LOCUS       NM_006112               4339 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens peptidylprolyl isomerase E (PPIE), transcript variant
            1, mRNA.
ACCESSION   NM_006112
VERSION     NM_006112.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4339)
  AUTHORS   Mihalic,F., Simonetti,L., Giudice,G., Sander,M.R., Lindqvist,R.,
            Peters,M.B.A., Benz,C., Kassa,E., Badgujar,D., Inturi,R., Ali,M.,
            Krystkowiak,I., Sayadi,A., Andersson,E., Aronsson,H., Soderberg,O.,
            Dobritzsch,D., Petsalaki,E., Overby,A.K., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Large-scale phage-based screening reveals extensive pan-viral
            mimicry of host short linear motifs
  JOURNAL   Nat Commun 14 (1), 2409 (2023)
   PUBMED   37100772
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4339)
  AUTHORS   Blatter,M., Meylan,C., Clery,A., Giambruno,R., Nikolaev,Y.,
            Heidecker,M., Solanki,J.A., Diaz,M.O., Gabellini,D. and Allain,F.H.
  TITLE     RNA binding induces an allosteric switch in Cyp33 to repress
            MLL1-mediated transcription
  JOURNAL   Sci Adv 9 (16), eadf5330 (2023)
   PUBMED   37075125
  REMARK    GeneRIF: RNA binding induces an allosteric switch in Cyp33 to
            repress MLL1-mediated transcription.
REFERENCE   3  (bases 1 to 4339)
  AUTHORS   Kruse,T., Benz,C., Garvanska,D.H., Lindqvist,R., Mihalic,F.,
            Coscia,F., Inturi,R., Sayadi,A., Simonetti,L., Nilsson,E., Ali,M.,
            Kliche,J., Moliner Morro,A., Mund,A., Andersson,E., McInerney,G.,
            Mann,M., Jemth,P., Davey,N.E., Overby,A.K., Nilsson,J. and
            Ivarsson,Y.
  TITLE     Large scale discovery of coronavirus-host factor protein
            interaction motifs reveals SARS-CoV-2 specific mechanisms and
            vulnerabilities
  JOURNAL   Nat Commun 12 (1), 6761 (2021)
   PUBMED   34799561
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4339)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4339)
  AUTHORS   Lloyd,N.R. and Wuttke,D.S.
  TITLE     Cyp33 binds AU-rich RNA motifs via an extended interface that
            competitively disrupts the gene repressive Cyp33-MLL1 interaction
            in vitro
  JOURNAL   PLoS One 16 (2), e0237956 (2021)
   PUBMED   33606679
  REMARK    GeneRIF: Cyp33 binds AU-rich RNA motifs via an extended interface
            that competitively disrupts the gene repressive Cyp33-MLL1
            interaction in vitro.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4339)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   7  (bases 1 to 4339)
  AUTHORS   Anderson,M., Fair,K., Amero,S., Nelson,S., Harte,P.J. and Diaz,M.O.
  TITLE     A new family of cyclophilins with an RNA recognition motif that
            interact with members of the trx/MLL protein family in Drosophila
            and human cells
  JOURNAL   Dev Genes Evol 212 (3), 107-113 (2002)
   PUBMED   11976948
REFERENCE   8  (bases 1 to 4339)
  AUTHORS   Fair,K., Anderson,M., Bulanova,E., Mi,H., Tropschug,M. and
            Diaz,M.O.
  TITLE     Protein interactions of the MLL PHD fingers modulate MLL target
            gene regulation in human cells
  JOURNAL   Mol Cell Biol 21 (10), 3589-3597 (2001)
   PUBMED   11313484
REFERENCE   9  (bases 1 to 4339)
  AUTHORS   Kim,J.O., Nau,M.M., Allikian,K.A., Makela,T.P., Alitalo,K.,
            Johnson,B.E. and Kelley,M.J.
  TITLE     Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc
            in small cell lung cancer cell lines
  JOURNAL   Oncogene 17 (8), 1019-1026 (1998)
   PUBMED   9747881
REFERENCE   10 (bases 1 to 4339)
  AUTHORS   Mi,H., Kops,O., Zimmermann,E., Jaschke,A. and Tropschug,M.
