LOCUS       NM_003660               4583 bp    mRNA    linear   PRI 14-MAR-2025
DEFINITION  Homo sapiens PTPRF interacting protein alpha 3 (PPFIA3), transcript
            variant 1, mRNA.
ACCESSION   NM_003660
VERSION     NM_003660.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4583)
  AUTHORS   Paul,M.S., Michener,S.L., Pan,H., Chan,H., Pfliger,J.M.,
            Rosenfeld,J.A., Lerma,V.C., Tran,A., Longley,M.A., Lewis,R.A.,
            Weisz-Hubshman,M., Bekheirnia,M.R., Bekheirnia,N., Massingham,L.,
            Zech,M., Wagner,M., Engels,H., Cremer,K., Mangold,E., Peters,S.,
            Trautmann,J., Mester,J.L., Guillen Sacoto,M.J., Person,R.,
            McDonnell,P.P., Cohen,S.R., Lusk,L., Cohen,A.S.A., Le Pichon,J.B.,
            Pastinen,T., Zhou,D., Engleman,K., Racine,C., Faivre,L.,
            Moutton,S., Denomme-Pichon,A.S., Koh,H.Y., Poduri,A., Bolton,J.,
            Knopp,C., Julia Suh,D.S., Maier,A., Toosi,M.B., Karimiani,E.G.,
            Maroofian,R., Schaefer,G.B., Ramakumaran,V., Vasudevan,P.,
            Prasad,C., Osmond,M., Schuhmann,S., Vasileiou,G., Russ-Hall,S.,
            Scheffer,I.E., Carvill,G.L., Mefford,H., Bacino,C.A., Lee,B.H. and
            Chao,H.T.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     A syndromic neurodevelopmental disorder caused by rare variants in
            PPFIA3
  JOURNAL   Am J Hum Genet 111 (1), 96-118 (2024)
   PUBMED   38181735
  REMARK    GeneRIF: A syndromic neurodevelopmental disorder caused by rare
            variants in PPFIA3.
            Erratum:[Am J Hum Genet. 2024 Apr 4;111(4):805. doi:
            10.1016/j.ajhg.2024.03.009. PMID: 38508193]
REFERENCE   2  (bases 1 to 4583)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4583)
  AUTHORS   Li,W.H., Zhou,Z.J., Huang,T.H., Guo,K., Chen,W., Wang,Y., Zhang,H.,
            Song,Y.C. and Chang,D.M.
  TITLE     Detection of OSR2, VAV3, and PPFIA3 Methylation in the Serum of
            Patients with Gastric Cancer
  JOURNAL   Dis Markers 2016, 5780538 (2016)
   PUBMED   27143812
  REMARK    GeneRIF: Results found that OSR2, VAV3, and PPFIA3 were
            significantly hypermethylated in gastric cancer (GC) patients
            offering a good alternative in a simple, promising, and noninvasive
            detection of GC.
REFERENCE   4  (bases 1 to 4583)
  AUTHORS   Joshi,C.S., Suryawanshi,A.R., Khan,S.A., Balasinor,N.H. and
            Khole,V.V.
  TITLE     Liprin alpha3: a putative estrogen regulated acrosomal protein
  JOURNAL   Histochem Cell Biol 139 (4), 535-548 (2013)
   PUBMED   23124857
REFERENCE   5  (bases 1 to 4583)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   6  (bases 1 to 4583)
  AUTHORS   Sudhof,T.C.
  TITLE     The synaptic vesicle cycle
  JOURNAL   Annu Rev Neurosci 27, 509-547 (2004)
   PUBMED   15217342
  REMARK    Review article
REFERENCE   7  (bases 1 to 4583)
  AUTHORS   Ko,J., Na,M., Kim,S., Lee,J.R. and Kim,E.
  TITLE     Interaction of the ERC family of RIM-binding proteins with the
            liprin-alpha family of multidomain proteins
  JOURNAL   J Biol Chem 278 (43), 42377-42385 (2003)
   PUBMED   12923177
REFERENCE   8  (bases 1 to 4583)
  AUTHORS   Serra-Pages,C., Medley,Q.G., Tang,M., Hart,A. and Streuli,M.
