LOCUS       NM_002704               1307 bp    mRNA    linear   PRI 11-MAY-2023
DEFINITION  Homo sapiens pro-platelet basic protein (PPBP), mRNA.
ACCESSION   NM_002704
VERSION     NM_002704.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1307)
  AUTHORS   Dada AO, Dada OA, Akinbami AA, Bamiro AR, Uche IE, Adeyemi OI,
            Kareem OA, Okunowo OB and Dosu MR.
  TITLE     An Evaluation of Platelet Factor 4, Beta-Thromboglobulin and Mean
            Platelet Volume in the Assessment of Thrombotic Risks in Subjects
            with Diabetes Mellitus at Lagos State University Teaching Hospital,
            Ikeja, Lagos, Nigeria
  JOURNAL   West Afr J Med 40 (4), 357-361 (2023)
   PUBMED   37115730
  REMARK    GeneRIF: An Evaluation of Platelet Factor 4, Beta-Thromboglobulin
            and Mean Platelet Volume in the Assessment of Thrombotic Risks in
            Subjects with Diabetes Mellitus at Lagos State University Teaching
            Hospital, Ikeja, Lagos, Nigeria.
REFERENCE   2  (bases 1 to 1307)
  AUTHORS   Bandow K, Smith A, Watkins T, Shenk S, Gerami-Naini B and Garlick
            JA.
  TITLE     CC chemokine ligand 20 (CCL20) positively regulates collagen type I
            production in 3D skin equivalent tissues
  JOURNAL   Exp Dermatol 32 (4), 379-391 (2023)
   PUBMED   36398464
REFERENCE   3  (bases 1 to 1307)
  AUTHORS   Liu Z, Wang Y, Ding Y, Wang H, Zhang J and Wang H.
  TITLE     CXCL7 aggravates the pathological manifestations of neuromyelitis
            optica spectrum disorder by enhancing the inflammatory infiltration
            of neutrophils, macrophages and microglia
  JOURNAL   Clin Immunol 245, 109139 (2022)
   PUBMED   36184052
  REMARK    GeneRIF: CXCL7 aggravates the pathological manifestations of
            neuromyelitis optica spectrum disorder by enhancing the
            inflammatory infiltration of neutrophils, macrophages and
            microglia.
REFERENCE   4  (bases 1 to 1307)
  AUTHORS   Mansanguan C and Maneerat Y.
  TITLE     PPBP gene as a biomarker for coronary heart disease risk in
            postmenopausal Thai women
  JOURNAL   PeerJ 10, e13615 (2022)
   PUBMED   35734636
  REMARK    GeneRIF: PPBP gene as a biomarker for coronary heart disease risk
            in postmenopausal Thai women.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1307)
  AUTHORS   Graham RLJ, McMullen AA, Moore G, Dempsey-Hibbert NC, Myers B and
            Graham C.
  TITLE     SWATH-MS identification of CXCL7, LBP, TGFbeta1 and PDGFRbeta as
            novel biomarkers in human systemic mastocytosis
  JOURNAL   Sci Rep 12 (1), 5087 (2022)
   PUBMED   35332176
  REMARK    GeneRIF: SWATH-MS identification of CXCL7, LBP, TGFbeta1 and
            PDGFRbeta as novel biomarkers in human systemic mastocytosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1307)
  AUTHORS   Krijgsveld J, Zaat SA, Meeldijk J, van Veelen PA, Fang G, Poolman
            B, Brandt E, Ehlert JE, Kuijpers AJ, Engbers GH, Feijen J and
            Dankert J.
  TITLE     Thrombocidins, microbicidal proteins from human blood platelets,
            are C-terminal deletion products of CXC chemokines
  JOURNAL   J Biol Chem 275 (27), 20374-20381 (2000)
   PUBMED   10877842
  REMARK    GeneRIF: The antimicrobial thrombocidin peptides are found in human
            blood platelets, are deletion products of CXC chemokines and have
            antibacterial and antifungal activity.
REFERENCE   7  (bases 1 to 1307)
  AUTHORS   Tunnacliffe A, Majumdar S, Yan B and Poncz M.
