LOCUS       NM_177423               4051 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens PTPRF interacting protein alpha 1 (PPFIA1), transcript
            variant 1, mRNA.
ACCESSION   NM_177423
VERSION     NM_177423.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4051)
  AUTHORS   Pehkonen,H., Filippou,A., Vaananen,J., Lindfors,I., Vanttinen,M.,
            Ianevski,P., Makela,A., Munne,P., Klefstrom,J., Toppila-Salmi,S.,
            Grenman,R., Hagstrom,J., Makitie,A.A., Karhemo,P.R. and Monni,O.
  TITLE     Liprin-alpha1 contributes to oncogenic MAPK signaling by
            counteracting ERK activity
  JOURNAL   Mol Oncol 18 (3), 662-676 (2024)
   PUBMED   38264964
  REMARK    GeneRIF: Liprin-alpha1 contributes to oncogenic MAPK signaling by
            counteracting ERK activity.
REFERENCE   2  (bases 1 to 4051)
  AUTHORS   Gao,Y., Guan,L., Jia,R., Xiao,W., Han,Y., Li,Y., Tang,P., Yu,Z. and
            Zhang,H.
  TITLE     High expression of PPFIA1 in human esophageal squamous cell
            carcinoma correlates with tumor metastasis and poor prognosis
  JOURNAL   BMC Cancer 23 (1), 417 (2023)
   PUBMED   37158817
  REMARK    GeneRIF: High expression of PPFIA1 in human esophageal squamous
            cell carcinoma correlates with tumor metastasis and poor prognosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4051)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4051)
  AUTHORS   Liang,M., Jin,G., Xie,X., Zhang,W., Li,K., Niu,F., Yu,C. and Wei,Z.
  TITLE     Oligomerized liprin-alpha promotes phase separation of ELKS for
            compartmentalization of presynaptic active zone proteins
  JOURNAL   Cell Rep 34 (12), 108901 (2021)
   PUBMED   33761347
  REMARK    GeneRIF: Oligomerized liprin-alpha promotes phase separation of
            ELKS for compartmentalization of presynaptic active zone proteins.
            Erratum:[Cell Rep. 2021 Jul 27;36(4):109476. doi:
            10.1016/j.celrep.2021.109476.. PMID: 34320361]
REFERENCE   5  (bases 1 to 4051)
  AUTHORS   Clapero,F., Tortarolo,D., Valdembri,D. and Serini,G.
  TITLE     Quantifying Polarized Extracellular Matrix Secretion in Cultured
            Endothelial Cells
  JOURNAL   Methods Mol Biol 2217, 301-311 (2021)
   PUBMED   33215388
  REMARK    GeneRIF: Quantifying Polarized Extracellular Matrix Secretion in
            Cultured Endothelial Cells.
REFERENCE   6  (bases 1 to 4051)
  AUTHORS   Ko,J., Kim,S., Valtschanoff,J.G., Shin,H., Lee,J.R., Sheng,M.,
            Premont,R.T., Weinberg,R.J. and Kim,E.
  TITLE     Interaction between liprin-alpha and GIT1 is required for AMPA
            receptor targeting
  JOURNAL   J Neurosci 23 (5), 1667-1677 (2003)
   PUBMED   12629171
REFERENCE   7  (bases 1 to 4051)
  AUTHORS   Wyszynski,M., Kim,E., Dunah,A.W., Passafaro,M., Valtschanoff,J.G.,
            Serra-Pages,C., Streuli,M., Weinberg,R.J. and Sheng,M.
  TITLE     Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA
            receptor targeting
  JOURNAL   Neuron 34 (1), 39-52 (2002)
   PUBMED   11931740
REFERENCE   8  (bases 1 to 4051)
  AUTHORS   Serra-Pages,C., Medley,Q.G., Tang,M., Hart,A. and Streuli,M.
  TITLE     Liprins, a family of LAR transmembrane protein-tyrosine
            phosphatase-interacting proteins
  JOURNAL   J Biol Chem 273 (25), 15611-15620 (1998)
   PUBMED   9624153
REFERENCE   9  (bases 1 to 4051)
  AUTHORS   Pulido,R., Serra-Pages,C., Tang,M. and Streuli,M.