  TITLE     Liprins, a family of LAR transmembrane protein-tyrosine
            phosphatase-interacting proteins
  JOURNAL   J Biol Chem 273 (25), 15611-15620 (1998)
   PUBMED   9624153
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA236900.1, AB014554.2,
            AI346749.1 and BX111585.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003660.3.
            
            Summary: The protein encoded by this gene is a member of the LAR
            protein-tyrosine phosphatase-interacting protein (liprin) family.
            Liprins interact with members of LAR family of transmembrane
            protein tyrosine phosphatases, which are known to be important for
            axon guidance and mammary gland development. Liprin family protein
            has been shown to localize phosphatase LAR to cell focal adhesions
            and may be involved in the molecular organization of presynaptic
            active zones. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes a functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB014554.2, BC101518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334186.9/ ENSP00000335614.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA236900.1         156-157
            3-4305              AB014554.2         141-4443
            4306-4581           AI346749.1         1-276               c
            4582-4583           BX111585.1         19-20               c
FEATURES             Location/Qualifiers
     source          1..4583
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..4583
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /note="PTPRF interacting protein alpha 3"
                     /db_xref="GeneID:8541"
                     /db_xref="HGNC:HGNC:9247"
                     /db_xref="MIM:603144"
     exon            1..179
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            180..434
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..3779
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /note="protein tyrosine phosphatase, receptor type, f
                     polypeptide, alpha 3; liprin; protein tyrosine phosphatase
                     receptor type f polypeptide-interacting protein alpha-3;
                     protein tyrosine phosphatase, receptor type, f polypeptide
                     (PTPRF), interacting protein (liprin), alpha 3"
                     /codon_start=1
                     /product="liprin-alpha-3"
                     /protein_id="NP_003651.1"
                     /db_xref="CCDS:CCDS12758.1"
                     /db_xref="GeneID:8541"
                     /db_xref="HGNC:HGNC:9247"
                     /db_xref="MIM:603144"
                     /translation="MMCEVMPTISEDGRRGSALGPDEAGGELERLMVTMLTERERLLE
                     TLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEE
                     IAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLF
                     EHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDG
                     QTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRE
                     LGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELA
                     SKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERH
                     GNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLK
                     ERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSSYSRS
                     LPGSALELRYSQAPTLPSGAHLDPYVAGSGRAGKRGRWSGVKEEPSKDWERSAPAGSI
                     PPPFPGELDGSDEEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEK
                     ETTEQRAEELESRVSSSGLDSLGRYRSSCSLPPSLTTSTLASPSPPSSGHSTPRLAPP
                     SPAREGTDKANHVPKEEAGAPRGEGPAIPGDTPPPTPRSARLERMTQALALQAGSLED
                     GGPPRGSEGTPDSLHKAPKKKSIKSSIGRLFGKKEKGRMGPPGRDSSSLAGTPSDETL
                     ATDPLGLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWLELWVGMPAW
                     YVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPASSR
                     TSTGNVWMTHEEMESLTATTKPETKEISWEQILAYGDMNHEWVGNDWLPSLGLPQYRS
