LOCUS       NM_005038               1830 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens peptidylprolyl isomerase D (PPID), mRNA.
ACCESSION   NM_005038
VERSION     NM_005038.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1830)
  AUTHORS   O'Brien,J.T., Jalilvand,S.P., Suji,N.A., Jupelly,R.K., Phensy,A.,
            Mwirigi,J.M., Elahi,H., Price,T.J. and Kroener,S.
  TITLE     Elevations in the Mitochondrial Matrix Protein Cyclophilin D
            Correlate With Reduced Parvalbumin Expression in the Prefrontal
            Cortex of Patients With Schizophrenia
  JOURNAL   Schizophr Bull 50 (5), 1197-1207 (2024)
   PUBMED   38412332
  REMARK    GeneRIF: Elevations in the Mitochondrial Matrix Protein Cyclophilin
            D Correlate With Reduced Parvalbumin Expression in the Prefrontal
            Cortex of Patients With Schizophrenia.
REFERENCE   2  (bases 1 to 1830)
  AUTHORS   Fan,H., Tian,H., Jin,F., Zhang,X., Su,S., Liu,Y., Wen,Z., He,X.,
            Li,X. and Duan,C.
  TITLE     CypD induced ROS output promotes intracranial aneurysm formation
            and rupture by 8-OHdG/NLRP3/MMP9 pathway
  JOURNAL   Redox Biol 67, 102887 (2023)
   PUBMED   37717465
  REMARK    GeneRIF: CypD induced ROS output promotes intracranial aneurysm
            formation and rupture by 8-OHdG/NLRP3/MMP9 pathway.
REFERENCE   3  (bases 1 to 1830)
  AUTHORS   Mok,D., Allan,R.K., Carrello,A., Wangoo,K., Walkinshaw,M.D. and
            Ratajczak,T.
  TITLE     The chaperone function of cyclophilin 40 maps to a cleft between
            the prolyl isomerase and tetratricopeptide repeat domains
  JOURNAL   FEBS Lett 580 (11), 2761-2768 (2006)
   PUBMED   16650407
  REMARK    GeneRIF: CyP40 chaperone function then, is localized within the
            linker that forms a binding cleft with potential to accommodate
            non-native substrates
REFERENCE   4  (bases 1 to 1830)
  AUTHORS   Ward,B.K., Allan,R.K., Mok,D., Temple,S.E., Taylor,P., Dornan,J.,
            Mark,P.J., Shaw,D.J., Kumar,P., Walkinshaw,M.D. and Ratajczak,T.
  TITLE     A structure-based mutational analysis of cyclophilin 40 identifies
            key residues in the core tetratricopeptide repeat domain that
            mediate binding to Hsp90
  JOURNAL   J Biol Chem 277 (43), 40799-40809 (2002)
   PUBMED   12145316
REFERENCE   5  (bases 1 to 1830)
  AUTHORS   Mark,P.J., Ward,B.K., Kumar,P., Lahooti,H., Minchin,R.F. and
            Ratajczak,T.
  TITLE     Human cyclophilin 40 is a heat shock protein that exhibits altered
            intracellular localization following heat shock
  JOURNAL   Cell Stress Chaperones 6 (1), 59-70 (2001)
   PUBMED   11525244
REFERENCE   6  (bases 1 to 1830)
  AUTHORS   Leverson,J.D. and Ness,S.A.
  TITLE     Point mutations in v-Myb disrupt a cyclophilin-catalyzed negative
            regulatory mechanism
  JOURNAL   Mol Cell 1 (2), 203-211 (1998)
   PUBMED   9659917
REFERENCE   7  (bases 1 to 1830)
  AUTHORS   Silverstein,A.M., Galigniana,M.D., Chen,M.S., Owens-Grillo,J.K.,
            Chinkers,M. and Pratt,W.B.
  TITLE     Protein phosphatase 5 is a major component of glucocorticoid
            receptor.hsp90 complexes with properties of an FK506-binding
            immunophilin
  JOURNAL   J Biol Chem 272 (26), 16224-16230 (1997)
   PUBMED   9195923
REFERENCE   8  (bases 1 to 1830)
  AUTHORS   Yokoi,H., Shimizu,Y., Anazawa,H., Lefebvre,C.A., Korneluk,R.G. and
            Ikeda,J.E.