  TITLE     A nuclear RNA-binding cyclophilin in human T cells
  JOURNAL   FEBS Lett 398 (2-3), 201-205 (1996)
   PUBMED   8977107
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA079924.1, BC004898.2,
            AL049824.4 and CK300365.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_006112.3.
            
            Summary: The protein encoded by this gene is a member of the
            peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases
            catalyze the cis-trans isomerization of proline imidic peptide
            bonds in oligopeptides and accelerate the folding of proteins. This
            protein contains a highly conserved cyclophilin (CYP) domain as
            well as an RNA-binding domain. It was shown to possess PPIase and
            protein folding activities, and it also exhibits RNA-binding
            activity. Alternative splicing results in multiple transcript
            variants. A related pseudogene, which is also located on chromosome
            1, has been identified. [provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1672125.1,
                                           SRR11853567.771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324379.10/ ENSP00000312769.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA079924.1         38-50
            14-1269             BC004898.2         1-1256
            1270-3741           AL049824.4         13913-16384
            3742-4339           CK300365.1         17-614              c
FEATURES             Location/Qualifiers
     source          1..4339
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..4339
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
                     /note="peptidylprolyl isomerase E"
                     /db_xref="GeneID:10450"
                     /db_xref="HGNC:HGNC:9258"
                     /db_xref="MIM:602435"
     exon            1..50
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..925
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peptidyl-prolyl cis-trans isomerase E; rotamase E; PPIase
                     E; cyclophilin-33; peptidylprolyl isomerase E (cyclophilin
                     E)"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase E isoform 1"
                     /protein_id="NP_006103.1"
                     /db_xref="CCDS:CCDS443.1"
                     /db_xref="GeneID:10450"
                     /db_xref="HGNC:HGNC:9258"
                     /db_xref="MIM:602435"
                     /translation="MATTKRVLYVGGLAEEVDDKVLHAAFIPFGDITDIQIPLDYETE
                     KHRGFAFVEFELAEDAAAAIDNMNESELFGRTIRVNLAKPMRIKEGSSRPVWSDDDWL
                     KKFSGKTLEENKEEEGSEPPKAETQEGEPIAKKARSNPQVYMDIKIGNKPAGRIQMLL
                     RSDVVPMTAENFRCLCTHEKGFGFKGSSFHRIIPQFMCQGGDFTNHNGTGGKSIYGKK
                     FDDENFILKHTGPGLLSMANSGPNTNGSQFFLTCDKTDWLDGKHVVFGEVTEGLDVLR
                     QIEAQGSKDGKPKQKVIIADCGEYV"
     exon            51..149
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
                     /inference="alignment:Splign:2.1.0"
     exon            150..193
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
                     /inference="alignment:Splign:2.1.0"
     exon            194..220
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
                     /inference="alignment:Splign:2.1.0"
     exon            221..302
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
                     /inference="alignment:Splign:2.1.0"
