LOCUS       NM_024299                827 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens pancreatic progenitor cell differentiation and
            proliferation factor (PPDPF), transcript variant 1, mRNA.
ACCESSION   NM_024299
VERSION     NM_024299.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 827)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 827)
  AUTHORS   Ma,N., Wang,Y.K., Xu,S., Ni,Q.Z., Zheng,Q.W., Zhu,B., Cao,H.J.,
            Jiang,H., Zhang,F.K., Yuan,Y.M., Zhang,E.B., Chen,T.W., Xia,J.,
            Ding,X.F., Chen,Z.H., Zhang,X.P., Wang,K., Cheng,S.Q., Qiu,L.,
            Li,Z.G., Yu,Y.C., Wang,X.F., Zhou,B., Li,J.J. and Xie,D.
  TITLE     PPDPF alleviates hepatic steatosis through inhibition of mTOR
            signaling
  JOURNAL   Nat Commun 12 (1), 3059 (2021)
   PUBMED   34031390
  REMARK    GeneRIF: PPDPF alleviates hepatic steatosis through inhibition of
            mTOR signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 827)
  AUTHORS   Geusz,R.J., Wang,A., Chiou,J., Lancman,J.J., Wetton,N.,
            Kefalopoulou,S., Wang,J., Qiu,Y., Yan,J., Aylward,A., Ren,B.,
            Dong,P.D.S., Gaulton,K.J. and Sander,M.
  TITLE     Pancreatic progenitor epigenome maps prioritize type 2 diabetes
            risk genes with roles in development
  JOURNAL   Elife 10, e59067 (2021)
   PUBMED   33544077
  REMARK    GeneRIF: Pancreatic progenitor epigenome maps prioritize type 2
            diabetes risk genes with roles in development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 827)
  AUTHORS   Liu,G., Shi,H., Deng,L., Zheng,H., Kong,W., Wen,X. and Bi,H.
  TITLE     Circular RNA circ-FOXM1 facilitates cell progression as ceRNA to
            target PPDPF and MACC1 by sponging miR-1304-5p in non-small cell
            lung cancer
  JOURNAL   Biochem Biophys Res Commun 513 (1), 207-212 (2019)
   PUBMED   30954221
  REMARK    GeneRIF: Circ-FOXM1 upregulated the level of pancreatic progenitor
            cell differentiation and proliferation factor (PPDPF) and
            metastasis-associated in colon cancer 1 (MACC1) by sponging
            miR-1304-5p, thereby increasing the proliferation and invasion of
            non-small cell lung cancer cells.
REFERENCE   5  (bases 1 to 827)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   6  (bases 1 to 827)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP325433.1, BC002531.2 and AL121829.30.
            
            On Nov 22, 2018 this sequence version replaced NM_024299.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279833.2717.1, BX442668.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370179.8/ ENSP00000359198.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BP325433.1         25-39
            16-792              BC002531.2         1-777
            793-827             AL121829.30        51177-51211
FEATURES             Location/Qualifiers
     source          1..827
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..827
                     /gene="PPDPF"
                     /gene_synonym="C20orf149; dJ697K14.9; exdpf"
                     /note="pancreatic progenitor cell differentiation and
                     proliferation factor"
                     /db_xref="GeneID:79144"
                     /db_xref="HGNC:HGNC:16142"
     exon            1..130
                     /gene="PPDPF"
                     /gene_synonym="C20orf149; dJ697K14.9; exdpf"
                     /inference="alignment:Splign:2.1.0"
     exon            131..210
                     /gene="PPDPF"
                     /gene_synonym="C20orf149; dJ697K14.9; exdpf"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..500
                     /gene="PPDPF"
                     /gene_synonym="C20orf149; dJ697K14.9; exdpf"
                     /note="isoform 1 is encoded by transcript variant 1;
                     exocrine differentiation and proliferation factor;
                     pancreatic progenitor cell differentiation and
                     proliferation factor homolog"
                     /codon_start=1
                     /product="pancreatic progenitor cell differentiation and
                     proliferation factor isoform 1"
                     /protein_id="NP_077275.1"
                     /db_xref="CCDS:CCDS13523.1"
                     /db_xref="GeneID:79144"
                     /db_xref="HGNC:HGNC:16142"
                     /translation="MAAIPSSGSLVATHDYYRRRLGSTSSNSSCSSTECPGEAIPHPP
                     GLPKADPGHWWASFFFGKSTLPFMATVLESAEHSEPPQASSSMTACGLARDAPRKQPG
                     GQSSTASAGPPS"
     exon            211..288
                     /gene="PPDPF"
                     /gene_synonym="C20orf149; dJ697K14.9; exdpf"
                     /inference="alignment:Splign:2.1.0"
     exon            289..827
                     /gene="PPDPF"
                     /gene_synonym="C20orf149; dJ697K14.9; exdpf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      764..769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPDPF"
                     /gene_synonym="C20orf149; dJ697K14.9; exdpf"
                     /note="hexamer: AATAAA"
     polyA_site      785
                     /gene="PPDPF"
                     /gene_synonym="C20orf149; dJ697K14.9; exdpf"
                     /note="major polyA site"
     polyA_site      827
                     /gene="PPDPF"
                     /gene_synonym="C20orf149; dJ697K14.9; exdpf"
ORIGIN      
        1 accccgcgcg cgcctctctg tcgtggcgcg gcttcccgcg gtcttctctg caaatgggct
       61 ccgtggccta gcgcccccgt ccccgccacc cgtgatcgtg cgccgaggcc cgcgaggggt
      121 cgccgcccag atcccaccag ccagcaagct aaagcatggc ggccatcccc tccagcggct
      181 cgctcgtggc cacccacgac tactaccggc gccgcctggg ttccacttcc agcaacagct
      241 cctgcagcag taccgagtgc cccggggaag ccattcccca ccccccaggt ctccccaagg
      301 ctgacccggg tcattggtgg gccagcttct ttttcgggaa gtccaccctc ccgttcatgg
      361 ccacggtgtt ggagtccgca gagcactcgg aacctcccca ggcctccagc agcatgaccg
      421 cctgtggcct ggctcgggac gccccgagga agcagcccgg cggtcagtcc agcacagcca
      481 gcgctgggcc cccgtcctga cctgagcggt taccaccagc cccaggcctg cggaggcgct
      541 agtccaccag agcccctccc cgcccctctc cccactccgc atccctcgcc cccctcccca
      601 cctcccaccc cccaccctgt aaactaggcg gctgcagcaa gcagaccttc gcatcaacac
      661 agcagacacc aaaaaccagt gagagccccg ctctctaccg cccggcccca gcactcgcta
      721 gctttcctga cacctggaac tgtgcacctg gcaccaagcg gaaaataaac tccaagcagc
      781 cagtagcccc gatggtgtgt gcctgagctg tgtggcccga ggttcca
//
