LOCUS       NM_001330510             873 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens peptidylprolyl isomerase H (PPIH), transcript variant
            2, mRNA.
ACCESSION   NM_001330510 XM_011540508
VERSION     NM_001330510.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 873)
  AUTHORS   Ye,J., Pang,Y., Yang,X., Zhang,C., Shi,L., Chen,Z., Huang,G.,
            Wang,X. and Lu,F.
  TITLE     PPIH gene regulation system and its prognostic significance in
            hepatocellular carcinoma: a comprehensive analysis
  JOURNAL   Aging (Albany NY) 15 (20), 11448-11470 (2023)
   PUBMED   37874737
  REMARK    GeneRIF: PPIH gene regulation system and its prognostic
            significance in hepatocellular carcinoma: a comprehensive analysis.
REFERENCE   2  (bases 1 to 873)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 873)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 873)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 873)
  AUTHORS   Trepte,P., Kruse,S., Kostova,S., Hoffmann,S., Buntru,A.,
            Tempelmeier,A., Secker,C., Diez,L., Schulz,A., Klockmeier,K.,
            Zenkner,M., Golusik,S., Rau,K., Schnoegl,S., Garner,C.C. and
            Wanker,E.E.
  TITLE     LuTHy: a double-readout bioluminescence-based two-hybrid technology
            for quantitative mapping of protein-protein interactions in
            mammalian cells
  JOURNAL   Mol Syst Biol 14 (7), e8071 (2018)
   PUBMED   29997244
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 873)
  AUTHORS   Reidt,U., Wahl,M.C., Fasshauer,D., Horowitz,D.S., Luhrmann,R. and
            Ficner,R.
  TITLE     Crystal structure of a complex between human spliceosomal
            cyclophilin H and a U4/U6 snRNP-60K peptide
  JOURNAL   J Mol Biol 331 (1), 45-56 (2003)
   PUBMED   12875835
  REMARK    GeneRIF: Free and complexed cyclophilin H have virtually identical
            conformations suggesting that the U4/U6-60K binding site is
            pre-shaped and the peptidyl-prolyl-cis/trans isomerase activity is
            unaffected by complex formation
REFERENCE   7  (bases 1 to 873)
  AUTHORS   Horowitz,D.S., Lee,E.J., Mabon,S.A. and Misteli,T.
  TITLE     A cyclophilin functions in pre-mRNA splicing
  JOURNAL   EMBO J 21 (3), 470-480 (2002)
   PUBMED   11823439
REFERENCE   8  (bases 1 to 873)
  AUTHORS   Reidt,U., Reuter,K., Achsel,T., Ingelfinger,D., Luhrmann,R. and
            Ficner,R.
  TITLE     Crystal structure of the human U4/U6 small nuclear
            ribonucleoprotein particle-specific SnuCyp-20, a nuclear
            cyclophilin
  JOURNAL   J Biol Chem 275 (11), 7439-7442 (2000)
   PUBMED   10713041
REFERENCE   9  (bases 1 to 873)
  AUTHORS   Teigelkamp,S., Achsel,T., Mundt,C., Gothel,S.F., Cronshagen,U.,
            Lane,W.S., Marahiel,M. and Luhrmann,R.
  TITLE     The 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel
            cyclophilin that forms a complex with the U4/U6-specific 60kD and
            90kD proteins
  JOURNAL   RNA 4 (2), 127-141 (1998)
   PUBMED   9570313
REFERENCE   10 (bases 1 to 873)
  AUTHORS   Horowitz,D.S., Kobayashi,R. and Krainer,A.R.
  TITLE     A new cyclophilin and the human homologues of yeast Prp3 and Prp4
            form a complex associated with U4/U6 snRNPs
  JOURNAL   RNA 3 (12), 1374-1387 (1997)
   PUBMED   9404889
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC098484.2.
            
            On May 31, 2019 this sequence version replaced NM_001330510.1.