  TITLE     The LAR/PTP delta/PTP sigma subfamily of transmembrane
            protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and
            PTP sigma isoforms are expressed in a tissue-specific manner and
            associate with the LAR-interacting protein LIP.1
  JOURNAL   Proc Natl Acad Sci U S A 92 (25), 11686-11690 (1995)
   PUBMED   8524829
REFERENCE   10 (bases 1 to 4051)
  AUTHORS   Serra-Pages,C., Kedersha,N.L., Fazikas,L., Medley,Q., Debant,A. and
            Streuli,M.
  TITLE     The LAR transmembrane protein tyrosine phosphatase and a
            coiled-coil LAR-interacting protein co-localize at focal adhesions
  JOURNAL   EMBO J 14 (12), 2827-2838 (1995)
   PUBMED   7796809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002336.5, AP000487.6 and KC877433.1.
            
            On Jan 23, 2020 this sequence version replaced NM_177423.2.
            
            Summary: The protein encoded by this gene is a member of the LAR
            protein-tyrosine phosphatase-interacting protein (liprin) family.
            Liprins interact with members of LAR family of transmembrane
            protein tyrosine phosphatases, which are known to be important for
            axon guidance and mammary gland development. This protein binds to
            the intracellular membrane-distal phosphatase domain of tyrosine
            phosphatase LAR, and appears to localize LAR to cell focal
            adhesions. This interaction may regulate the disassembly of focal
            adhesion and thus help orchestrate cell-matrix interactions.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) differs in the 3' end, which
            includes a part of the coding region and 3' UTR, as compared to
            variant 2. The resulting protein (isoform a) has a distinct and
            shorter C-terminus, as compared to isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U22815.1, SRR14038194.930459.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AP002336.5         28503-28727
            226-489             AP002336.5         29986-30249
            490-591             AP002336.5         82215-82316
            592-756             AP002336.5         82660-82824
            757-831             AP002336.5         83313-83387
            832-933             AP002336.5         84075-84176
            934-1155            AP002336.5         84410-84631
            1156-1302           AP002336.5         87986-88132
            1303-1437           AP002336.5         89773-89907
            1438-1521           AP002336.5         91283-91366
            1522-1653           AP002336.5         93376-93507
            1654-1716           AP002336.5         95178-95240
            1717-1796           AP002336.5         96187-96266
            1797-1932           AP002336.5         96984-97119
            1933-2156           AP002336.5         101482-101705
            2157-2388           AP002336.5         106002-106233
            2389-2540           AP002336.5         112114-112265
            2541-2713           AP000487.6         53269-53441
            2714-2807           AP000487.6         53791-53884
            2808-2889           KC877433.1         113-194
            2890-3074           KC877433.1         306-490
            3075-3090           AP000487.6         60103-60118
            3091-3266           AP000487.6         69845-70020
            3267-3364           AP000487.6         70107-70204
            3365-3540           AP000487.6         72548-72723
            3541-3609           AP000487.6         74162-74230
            3610-4051           AP000487.6         75660-76101
FEATURES             Location/Qualifiers
     source          1..4051
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.3"
     gene            1..4051
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /note="PTPRF interacting protein alpha 1"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
     exon            1..225
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..3783
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /note="isoform a is encoded by transcript variant 1;
                     Liprin-alpha1; LAR-interacting protein 1; liprin-alpha-1;
                     LIP-1; protein tyrosine phosphatase receptor type f
                     polypeptide-interacting protein alpha-1; protein tyrosine
                     phosphatase, receptor type, f polypeptide (PTPRF),
                     interacting protein (liprin), alpha 1"
