LOCUS       NM_133263              10569 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens PPARG coactivator 1 beta (PPARGC1B), transcript
            variant 1, mRNA.
ACCESSION   NM_133263
VERSION     NM_133263.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10569)
  AUTHORS   Huang,M., Prasad,R.B., Coral,D.E., Hjort,L., Minja,D.T.R.,
            Mulder,H., Franks,P.W. and Kalamajski,S.
  TITLE     Human Genetic Variation at rs10071329 Correlates With
            Adiposity-Related Traits, Modulates PPARGC1B Expression, and Alters
            Brown Adipocyte Function
  JOURNAL   Diabetes 73 (4), 637-645 (2024)
   PUBMED   38190589
  REMARK    GeneRIF: Human Genetic Variation at rs10071329 Correlates With
            Adiposity-Related Traits, Modulates PPARGC1B Expression, and Alters
            Brown Adipocyte Function.
REFERENCE   2  (bases 1 to 10569)
  AUTHORS   Shimoda,F., Naito,T., Kakuta,Y., Kawai,Y., Tokunaga,K.,
            Shimoyama,Y., Moroi,R., Shiga,H., Nagasaki,M., Kinouchi,Y. and
            Masamune,A.
  CONSRTM   NCBN Controls WGS Consortium
  TITLE     HLA-DQA1*05 and upstream variants of PPARGC1B are associated with
            infliximab persistence in Japanese Crohn's disease patients
  JOURNAL   Pharmacogenomics J 23 (6), 141-148 (2023)
   PUBMED   37460671
  REMARK    GeneRIF: HLA-DQA1*05 and upstream variants of PPARGC1B are
            associated with infliximab persistence in Japanese Crohn's disease
            patients.
REFERENCE   3  (bases 1 to 10569)
  AUTHORS   Torres,H.M., Yeo,D. and Westendorf,J.J.
  TITLE     Pulling rank with RNA: RANKL promotes the association of
            PGC-1beta/RNA complexes with NCoR/HDAC3 to activate gene expression
            in osteoclasts
  JOURNAL   Mol Cell 83 (19), 3397-3399 (2023)
   PUBMED   37802020
  REMARK    GeneRIF: Pulling rank with RNA: RANKL promotes the association of
            PGC-1beta/RNA complexes with NCoR/HDAC3 to activate gene expression
            in osteoclasts.
REFERENCE   4  (bases 1 to 10569)
  AUTHORS   Chen,S., Zhang,P., Feng,J., Li,R., Chen,J., Zheng,W.V., Zhang,H.
            and Yao,P.
  TITLE     LMP1 mediates tumorigenesis through persistent epigenetic
            modifications and PGC1beta upregulation
  JOURNAL   Oncol Rep 49 (3) (2023)
   PUBMED   36734290
  REMARK    GeneRIF: LMP1 mediates tumorigenesis through persistent epigenetic
            modifications and PGC1beta upregulation.
REFERENCE   5  (bases 1 to 10569)
  AUTHORS   Chen,B., Wang,Y., Tang,W., Chen,Y., Liu,C., Kang,M. and Xie,J.
  TITLE     Association between PPARgamma, PPARGC1A, and PPARGC1B genetic
            variants and susceptibility of gastric cancer in an Eastern Chinese
            population
  JOURNAL   BMC Med Genomics 15 (1), 274 (2022)
   PUBMED   36587194
  REMARK    GeneRIF: Association between PPARgamma, PPARGC1A, and PPARGC1B
            genetic variants and susceptibility of gastric cancer in an Eastern
            Chinese population.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10569)
  AUTHORS   Meirhaeghe,A., Crowley,V., Lenaghan,C., Lelliott,C., Green,K.,
            Stewart,A., Hart,K., Schinner,S., Sethi,J.K., Yeo,G., Brand,M.D.,
            Cortright,R.N., O'Rahilly,S., Montague,C. and Vidal-Puig,A.J.