  TITLE     The structure and complete nucleotide sequence of the human
            cyclophilin 40 (PPID) gene
  JOURNAL   Genomics 35 (3), 448-455 (1996)
   PUBMED   8812478
REFERENCE   9  (bases 1 to 1830)
  AUTHORS   Kieffer,L.J., Seng,T.W., Li,W., Osterman,D.G., Handschumacher,R.E.
            and Bayney,R.M.
  TITLE     Cyclophilin-40, a protein with homology to the P59 component of the
            steroid receptor complex. Cloning of the cDNA and further
            characterization
  JOURNAL   J Biol Chem 268 (17), 12303-12310 (1993)
   PUBMED   8509368
REFERENCE   10 (bases 1 to 1830)
  AUTHORS   Kieffer,L.J., Thalhammer,T. and Handschumacher,R.E.
  TITLE     Isolation and characterization of a 40-kDa cyclophilin-related
            protein
  JOURNAL   J Biol Chem 267 (8), 5503-5507 (1992)
   PUBMED   1544925
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG699755.1, L11667.1,
            BC030707.2 and BU726810.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005038.2.
            
            Summary: The protein encoded by this gene is a member of the
            peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases
            catalyze the cis-trans isomerization of proline imidic peptide
            bonds in oligopeptides and accelerate the folding of proteins. This
            protein has been shown to possess PPIase activity and, similar to
            other family members, can bind to the immunosuppressant cyclosporin
            A. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030707.2, L11667.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307720.4/ ENSP00000303754.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BG699755.1         10-56
            48-1570             L11667.1           39-1561
            1571-1823           BC030707.2         1571-1823
            1824-1830           BU726810.1         18-24               c
FEATURES             Location/Qualifiers
     source          1..1830
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.1"
     gene            1..1830
                     /gene="PPID"
                     /gene_synonym="CYP-40; CYPD"
                     /note="peptidylprolyl isomerase D"
                     /db_xref="GeneID:5481"
                     /db_xref="HGNC:HGNC:9257"
                     /db_xref="MIM:601753"
     exon            1..193
                     /gene="PPID"
                     /gene_synonym="CYP-40; CYPD"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1221
                     /gene="PPID"
                     /gene_synonym="CYP-40; CYPD"
                     /EC_number="5.2.1.8"
                     /note="cyclophilin D; 40 kDa peptidyl-prolyl cis-trans
                     isomerase D; cyclophilin-related protein; cyclophilin 40;
                     PPIase D; rotamase D; testicular tissue protein Li 147"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase D"
                     /protein_id="NP_005029.1"
                     /db_xref="CCDS:CCDS3801.1"
                     /db_xref="GeneID:5481"
                     /db_xref="HGNC:HGNC:9257"
                     /db_xref="MIM:601753"
                     /translation="MSHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKT
                     AENFRALCTGEKGIGHTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEK
                     FEDENFHYKHDREGLLSMANAGRNTNGSQFFITTVPTPHLDGKHVVFGQVIKGIGVAR
                     ILENVEVKGEKPAKLCVIAECGELKEGDDGGIFPKDGSGDSHPDFPEDADIDLKDVDK
                     ILLITEDLKNIGNTFFKSQNWEMAIKKYAEVLRYVDSSKAVIETADRAKLQPIALSCV
                     LNIGACKLKMSNWQGAIDSCLEALELDPSNTKALYRRAQGWQGLKEYDQALADLKKAQ
                     GIAPEDKAIQAELLKVKQKIKAQKDKEKAVYAKMFA"
     exon            194..334
                     /gene="PPID"
                     /gene_synonym="CYP-40; CYPD"
                     /inference="alignment:Splign:2.1.0"
