LOCUS       NM_021823               2215 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens phosphopantothenoylcysteine decarboxylase (PPCDC),
            transcript variant 1, mRNA.
ACCESSION   NM_021823
VERSION     NM_021823.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2215)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2215)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2215)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2215)
  AUTHORS   Abrie,J.A., Molero,C., Arino,J. and Strauss,E.
  TITLE     Complex stability and dynamic subunit interchange modulates the
            disparate activities of the yeast moonlighting proteins Hal3 and
            Vhs3
  JOURNAL   Sci Rep 5, 15774 (2015)
   PUBMED   26514574
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2215)
  AUTHORS   Evans,D.M., Zhu,G., Dy,V., Heath,A.C., Madden,P.A., Kemp,J.P.,
            McMahon,G., St Pourcain,B., Timpson,N.J., Golding,J., Lawlor,D.A.,
            Steer,C., Montgomery,G.W., Martin,N.G., Smith,G.D. and
            Whitfield,J.B.
  TITLE     Genome-wide association study identifies loci affecting blood
            copper, selenium and zinc
  JOURNAL   Hum Mol Genet 22 (19), 3998-4006 (2013)
   PUBMED   23720494
REFERENCE   6  (bases 1 to 2215)
  AUTHORS   Cornelis,M.C., Monda,K.L., Yu,K., Paynter,N., Azzato,E.M.,
            Bennett,S.N., Berndt,S.I., Boerwinkle,E., Chanock,S.,
            Chatterjee,N., Couper,D., Curhan,G., Heiss,G., Hu,F.B.,
            Hunter,D.J., Jacobs,K., Jensen,M.K., Kraft,P., Landi,M.T.,
            Nettleton,J.A., Purdue,M.P., Rajaraman,P., Rimm,E.B., Rose,L.M.,
            Rothman,N., Silverman,D., Stolzenberg-Solomon,R., Subar,A.,
            Yeager,M., Chasman,D.I., van Dam,R.M. and Caporaso,N.E.
  TITLE     Genome-wide meta-analysis identifies regions on 7p21 (AHR) and
            15q24 (CYP1A2) as determinants of habitual caffeine consumption
  JOURNAL   PLoS Genet 7 (4), e1002033 (2011)
   PUBMED   21490707
REFERENCE   7  (bases 1 to 2215)
  AUTHORS   Strauss,E., Zhai,H., Brand,L.A., McLafferty,F.W. and Begley,T.P.
  TITLE     Mechanistic studies on phosphopantothenoylcysteine decarboxylase:
            trapping of an enethiolate intermediate with a mechanism-based
            inactivating agent
  JOURNAL   Biochemistry 43 (49), 15520-15533 (2004)
   PUBMED   15581364
REFERENCE   8  (bases 1 to 2215)
  AUTHORS   Manoj,N. and Ealick,S.E.
  TITLE     Unusual space-group pseudosymmetry in crystals of human
            phosphopantothenoylcysteine decarboxylase
  JOURNAL   Acta Crystallogr D Biol Crystallogr 59 (Pt 10), 1762-1766 (2003)
   PUBMED   14501115
REFERENCE   9  (bases 1 to 2215)
  AUTHORS   Daugherty,M., Polanuyer,B., Farrell,M., Scholle,M., Lykidis,A., de
            Crecy-Lagard,V. and Osterman,A.
  TITLE     Complete reconstitution of the human coenzyme A biosynthetic
            pathway via comparative genomics
  JOURNAL   J Biol Chem 277 (24), 21431-21439 (2002)
   PUBMED   11923312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF243417.1, AY358848.1, DW437029.1 and BC005877.2.
            
            On Nov 23, 2018 this sequence version replaced NM_021823.4.
            
            Summary: Biosynthesis of coenzyme A (CoA) from pantothenic acid
            (vitamin B5) is an essential universal pathway in prokaryotes and
            eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this
            pathway, converts phosphopantothenoylcysteine to
            4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed
            11923312]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027491.1, SRR1660809.231467.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342932.8/ ENSP00000343190.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BF243417.1         37-45
            10-342              AY358848.1         1-333
            343-459             DW437029.1         134-250
            460-1229            AY358848.1         451-1220
            1230-2215           BC005877.2         27-1012
FEATURES             Location/Qualifiers
     source          1..2215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.2"
     gene            1..2215
                     /gene="PPCDC"
                     /gene_synonym="coaC; MDS018; PPC-DC"
                     /note="phosphopantothenoylcysteine decarboxylase"
                     /db_xref="GeneID:60490"
                     /db_xref="HGNC:HGNC:28107"
                     /db_xref="MIM:609854"
     exon            1..37
                     /gene="PPCDC"
                     /gene_synonym="coaC; MDS018; PPC-DC"
                     /inference="alignment:Splign:2.1.0"
     exon            38..244
                     /gene="PPCDC"
                     /gene_synonym="coaC; MDS018; PPC-DC"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..724
                     /gene="PPCDC"
                     /gene_synonym="coaC; MDS018; PPC-DC"
