LOCUS       NM_000942                893 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens peptidylprolyl isomerase B (PPIB), mRNA.
ACCESSION   NM_000942
VERSION     NM_000942.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 893)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 893)
  AUTHORS   Sarro,E., Duran,M., Rico,A., Bou-Teen,D., Fernandez-Majada,V.,
            Croatt,A.J., Nath,K.A., Salcedo,M.T., Gundelach,J.H., Batlle,D.,
            Bram,R.J. and Meseguer,A.
  TITLE     Cyclophilins A and B oppositely regulate renal tubular epithelial
            cell phenotype
  JOURNAL   J Mol Cell Biol 12 (7), 499-514 (2020)
   PUBMED   32162654
  REMARK    GeneRIF: Cyclophilins A and B oppositely regulate renal tubular
            epithelial cell phenotype.
REFERENCE   3  (bases 1 to 893)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 893)
  AUTHORS   Ma-Lauer,Y., Zheng,Y., Malesevic,M., von Brunn,B., Fischer,G. and
            von Brunn,A.
  TITLE     Influences of cyclosporin A and non-immunosuppressive derivatives
            on cellular cyclophilins and viral nucleocapsid protein during
            human coronavirus 229E replication
  JOURNAL   Antiviral Res 173, 104620 (2020)
   PUBMED   31634494
  REMARK    GeneRIF: Influences of cyclosporin A and non-immunosuppressive
            derivatives on cellular cyclophilins and viral nucleocapsid protein
            during human coronavirus 229E replication.
REFERENCE   5  (bases 1 to 893)
  AUTHORS   Teng,M.R., Huang,J.A., Zhu,Z.T., Li,H., Shen,J.F. and Chen,Q.
  TITLE     Cyclophilin B promotes cell proliferation, migration, invasion and
            angiogenesis via regulating the STAT3 pathway in non-small cell
            lung cancer
  JOURNAL   Pathol Res Pract 215 (6), 152417 (2019)
   PUBMED   31043353
  REMARK    GeneRIF: findings suggested that CypB silencing may suppress the
            proliferation, invasion, migration and angiogenesis of A549 cells
            via inhibiting STAT3 pathway.
REFERENCE   6  (bases 1 to 893)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   7  (bases 1 to 893)
  AUTHORS   Arber,S., Krause,K.H. and Caroni,P.
  TITLE     s-cyclophilin is retained intracellularly via a unique
            COOH-terminal sequence and colocalizes with the calcium storage
            protein calreticulin
  JOURNAL   J Cell Biol 116 (1), 113-125 (1992)
   PUBMED   1530944
REFERENCE   8  (bases 1 to 893)
  AUTHORS   Peddada,L.B., McPherson,J.D., Law,R., Wasmuth,J.J., Youderian,P.
            and Deans,R.J.
  TITLE     Somatic cell mapping of the human cyclophilin B gene (PPIB) to
            chromosome 15
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 219-221 (1992)
   PUBMED   1505219
REFERENCE   9  (bases 1 to 893)
  AUTHORS   Hasel,K.W., Glass,J.R., Godbout,M. and Sutcliffe,J.G.
  TITLE     An endoplasmic reticulum-specific cyclophilin
  JOURNAL   Mol Cell Biol 11 (7), 3484-3491 (1991)
   PUBMED   1710767
REFERENCE   10 (bases 1 to 893)
  AUTHORS   Price,E.R., Zydowsky,L.D., Jin,M.J., Baker,C.H., McKeon,F.D. and
            Walsh,C.T.
  TITLE     Human cyclophilin B: a second cyclophilin gene encodes a
            peptidyl-prolyl isomerase with a signal sequence
  JOURNAL   Proc Natl Acad Sci U S A 88 (5), 1903-1907 (1991)
   PUBMED   2000394
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC008848.2 and BC001125.2.
            
            On Dec 4, 2019 this sequence version replaced NM_000942.4.
            
            Summary: The protein encoded by this gene is a cyclosporine-binding
            protein and is mainly located within the endoplasmic reticulum. It
            is associated with the secretory pathway and released in biological
            fluids. This protein can bind to cells derived from T- and
            B-lymphocytes, and may regulate cyclosporine A-mediated
            immunosuppression. Variants have been identified in this protein
            that give rise to recessive forms of osteogenesis imperfecta.