                     YFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYDRKDLERRREE
                     SQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDYSDLALLLQ
                     IPTQNAQARQLLEKEFSNLISLGTDRRLDEDSAKSFSRSPSWRKMFREKDLRGVTPDS
                     AEMLPPNFRSAAAGALGSPGLPLRKLQPEGQTSGSSRADGVSVRTYSC"
     exon            435..536
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            537..701
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            702..776
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            777..851
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1073
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1220
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1355
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1439
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1571
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1634
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1714
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1859
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2047
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2270
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2434
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2562
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2656
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2738
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2939
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3002
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3029
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3205
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3303
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3479
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            3480..3548
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..3720
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            3721..3792
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..4583
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4583
                     /gene="PPFIA3"
                     /gene_synonym="LPNA3; NEDPACH"
                     /note="major polyA site"
ORIGIN      
        1 agcgcccaag ccggagccag agacgcggag cccgcgcgag cgtcggagac agggctccag
       61 ggctccgaag cgacagagcc gggccccggc cgctgccagg ggccccgccc ggccccccca
      121 ctccacccca cgtccctcct gcagcccagc tccgcccgca gccgccgcgg accaggcagg
      181 cccgcaccgc cgccatgatg tgcgaggtga tgcccaccat cagcgaggat ggccggcggg
      241 gctcggcgct gggcccggac gaggcgggcg gggagctgga gcgcctcatg gtcacgatgc
      301 tcacggagcg cgagcgcctg ctggagacgc tgcgcgaggc acaggacggg ttggctacag
      361 cgcagctgcg gctgcgcgag ctcggccacg agaaggactc gctgcagcgc cagctcagca
      421 tcgcgctgcc ccaggagttt gcagctctga cgaaggagct gaacttatgt cgggagcagc
      481 tgctggagag ggaggaagag attgcagagc tgaaggcgga acggaacaac acgcggctgc
      541 tcctggaaca cctggagtgc ctggtgtcca ggcacgagag gtcactgcgc atgaccgtgg
      601 tgaagcgcca ggcccagtcc ccgggtgggg tctcctcgga ggtagaagtg ctcaaagctc
      661 taaagtctct cttcgagcac cacaaggccc tggatgagaa ggtccgggag cggctgcgga
      721 tggcgctgga gcgcgtggca gtgctcgagg aggagctgga actgagcaat caggagactc
      781 tgaaccttcg agaacagctg tctaggcggc ggtcagggct ggaagagccg ggcaaggatg
      841 gggatgggca gactcttgcc aatggcctgg gtcctggcgg ggattccaac cggcgcacag
      901 cagagctgga ggaggccctg gagcggcagc gcgccgaggt gtgccagctg cgggagcgcc
      961 tggcggtgct gtgccgtcag atgagccagc tggaggagga gttgggcacc gcgcaccgtg
     1021 agctgggcaa ggcagaggaa gccaactcca agctgcagcg cgacctcaag gaggcgctgg
     1081 cgcagcggga agatatggag gagcggatta caacactgga gaagcgctac ctgagcgccc
     1141 agcgggaggc cacgtctctg cacgacgcca acgacaaact ggagaacgag ttagctagca
     1201 aggagtcgtt gtatcggcag agtgaagaga agagccgtca gctggccgag tggttggacg
     1261 acgccaagca gaagctgcag cagacgctgc agaaagcgga gaccttgccc gagatagagg
     1321 cgcagctggc gcagcgcgtg gcggcgctca acaaggccga ggaacgtcat gggaattttg
