LOCUS       NM_021130               2237 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens peptidylprolyl isomerase A (PPIA), transcript variant
            1, mRNA.
ACCESSION   NM_021130 NM_001008741
VERSION     NM_021130.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2237)
  AUTHORS   Zhang,X., Ding,T., Yang,F., Zhang,J., Xu,H., Bai,Y., Shi,Y.,
            Yang,J., Chen,C., Zhu,C. and Zhang,H.
  TITLE     Peptidylprolyl isomerase A guides SENP5/GAU1 DNA-lncRNA triplex
            generation for driving tumorigenesis
  JOURNAL   Nat Commun 15 (1), 9068 (2024)
   PUBMED   39433793
  REMARK    GeneRIF: Peptidylprolyl isomerase A guides SENP5/GAU1 DNA-lncRNA
            triplex generation for driving tumorigenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2237)
  AUTHORS   Chen,S., Zhao,X., Tan,J., Lu,H., Qi,Z., Huang,Q., Zeng,X.,
            Zhang,M., Jiang,S., Jiang,H. and Yu,L.
  TITLE     Structure-based identification of small molecule compounds
            targeting cell cyclophilin A with anti-HIV-1 activity
  JOURNAL   Eur J Pharmacol 565 (1-3), 54-59 (2007)
   PUBMED   17449029
REFERENCE   3  (bases 1 to 2237)
  AUTHORS   Piotukh,K., Gu,W., Kofler,M., Labudde,D., Helms,V. and Freund,C.
  TITLE     Cyclophilin A binds to linear peptide motifs containing a consensus
            that is present in many human proteins
  JOURNAL   J Biol Chem 280 (25), 23668-23674 (2005)
   PUBMED   15845542
  REMARK    GeneRIF: The peptide FGPDLPAGD showed inhibition of the isomerase
            reaction and NMR chemical shift mapping experiments highlight the
            cyclophilin A interaction epitope
REFERENCE   4  (bases 1 to 2237)
  AUTHORS   Ivery,M.T.
  TITLE     Immunophilins: switched on protein binding domains?
  JOURNAL   Med Res Rev 20 (6), 452-484 (2000)
   PUBMED   11058892
  REMARK    Review article
REFERENCE   5  (bases 1 to 2237)
  AUTHORS   Braaten,D., Ansari,H. and Luban,J.
  TITLE     The hydrophobic pocket of cyclophilin is the binding site for the
            human immunodeficiency virus type 1 Gag polyprotein
  JOURNAL   J Virol 71 (3), 2107-2113 (1997)
   PUBMED   9032343
REFERENCE   6  (bases 1 to 2237)
  AUTHORS   Willenbrink,W., Halaschek,J., Schuffenhauer,S., Kunz,J. and
            Steinkasserer,A.
  TITLE     Cyclophilin A, the major intracellular receptor for the
            immunosuppressant cyclosporin A, maps to chromosome 7p11.2-p13:
            four pseudogenes map to chromosomes 3, 10, 14, and 18
  JOURNAL   Genomics 28 (1), 101-104 (1995)
   PUBMED   7590732
REFERENCE   7  (bases 1 to 2237)
  AUTHORS   Luban,J., Bossolt,K.L., Franke,E.K., Kalpana,G.V. and Goff,S.P.
  TITLE     Human immunodeficiency virus type 1 Gag protein binds to
            cyclophilins A and B
  JOURNAL   Cell 73 (6), 1067-1078 (1993)
   PUBMED   8513493
REFERENCE   8  (bases 1 to 2237)
  AUTHORS   Charneau,P., Alizon,M. and Clavel,F.
  TITLE     A second origin of DNA plus-strand synthesis is required for
            optimal human immunodeficiency virus replication
  JOURNAL   J Virol 66 (5), 2814-2820 (1992)
   PUBMED   1560526
REFERENCE   9  (bases 1 to 2237)
  AUTHORS   Kallen,J., Spitzfaden,C., Zurini,M.G., Wider,G., Widmer,H.,
            Wuthrich,K. and Walkinshaw,M.D.