  TITLE     Characterization of the human, mouse and rat PGC1 beta
            (peroxisome-proliferator-activated receptor-gamma co-activator 1
            beta) gene in vitro and in vivo
  JOURNAL   Biochem J 373 (Pt 1), 155-165 (2003)
   PUBMED   12678921
REFERENCE   7  (bases 1 to 10569)
  AUTHORS   Lin,J., Puigserver,P., Donovan,J., Tarr,P. and Spiegelman,B.M.
  TITLE     Peroxisome proliferator-activated receptor gamma coactivator 1beta
            (PGC-1beta), a novel PGC-1-related transcription coactivator
            associated with host cell factor
  JOURNAL   J Biol Chem 277 (3), 1645-1648 (2002)
   PUBMED   11733490
REFERENCE   8  (bases 1 to 10569)
  AUTHORS   Ek,J., Andersen,G., Urhammer,S.A., Gaede,P.H., Drivsholm,T.,
            Borch-Johnsen,K., Hansen,T. and Pedersen,O.
  TITLE     Mutation analysis of peroxisome proliferator-activated
            receptor-gamma coactivator-1 (PGC-1) and relationships of
            identified amino acid polymorphisms to Type II diabetes mellitus
  JOURNAL   Diabetologia 44 (12), 2220-2226 (2001)
   PUBMED   11793024
REFERENCE   9  (bases 1 to 10569)
  AUTHORS   Knutti,D., Kaul,A. and Kralli,A.
  TITLE     A tissue-specific coactivator of steroid receptors, identified in a
            functional genetic screen
  JOURNAL   Mol Cell Biol 20 (7), 2411-2422 (2000)
   PUBMED   10713165
REFERENCE   10 (bases 1 to 10569)
  AUTHORS   Esterbauer,H., Oberkofler,H., Krempler,F. and Patsch,W.
  TITLE     Human peroxisome proliferator activated receptor gamma coactivator
            1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal
            localization, and tissue expression
  JOURNAL   Genomics 62 (1), 98-102 (1999)
   PUBMED   10585775
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC132971.1, AC008545.3 and
            CA435617.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_133263.3.
            
            Summary: The protein encoded by this gene stimulates the activity
            of several transcription factors and nuclear receptors, including
            estrogen receptor alpha, nuclear respiratory factor 1, and
            glucocorticoid receptor. The encoded protein may be involved in fat
            oxidation, non-oxidative glucose metabolism, and the regulation of
            energy expenditure. This protein is downregulated in prediabetic
            and type 2 diabetes mellitus patients. Certain allelic variations
            in this gene increase the risk of the development of obesity. Three
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY188947.1, AK095391.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309241.10/ ENSP00000312649.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3225              BC132971.1         59-3283
            3226-10163          AC008545.3         78421-85358
            10164-10569         CA435617.1         16-421              c
FEATURES             Location/Qualifiers
     source          1..10569
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..10569
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /note="PPARG coactivator 1 beta"
                     /db_xref="GeneID:133522"
                     /db_xref="HGNC:HGNC:30022"
