LOCUS       NM_003621               3328 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens PPFIA binding protein 2 (PPFIBP2), transcript variant
            1, mRNA.
ACCESSION   NM_003621 XM_084578
VERSION     NM_003621.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3328)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 3328)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3328)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3328)
  AUTHORS   Wu,Y., Yu,H., Zheng,S.L., Feng,B., Kapron,A.L., Na,R., Boyle,J.L.,
            Shah,S., Shi,Z., Ewing,C.M., Wiley,K.E., Luo,J., Walsh,P.C.,
            Carter,H.B., Helfand,B.T., Cooney,K.A., Xu,J. and Isaacs,W.B.
  TITLE     Germline mutations in PPFIBP2 are associated with lethal prostate
            cancer
  JOURNAL   Prostate 78 (16), 1222-1228 (2018)
   PUBMED   30043417
  REMARK    GeneRIF: germline mutations in a novel gene, PPFIBP2,
            differentiated risk for lethal prostate cancer from low-risk cases
            and were associated with shorter survival times after diagnosis.
REFERENCE   5  (bases 1 to 3328)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3328)
  AUTHORS   von Thun,A., Birtwistle,M., Kalna,G., Grindlay,J., Strachan,D.,
            Kolch,W., von Kriegsheim,A. and Norman,J.C.
  TITLE     ERK2 drives tumour cell migration in three-dimensional
            microenvironments by suppressing expression of Rab17 and
            liprin-beta2
  JOURNAL   J Cell Sci 125 (Pt 6), 1465-1477 (2012)
   PUBMED   22328529
  REMARK    GeneRIF: Knockdown of either Rab17 or liprin-beta2 restores
            invasiveness of ERK2-depleted cells, indicating that ERK2 drives
            invasion of MDA-MB-231 cells by suppressing expression of these
            genes.
REFERENCE   7  (bases 1 to 3328)
  AUTHORS   Colas,E., Perez,C., Cabrera,S., Pedrola,N., Monge,M., Castellvi,J.,
            Eyzaguirre,F., Gregorio,J., Ruiz,A., Llaurado,M., Rigau,M.,
            Garcia,M., Ertekin,T., Montes,M., Lopez-Lopez,R., Carreras,R.,
            Xercavins,J., Ortega,A., Maes,T., Rosell,E., Doll,A., Abal,M.,
            Reventos,J. and Gil-Moreno,A.
  TITLE     Molecular markers of endometrial carcinoma detected in uterine
            aspirates
  JOURNAL   Int J Cancer 129 (10), 2435-2444 (2011)
   PUBMED   21207424
  REMARK    Erratum:[Int J Cancer. 2012 Jun 15;130(12):E4]
REFERENCE   8  (bases 1 to 3328)
  AUTHORS   Stafford,R.L., Tang,M.Y., Sawaya,M.R., Phillips,M.L. and Bowie,J.U.
  TITLE     Crystal structure of the central coiled-coil domain from human
            liprin-beta2
  JOURNAL   Biochemistry 50 (18), 3807-3815 (2011)
   PUBMED   21462929
  REMARK    GeneRIF: analysis of crystal structure of the central coiled-coil
            domain from human liprin-beta2
REFERENCE   9  (bases 1 to 3328)
  AUTHORS   Xin,X., Rual,J.F., Hirozane-Kishikawa,T., Hill,D.E., Vidal,M.,
            Boone,C. and Thierry-Mieg,N.
  TITLE     Shifted Transversal Design smart-pooling for high coverage
            interactome mapping
  JOURNAL   Genome Res 19 (7), 1262-1269 (2009)
   PUBMED   19447967
REFERENCE   10 (bases 1 to 3328)
  AUTHORS   Serra-Pages,C., Medley,Q.G., Tang,M., Hart,A. and Streuli,M.
  TITLE     Liprins, a family of LAR transmembrane protein-tyrosine
            phosphatase-interacting proteins
  JOURNAL   J Biol Chem 273 (25), 15611-15620 (1998)
   PUBMED   9624153
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107884.15 and AC104237.2.
            
            On May 21, 2020 this sequence version replaced NM_003621.4.