  TITLE     Structure of human cyclophilin and its binding site for cyclosporin
            A determined by X-ray crystallography and NMR spectroscopy
  JOURNAL   Nature 353 (6341), 276-279 (1991)
   PUBMED   1896075
REFERENCE   10 (bases 1 to 2237)
  AUTHORS   Takahashi,N., Hayano,T. and Suzuki,M.
  TITLE     Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding
            protein cyclophilin
  JOURNAL   Nature 337 (6206), 473-475 (1989)
   PUBMED   2644542
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC137057.1 and AC013436.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021130.4.
            
            Summary: This gene encodes a member of the peptidyl-prolyl
            cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans
            isomerization of proline imidic peptide bonds in oligopeptides and
            accelerate the folding of proteins. The encoded protein is a
            cyclosporin binding-protein and may play a role in cyclosporin
            A-mediated immunosuppression. The protein can also interact with
            several HIV proteins, including p55 gag, Vpr, and capsid protein,
            and has been shown to be necessary for the formation of infectious
            HIV virions. Multiple pseudogenes that map to different chromosomes
            have been reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1105482.1, AK130101.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000468812.6/ ENSP00000419425.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-626               BC137057.1         46-671
            627-2237            AC013436.5         19062-20672         c
FEATURES             Location/Qualifiers
     source          1..2237
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..2237
                     /gene="PPIA"
                     /gene_synonym="CYPA; CYPH; HEL-S-69p"
                     /note="peptidylprolyl isomerase A"
                     /db_xref="GeneID:5478"
                     /db_xref="HGNC:HGNC:9253"
                     /db_xref="MIM:123840"
     exon            1..113
                     /gene="PPIA"
                     /gene_synonym="CYPA; CYPH; HEL-S-69p"
                     /inference="alignment:Splign:2.1.0"
     exon            114..144
                     /gene="PPIA"
                     /gene_synonym="CYPA; CYPH; HEL-S-69p"
                     /inference="alignment:Splign:2.1.0"
     exon            145..233
                     /gene="PPIA"
                     /gene_synonym="CYPA; CYPH; HEL-S-69p"
                     /inference="alignment:Splign:2.1.0"
     exon            234..406
                     /gene="PPIA"
                     /gene_synonym="CYPA; CYPH; HEL-S-69p"
                     /inference="alignment:Splign:2.1.0"
     exon            407..2237
                     /gene="PPIA"
                     /gene_synonym="CYPA; CYPH; HEL-S-69p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      730..735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIA"
                     /gene_synonym="CYPA; CYPH; HEL-S-69p"
                     /note="hexamer: AATAAA"
     regulatory      737..742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIA"
                     /gene_synonym="CYPA; CYPH; HEL-S-69p"
                     /note="hexamer: ACTAAA"
     polyA_site      762
                     /gene="PPIA"