                     /db_xref="MIM:608886"
     exon            1..111
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..3105
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PGC-1-related estrogen receptor alpha coactivator;
                     PPARGC-1-beta; PPAR-gamma coactivator 1-beta; peroxisome
                     proliferator-activated receptor gamma, coactivator 1 beta;
                     PPARgamma coactivator 1 beta; PPARAGCIbeta"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator 1-beta isoform 1"
                     /protein_id="NP_573570.3"
                     /db_xref="CCDS:CCDS4298.1"
                     /db_xref="GeneID:133522"
                     /db_xref="HGNC:HGNC:30022"
                     /db_xref="MIM:608886"
                     /translation="MAGNDCGALLDEELSSFFLNYLADTQGGGSGEEQLYADFPELDL
                     SQLDASDFDSATCFGELQWCPENSETEPNQYSPDDSELFQIDSENEALLAELTKTLDD
                     IPEDDVGLAAFPALDGGDALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLLQKLL
                     LATSYPTSSSDTQKEGTAWRQAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHK
                     HLTSAQCCLQDRGLQPPCLQSPRLPAKEDKEPGEDCPSPQPAPASPRDSLALGRADPG
                     APVSQEDMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSK
                     ASWAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVE
                     EVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEE
                     WGRKRPGRGLPWTKLGRKLESSVCPVRRSRRLNPELGPWLTFADEPLVPSEPQGALPS
                     LCLAPKAYDVERELGSPTDEDSGQDQQLLRGPQIPALESPCESGCGDMDEDPSCPQLP
                     PRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCGTAGLTPPTTPPYKPTEEDPFKPDI
                     KHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPERSELLSHLRHATAQPASQAGQK
                     RPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREED
                     RSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFEDSSSS
                     SGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSPPSKANRQLCSRSRSSS
                     GSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAIGEGRVVYIQNLSSDMS
                     SRELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTKGAALRKRNEPSF
                     QLSYGGLRHFCWPRYTDYDSNSEEALPASGKSKYEAMDFDSLLKEAQQSLH"
     exon            112..285
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            286..498
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            499..615
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            616..1738
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1775
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1840
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2651
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2727
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2849
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..3004
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..10569
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10532..10537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /note="hexamer: AATACA"
