LOCUS       NM_005729               2196 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens peptidylprolyl isomerase F (PPIF), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_005729
VERSION     NM_005729.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2196)
  AUTHORS   Guan,B., Huang,C., Meng,L., Zhang,S., Liu,Q., Wang,X., Li,X. and
            Hao,Z.
  TITLE     Dissecting prostate Cancer: Single-Cell insight into Macrophage
            Diversity, molecular Prognosticators, and the role of
            Peptidylprolyl Isomerase F
  JOURNAL   Int Immunopharmacol 138, 112599 (2024)
   PUBMED   38959543
  REMARK    GeneRIF: Dissecting prostate Cancer: Single-Cell insight into
            Macrophage Diversity, molecular Prognosticators, and the role of
            Peptidylprolyl Isomerase F.
REFERENCE   2  (bases 1 to 2196)
  AUTHORS   Dikalova,A., Fehrenbach,D., Mayorov,V., Panov,A., Ao,M.,
            Lantier,L., Amarnath,V., Lopez,M.G., Billings,F.T. 4th, Sack,M.N.
            and Dikalov,S.
  TITLE     Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and
            Hypertension
  JOURNAL   Circ Res 134 (11), 1451-1464 (2024)
   PUBMED   38639088
  REMARK    GeneRIF: Mitochondrial CypD Acetylation Promotes Endothelial
            Dysfunction and Hypertension.
REFERENCE   3  (bases 1 to 2196)
  AUTHORS   Eliseev,R.A., Malecki,J., Lester,T., Zhang,Y., Humphrey,J. and
            Gunter,T.E.
  TITLE     Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic
            effect
  JOURNAL   J Biol Chem 284 (15), 9692-9699 (2009)
   PUBMED   19228691
REFERENCE   4  (bases 1 to 2196)
  AUTHORS   He,Y., Ge,J. and Tombran-Tink,J.
  TITLE     Mitochondrial defects and dysfunction in calcium regulation in
            glaucomatous trabecular meshwork cells
  JOURNAL   Invest Ophthalmol Vis Sci 49 (11), 4912-4922 (2008)
   PUBMED   18614807
  REMARK    GeneRIF: There was increased [Ca(2+)](c), [Ca(2+)](m), mCICR, MPTP
            opening, and expression of cyclophilin D and decreased DeltaPsim in
            POAG TM cells compared with control cells.
REFERENCE   5  (bases 1 to 2196)
  AUTHORS   Kajitani,K., Fujihashi,M., Kobayashi,Y., Shimizu,S., Tsujimoto,Y.
            and Miki,K.
  TITLE     Crystal structure of human cyclophilin D in complex with its
            inhibitor, cyclosporin A at 0.96-A resolution
  JOURNAL   Proteins 70 (4), 1635-1639 (2008)
   PUBMED   18076075
  REMARK    GeneRIF: Crystal structure of human cyclophilin D in complex with
            its inhibitor, cyclosporin A at 0.96-A resolution, using a K133I
            mutant of human CypD
REFERENCE   6  (bases 1 to 2196)
  AUTHORS   Lin,D.T. and Lechleiter,J.D.
  TITLE     Mitochondrial targeted cyclophilin D protects cells from cell death
            by peptidyl prolyl isomerization
  JOURNAL   J Biol Chem 277 (34), 31134-31141 (2002)
   PUBMED   12077116
  REMARK    GeneRIF: Cyclophilin D protects cell from cell death.
REFERENCE   7  (bases 1 to 2196)
  AUTHORS   Bowles,K.R., Abraham,S.E., Brugada,R., Zintz,C., Comeaux,J.,
            Sorajja,D., Tsubata,S., Li,H., Brandon,L., Gibbs,R.A.,
            Scherer,S.E., Bowles,N.E. and Towbin,J.A.
  TITLE     Construction of a high-resolution physical map of the chromosome
            10q22-q23 dilated cardiomyopathy locus and analysis of candidate
            genes
  JOURNAL   Genomics 67 (2), 109-127 (2000)
   PUBMED   10903836
REFERENCE   8  (bases 1 to 2196)
  AUTHORS   Bowles,K.R., Zintz,C., Abraham,S.E., Brandon,L., Bowles,N.E. and
            Towbin,J.A.
  TITLE     Genomic characterization of the human
            peptidyl-prolyl-cis-trans-isomerase, mitochondrial precursor gene:
            assessment of its role in familial dilated cardiomyopathy
  JOURNAL   Hum Genet 105 (6), 582-586 (1999)
   PUBMED   10647893
REFERENCE   9  (bases 1 to 2196)
  AUTHORS   Crompton,M., Virji,S. and Ward,J.M.