                     /codon_start=1
                     /product="liprin-alpha-1 isoform a"
                     /protein_id="NP_803172.1"
                     /db_xref="CCDS:CCDS31628.1"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
                     /translation="MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSML
                     EERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCRE
                     QLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEV
                     LKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTD
                     GVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASL
                     SSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQR
                     EATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVE
                     AELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDT
                     VDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALR
                     AELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDE
                     PSKVQTLNEQDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQAD
                     AHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMSSIP
                     PYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREEVRDDKTTIKCET
                     SPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAP
                     KKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQAEKNR
                     KLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSAL
                     SDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWL
                     PSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYD
                     RKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETF
                     DFSALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSWRKKFRP
                     KDIRGLAAGSAETLPANFRVTSSMSSPSMQPKKMQMDGM"
     exon            226..489
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            490..591
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            592..756
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            757..831
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            832..933
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1155
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1302
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1437
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1521
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1653
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1716
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1796
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1932
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2156
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2388
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2540
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2713
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2807
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2889
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3090
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3091..3266
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3267..3364
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3540
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3609
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3610..4051
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3958..3963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /note="hexamer: AATAAT"
     polyA_site      3978
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /note="major polyA site"
     regulatory      4016..4021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /note="hexamer: AATAAA"
     polyA_site      4051
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
ORIGIN      
        1 agacgccggc gccgcgcagc cgggcccgct cctcctccgc tccgccagtg tccggccgcg
       61 ggccggcctt agtgactggg gcggcgggcc ccggggccgc ggcgtggggc gggcaggcgg
      121 acgccggccg cgggctgctt tcgtcggctc ccaagctctc ccggagcgag cagccgcccg
      181 cgagccgccg cggagcctcc tcgcccgctc ccgccggcga gcaagatgat gtgcgaggtg
      241 atgccgacca tcagcgaagc agaaggcccc cctggaggag gtggaggcca tggttccggc
      301 tccccttcac agccagatgc agattcacat tttgaacagt tgatggtctc catgctagaa
      361 gaaagggacc gccttcttga tacactgaga gagactcaag aaacgctggc cttaacccag
      421 gggaagttac acgaggttgg tcatgaaaga gattccttgc agagacagct caacacggca