     regulatory      10546..10551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /note="hexamer: ATTAAA"
     polyA_site      10558
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
     polyA_site      10569
                     /gene="PPARGC1B"
                     /gene_synonym="ERRL1; PERC; PGC-1(beta); PGC1B"
                     /note="major polyA site"
ORIGIN      
        1 gactccgccg cacgctgcag ccgcggctgg aagatggcgg ggaacgactg cggcgcgctg
       61 ctggacgaag agctctcctc cttcttcctc aactatctcg ctgacacgca gggtggaggg
      121 tccggggagg agcaactcta tgctgacttt ccagaacttg acctctccca gctggatgcc
      181 agcgactttg actcggccac ctgctttggg gagctgcagt ggtgcccaga gaactcagag
      241 actgaaccca accagtacag ccccgatgac tccgagctct tccagattga cagtgagaat
      301 gaggccctcc tggcagagct caccaagacc ctggatgaca tccctgaaga tgacgtgggt
      361 ctggctgcct tcccagccct ggatggtgga gacgctctat catgcacctc agcttcgcct
      421 gccccctcat ctgcaccccc cagccctgcc ccggagaagc cctcggcccc agcccctgag
      481 gtggacgagc tctcactgct gcagaagctc ctcctggcca catcctaccc aacatcaagc
      541 tctgacaccc agaaggaagg gaccgcctgg cgccaggcag gcctcagatc taaaagtcaa
      601 cggccttgtg ttaaggcgga cagcacccaa gacaagaagg ctcccatgat gcagtctcag
      661 agccgaagtt gtacagaact acataagcac ctcacctcgg cacagtgctg cctgcaggat
      721 cggggtctgc agccaccatg cctccagagt ccccggctcc ctgccaagga ggacaaggag
      781 ccgggtgagg actgcccgag cccccagcca gctccagcct ctccccggga ctccctagct
      841 ctgggcaggg cagaccccgg tgccccggtt tcccaggaag acatgcaggc gatggtgcaa
      901 ctcatacgct acatgcacac ctactgcctc ccccagagga agctgccccc acagacccct
      961 gagccactcc ccaaggcctg cagcaacccc tcccagcagg tcagatcccg gccctggtcc
     1021 cggcaccact ccaaagcctc ctgggctgag ttctccattc tgagggaact tctggctcaa
     1081 gacgtgctct gtgatgtcag caaaccctac cgtctggcca cgcctgttta tgcctccctc
     1141 acacctcggt caaggcccag gccccccaaa gacagtcagg cctcccctgg tcgcccgtcc
     1201 tcggtggagg aggtaaggat cgcagcttca cccaagagca ccgggcccag accaagcctg
     1261 cgcccactgc ggctggaggt gaaaagggag gtccgccggc ctgccagact gcagcagcag
     1321 gaggaggaag acgaggaaga agaggaggag gaagaggaag aagaaaaaga ggaggaggag
     1381 gagtggggca ggaaaaggcc aggccgaggc ctgccatgga cgaagctggg gaggaagctg
     1441 gagagctctg tgtgccccgt gcggcgttct cggagactga accctgagct gggcccctgg
     1501 ctgacatttg cagatgagcc gctggtcccc tcggagcccc aaggtgctct gccctcactg
     1561 tgcctggctc ccaaggccta cgacgtagag cgggagctgg gcagccccac ggacgaggac
     1621 agtggccaag accagcagct cctacgggga ccccagatcc ctgccctgga gagcccctgt
     1681 gagagtgggt gtggggacat ggatgaggac cccagctgcc cgcagctccc tcccagagac
     1741 tctcccaggt gcctcatgct ggccttgtca caaagcgacc caacttttgg caagaagagc
     1801 tttgagcaga ccttgacagt ggagctctgt ggcacagcag gactcacccc acccaccaca
     1861 ccaccgtaca agcccacaga ggaggatccc ttcaaaccag acatcaagca tagtctaggc
     1921 aaagaaatag ctctcagcct cccctcccct gagggcctct cactcaaggc caccccaggg
     1981 gctgcccaca agctgccaaa gaagcaccca gagcgaagtg agctcctgtc ccacctgcga
     2041 catgccacag cccagccagc ctcccaggct ggccagaagc gtcccttctc ctgttccttt
     2101 ggagaccatg actactgcca ggtgctccga ccagaaggcg tcctgcaaag gaaggtgctg
     2161 aggtcctggg agccgtctgg ggttcacctt gaggactggc cccagcaggg tgccccttgg
     2221 gctgaggcac aggcccctgg cagggaggaa gacagaagct gtgatgctgg cgccccaccc