                     /EC_number="4.1.1.36"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="phosphopantothenoylcysteine decarboxylase
                     isoform a"
                     /protein_id="NP_068595.3"
                     /db_xref="CCDS:CCDS10275.1"
                     /db_xref="GeneID:60490"
                     /db_xref="HGNC:HGNC:28107"
                     /db_xref="MIM:609854"
                     /translation="MEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIP
                     GLEVAVVTTERAKHFYSPQDIPVTLYSDADEWEIWKSRSDPVLHIDLRRWADLLLVAP
                     LDANTLGKVASGICDNLLTCVMRAWDRSKPLLFCPAMNTAMWEHPITAQQVDQLKAFG
                     YVEIPCVAKKLVCGDEGLGAMAEVGTIVDKVKEVLFQHSGFQQS"
     exon            245..340
                     /gene="PPCDC"
                     /gene_synonym="coaC; MDS018; PPC-DC"
                     /inference="alignment:Splign:2.1.0"
     exon            341..469
                     /gene="PPCDC"
                     /gene_synonym="coaC; MDS018; PPC-DC"
                     /inference="alignment:Splign:2.1.0"
     exon            470..638
                     /gene="PPCDC"
                     /gene_synonym="coaC; MDS018; PPC-DC"
                     /inference="alignment:Splign:2.1.0"
     exon            639..2215
                     /gene="PPCDC"
                     /gene_synonym="coaC; MDS018; PPC-DC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1210..1215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPCDC"
                     /gene_synonym="coaC; MDS018; PPC-DC"
                     /note="hexamer: AATAAA"
     polyA_site      1229
                     /gene="PPCDC"
                     /gene_synonym="coaC; MDS018; PPC-DC"
                     /note="major polyA site"
     regulatory      2193..2198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPCDC"
                     /gene_synonym="coaC; MDS018; PPC-DC"
                     /note="hexamer: AATAAA"
     polyA_site      2215
                     /gene="PPCDC"
                     /gene_synonym="coaC; MDS018; PPC-DC"
ORIGIN      
        1 gatatttggg agcggccccg agacgcgcct ggcgcggatc ctaaatcccg acagctttat
       61 agagcccagg cctggcaggc tcccagaact tgaagccacc agaccccaca tggaaccaaa
      121 ggcctcctgt ccagctgctg cacccttgat ggagagaaaa ttccatgttc ttgtgggtgt
      181 cacggggagt gtcgcagccc tgaagttgcc tcttctggtg tcaaagcttt tggacattcc
      241 tgggctggaa gtagcagtgg tcacaactga gagagccaaa catttctaca gcccccagga
      301 cattcctgtc accctctaca gcgacgctga tgaatgggag atatggaaga gccgctctga
      361 cccagttctg cacattgacc tgcggaggtg ggcagacctc ctgctggtgg ctcctcttga
      421 tgccaacact ctggggaagg tggccagtgg catctgtgac aacttgctta cctgcgtcat
      481 gcgggcctgg gaccgcagca agcccctgct cttctgcccg gccatgaaca ccgccatgtg
      541 ggagcacccg atcacagcgc agcaggtaga ccagctcaag gcctttggct atgtcgagat
      601 cccctgtgtg gccaagaagc tggtgtgcgg agatgaaggt ctcggggcca tggctgaagt
      661 ggggaccatc gtggacaaag tgaaagaagt cctcttccag cacagtggct tccagcagag
      721 ttgacctggg atttctgtca tgggtgtccc tctgtactca gaatgggttc aggccaagtc
      781 ggtgaagatg gatgttggca aaataggagg ataccctcat ttgctgaatg ggggacctgc
      841 tctgagcctg cccaggggcc aggcctgctc caggttaaac tggacggaag gcccaggtct
      901 cagtttcttt caaccaggag aggccgctgc ctagagcccc tccccacctt ttcctggatg
      961 ggtgaggcaa gccaggagag caagcagtgt tgtcctcacg ggaggaggac tgagcgactg
     1021 ggaaaactcg gctctacatc tcacccagaa cggcttttag aaacaccaca gctggagagt
     1081 cctggctgag ccttgggagt ttcagctctt tggcggggtg cccaggtgcc atgcgatcag
     1141 cgaagcctgc gagttggcag gactctgagg tttcctgcag accatgccat gagattgaag
     1201 gtgcggggaa ataaagaaaa atcaccattt aggagactcc attctttccc tacaacccag
     1261 ctgtggtccc agagatcagg gggtgttgcc aggtgtggct ggggaagggt ctgggttcac
     1321 aactcaccgg cactctttag tccccgtata acatggtggt taaggataaa gatctgaagc
     1381 cagacagccc ctagttccaa tcccagctct gccgcttact agcagtggca gtttggttca
     1441 ggacttagcc ttcctgacct tcacttacct cagctatctt gttatcctac cctcagggag
     1501 ttgttgagag gattcagtga aattttgtgt gcagaatacc catgccactg agtgcctgga
     1561 acgtagtaaa tgtcaaatca atggaagtta aaactaggca tgcatatatg ccagagagct
     1621 ttcctagcat ttactgcaat gccctgtctc attttgggaa aaaggaaatc ctggatgcta
     1681 agttgacaca tccctttatg caagtgacag gtaagcagcc aggagggttg accctgccct
     1741 gggtcccagg cctcttgcct gcttcttggt ttcctctgtt ctcatccttt cagctttgct
     1801 ggacctgagg caggggcctg ggtgtctgtg cctccctacc ccccagtaca catgaccaag
     1861 ggaagtagat ccagagacac catgcactct ggcccagaaa ccctctgcta cccagctttt
     1921 gacttaattg ccatttggtg tggctgcagc ggggagggct tgtctgcgta tttggagctg
     1981 aggctgaggc tggcttcctg ccctctggct tccaggccag gtgtgaggga catcccatgt
     2041 gggctctgag agcactgaga gtagaggtgc cttgagggga ccaggaagcc tactggctgg
     2101 aatcagtgct ccagcagcct ccacagcctt tatctcaaca gcacttgact tcaccaggtg
     2161 accctttggg ataaaattgc cttagggtat gaaataaact ataactaaaa tggta
//