     exon            303..403
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
                     /inference="alignment:Splign:2.1.0"
     exon            404..527
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
                     /inference="alignment:Splign:2.1.0"
     exon            528..713
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
                     /inference="alignment:Splign:2.1.0"
     exon            714..856
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
                     /inference="alignment:Splign:2.1.0"
     exon            857..4339
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1252..1257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
                     /note="hexamer: AATAAA"
     polyA_site      1269
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
                     /note="major polyA site"
     regulatory      1593..1598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
                     /note="hexamer: AATGAA"
     polyA_site      1614
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
     polyA_site      1749
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
     regulatory      4318..4323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
                     /note="hexamer: AATAAA"
     polyA_site      4339
                     /gene="PPIE"
                     /gene_synonym="CYP-33; CYP33; CypE"
ORIGIN      
        1 ggaaaagcgc gcgagcaaga tggccaccac caagcgcgtc ttgtacgtgg gtggactggc
       61 agaggaagtg gacgacaaag ttcttcatgc tgcgttcatt ccttttggag acatcacaga
      121 tattcagatt cctctggatt atgaaacaga aaagcaccga ggatttgctt ttgttgaatt
      181 tgagttggca gaggatgctg cagcagctat cgacaacatg aatgaatctg agctttttgg
      241 acgtacaatt cgtgtcaatt tggccaaacc aatgagaatt aaggaaggct cttccaggcc
      301 agtttggtca gatgatgact ggttgaagaa gttttctggg aagacgcttg aagagaataa
      361 agaggaagaa gggtcagagc ctcccaaagc agagacccag gagggagagc ccattgctaa
      421 aaaggcccgc tcaaatcctc aggtgtacat ggacatcaag attgggaaca agccggctgg
      481 ccgcatccag atgctcctgc gttctgatgt cgtgcccatg acagcagaga atttccgctg
      541 cctgtgcact catgaaaagg gctttggctt taagggaagc agcttccacc gcatcatccc
      601 ccagttcatg tgccagggcg gtgatttcac aaaccacaat ggcactgggg gcaagtccat
      661 ctatgggaag aagttcgatg atgaaaactt tatcctcaag catacgggac caggtctact
      721 atccatggcc aactctggcc caaacaccaa tggctctcag ttcttcctga catgtgacaa
      781 gacagactgg ctggatggca agcatgtggt gtttggagag gtcaccgaag gcctagatgt
      841 cttgcggcaa attgaggccc agggcagcaa ggacgggaag ccaaagcaga aggtgatcat
      901 cgccgactgt ggggagtacg tgtgaggcgg cactctctct gcttccccct ccgctcttga
      961 ccctgcatat ccaggaagga actgccagcc tcagaggagg cagcaccgag ggtgcctgtt
     1021 tgaagcaagc agcatttggg atatgtgccc ttcctcaggg tctgcttgga gcagctcctc
     1081 tgcaggcaca gcctggacta ttcccaggca cagctgtggg cccaggagcc agctcaggtg
     1141 ctcccctcca ccatgggcag gctgtgcaaa aagccactgg cttttctcag catttgctgc
     1201 tgggcctctc ctgggactac cagtgtggct cttacgtgtt ttctttgcta aaataaaccc
     1261 tagttcttat attgctcttc ctgctagttc ttgggagttg tcagagattg tgtctgtggc
     1321 taagctggac ctctgaggca ggctggtgag tggggagagc agagcatctt tttcacagct
     1381 ttcatttcct cccttgggcc gatcccctta gatgtcaggt gatgtatctt cacaccaggc
     1441 atcgatgtca gggcaacgga aattaaagac tggaaagctc cggtcttctg ctgcctctgc
     1501 tcctaaaccc agctgccggc cttacagcca gcaagtgtac tctcagtggt tcatttgttt
     1561 atttgttcac tttcacccta cagattttaa aaaatgaaat ttttataact caaagtgcct