     2281 aaggacagca cgctgctgag agaccatgag atccgtgcca gcctcaccaa acactttggg
     2341 ctgctggaga ccgccctgga ggaggaagac ctggcctcct gcaagagccc tgagtatgac
     2401 actgtctttg aagacagcag cagcagcagc ggcgagagca gcttcctccc agaggaggaa
     2461 gaggaagaag gggaggagga ggaggaggac gatgaagaag aggactcagg ggtcagcccc
     2521 acttgctctg accactgccc ctaccagagc ccaccaagca aggccaaccg gcagctctgt
     2581 tcccgcagcc gctcaagctc tggctcttca ccctgccact cctggtcacc agccactcga
     2641 aggaacttca gatgtgagag cagagggccg tgttcagaca gaacgccaag catccggcac
     2701 gccaggaagc ggcgggaaaa ggccattggg gaaggccgcg tggtgtacat tcaaaatctc
     2761 tccagcgaca tgagctcccg agagctgaag aggcgctttg aagtgtttgg tgagattgag
     2821 gagtgcgagg tgctgacaag aaataggaga ggcgagaagt acggcttcat cacctaccgg
     2881 tgttctgagc acgcggccct ctctttgaca aagggcgctg ccctgaggaa gcgcaacgag
     2941 ccctccttcc agctgagcta cggagggctc cggcacttct gctggcccag atacactgac
     3001 tacgattcca attcagaaga ggcccttcct gcgtcaggga aaagcaagta tgaagccatg
     3061 gattttgaca gcttactgaa agaggcccag cagagcctgc attgataaca gccttaaccc
     3121 tcgaggaata cctcaatacc tcagacaagg cccttccaat atgtttacgt tttcaaagaa
     3181 atcaagtata tgaggagagc gagcgagcgt gagagaacac ccgtgagaga gacttgaaac
     3241 tgctgtcctt taaaaaaaaa aaaaatcaat gtttacattg aacaaagctg cttctgtctg
     3301 tgagtttcca tggtgttgac gttccactgc cacattagtg tcctcgcttc caacgggttg
     3361 tcccgggtgc acctcgaagt gccgggtccg tcacccatcg ccccttcctt cccgactgac
     3421 ttcctctcgt agacttgcag ctgtgttcac cataacattt cttgtctgta gtgtgtgatg
     3481 atgaaattgt tacttgtgaa tagaatcagg actataaact tcatttttaa ttgaaaaaaa
     3541 aagtatatcc ttaaaataat gtatttatgg ctcagatgta ctgtgcctgg gattattgta
     3601 ttgcttcctt gattttttaa ctatgcactg tcatgaggtg tttgccactg agctgccctg
     3661 ctccccttgc cagattgccc tggaggtgct gggtggccgc taggctggtc tgcaggaaag
     3721 cgcggcctgc cgtttccggg ccgtatctgc caagccctgc cttgtctctt actgagcaag
     3781 tttggctcaa attataggag cccccatctt gtgcccagct catgctccaa gtgtgtgtct
     3841 atccatttgt actcagactc ttgagtacct tgtaaggaag gcggggcaag ctgcatcatt
     3901 cctgttttcc aggggaggct ggcagctcct caagaggcga aatgactgtg ggaggtccgg
     3961 ttaccagtga ggaggcagag cggtgaccca gaccaggcct tctggttctt ggtcccgtgc
     4021 ttccgtagta gctggggtaa agacaccgtt tcagggactg gtagaggtga gttcggctaa
     4081 attgggcacc gggctagaag cctaagggct cattttaggg gttacattag gtgttgattc
     4141 accagcatca ggtgaattca agccctggca tgtgtcttgg atgcaccatc agctttgatc
     4201 ctgagtggtc ctgcggtttg tctgtgcctg tggacacact gtcagaactt cagtgacacc
     4261 cctggcagcg gtacagacag gtggtctggg agcagtcatc ttttttgggc cagccaccag
     4321 cccatcctac tccctcaggt agtccttcgt ctttaccttg tccttgtctg taaagttgtt
     4381 ttggtggctg gggcagggga gccaggagga gggagtgaag gttgggaata gataggacaa
     4441 tctcctagct ctcctccaat tgagaaaaca ctccaattgg gctttgcttt aaactttgtg
     4501 ttcttaagtg atgtcaaagc catttccagc ttaatgttct gtgggtacct tgggggccat
     4561 tcatgcaggg agcatggcca ggcagggtat gagtacattg tttctgattt ctttcataca
     4621 tcagggttcc tcgggaaatt tttgtatttt ttttttaagt cctgctgctt taaaaatttg
     4681 aaagtggctc attaaactaa acaggctaat gtaatttgtt gcttatgcca agcctagact
     4741 gttgagaatt gacgttttta aagattatca aatacctcag taggtaaaat gagcccatga