            [provided by RefSeq, Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX421459.2, BQ276360.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300026.4/ ENSP00000300026.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-749               BC008848.2         105-853
            750-893             BC001125.2         732-875
FEATURES             Location/Qualifiers
     source          1..893
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..893
                     /gene="PPIB"
                     /gene_synonym="CYP-S1; CYPB; HEL-S-39; OI9; SCYLP"
                     /note="peptidylprolyl isomerase B"
                     /db_xref="GeneID:5479"
                     /db_xref="HGNC:HGNC:9255"
                     /db_xref="MIM:123841"
     exon            1..171
                     /gene="PPIB"
                     /gene_synonym="CYP-S1; CYPB; HEL-S-39; OI9; SCYLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..687
                     /gene="PPIB"
                     /gene_synonym="CYP-S1; CYPB; HEL-S-39; OI9; SCYLP"
                     /EC_number="5.2.1.8"
                     /note="peptidyl-prolyl cis-trans isomerase B;
                     peptidylprolyl isomerase B (cyclophilin B);
                     cyclophilin-like protein; S-cyclophilin; PPIase B;
                     rotamase B; epididymis secretory protein Li 39"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase B precursor"
                     /protein_id="NP_000933.1"
                     /db_xref="CCDS:CCDS10191.1"
                     /db_xref="GeneID:5479"
                     /db_xref="HGNC:HGNC:9255"
                     /db_xref="MIM:123841"
                     /translation="MLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTV
                     KVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMI
                     QGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTA
                     WLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE"
     exon            172..285
                     /gene="PPIB"
                     /gene_synonym="CYP-S1; CYPB; HEL-S-39; OI9; SCYLP"
                     /inference="alignment:Splign:2.1.0"
     exon            286..379
                     /gene="PPIB"
                     /gene_synonym="CYP-S1; CYPB; HEL-S-39; OI9; SCYLP"
                     /inference="alignment:Splign:2.1.0"
     exon            380..564
                     /gene="PPIB"
                     /gene_synonym="CYP-S1; CYPB; HEL-S-39; OI9; SCYLP"
                     /inference="alignment:Splign:2.1.0"
     exon            565..893
                     /gene="PPIB"
                     /gene_synonym="CYP-S1; CYPB; HEL-S-39; OI9; SCYLP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagctgtc cgggctgctt tcgcctccgc ctgtggatgc tgcgcctctc cgaacgcaac
       61 atgaaggtgc tccttgccgc cgccctcatc gcggggtccg tcttcttcct gctgctgccg
      121 ggaccttctg cggccgatga gaagaagaag gggcccaaag tcaccgtcaa ggtgtatttt
      181 gacctacgaa ttggagatga agatgtaggc cgggtgatct ttggtctctt cggaaagact
      241 gttccaaaaa cagtggataa ttttgtggcc ttagctacag gagagaaagg atttggctac
      301 aaaaacagca aattccatcg tgtaatcaag gacttcatga tccagggcgg agacttcacc
      361 aggggagatg gcacaggagg aaagagcatc tacggtgagc gcttccccga tgagaacttc
      421 aaactgaagc actacgggcc tggctgggtg agcatggcca acgcaggcaa agacaccaac
      481 ggctcccagt tcttcatcac gacagtcaag acagcctggc tagatggcaa gcatgtggtg
      541 tttggcaaag ttctagaggg catggaggtg gtgcggaagg tggagagcac caagacagac
      601 agccgggata aacccctgaa ggatgtgatc atcgcagact gcggcaagat cgaggtggag
      661 aagccctttg ccatcgccaa ggagtagggc acagggacat ctttctttga gtgaccgtct
      721 gtgcaggccc tgtagtccgc cacagggctc tgagctgcac tggccccggt gctggcatct
      781 ggtggagcgg acccactccc ctcacattcc acaggcccat ggactcactt ttgtaacaaa
      841 ctcctaccaa cactgaccaa taaaaaaaaa tgtgggtttt ttttttttta ata
//