            
            Summary: The protein encoded by this gene is a member of the
            peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases
            catalyze the cis-trans isomerization of proline imidic peptide
            bonds in oligopeptides and accelerate the folding of proteins. This
            protein is a specific component of the complex that includes
            pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as
            U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase
            activity and may act as a protein chaperone that mediates the
            interactions between different proteins inside the spliceosome.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct N-terminus compared to isoformn 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.145919.1,
                                           SRR1163657.236876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC098484.2         6401-6490
            91-155              AC098484.2         6822-6886
            156-298             AC098484.2         7206-7348
            299-343             AC098484.2         7500-7544
            344-386             AC098484.2         8840-8882
            387-479             AC098484.2         12841-12933
            480-567             AC098484.2         13958-14045
            568-608             AC098484.2         14525-14565
            609-698             AC098484.2         15329-15418
            699-873             AC098484.2         24562-24736
FEATURES             Location/Qualifiers
     source          1..873
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..873
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /note="peptidylprolyl isomerase H"
                     /db_xref="GeneID:10465"
                     /db_xref="HGNC:HGNC:14651"
                     /db_xref="MIM:606095"
     exon            1..90
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     exon            91..155
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     exon            156..298
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..677
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /EC_number="5.2.1.8"
                     /note="isoform 2 is encoded by transcript variant 2;
                     USA-CyP SnuCyp-20; cyclophilin H; U-snRNP-associated
                     cyclophilin SunCyp-20; small nuclear ribonucleoprotein
                     particle-specific cyclophilin H; rotamase H;
                     peptidyl-prolyl cis-trans isomerase H; PPIase h;
                     U-snRNP-associated cyclophilin SnuCyp-20"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase H isoform 2"
                     /protein_id="NP_001317439.1"
                     /db_xref="GeneID:10465"
                     /db_xref="HGNC:HGNC:14651"
                     /db_xref="MIM:606095"
                     /translation="MIAGDSDRRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGV
                     ASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKII
                     DGLLVMRKIENVPTGPNNKPKLPVVISQCGEM"
     exon            299..343
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     exon            344..386
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     exon            387..479
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     exon            480..567
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     exon            568..608
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     exon            609..698
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     exon            699..873
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      851..856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /note="hexamer: AATAAA"
     polyA_site      873
                     /gene="PPIH"
                     /gene_synonym="CYP-20; CYPH; SnuCyp-20; USA-CYP"
                     /note="major polyA site"
ORIGIN      
        1 gacttctgct tccgggtcgg agccatggcg gtggcaaatt caagtcctgt taaccccgtg
       61 gtgttctttg atgtcagtat tggcggtcag gaagttggcc gcatgaagat cgagctcttt
      121 gcagacgttg tgcctaagac ggccgagaac tttaggcagt tctgcaccgg agaattcagg
      181 tcagtttcag atgtgtttga cttctttgcc tgctccagag gggtgttctg gggctgcagt
      241 gagggtatcg gtgaaccacc tgctggcctt gaatgattgc tggtgacagt gatagaagga
      301 aagatggggt tccaatagga tacaaaggaa gcaccttcca cagggtcata aaggatttca
      361 tgattcaggg tggagatttt gttaatggag atggtactgg agtcgccagt atttaccggg
      421 ggccatttgc agatgaaaat tttaaactta gacactcagc tccaggcctg ctttccatgg
      481 cgaacagtgg tccaagtaca aatggctgtc agttctttat cacctgctct aagtgcgatt
      541 ggctggatgg gaagcatgtg gtgtttggaa aaatcatcga tggacttcta gtgatgagaa
      601 agattgagaa tgttcccaca ggccccaaca ataagcccaa gctacctgtg gtgatctcgc
      661 agtgtgggga gatgtagtcc agacaaagac tgaatcaggc cttcccttct tcttggtggt
      721 gttcttgagt aagataatct ggactggccc ccgtctttgc ttccctgcct gctgctgccc
      781 catttgatca agagaccatg gaagtgtcag agattcagaa tccaagattg tctttaagtt
      841 ttcaactgta aataaagttt ttttgtatgc gta
//