     4801 tcttccactg agtggtgagc atactcccag cccatggaca aggccggaag agacaggctt
     4861 tagtaggggt agggaatttg aactgttgtg tgtcacagca gttgacctct ctggactcca
     4921 atttcctttc ctgtgaaatg aactgattag acatgtttca acattgttag cttctgctga
     4981 ggcagtgtct agcccaagat ggcaaataca tagctcatgt gccactactc ccacctcctt
     5041 gaccaataca gacataacta atcaatcaca ccactcaggt tccctgagcc tggatgtgct
     5101 ataagaatcc tgaaatcagt gctctggtaa gtcattacta attgattaga gttcaatcta
     5161 tttgacatct tgggctaatc tttggaaggt ttccaacaat cacacaaaac catatgctgg
     5221 ctgggtttca tgctggccta tccctgtctg tgatgttccg ttccatgaga gaaaactccc
     5281 ctaatgctat tccatggcgt aacactccca atactatttt gacgcccacg tccccttgca
     5341 gagggtgcag ggggcggtag acgaatgaca gacaggaaca tatttgggga aggcagggct
     5401 taggaagatg gaccaaaaag ggacttccca cagcacagac ctgatcattc ggatttcctc
     5461 tttagctatt cactgcctag cacatagtag gcacacaata aatgattatg gaatgggata
     5521 aaatttagat ctttctgctg cctccactaa gttaagtcct gatttacatc aaggagagaa
     5581 ctgagatagg aaagaacact agattccaag tctggagagt tgggggagtc cagattctac
     5641 caagaatttc ctttgtaact ttggtaagtc ccttttactc cctggcaccc cggtgtgctg
     5701 aaaggagttg gtccatatat gatctcttag cccctcctat ttgcttcttc cttgattgct
     5761 cttggtcaaa gggtcagcct tgggctggtg atactttaga gtaaagaaat ggagagtttt
     5821 agcaaaggac cagtctgtcc ctccctgctt tggggtcagc taaagctgtc ctttcatgtc
     5881 agattaacct aggacacttg tagttagctt agacgttggc ccttgagcag agacctgagc
     5941 gtggcattgg gacatgacat acctaaagtc agggctaggg gacgctgcct gccaagggca
     6001 tcgagtagtc tctacttgct atcccgtaca taaaatgcta caagttctaa aatttaccga
     6061 ccctgcagac aacctctatc ccgaaggact cattcggtgc tgtgtattat ttagggcaac
     6121 tccaaggtct attcagaaaa acgagtgaac cttggtctct ttcccaccaa attgaggagt
     6181 aacccagagg gagcagctgc cattggcaac catctcgttg tagctctgtc ctagtgtttg
     6241 ctcttgatga tgtttacatg tgatcgccat aaagcttgct gtagactgtg tcgatagccg
     6301 cccgcacagg gcaggtcgta ctgtccgttt ctgtgccgtg ctggtgtttt ccaaaaatgt
     6361 ctgatccaac cactaagtgg aattcttcca tctccttcct cagtctgtac aaggctgaat
     6421 cagaatcccc attctcgggg gctctggtta ccgaaggaaa atgcatcaaa gagttaaaga
     6481 atatgagtgg atggagtgca gctaaggccc ccaccccctg ctccgtcaca acttgccccc
     6541 tcaaccaaaa agctgctttg agtcaaaaag cacccataag atacctgcat ctgccttgaa
     6601 atcttgcagc atggagtgtc atatgtactc aggagagagg cagggctttg cgggcaggag
     6661 aaggaaggga ggaatgctct gagctgcaaa gacccagtac tcaagttctg acgtgggagg
     6721 agatgcagtg agacgtctct tgttgcctaa agcctgttcc tgttggtttt cttagagtga
     6781 tttctcctag acatgtgcag taggcccact ggggctgctg tgcagtggtg agtaaaaggg
     6841 cagggaaggc atggacagcc tggtccttct gcatggacag ctcagtccat ggcccatccc
     6901 aggtatagag ttcagttaat cccatttgag cctgcagctt aagagatggc tcatcctaac
     6961 tgtgaagcaa aatcagcccc agaggatgta ttgatctgac tcactgatgt caaaattgca
     7021 gtattttttt agcatttgag atttagcagc tgccttcagt ttggggttac ccacatccca
     7081 gcatcagata tgattaagga aagaaattgg atgtacaaca gcaaagaaag tgaatgtcat
     7141 ggtttccctg gccaaagaag agggaccctg tcatccttac caatggggaa gaagaaaact
     7201 agtgcatgtg caatatgtca aagttagtcc cctagtccct gaggggtttt tacacacaga
     7261 tgggctccag gtctgctcgt caagtttgga ggtaccgggt aaatggaggg gagctgcaga
