LOCUS       NM_001256597            1358 bp    mRNA    linear   PRI 12-FEB-2024
DEFINITION  Homo sapiens pancreatic progenitor cell differentiation and
            proliferation factor like (PPDPFL), transcript variant 3, mRNA.
ACCESSION   NM_001256597
VERSION     NM_001256597.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1358)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA900243.1, BC017981.1 and AC044893.5.
            
            On Jun 2, 2019 this sequence version replaced NM_001256597.1.
            
            Transcript Variant: This variant (3) uses an alternate splice site
            in the 3' coding region, which results in a frameshift, compared to
            variant 1. It encodes isoform b, which has a longer and distinct
            C-terminus, compared to isoform a. Variants 2 and 3 encode the same
            isoform (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.36284.1, BF670419.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000522267.6/ ENSP00000428773.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-567               DA900243.1         4-570
            568-924             BC017981.1         481-837
            925-925             AC044893.5         110347-110347
            926-1348            BC017981.1         839-1261
            1349-1358           AC044893.5         110771-110780
FEATURES             Location/Qualifiers
     source          1..1358
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.21"
     gene            1..1358
                     /gene="PPDPFL"
                     /gene_synonym="C8orf22"
                     /note="pancreatic progenitor cell differentiation and
                     proliferation factor like"
                     /db_xref="GeneID:492307"
                     /db_xref="HGNC:HGNC:31745"
     exon            1..139
                     /gene="PPDPFL"
                     /gene_synonym="C8orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            140..238
                     /gene="PPDPFL"
                     /gene_synonym="C8orf22"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..438
                     /gene="PPDPFL"
                     /gene_synonym="C8orf22"
                     /note="isoform b is encoded by transcript variant 3;
                     pancreatic progenitor cell differentiation and
                     proliferation factor-like protein; exocrine
                     differentiation and proliferation factor-like protein"
                     /codon_start=1
                     /product="pancreatic progenitor cell differentiation and
                     proliferation factor-like protein isoform b"
                     /protein_id="NP_001243526.1"
                     /db_xref="CCDS:CCDS59102.1"
                     /db_xref="GeneID:492307"
                     /db_xref="HGNC:HGNC:31745"
                     /translation="MASVPSIGCLLARNQYYRKSSVSSVSSLTSSDSVNFIDDDKPQQ
                     GLPEVAESTWWFKSFFHSEPVLSNVRIKDLSATGLQMSTL"
     exon            239..316
                     /gene="PPDPFL"
                     /gene_synonym="C8orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            317..416
                     /gene="PPDPFL"
                     /gene_synonym="C8orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            417..1358
                     /gene="PPDPFL"
                     /gene_synonym="C8orf22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      842..847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPDPFL"
                     /gene_synonym="C8orf22"
                     /note="hexamer: ATTAAA"
     polyA_site      867
                     /gene="PPDPFL"
                     /gene_synonym="C8orf22"
                     /note="major polyA site"
     regulatory      1335..1340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPDPFL"
                     /gene_synonym="C8orf22"
                     /note="hexamer: AATAAA"
     polyA_site      1358
                     /gene="PPDPFL"
                     /gene_synonym="C8orf22"
ORIGIN      
        1 acggacctac cactggccct gcgtatgtgg tgcagcctct cttcaatccc taagaactgg
       61 ttctttcaaa gcatgtattt tctgaagaaa ctttagaacc acgtttattt taaaagaacg
      121 aattggagaa aacaaatcga ttaatgctca cagcttcttg ggtgctttct cacgggtaaa
      181 gccatggcat ccgtaccttc cattggttgc cttctagcca gaaatcagta ttatcgaaag
      241 tccagtgttt cttcagttag ttctttaact agctctgatt ctgttaactt catagatgac
      301 gacaaaccac agcaagggtt gcctgaagtg gcagaatcca cctggtggtt taaatcgttt
      361 ttccattctg aacctgtgct ttcaaatgtg agaataaaag atctgtctgc tactggatta
      421 cagatgagca ctttgtagct gatcatcttt gcactgccat ttgatgaaca tgttggtaac
      481 ggttgcctgc cttatgtagc atgaacagtt gattctgaca atcaagatcc tctgcctgct
      541 gcagtggtcc atacatgaac agctcccctt cagcgcccca gctattccag gactcttctc
      601 cattgtaaga agacagaaat gtgtctgaga tctcatttat gagacaagat cacagcagcc
      661 actgatataa aaaaagttta ggcatttttc tcaacacaaa gactatcgct ggaagtggca
      721 cttgctacct ggtgcatctt tgaaaagtgt gcctttagaa acaagacacc cttttaaagt
      781 aatatgtctt caaatgttgt gacttacata aagtagctct ttcatttttt atatcatttt
      841 tattaaaaaa acttaagtta gactcttttt ctgtctgttg agtgatttat ttattatgcc
      901 ttaaaactga cttgtcaatg tttcacataa tggtttaaag ggcattgaat tcgaaatttt
      961 agaaaataat tgtaaaaatt caattttttt aaaagaatga aggttggaaa tagcatatgt
     1021 atcattaagt atattagagc taatcaattg gtcattgtat agactttaaa atttatgact
     1081 ttaaataata tttaataaca tggaaaatta tattatggca ttaaaaatta gcataataca
     1141 ccatatatgg tacaatcgta gttgtattaa aaagttacat atgcataaag atagactgga
     1201 aggaactgta ccaaaatgct gacagggcta tttctggaga tgggattatg ggcgtttttc
     1261 attctctttt taatatattt ttccatatct cccaattttt ctaatatgac aagtattgtg
     1321 cgtaattaga aaataataaa tgttaatata aaaaagca
//