            
            Summary: This gene encodes a member of the LAR protein-tyrosine
            phosphatase-interacting protein (liprin) family. The encoded
            protein is a beta liprin and plays a role in axon guidance and
            neuronal synapse development by recruiting LAR protein-tyrosine
            phosphatases to the plasma membrane. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1), as well as variant 13,
            encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK308398.1, BC021714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299492.9/ ENSP00000299492.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC107884.15        74591-74713         c
            124-223             AC107884.15        39173-39272         c
            224-438             AC107884.15        22945-23159         c
            439-531             AC104237.2         158873-158965       c
            532-645             AC104237.2         154424-154537       c
            646-777             AC104237.2         141675-141806       c
            778-870             AC104237.2         131070-131162       c
            871-985             AC104237.2         126206-126320       c
            986-1047            AC104237.2         123751-123812       c
            1048-1123           AC104237.2         122563-122638       c
            1124-1227           AC104237.2         121069-121172       c
            1228-1295           AC104237.2         119163-119230       c
            1296-1353           AC104237.2         117545-117602       c
            1354-1395           AC104237.2         116504-116545       c
            1396-1534           AC104237.2         112227-112365       c
            1535-1676           AC104237.2         110477-110618       c
            1677-1805           AC104237.2         109671-109799       c
            1806-1956           AC104237.2         103560-103710       c
            1957-2068           AC104237.2         103186-103297       c
            2069-2157           AC104237.2         102862-102950       c
            2158-2280           AC104237.2         102443-102565       c
            2281-2406           AC104237.2         101132-101257       c
            2407-2595           AC104237.2         100253-100441       c
            2596-3328           AC104237.2         98341-99073         c
FEATURES             Location/Qualifiers
     source          1..3328
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..3328
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /note="PPFIA binding protein 2"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
     exon            1..123
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            124..223
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..2790
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein tyrosine phosphatase receptor type f
                     polypeptide-interacting protein-binding protein 2; PTPRF
                     interacting protein, binding protein 2 (liprin beta 2)"
                     /codon_start=1
                     /product="liprin-beta-2 isoform 1"
                     /protein_id="NP_003612.3"
                     /db_xref="CCDS:CCDS31419.1"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
                     /translation="MASDASHALEAALEQMDGIIAGTKTGADLSDGTCEPGLASPASY
                     MNPFPVLHLIEDLRLALEMLELPQERAALLSQIPGPTAAYIKEWFEESLSQVNHHSAA
                     SNETYQERLARLEGDKESLILQVSVLTDQVEAQGEKIRDLEVCLEGHQVKLNAAEEML
                     QQELLSRTSLETQKLDLMTEVSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIK
                     VEELENERNQYEWKLKATKAEVAQLQEQVALKDAEIERLHSQLSRTAALHSESHTERD
                     QEIQRLKMGMETLLLANEDKDRRIEELTGLLNQYRKVKEIVMVTQGPSERTLSINEEE
                     PEGGFSKWNATNKDPEELFKQEMPPRCSSPTVGPPPLPQKSLETRAQKKLSCSLEDLR
                     SESVDKCMDGNQPFPVLEPKDSPFLAEHKYPTLPGKLSGATPNGEAAKSPPTICQPDA
                     TGSSLLRLRDTESGWDDTAVVNDLSSTSSGTESGPQSPLTPDGKRNPKGIKKFWGKIR
                     RTQSGNFYTDTLGMAEFRRGGLRATAGPRLSRTRDSKGQKSDANAPFAQWSTERVCAW
                     LEDFGLAQYVIFARQWVSSGHTLLTATPQDMEKELGIKHPLHRKKLVLAVKAINTKQE
                     EKSALLDHIWVTRWLDDIGLPQYKDQFHESRVDRRMLQYLTVNDLLFLKVTSQLHHLS
                     IKCAIHVLHVNKFNPHCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLR
                     GSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLRRHLTTKFNALIGPEAEQEKREKMA
                     SPAYTPLTTTAKVRPRKLGFSHFGNIRKKKFDESTDYICPMEPSDGVSDSHRVYSGYR
                     GLSPLDAPELDGLDQVGQIS"
     exon            224..438
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..531
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..645
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..777
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..870
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            871..985
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1047
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1123
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1227
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1295