  TITLE     Genes for beta-thromboglobulin and platelet factor 4 are closely
            linked and form part of a cluster of related genes on chromosome 4
  JOURNAL   Blood 79 (11), 2896-2900 (1992)
   PUBMED   1316786
REFERENCE   8  (bases 1 to 1307)
  AUTHORS   Kaplan,K.L., Broekman,M.J., Chernoff,A., Lesznik,G.R. and
            Drillings,M.
  TITLE     Platelet alpha-granule proteins: studies on release and subcellular
            localization
  JOURNAL   Blood 53 (4), 604-618 (1979)
   PUBMED   426909
REFERENCE   9  (bases 1 to 1307)
  AUTHORS   Begg,G.S., Pepper,D.S., Chesterman,C.N. and Morgan,F.J.
  TITLE     Complete covalent structure of human beta-thromboglobulin
  JOURNAL   Biochemistry 17 (9), 1739-1744 (1978)
   PUBMED   77677
REFERENCE   10 (bases 1 to 1307)
  AUTHORS   Moore,S., Pepper,D.S. and Cash,J.D.
  TITLE     The isolation and characterisation of a platelet-specific
            beta-globulin (beta-thromboglobulin) and the detection of
            antiurokinase and antiplasmin released from thrombin-aggregated
            washed human platelets
  JOURNAL   Biochim Biophys Acta 379 (2), 360-369 (1975)
   PUBMED   47244
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA419455.1 and AC097709.3.
            
            On May 15, 2010 this sequence version replaced NM_002704.2.
            
            Summary: The protein encoded by this gene is a platelet-derived
            growth factor that belongs to the CXC chemokine family. This growth
            factor is a potent chemoattractant and activator of neutrophils. It
            has been shown to stimulate various cellular processes including
            DNA synthesis, mitosis, glycolysis, intracellular cAMP
            accumulation, prostaglandin E2 secretion, and synthesis of
            hyaluronic acid and sulfated glycosaminoglycan. It also stimulates
            the formation and secretion of plasminogen activator by synovial
            cells. The protein also is an antimicrobial protein with
            bactericidal and antifungal activity. [provided by RefSeq, Nov
            2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA419455.1, DA419328.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2149004,
                                           SAMN03267774 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000296028.4/
                                                  ENSP00000296028.3
            Protein has antimicrobial activity :: PMID: 10877842
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               DA419455.1         1-558
            559-1307            AC097709.3         72388-73136         c
FEATURES             Location/Qualifiers
     source          1..1307
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..1307
                     /gene="PPBP"
                     /gene_synonym="B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII;
                     CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2;
                     TGB; TGB1; THBGB; THBGB1"
                     /note="pro-platelet basic protein"
                     /db_xref="GeneID:5473"
                     /db_xref="HGNC:HGNC:9240"
                     /db_xref="MIM:121010"
     exon            1..235
                     /gene="PPBP"
                     /gene_synonym="B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII;
                     CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2;
                     TGB; TGB1; THBGB; THBGB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..474
                     /gene="PPBP"
                     /gene_synonym="B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII;
                     CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2;
                     TGB; TGB1; THBGB; THBGB1"
                     /note="beta-thromboglobulin; CXC chemokine ligand 7; small
                     inducible cytokine subfamily B, member 7; thromboglobulin,
                     beta-1; thrombocidin 1; thrombocidin 2; small inducible
                     cytokine B7; low-affinity platelet factor IV; connective
                     tissue-activating peptide III; neutrophil-activating
                     peptide 2; leukocyte-derived growth factor;
                     macrophage-derived growth factor; chemokine (C-X-C motif)
                     ligand 7; platelet basic protein; C-X-C motif chemokine 7"
                     /codon_start=1
                     /product="platelet basic protein preproprotein"
                     /protein_id="NP_002695.1"
                     /db_xref="CCDS:CCDS3563.1"