     1621 tctctgtgcc aagtactatg cctatttgtc aggagacagg aagccaacaa actacatgtg
     1681 cctaatccag cccactgcct gtttttatga atcaggtttt attggaacac agccacgtcc
     1741 atttatttac atattgtcca tggtggtttc ttactgcagt ggcagaggtg cgtaaggggc
     1801 tatagacaca atacaggcta tggtccctgt attagggttt tctagagaag cagaaccaat
     1861 agggtgtgta tatatgtaga aagagattta ttttaaggaa ctggctcaag cagtggtagg
     1921 agctggcaag tctgcaatct gcacaacaga ccagcaggct ggagactcag gaaaaaaact
     1981 gatgttgcag ttcagctctg aggcagtttg gaagcagaat tcttcctcca gtgatctcag
     2041 tcttttttct cttaagaatt tcaactgatt ggatgaggcc tacccacatt atggagggta
     2101 atctgcttta ctctctactg acttaaatat taatccatct aaaaaatagg ccaggcatgg
     2161 tggctcatgc ctataattcc accactattg ggaggctgag gcaggaggat cacttgagcc
     2221 caggagttca agaccagcct gggcaatgta gagaccccca tctctagggg gagaaaaaaa
     2281 agccaggtat ggtagtgcac acctatagtc ccagctactc agaaggctga ggtgggagga
     2341 tcgcttgaac ctgggaggtt gaggctgcag tcagccatgg tcatgccact gtactccagc
     2401 ctgggtgaca agagggagac cctgtcttga aaaaaagaaa ccatcatcac agcaacatct
     2461 agactagtgt ttgactaaaa actggatacc atggcctagc caaattgaca cacaaaatag
     2521 accatcacag tcccaaggcc taaaatactt actatctgag cctttacaaa acaggattgc
     2581 cagccactga agagaacaaa tggtcccacc ccctgctgag ctcacagtct ggctctcctg
     2641 tgtgcagcca cttcttggag ctggcttctc tccactcccc ctccagatgc tggtcagcca
     2701 ggcggttata aagaatctca tctgctgaag gcttttagca gggactgagt cctgtagctg
     2761 ttggacacct cctgtgggtt gggtcactca gaccattcag aatccactga gctgagcttt
     2821 tgcatcttgg attgagatct ggatgagcca ggaggcagga gaggctaggt ggtcctcatg
     2881 accctaggat agctcttgct gagggatggt ggcattctgc cctacctctg gctcccatgt
     2941 gccgactgga ctttgtgagc tccagctgct acagttgact gagttcaggc tccatgtagc
     3001 tgggatatac tacatggtta cccctcaccc ctatggagct tccaaaagag accctccctc
     3061 aaagcacagc cccttctctg agtgcaaata atggccatca gaggtcagtc acaggtgtta
     3121 ggcaggcatc tatgaagctg gggatgatag cactgacttc agtgcttgga cgagaaccag
     3181 gagagagtgt gtagaaaaag cacagccagc ctcccataaa aggacagact cctgtgacaa
     3241 ccttgtcact ctgttcctcc ctgatactct ggggaggtgg aggccagtgg gcagttctga
     3301 aagctcagca ggtttggagc cattgggtgt ggactcctct cccagtgttc ctcctgggtg
     3361 ttcacagatg ttattgaatg cacactggaa ccctgcacag gtaaactgag gctttattgg
     3421 cgtgactgcc aaaggtcaca cagggtggtt tggcagagct gggattagaa gcccagcctg
     3481 tctctcttca gtagtaatgg agtcctggga ggtttactag gctttagcct caatctgtgg
     3541 cggcagggtc cacagccctg gggagtgaca cagtcatggt ccccatgatt ggccaggacc
     3601 tgtgtggaga gacacaggag acaagaccct gctcttccag gccagaaggg aggggagccc
     3661 cagagctggg cagtggcatg ccccacagcc tggccacctg cttcggctac gcaccatgca
     3721 gcagctgcac ctggctgcct cgggaaaact ctgacctctc tgggaagtgg agccagtggc
     3781 tctgtgggcg tcctttcctg cagcctggag agcaaagcgg ctttccctgg gactgtgtgg
     3841 ctcctgtccc aactggcctc cccattccac attcccattg ctggaccagc accaggactg
     3901 ggcacagggc ttccttttgc tgattcattt cccccctaac tcattcagag ttgagcccca
     3961 tctgagtccc cacatgctgg ccctgaaacg gttacaaagg ctgaaaccag ggatggcagg
     4021 cccaggatca gtgctgtggc tgttggagtg tcctctccaa cagcatgaca gccgcctcca
     4081 ggtgctccca gcatctgttg cagtcatggc agcctcacgg caacctctga agaaggaatt
     4141 atagaaccaa ctttttattg ttgaaaatgg agtcttgtag agttcagtga tgggaaacta
     4201 aagtagaaaa agcacatcac aaagaaacat atatagtaca gtgtgatccc aattttgtaa
     4261 aaatatctgt aatatgtaag cataggtatt tgtatatctt aagaaaaaaa gcctagaaat
     4321 aaagccacaa aaatattaa
//