      481 cttccacagg agttcgcagc acttactaaa gaactcaatg tatgcaggga acagctcctt
      541 gaaagggaag aagaaattgc tgaactgaaa gcagaaagga ataacaccag gctgctgtta
      601 gagcatttgg aatgccttgt ctccaggcat gagcggtctc ttaggatgac cgtggtgaag
      661 agacaagcgc agtctccagc aggcgtgtcc agcgaagtgg aagtgctgaa agcactgaag
      721 tccttatttg aacaccacaa agctctggat gaaaaggtga gagagcgatt acgagtagca
      781 cttgaaagat gtagtttgtt agaagaggaa ttaggtgcca cacacaaaga gctaatgatt
      841 cttaaagaac agaataatca gaaaaaaact ctaacagatg gagtgctgga cataaaccat
      901 gaacaagaaa atacaccaag cacgagtgga aagagatctt ctgatggttc tttaagccac
      961 gaggaagacc ttgctaaagt aattgagctc caagaaatca taagtaagca gtcaagggaa
     1021 cagagccaaa tgaaagaacg cctggcttcc ctttccagtc atgtgacaga actggaagag
     1081 gatctggaca cggctagaaa agatctcatc aaatctgaag aaatgaacac aaaattgcaa
     1141 cgagatgtcc gtgaagccat ggcccaaaag gaagatatgg aagagagaat cactactctt
     1201 gaaaaacgct acctcgctgc acagcgtgaa gccacatctg tgcatgacct caatgataaa
     1261 cttgaaaatg aaattgcaaa taaagattct atgcatcgac agactgaaga taaaaaccgc
     1321 cagttacagg agcgcttgga attggcagag caaaagctgc aacagacact gaggaaggca
     1381 gagacgctcc cggaggtgga ggcggagctg gcccagaggg tggcagcgct ttccaaggct
     1441 gaagagagac acggcaacat tgaagaaagg ttacgacaga tggaagcaca gttggaggag
     1501 aagaatcaag aactgcagcg ggcaaggcaa agagaaaaaa tgaacgaaga acataataaa
     1561 cgtttatcag acactgttga caagctgctt tcagaatcta atgagaggct tcaacttcat
     1621 cttaaagaga gaatggctgc tttggaagat aagaactctc ttttaagaga agttgaaagt
     1681 gcaaaaaagc agttagaaga aacacaacac gataaggatc agcttgtcct aaacattgaa
     1741 gcactgaggg ctgaactaga ccacatgaga ctaagaggtg cttcacttca tcatggccga
     1801 ccccacttgg gcagtgtccc agatttcagg ttccccatgg cagacggcca cacagactcc
     1861 tacagcacca gtgcagtgct gcggcgccca cagaaaggcc ggctggcagc cctgcgagat
     1921 gagccttcca aggtacaaac tcttaatgag caggattggg aacgtgccca gcaagctagt
     1981 gtcttggcaa atgtagcaca agcattcgag agtgatgctg acgtgtctga tggtgaagat
     2041 gacagggaca ctctcctcag ctcagttgac ctgctatcgc ccagcgggca ggccgacgcg
     2101 cacacactag ccatgatgct tcaggagcag ctggacgcca tcaacaaaga gatcaggttg
     2161 attcaggaag aaaaagaaaa tacagagcag cgggcagagg agattgaaag tcgagttggc
     2221 agtggaagtc tagacaatct tggtcgtttt agatcaatga gctccattcc cccctaccct
     2281 gcttcctcgc ttgctagctc ctcccctccg ggcagtgggc gctccacccc acgaaggatc
     2341 cctcacagcc cagctcggga agtggacaga ctgggcgtca tgaccctttt gccaccttcc
     2401 agagaagagg tacgagatga caagacaacc ataaagtgtg aaacctcccc gccttcctcc
     2461 ccgagagccc ttcggttaga ccggctgcac aaaggggcgc tgcacaccgt cagccacgag
     2521 gacatcaggg acataaggaa ctccacaggc tcccaggatg gtcccgtgag caaccccagc
     2581 agtagcaaca gtagccagga ctcgctccac aaagccccaa agaagaaagg cattaagtcc
     2641 tccattggcc gcttgtttgg caagaaagaa aagggccgac ctggacaaac tggcaaagaa
     2701 gcattaggac aagctggtgt ttccgagacg gataactcat ctcaggatgc cttgggactt
     2761 agcaaattgg ggggacaggc tgaaaaaaat cgtaaacttc aaaaaaagca tgaattgctg
     2821 gaggaagccc ggagacaagg tttacctttt gcccaatggg acgggccaac ggttgtggtc
     2881 tggctagagc tctgggttgg gatgccagcc tggtatgtgg ctgcctgccg agcaaacgtg
     2941 aaaagcgggg ccatcatgtc ggccctgtcc gacacagaga tccagcgtga gattggcatc
     3001 agcaaccccc tgcacaggct gaagctgagg ctggccatcc aggagatcat gtcgctgacc
     3061 agcccgtctg ccccgcccac atctagaacg acactcgcct atggggacat gaaccacgag
     3121 tggatcggca acgagtggct ccccagcctg ggcctccccc agtaccgcag ctacttcatg
     3181 gagtgccttg tagacgccag gatgctggac cacttgacca agaaagacct tcgagggcag
     3241 ctgaaaatgg tcgacagttt tcacagaaac agtttccagt gtggaattat gtgcctgaga
     3301 aggttaaatt atgaccggaa agaactggaa agaaaaagag aagaaagtca gagtgaaata
     3361 aaagacgtgc ttgtttggag caatgatcga gtgattcgct ggatcctgtc aattggcctt
     3421 aaagaatatg caaacaatct tatagagagt ggtgttcacg gagcacttct ggccttagat
     3481 gaaaccttcg acttcagtgc actggcactg ctgttacaga tcccgacgca gaacacacag
     3541 gctcgtgctg tcttggaaag agaatttaac aaccttttgg tcatggggac tgatagaagg
     3601 tttgatgaag atgatgataa aagctttagg agagcacctt catggagaaa aaagtttaga
     3661 ccaaaggaca ttcgtggctt agctgctggg tcagcagaga ctctccctgc aaacttccgg
     3721 gtgacttctt ctatgtcttc cccctctatg cagccaaaga agatgcagat ggacggtatg
     3781 tgatgggtca cactaacctg tcacttgttg ggagcatgag cagctttctg tctggaacat
     3841 taataatgat ctaaaacggc ctatttaata tgttacaagg cacttgagta tggttgcatg
     3901 tccaaatata aatgttttta aattaactct aacatttgtt tataaaagtt taaccataat
     3961 aatagaattt ttaaaacacg cttgtctggt tgaatcttag catatttttc caactaataa
     4021 agctcagtat tcgtctgtgt tctcagagag a
//