                     /db_xref="GeneID:5473"
                     /db_xref="HGNC:HGNC:9240"
                     /db_xref="MIM:121010"
                     /translation="MSLRLDTTPSCNSARPLHALQVLLLLSLLLTALASSTKGQTKRN
                     LAKGKEESLDSDLYAELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGR
                     KICLDPDAPRIKKIVQKKLAGDESAD"
     exon            236..371
                     /gene="PPBP"
                     /gene_synonym="B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII;
                     CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2;
                     TGB; TGB1; THBGB; THBGB1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..1307
                     /gene="PPBP"
                     /gene_synonym="B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII;
                     CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2;
                     TGB; TGB1; THBGB; THBGB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      579..584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPBP"
                     /gene_synonym="B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII;
                     CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2;
                     TGB; TGB1; THBGB; THBGB1"
                     /note="hexamer: ATTAAA"
     polyA_site      602
                     /gene="PPBP"
                     /gene_synonym="B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII;
                     CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2;
                     TGB; TGB1; THBGB; THBGB1"
                     /note="major polyA site"
     regulatory      672..677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPBP"
                     /gene_synonym="B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII;
                     CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2;
                     TGB; TGB1; THBGB; THBGB1"
                     /note="hexamer: AATAAG"
     polyA_site      696
                     /gene="PPBP"
                     /gene_synonym="B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII;
                     CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2;
                     TGB; TGB1; THBGB; THBGB1"
                     /note="major polyA site"
     regulatory      1289..1294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPBP"
                     /gene_synonym="B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII;
                     CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2;
                     TGB; TGB1; THBGB; THBGB1"
                     /note="hexamer: AATAAA"
     polyA_site      1307
                     /gene="PPBP"
                     /gene_synonym="B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII;
                     CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2;
                     TGB; TGB1; THBGB; THBGB1"
ORIGIN      
        1 acttatctgc agacttgtag gcagcaactc accctcactc agaggtcttc tggttctgga
       61 aacaactcta gctcagcctt ctccaccatg agcctcagac ttgataccac cccttcctgt
      121 aacagtgcga gaccacttca tgccttgcag gtgctgctgc ttctgtcatt gctgctgact
      181 gctctggctt cctccaccaa aggacaaact aagagaaact tggcgaaagg caaagaggaa
      241 agtctagaca gtgacttgta tgctgaactc cgctgcatgt gtataaagac aacctctgga
      301 attcatccca aaaacatcca aagtttggaa gtgatcggga aaggaaccca ttgcaaccaa
      361 gtcgaagtga tagccacact gaaggatggg aggaaaatct gcctggaccc agatgctccc
      421 agaatcaaga aaattgtaca gaaaaaattg gcaggtgatg aatctgctga ttaatttgtt
      481 ctgtttctgc caaacttctt taactcccag gaagggtaga attttgaaac cttgattttc
      541 tagagttctc atttattcag gatacctatt cttactgtat taaaatttgg atatgtgttt
      601 cattctgtct caaaaatcac attttattct gagaaggttg gttaaaagat ggcagaaaga
      661 agatgaaaat aaataagcct ggtttcaacc ctctaattct tgcctaaaca ttggactgta
      721 ctttgcattt ttttctttaa aaatttctat tctaacacaa cttggttgat ttttcctggt
      781 ctactttatg gttattagac atactcatgg gtattattag atttcataat ggtcaatgat
      841 aataggaatt acatggagcc caacagagaa tatttgctca atacattttt gttaatatat
      901 ttaggaactt aatggagtct ctcagtgtct tagtcctagg atgtcttatt taaaatactc
      961 cctgaaagtt tattctgatg tttattttag ccatcaaaca ctaaaataat aaattggtga
     1021 atatgaatct tataaactgt ggttagctgg tttaaagtga atatatttgc cactagtaga
     1081 acaaaaatag atgatgaaaa tgaattaaca tatctacata gttataattc tatcattaga
     1141 atgagcctta taaataagta caatatagga cttcaacctt actagactcc taattctaaa
     1201 ttctactttt ttcatcaaca gaactttcat tcatttttta aaccctaaaa cttataccca
     1261 cactattctt acaaaaatat tcacatgaaa taaaaatttg ctattga
//
