LOCUS       NM_001143883             760 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens peptidylprolyl isomerase A like 4A (PPIAL4A), mRNA.
ACCESSION   NM_001143883 NM_178230 XM_927767
VERSION     NM_001143883.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 760)
  AUTHORS   Xue,Z., Yuan,W., Li,J., Zhou,H., Xu,L., Weng,J., Li,X., Zhang,X.,
            Wang,Z. and Yan,J.
  TITLE     Cyclophilin A mediates the ox-LDL-induced activation and apoptosis
            of macrophages via autophagy
  JOURNAL   Int J Cardiol 230, 142-148 (2017)
   PUBMED   28038796
  REMARK    GeneRIF: CyPA mediates the ox-LDL-induced activation and apoptosis
            in RAW264.7 cells by regulating autophagy.
REFERENCE   2  (bases 1 to 760)
  AUTHORS   Nilsson,M., Meza-Zepeda,L.A., Mertens,F., Forus,A., Myklebost,O.
            and Mandahl,N.
  TITLE     Amplification of chromosome 1 sequences in lipomatous tumors and
            other sarcomas
  JOURNAL   Int J Cancer 109 (3), 363-369 (2004)
   PUBMED   14961574
REFERENCE   3  (bases 1 to 760)
  AUTHORS   Meza-Zepeda,L.A., Forus,A., Lygren,B., Dahlberg,A.B., Godager,L.H.,
            South,A.P., Marenholz,I., Lioumi,M., Florenes,V.A.,
            Maelandsmo,G.M., Serra,M., Mischke,D., Nizetic,D., Ragoussis,J.,
            Tarkkanen,M., Nesland,J.M., Knuutila,S. and Myklebost,O.
  TITLE     Positional cloning identifies a novel cyclophilin as a candidate
            amplified oncogene in 1q21
  JOURNAL   Oncogene 21 (14), 2261-2269 (2002)
   PUBMED   11948409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC253572.3.
            
            On Apr 8, 2021 this sequence version replaced NM_001143883.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB084917.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000577856.3/ ENSP00000485206.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-760               AC253572.3         190106-190865
FEATURES             Location/Qualifiers
     source          1..760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p11.2"
     gene            1..760
                     /gene="PPIAL4A"
                     /gene_synonym="COAS-2; COAS2; PPIAL4; PPIAL4B"
                     /note="peptidylprolyl isomerase A like 4A"
                     /db_xref="GeneID:653505"
                     /db_xref="HGNC:HGNC:24369"
     exon            1..760
                     /gene="PPIAL4A"
                     /gene_synonym="COAS-2; COAS2; PPIAL4; PPIAL4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..545
                     /gene="PPIAL4A"
                     /gene_synonym="COAS-2; COAS2; PPIAL4; PPIAL4B"
                     /EC_number="5.2.1.8"
                     /note="chromosome 1-amplified sequence 2; cyclophilin
                     homolog overexpressed in liver cancer; peptidylprolyl
                     isomerase A (cyclophilin A)-like 4B; peptidyl-prolyl
                     cis-trans isomerase A-like 4A/B/C; cyclophilin-LC (COAS2);
                     PPIase A-like 4B; peptidylprolyl isomerase A (cyclophilin
                     A)-like 4A; peptidylprolyl cis-trans isomerase A-like 4B;
                     PPIase A-like 4G; chromosome one-amplified sequence 2"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase A-like 4A"
                     /protein_id="NP_001137355.1"
                     /db_xref="CCDS:CCDS76197.1"
                     /db_xref="GeneID:653505"
                     /db_xref="HGNC:HGNC:24369"
                     /translation="MVNSVVFFDITVDGKPLGRISIKLFADKILKTAENFRALSTGEK
                     GFRYKGSCFHRIIPGFMCQGGDFTRHNGTGDKSIYGEKFDDENLIRKHTGSGILSMAN
                     AGPNTNGSQFFICAAKTEWLDGKHVAFGKVKERVNIVEAMEHFGYRNSKTSKKITIAD
                     CGQF"
ORIGIN      
        1 tggttatctt tgcagacgcc accatcactg tgagccctgt actatcagcc atggtcaact
       61 ccgtcgtctt ttttgacatc accgtcgacg gcaagccctt gggccgcatc tccatcaaac
      121 tgtttgcaga caagattcta aagacagcgg aaaactttcg tgctctgagc actggagaga
      181 aaggatttcg ttataagggt tcctgctttc acagaattat tccagggttt atgtgtcagg
      241 gtggtgactt cacacgccat aatggcactg gtgacaagtc catctatggg gagaaatttg
      301 atgatgagaa cctcatccga aagcatacag gttctggcat cttgtccatg gcaaatgctg
      361 gacccaacac aaatggttcc cagtttttca tctgtgctgc caagactgag tggttggatg
      421 gcaagcatgt ggcctttggc aaggtgaaag aacgtgtgaa tattgtggaa gccatggagc
      481 actttgggta caggaatagc aagaccagca agaagatcac cattgctgac tgtggacaat
      541 tctaatgagt ttgacttgtg ttttattttc accaccagac ccattccttc tgtagctcag
      601 gagagcaccc ctccaccaca tttgcttgca atatcctaga atctttgtgc tcttgctgca
      661 gttccctttg ggttccatgt tttccttgtt cccttccatg cctagctgga ttgcagagtt
      721 gagttaagtt tatgattatg aaataaaaac taagtaacaa
//