     1381 aggagcggct tcggcagctg gaggcccagc tggaagagaa gaatcaagag ctgcagcggg
     1441 cccggcagcg ggagaagatg aacgatgacc acaataagcg gctgtccgag acggtggaca
     1501 agctgctgag cgagtccaac gagcgcttac agcttcacct caaggagcgc atgggggcgc
     1561 tggaggagaa gaactccctg agcgaggaga tagccaacat gaagaagctt caggatgagt
     1621 tgctgctaaa caaggagcag ctcttggccg aaatggagcg gatgcagatg gagatcgacc
     1681 agctgcgggg gaggccacca tcctcctact ccaggtctct ccctggcagt gccctggagc
     1741 tccgttactc tcaggcaccc actttacctt ctggtgccca cctggatccc tatgtggctg
     1801 gcagtggtcg ggcaggcaag aggggccgct ggtcaggggt caaggaggag ccctccaagg
     1861 attgggagcg gtctgcccct gcgggctcca taccaccccc attccctggg gaactggacg
     1921 gctccgatga ggaggaggca gaggggatgt ttggggccga gctgctgtcc cccagtgggc
     1981 aggctgacgt gcagacgctg gccatcatgc ttcaggagca gctggaggcc atcaacaagg
     2041 agatcaagct gatccaagag gagaaggaga caacagaaca gagggcagag gagctggaga
     2101 gtcgggtgtc cagctctggc ttggactcgt tgggccgcta ccgcagcagc tgctccctgc
     2161 ccccctccct caccacctct acccttgcca gcccctcccc tcccagctct ggccactcaa
     2221 caccccgcct ggcaccccct agccctgccc gtgagggcac cgacaaggct aatcatgtcc
     2281 ctaaggagga agctggagct ccacgagggg aggggccggc catcccagga gacaccccac
     2341 cacccactcc ccgctctgcc cgtcttgaga gaatgaccca ggccttggca ctgcaggcgg
     2401 ggtccctgga agatggggga cccccacggg gaagtgaggg caccccagat tctctgcaca
     2461 aagcccccaa gaagaagagc atcaagtcat ccataggccg tctctttggc aagaaagaga
     2521 agggacgaat gggaccccca ggccgggaca gctcttctct ggctggaaca ccctcagatg
     2581 agacactggc cactgaccct ctggggctag ccaagctgac aggcccagga gacaaggacc
     2641 gaaggaacaa gaggaagcat gaactcctgg aggaggcctg ccgccagggc ctaccttttg
     2701 ctgcctggga cgggcccacc gtggtgtcct ggctggagct gtgggtgggc atgcctgcct
     2761 ggtatgtggc cgcctgccgg gccaatgtca agagcggtgc catcatggcc aacctgtcag
     2821 acacggagat ccagcgcgag atcggcatca gcaacccgct gcaccgactc aagctacgcc
     2881 tcgccatcca ggagatggtc tcgctcacct cgccctcagc ccccgcctcc tcccgcactt
     2941 ccacaggaaa cgtgtggatg acacacgagg agatggagtc ccttacggcc acgaccaagc
     3001 ccgagaccaa ggagatcagc tgggagcaga tcctggcata tggcgacatg aaccacgagt
     3061 gggtggggaa cgactggctg cccagcctgg ggctgcccca ataccgcagc tacttcatgg
     3121 agtcgctggt ggacgctcga atgttagatc accttaacaa gaaggagctc cggggccaac
     3181 tcaagatggt ggacagcttt cacagggtga gtctacatta tgggattatg tgcctgaaac
     3241 ggctcaacta tgaccggaag gacctggagc ggaggcggga agaaagtcag acccagatcc
     3301 gagacgtgat ggtgtggtcc aatgagcggg tcatgggttg ggtgtccggg ctgggcctga
     3361 aggaatttgc cacgaacctc acggagagcg gggtacacgg ggcactgctc gccctggacg
     3421 agaccttcga ctactccgac ctggccttgc tcctgcagat ccccacgcag aatgcacagg
     3481 cccggcagct tctggagaag gaattcagca accttatctc cttaggcaca gacaggcggc
     3541 tggacgagga cagcgccaag tctttcagcc gctccccatc ctggcggaag atgttccggg
     3601 agaaggacct ccgaggcgta actcccgact cagctgagat gttgcccccc aactttcgtt
     3661 cggctgcagc gggagccctg ggctctccgg ggctccctct ccgcaagctg cagccagaag
     3721 gccagacttc tgggagttcc cgggcagacg gcgtttcggt ccggacctat tcctgctagt
     3781 gcaggcctcc aggtgacctc actcggacgg aagaatcttc ccgaggctgg gctgttccct
     3841 ctcctgcccg gactgtggcc tcgccgggga gagcgggcgg gggagctcgc gccgaggact
     3901 ggaccatctg tacagaccag cgggagtgcg cgcgcccgcc tcgcacaggg ccggggcctg
     3961 gaccaaacca catgaactgg actgagaggg ggaagaagcg gggaggaaga aatcccgccc
     4021 caaacgtccg ctttcctttt ctctactttg taatttattg atcagtttct gttgggagac
     4081 gggtgtcctt tacccgcggg aagggggcgg ggcttccctc ccgggccgca tgcggggaga
     4141 ggctgctccc tccccttttt cctgcccagt cgcggggccc aagtcttcct tcttcgtccg
     4201 aaaggagggg aggggggact cgctgctaca agcctcgccc cctgtgccac tcagctccgc
     4261 cccgccgcgt ccggtcgccg gtcccccggg tcatctgcgg gcgggttccc ctctccctcc
     4321 cccgtgtctc gtgtccccgg ggcctcaccg ccccccgtgc tgtggccgtg tccgtgcccc
     4381 gggggtaggg ggcgcagaat ggcgcttccc cttctcctct ggctccgggg tttgcatggg
     4441 agaatcctct ttccacgatg ccgctgggcg acgtggcgtg ggggcagggg gacggtgggg
     4501 gagccctcgc ccccgactct cggtcggcct ccccgcccca ggcgtcactc agtgatcacg
     4561 ggtaaagaga actgtttcaa aaa
//