                     /gene_synonym="CYPA; CYPH; HEL-S-69p"
                     /note="major polyA site"
     polyA_site      767
                     /gene="PPIA"
                     /gene_synonym="CYPA; CYPH; HEL-S-69p"
     regulatory      2212..2217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPIA"
                     /gene_synonym="CYPA; CYPH; HEL-S-69p"
                     /note="hexamer: AATAAA"
     polyA_site      2237
                     /gene="PPIA"
                     /gene_synonym="CYPA; CYPH; HEL-S-69p"
ORIGIN      
        1 gttttgcaga cgccaccgcc gaggaaaacc gtgtactatt agccatggtc aaccccaccg
       61 tgttcttcga cattgccgtc gacggcgagc ccttgggccg cgtctccttt gagctgtttg
      121 cagacaaggt cccaaagaca gcagaaaatt ttcgtgctct gagcactgga gagaaaggat
      181 ttggttataa gggttcctgc tttcacagaa ttattccagg gtttatgtgt cagggtggtg
      241 acttcacacg ccataatggc actggtggca agtccatcta tggggagaaa tttgaagatg
      301 agaacttcat cctaaagcat acgggtcctg gcatcttgtc catggcaaat gctggaccca
      361 acacaaatgg ttcccagttt ttcatctgca ctgccaagac tgagtggttg gatggcaagc
      421 atgtggtgtt tggcaaagtg aaagaaggca tgaatattgt ggaggccatg gagcgctttg
      481 ggtccaggaa tggcaagacc agcaagaaga tcaccattgc tgactgtgga caactcgaat
      541 aagtttgact tgtgttttat cttaaccacc agatcattcc ttctgtagct caggagagca
      601 cccctccacc ccatttgctc gcagtatcct agaatctttg tgctctcgct gcagttccct
      661 ttgggttcca tgttttcctt gttccctccc atgcctagct ggattgcaga gttaagttta
      721 tgattatgaa ataaaaacta aataacaatt gtcctcgttt gagttaagag tgttgatgta
      781 ggctttattt taagcagtaa tgggttactt ctgaaacatc acttgtttgc ttaattctac
      841 acagtactta gatttttttt actttccagt cccaggaagt gtcaatgttt gttgagtgga
      901 atattgaaaa tgtaggcagc aactgggcat ggtggctcac tgtctgtaat gtattacctg
      961 aggcagaaga ccacctgagg gtaggagtca agatcagcct gggcaacata gtgagacgct
     1021 gtctctacaa aaaataatta gcctggcctg gtggtgcatg cctagtccta gctgatctgg
     1081 aggctgacgt gggaggattg cttgagccta gagtgagcta ttatcatgcc actgtacagc
     1141 ctgggtgttc acagatcttg tgtctcaaag gtaggcagag gcaggaaaag caaggagcca
     1201 gaattaagag gttgggtcag tctgcagtga gttcatgcat ttagaggtgt tcttcaagat
     1261 gactaatgtc aaaaattgag acatctgttg cggttttttt tttttttttt tcccctggaa
     1321 tgcagtggcg tgatctcagc tcactgcagc ctccgcctcc tgggttcaag tgattctagt
     1381 gcctcagcct cctgagtagc tgggataatg ggcgtgtgcc accatgccca gctaattttt
     1441 gtatttttag tatagatggg gtttcatcat tttgaccagg ctggtctcaa actcttgacc
     1501 tcagctgatg cgcctgcctt ggcctcccaa actgctgaga ttacagatgt gagccaccgc
     1561 accctacctc attttctgta acaaagctaa gcttgaacac tgttgatgtt cttgagggaa
     1621 gcatattggg ctttaggctg taggtcaagt ttatacatct taattatggt ggaattccta
     1681 tgtagagtct aaaaagccag gtacttggtg ctacagtcag tctccctgca gagggttaag
     1741 gcgcagacta cctgcagtga ggaggtactg cttgtagcat atagagcctc tccctagctt
     1801 tggttatgga ggctttgagg ttttgcaaac ctgaccaatt taagccataa gatctggtca
     1861 aagggatacc cttcccacta aggacttggt ttctcaggaa attatatgta cagtgcttgc
     1921 tggcagttag atgtcaggac aatctaagct gagaaaaccc cttctctgcc caccttaaca
     1981 gacctctagg gttcttaacc cagcaatcaa gtttgcctat cctagaggtg gcggatttga
     2041 tcatttggtg tgttgggcaa tttttgtttt actgtctggt tccttctgcg tgaattacca
     2101 ccaccaccac ttgtgcatct cagtcttgtg tgttgtctgg ttacgtattc cctgggtgat
     2161 accattcaat gtcttaatgt acttgtggct cagacctgag tgcaaggtgg aaataaacat
     2221 caaacatctt ttcatta
//