  TITLE     Cyclophilin-D binds strongly to complexes of the voltage-dependent
            anion channel and the adenine nucleotide translocase to form the
            permeability transition pore
  JOURNAL   Eur J Biochem 258 (2), 729-735 (1998)
   PUBMED   9874241
REFERENCE   10 (bases 1 to 2196)
  AUTHORS   Bergsma,D.J., Eder,C., Gross,M., Kersten,H., Sylvester,D.,
            Appelbaum,E., Cusimano,D., Livi,G.P., McLaughlin,M.M., Kasyan,K. et
            al.
  TITLE     The cyclophilin multigene family of peptidyl-prolyl isomerases.
            Characterization of three separate human isoforms
  JOURNAL   J Biol Chem 266 (34), 23204-23214 (1991)
   PUBMED   1744118
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE791220.1 and BC013204.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005729.3.
            
            Summary: The protein encoded by this gene is a member of the
            peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases
            catalyze the cis-trans isomerization of proline imidic peptide
            bonds in oligopeptides and accelerate the folding of proteins. This
            protein is part of the mitochondrial permeability transition pore
            in the inner mitochondrial membrane. Activation of this pore is
            thought to be involved in the induction of apoptotic and necrotic
            cell death. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.241077.1,
                                           SRR1803613.160048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000225174.8/
                                                  ENSP00000225174.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-532               BE791220.1         22-553
            533-2196            BC013204.1         515-2178
FEATURES             Location/Qualifiers
     source          1..2196
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.3"
     gene            1..2196
                     /gene="PPIF"
                     /gene_synonym="Cyp-D; CyP-M; CYP3; CypD"
                     /note="peptidylprolyl isomerase F"
                     /db_xref="GeneID:10105"
                     /db_xref="HGNC:HGNC:9259"
                     /db_xref="MIM:604486"
     exon            1..275
                     /gene="PPIF"
                     /gene_synonym="Cyp-D; CyP-M; CYP3; CypD"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..704
                     /gene="PPIF"
                     /gene_synonym="Cyp-D; CyP-M; CYP3; CypD"
                     /EC_number="5.2.1.8"
                     /note="cyclophilin F; cyclophilin 3; peptidyl-prolyl
                     cis-trans isomerase, mitochondrial; peptidyl-prolyl
                     cis-trans isomerase F, mitochondrial; cyclophilin D;
                     PPIase F; rotamase F; mitochondrial cyclophilin"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase F,
                     mitochondrial precursor"
                     /protein_id="NP_005720.1"
                     /db_xref="CCDS:CCDS7358.1"
                     /db_xref="GeneID:10105"
                     /db_xref="HGNC:HGNC:9259"
                     /db_xref="MIM:604486"
                     /translation="MLALRCGSRWLGLLSVPRSVPLRLPAARACSKGSGDPSSSSSSG
                     NPLVYLDVDANGKPLGRVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPSF
                     MCQAGDFTNHNGTGGKSIYGSRFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIK
                     TDWLDGKHVVFGHVKEGMDVVKKIESFGSKSGRTSKKIVITDCGQLS"
     exon            276..306
                     /gene="PPIF"
                     /gene_synonym="Cyp-D; CyP-M; CYP3; CypD"
                     /inference="alignment:Splign:2.1.0"
     exon            307..395
                     /gene="PPIF"
                     /gene_synonym="Cyp-D; CyP-M; CYP3; CypD"
                     /inference="alignment:Splign:2.1.0"
     exon            396..492
                     /gene="PPIF"