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1353
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1395
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1534
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1676
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1805
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1956
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2068
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2157
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2280
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2406
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2595
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..3328
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3304..3309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /note="hexamer: AATAAA"
     polyA_site      3328
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /note="major polyA site"
ORIGIN      
        1 agttggtcgg tgggccagtg gcccgtcgct cgcttctggg ctctcatgtt tgaaggtggg
       61 agggacacgg gagcggcccg cacacctgag ccgcccggag aggagcctcg gccccgtacc
      121 cagtaagaag aggaggaggc caggcaggca aaaggagtca tggcttctga tgctagtcat
      181 gcgctggaag ctgccctgga gcaaatggac gggatcattg caggcactaa aacaggtgca
      241 gatcttagtg atggtacttg tgagcctgga ctggcttccc cggcctccta catgaacccc
      301 ttcccggtgc tccatctcat cgaggacttg aggctggcct tggagatgct ggagcttcct
      361 caggagagag cagccctcct gagccagatc cctggcccaa cagctgccta cataaaggaa
      421 tggtttgaag agagcttgtc ccaggtaaac caccacagtg ctgctagtaa tgaaacctac
      481 caggaacgct tggcacgtct agaaggggat aaggagtccc tcatattgca ggtgagtgtc
      541 ctcacagacc aagtagaagc ccagggagaa aagattcgag acctggaagt gtgtctggaa
      601 ggacaccagg tgaaactcaa tgctgctgaa gagatgcttc aacaggagct gctaagccgc
      661 acatctcttg agacccagaa gctcgatctg atgactgaag tgtctgagct gaagctcaag
      721 ctggttggca tggagaagga gcagagagag caggaggaga agcagagaaa agcagaggag
      781 ttactgcaag agctcaggca cctcaaaatc aaagtggaag agttggaaaa tgaaaggaat
      841 cagtatgaat ggaagctaaa ggccactaag gctgaagtcg cccagctgca agaacaggtg
      901 gccctgaaag atgcagaaat tgagcgtctg cacagccagc tctcccggac agcagctctc
      961 cacagtgaga gtcacacaga gagagaccaa gaaattcaac gtctgaaaat ggggatggaa
     1021 actttgctgc ttgccaatga agataaggac cgtcggatag aggagcttac ggggctgtta
     1081 aaccagtacc ggaaggtaaa ggagattgtg atggtcactc aagggccttc ggagagaact
     1141 ctctcaatca atgaagaaga accggaggga ggtttcagca agtggaacgc tacaaataag
     1201 gaccctgaag aattatttaa acaagagatg cctccaagat gtagctctcc tacagtgggg
     1261 ccacctccat tgccacagaa atcactggaa accagggctc agaaaaagct ctcttgtagt
     1321 ctagaagact tgagaagtga atctgtggat aagtgtatgg atgggaacca gcccttcccg
     1381 gtgttagaac ccaaggacag ccctttcttg gcggagcaca aatatcccac tttacctggg
     1441 aagctttcag gagccacgcc caatggagag gctgccaaat ctcctcccac catctgccag
     1501 cctgacgcca cggggagcag cctgctgagg ctgagagaca cagaaagtgg ctgggacgac
     1561 actgctgtgg tcaatgacct ctcatccaca tcatcgggca ctgaatcagg tcctcagtct
     1621 cctctgacac cagatggtaa acggaatccc aaaggcatta agaagttctg gggaaaaatc
     1681 cgaagaactc agtcaggaaa tttctacact gacacgctgg ggatggcaga gtttcgacga
     1741 ggtgggctcc gggcaaccgc agggccaaga ctctctagga ccagggactc caagggacag
     1801 aaaagtgacg ccaatgcccc ctttgcccag tggagcacag agcgtgtgtg tgcatggctg
     1861 gaggactttg gcctggctca gtatgtgatc tttgccaggc agtgggtatc ttctggccac
     1921 accttattga cagccacccc tcaggacatg gaaaaggagc taggaattaa gcacccactc
     1981 cacaggaaga agcttgtttt agcagtgaaa gccatcaaca ccaaacagga ggagaagtct
     2041 gcactgctag accacatttg ggtgacaagg tggcttgatg atattggctt accccagtac
     2101 aaagaccagt ttcatgaatc tagagttgac agacgaatgc tgcaatacct aactgtgaac
     2161 gatttactct tcttaaaagt caccagccaa ctacatcatc tcagcatcaa atgtgccatt
     2221 cacgtgctgc atgtcaacaa gttcaacccc cactgcctgc accggcggcc agctgatgag
     2281 agtaaccttt ctccttcaga agttgtacag tggtccaacc acagggtgat ggagtggtta
     2341 cgatctgtgg acctggcaga gtatgcaccc aatcttcgag ggagtggagt ccatggaggc
     2401 ctcattatcc tggagccacg cttcactggg gacaccctgg ctatgcttct caacatcccc
     2461 ccacaaaaga cgctcctcag gcgccacctg accaccaagt tcaatgcctt gattggtccg
     2521 gaggctgaac aggagaagcg agagaaaatg gcctcaccag cttacacacc actgaccacc
     2581 acagccaaag tccggccaag gaaactagga ttttcacact tcggaaacat aagaaaaaag
     2641 aagttcgatg aatcgacgga ctacatttgc ccaatggagc ccagtgacgg tgtcagtgat
     2701 agtcacaggg tctacagtgg ctaccggggc ctcagccccc ttgatgcccc tgaactggat
     2761 gggctggacc aggtgggaca gattagctga tgcccttgtc acctgccctc tgtgcaccct
     2821 gagagctcac agtaacactg tgtgtgtcac catataactg cacctcaccc ccgcacgtgt
     2881 gcatgactcg cagagaatat tccagcaatt gtgtacccct gggccagtct ctttgaaccc
     2941 tgagggtggc caggatctgg agctgcatct ctaaggggcc aggctttggg gaccattgcc
     3001 aaaggtggac tcaggaggaa agacacttaa agacactttt acatgtctag taattcttga
     3061 tgttcatctt cagcaccagt ggaaacacat gaacttcgat gcaggtccag agaccatgga
     3121 cactcccacg aggctcagct ctcaggcacc ccctacactt cagttgaggg aaaagctcaa
     3181 gtgccttagg cccgtggacc acagtcttgg ctgagatcaa agggatgagc aacagggact
     3241 tctgccacag tgacaatgga attgtgttgt gccttacttc agaggtggtc tcttctttct
     3301 tgtaataaaa gcaatattta tgcggaaa
//
