C., Fasshauer,D., Horowitz,D.S., Luhrmann,R. and
            Ficner,R.
  TITLE     Crystal structure of a complex between human spliceosomal
            cyclophilin H and a U4/U6 snRNP-60K peptide
  JOURNAL   J Mol Biol 331 (1), 45-56 (2003)
   PUBMED   12875835
  REMARK    GeneRIF: Free and complexed cyclophilin H have virtually identical
            conformations suggesting that the U4/U6-60K binding site is
            pre-shaped and the peptidyl-prolyl-cis/trans isomerase activity is
            unaffected by complex formation
REFERENCE   7  (bases 1 to 754)
  AUTHORS   Horowitz,D.S., Lee,E.J., Mabon,S.A. and Misteli,T.
  TITLE     A cyclophilin functions in pre-mRNA splicing
  JOURNAL   EMBO J 21 (3), 470-480 (2002)
   PUBMED   11823439
REFERENCE   8  (bases 1 to 754)
  AUTHORS   Reidt,U., Reuter,K., Achsel,T., Ingelfinger,D., Luhrmann,R. and
            Ficner,R.
  TITLE     Crystal structure of the human U4/U6 small nuclear
            ribonucleoprotein particle-specific SnuCyp-20, a nuclear
            cyclophilin
  JOURNAL   J Biol Chem 275 (11), 7439-7442 (2000)
   PUBMED   10713041
REFERENCE   9  (bases 1 to 754)
  AUTHORS   Teigelkamp,S., Achsel,T., Mundt,C., Gothel,S.F., Cronshagen,U.,
            Lane,W.S., Marahiel,M. and Luhrmann,R.
  TITLE     The 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel
            cyclophilin that forms a complex with the U4/U6-specific 60kD and
            90kD proteins
  JOURNAL   RNA 4 (2), 127-141 (1998)
   PUBMED   9570313
REFERENCE   10 (bases 1 to 754)
  AUTHORS   Horowitz,D.S., Kobayashi,R. and Krainer,A.R.
  TITLE     A new cyclophilin and the human homologues of yeast Prp3 and Prp4
            form a complex associated with U4/U6 snRNPs
  JOURNAL   RNA 3 (12), 1374-1387 (1997)
   PUBMED   9404889
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU955702.1 and BC003412.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006347.3.
            
            Summary: The protein encoded by this gene is a member of the
            peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases
            catalyze the cis-trans isomerization of proline imidic peptide
            bonds in oligopeptides and accelerate the folding of proteins. This
            protein is a specific component of the complex that includes
            pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as
            U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase
            activity and may act as a protein chaperone that mediates the
            interactions between different proteins inside the spliceosome.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.183852.1,
                                           SRR5189661.140739.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304979.8/ ENSP00000306614.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BU955702.1         56-57
            3-754               BC003412.1         1-752
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..754
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /note="peptidylprolyl isomerase H"
                     /db_xref="GeneID:10465"
                     /db_xref="HGNC:HGNC:14651"
                     /db_xref="MIM:606095"
     exon            1..90
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..558
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     USA-CyP SnuCyp-20; cyclophilin H; U-snRNP-associated
                     cyclophilin SunCyp-20; small nuclear ribonucleoprotein
                     particle-specific cyclophilin H; rotamase H;
                     peptidyl-prolyl cis-trans isomerase H; PPIase h;
                     U-snRNP-associated cyclophilin SnuCyp-20"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase H isoform 1"
                     /protein_id="NP_006338.1"
                     /db_xref="CCDS:CCDS469.1"
                     /db_xref="GeneID:10465"
                     /db_xref="HGNC:HGNC:14651"
                     /db_xref="MIM:606095"
                     /translation="MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFR
                     QFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKL
                     RHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTG
                     PNNKPKLPVVISQCGEM"
     exon            91..155
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     exon            156..179
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     exon            180..224
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     exon            225..267
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     exon            268..360
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     exon            361..448
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     exon            449..489
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     exon            490..579
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     exon            580..754
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      732..737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /note="hexamer: AATAAA"
     polyA_site      754
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /note="major polyA site"
ORIGIN      
        1 gacttctgct tccgggtcgg agccatggcg gtggcaaatt caagtcctgt taaccccgtg
       61 gtgttctttg atgtcagtat tggcggtcag gaagttggcc gcatgaagat cgagctcttt
      121 gcagacgttg tgcctaagac ggccgagaac tttaggcagt tctgcaccgg agaattcagg
      181 aaagatgggg ttccaatagg atacaaagga agcaccttcc acagggtcat aaaggatttc
      241 atgattcagg gtggagattt tgttaatgga gatggtactg gagtcgccag tatttaccgg
      301 gggccatttg cagatgaaaa ttttaaactt agacactcag ctccaggcct gctttccatg
      361 gcgaacagtg gtccaagtac aaatggctgt cagttcttta tcacctgctc taagtgcgat
      421 tggctggatg ggaagcatgt ggtgtttgga aaaatcatcg atggacttct agtgatgaga
      481 aagattgaga atgttcccac aggccccaac aataagccca agctacctgt ggtgatctcg
      541 cagtgtgggg agatgtagtc cagacaaaga ctgaatcagg ccttcccttc ttcttggtgg
      601 tgttcttgag taagataatc tggactggcc cccgtctttg cttccctgcc tgctgctgcc
      661 ccatttgatc aagagaccat ggaagtgtca gagattcaga atccaagatt gtctttaagt
      721 tttcaactgt aaataaagtt tttttgtatg cgta
//