                     /gene_synonym="Cyp-D; CyP-M; CYP3; CypD"
                     /inference="alignment:Splign:2.1.0"
     exon            493..568
                     /gene="PPIF"
                     /gene_synonym="Cyp-D; CyP-M; CYP3; CypD"
                     /inference="alignment:Splign:2.1.0"
     exon            569..2196
                     /gene="PPIF"
                     /gene_synonym="Cyp-D; CyP-M; CYP3; CypD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1557..1562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIF"
                     /gene_synonym="Cyp-D; CyP-M; CYP3; CypD"
                     /note="hexamer: AATAAA"
     polyA_site      1579
                     /gene="PPIF"
                     /gene_synonym="Cyp-D; CyP-M; CYP3; CypD"
                     /note="major polyA site"
     regulatory      2175..2180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIF"
                     /gene_synonym="Cyp-D; CyP-M; CYP3; CypD"
                     /note="hexamer: ATTAAA"
     polyA_site      2196
                     /gene="PPIF"
                     /gene_synonym="Cyp-D; CyP-M; CYP3; CypD"
                     /note="major polyA site"
ORIGIN      
        1 actcggcctt ctgggcgcgc gcgacgtcag tttgagttct gtgttctccc cgcccgtgtc
       61 ccgcccgacc cgcgcccgcg atgctggcgc tgcgctgcgg ctcccgctgg ctcggcctgc
      121 tctccgtccc gcgctccgtg ccgctgcgcc tccccgcggc ccgcgcctgc agcaagggct
      181 ccggcgaccc gtcctcttcc tcctcctccg ggaacccgct cgtgtacctg gacgtggacg
      241 ccaacgggaa gccgctcggc cgcgtggtgc tggagctgaa ggcagatgtc gtcccaaaga
      301 cagctgagaa cttcagagcc ctgtgcactg gtgagaaggg cttcggctac aaaggctcca
      361 ccttccacag ggtgatccct tccttcatgt gccaggcggg cgacttcacc aaccacaatg
      421 gcacaggcgg gaagtccatc tacggaagcc gctttcctga cgagaacttt acactgaagc
      481 acgtggggcc aggtgtcctg tccatggcta atgctggtcc taacaccaac ggctcccagt
      541 tcttcatctg caccataaag acagactggt tggatggcaa gcatgttgtg ttcggtcacg
      601 tcaaagaggg catggacgtc gtgaagaaaa tagaatcttt cggctctaag agtgggagga
      661 catccaagaa gattgtcatc acagactgtg gccagttgag ctaatctgtg gccagggtgc
      721 tggcatggtg gcagctgcaa atgtccatgc acccaggtgg ccgcgttggg ctgtcagcca
      781 aggtgcctga aacgatacgt gtgcccactc cactgtcaca gtgtgcctga ggaaggctgc
      841 tagggatgtt agacctcggc caggacccac cacattgctt cctaataccc acccttcctc
      901 acgacctcat ttctgggcat ctttgtggac atgatgtcac ccaccccttg tcaagcattg
      961 cctgtgattg cccagcccag attcatctgt gccttggaca tggtgatggt gatgggttgc
     1021 catccaagtg aaagtctttt ccttgaccaa gggggacagt cagttttgca aaaggactct
     1081 aatacctgtt taatattgtc ttcctaattg ggataattta attaacaaga ttgactagaa
     1141 gtgaaactgc aacactaact tccccgtgct gtggtgtgac ctgagttggt gacacaggcc
     1201 acagacccca gagcttggct tttgaaacac aactcagggc ttttgtgaag gttcccccgc
     1261 tgagatcttt cctcctggtt actgtgaagc ctgttggttt gctgctgtcg tttttgagga
     1321 gggcccatgg gggtaggagc agttgaacct gggaacaaac ctcacttgag ctgtgcctag
     1381 acaatgtgaa ttcctgtgtt gctaacagaa gtggcctgta agctcctgtg ctccggaggg
     1441 aagcatttcc tggtaggctt tgatttttct gtgtgttaaa gaaattcaat ctactcatga
     1501 tgtgttatgc ataaaacatt tctggaacat ggatttgtgt tcaccttaaa tgtgaaaata
     1561 aatcctattt tctatggaag actggtacct ggtttctgga agaggggtct gtgacttgga
     1621 gctgatcttt actgagctcg ccgtggcaga tgccatgctc aggacgttca tgtggatggt
     1681 ttcatgtcat cgtgctggca acttgtcctc cctgccttag agatgaggct cagacaaacg
     1741 accttagcac ccatagccta tgccatgagc actggctcca ccctgaatcc cagctcctcc
     1801 ccttagtgac cccaagtctg tttccctcag ctgcataagg aggcgatata gtttgaatat
     1861 ttgtccccag ccaaatctca tgttgaactg taatccccag tgctggaggt ggggcctgct
     1921 acgaggtgtt tggatcatgg ggacgggtat ttcatggctt ggtgctgttt tcttgatggt
     1981 gaattattgc aagatacggt catttaaaat tgtgtggcac ctccccctgc ccccttcttg
     2041 ctcctgcttt caccatgtga catgcctgat cccccttcac cttttgccat ggtcataagc
     2101 ttcctgaggc ctccctggaa gctgagcaga tgccagcacc atgcttcctg tacatcctgc
     2161 agaaccataa gccaattaaa cctttttaat aataaa
//