     exon            335..441
                     /gene="PPID"
                     /gene_synonym="CYP-40; CYPD"
                     /inference="alignment:Splign:2.1.0"
     exon            442..630
                     /gene="PPID"
                     /gene_synonym="CYP-40; CYPD"
                     /inference="alignment:Splign:2.1.0"
     exon            631..753
                     /gene="PPID"
                     /gene_synonym="CYP-40; CYPD"
                     /inference="alignment:Splign:2.1.0"
     exon            754..860
                     /gene="PPID"
                     /gene_synonym="CYP-40; CYPD"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1002
                     /gene="PPID"
                     /gene_synonym="CYP-40; CYPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1089
                     /gene="PPID"
                     /gene_synonym="CYP-40; CYPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1132
                     /gene="PPID"
                     /gene_synonym="CYP-40; CYPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1830
                     /gene="PPID"
                     /gene_synonym="CYP-40; CYPD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1803..1808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPID"
                     /gene_synonym="CYP-40; CYPD"
                     /note="hexamer: AATAAA"
     polyA_site      1830
                     /gene="PPID"
                     /gene_synonym="CYP-40; CYPD"
                     /note="major polyA site"
ORIGIN      
        1 ggtcagcgtc gctgccggtc tccggcggag acggactctg gagtttgggc ggcccgggcg
       61 gccactaggt actctgatat tccgtactaa acacgtctgc aagtcaagat gtcgcacccg
      121 tccccccaag ccaagccctc caaccccagt aaccctcgag tcttctttga cgtggacatc
      181 ggaggggagc gagttggtcg aattgtctta gaattgtttg cagatatcgt acccaaaact
      241 gcggaaaatt ttcgtgcact gtgtacagga gaaaaaggca ttggacacac gactgggaaa
      301 cctctccatt tcaaaggatg cccttttcat cgaattatta agaaatttat gattcagggt
      361 ggagacttct caaatcagaa tgggacaggt ggagaaagta tttatggtga aaaatttgaa
      421 gatgaaaatt tccattacaa gcatgatcgg gagggtttac tgagcatggc aaatgcaggc
      481 cgcaacacaa acggttctca gttttttatc acaacagttc caactcctca tttggatggg
      541 aaacatgtgg tgtttggcca agtaattaaa ggaataggag tggcaaggat attggaaaat
      601 gtggaagtga aaggtgaaaa acctgctaaa ttgtgcgtta ttgcagaatg tggagaattg
      661 aaggaaggag atgacggggg aatattccca aaagatggct ctggcgacag tcatccagat
      721 ttccctgagg atgcggatat agatttaaaa gatgtagata aaattttatt aataacagaa
      781 gacttaaaaa acattggaaa tacttttttc aaatcccaga actgggagat ggctattaaa
      841 aaatatgcag aagttttaag atacgtggac agttcaaagg ctgttattga gacagcagat
      901 agagccaagc tgcaacctat agctttaagc tgtgtactga atattggtgc ttgtaaactg
      961 aagatgtcaa attggcaggg agcaattgac agttgtttag aggctcttga actagaccca
     1021 tcaaatacca aagcattgta ccgcagagct caaggatggc aaggattaaa agaatatgat
     1081 caagcattgg ctgatcttaa gaaagctcag gggatagcac cagaagataa agctatccag
     1141 gcagaattgc tgaaagtcaa acaaaagata aaggcacaga aagataaaga gaaggcagta
     1201 tatgcaaaaa tgtttgctta gaaaggattc agttttgctt attgtgtgtt gattgtataa
     1261 atgcaataag aaaatgtaaa ggtttttgtc tatgaatatg atccctaatg tgtttctttt
     1321 gacaccttag ttccttactg tttacagttt aggagtactg ataggggttc atgcttaata
     1381 aacatgtcac aatacagtaa gtaaagtggt tttgtttgtt tctttgagat ggagtcttgc
     1441 tctgtcaccc aggctggagt gcggtggcgc aatctcggct cactgcatcc tctgcctccc
     1501 gggttcaagc aattctcctg cctcagcttc ccaagtagct gggattacag gcacgtgcca
     1561 ccacgcccag ctaatttttg tatttttagt agagatgggg tttcaccata ttggtcacgt
     1621 cacgttggtc ttgaactcct gaccttgtga tccaccccgc cttggcctcc caaagtgctg
     1681 ggattacagg tgtgagccac cgtgcccggc caagtaaaat gttttttaaa atggttatgt
     1741 gcattattca taaaaaataa tggtgtccag tctttttaaa cttgtaaaga cacatcttat
     1801 tgaataaaga gatgagagct taagtttgta
//