     7321 gttggaaacc cacatgcatg gatgtgtcct tggcccagaa ccaccatggg atgggggagg
     7381 ccctgagccg gctacaagac acccaggaag taggcaaagg ctgactttgc attaaacaat
     7441 aaaagcactt tgagaaaacc ccaacacttc agcctgggtc cgtgtttcta cactggaaaa
     7501 tacgagtctc ctttggctgt gtgaagtgat cttctagaga ctgggacagg gagtttggga
     7561 atggggctgc tgtcaggtag gagagagcag agatgccttt ggagatgtca gcagcaggag
     7621 agccagtgct ggggccaacc ctttgctggc cttttgttgg aagcccttga aacagggagc
     7681 catgggttta gatcttggta cctaccttta cagaaagatg aaaacagccc agctgagtga
     7741 aatgagtttg tagagtaagt cacttaactg taagccatct cagaatcaga aaccctaatg
     7801 tttcttactt gctatgtgac cttgggcccc tgtttcctca tctaccaaat gagaatgttg
     7861 aatatgagca ttaaagtccc tttcacctct gagaggctca gatccccaac caggagcatt
     7921 gggaatccat cactcctcct tgaaactgat tccattctct gacttgaccc agctcctgtt
     7981 cagggtgagg gttctctgca agaaccaacc agcagtaggt tcaatcccac tgtgtcctgg
     8041 ctgagttgcc ttatccaaga agaccagctc cccgggacag atctaagcca tagtttctag
     8101 tggggacagt aaggaattaa acccccaact tggctaggta acgatgtcaa atctcacatt
     8161 aaccttgtct ttgtccccac tggatagctg ttaatccgaa tgttgtgacc atttggctgt
     8221 ttctctcttg ttctcagaca atactagcaa tacacttttt tttttttttt ttaaagaaaa
     8281 acagcttagg agcttttcac acatttcttt caaatgattg taaaacatat ggggcaacag
     8341 gaggcattga tcgcgctgca tatgtttagg gcagcttttg ttttttgttt ctttaatggt
     8401 atagcagcag tgactgagcc ttcgtgattc ctggggacag cttttcagat actctgtttc
     8461 atcagtatgc tttgcacatc cggaaggagt acaaaaatcc aactgcccaa atttggggct
     8521 tggaaaatag gttttatagg tggtcggtcc ctgggctgtg caacaactcc tcaaagaggg
     8581 gtttatataa ctagaacccc cctgggctgt atttttggtc aaaggagtct ccaaggcggc
     8641 ttacaaaagc ttcctttttc acttgaccac ccttgctcat tggttacttg tgaagggaat
     8701 tggtcagttt ccacctcagc actttgcctt atcaacatgc ggtcgccatc tagtggccaa
     8761 aggttgtctc caccagctac ccagatggaa ggcaaataaa tcctttcggc caccctgctg
     8821 tccatcgtga actttgggaa tgaaatataa tggcctgaac gaactgcctt tgtgttcaga
     8881 gatcagtgca acactagggt cagaagactc cagaagcagc cacttagtag actctcacgc
     8941 agaactgaga aatgcactag ctgtcctgtg ggcagaagag acaggagtgg accaggagag
     9001 gtccaggtgc ccgggaaggg tttactgtaa ctgcaatact ggcagcccag ctgctgacct
     9061 tgttaagtaa acctttgctg ggtggtccga attctgccct caaggcaaga taagaagttg
     9121 ggtgtaagga ttttgtgggg ggcctggcca tgatctttga tatgatcccc gaatagccaa
     9181 atagtttttt ttgttcaatt ttttgtttct gtattttgta tttttaaaat cttgtcaaat
     9241 gtttttgtgt taggaataaa aagtcataaa ctattcccaa ctttgtttct tgagggatgt
     9301 tctgattcca atggaaacag gtgggaaatc tcaaggggag cgtggacaag gtggtatgtg
     9361 cagcagggga atagactgct tggatttcca aatggtttct ggggaagatg accatccaga
     9421 agtccagctt agtgcagtct gctctggaat tcacacccac cccctcgcct ccttgtgcca
     9481 tgttgttagc attggcttgg agcatctgct tcttccagag gcagctgcta atgttgaaac
     9541 caacacgagc cctctcccca accccaggtt tctaaagaag gtgtctgtag ccagccttaa
     9601 tcaactgggc aaggtggtcc ctatggtcct ttccagcatt tccaaatctt ggactcaaat
     9661 tattttctct tggtgtgacc acacagccta gagaattctg agcaatagga gccagggctt
     9721 tccctgactc tgcgacaggg tcaaaccaag gaatggctaa acctgtgagg ttttgtcatc
     9781 cccgggggta ctactgtagg gggcattatt tattaggaag cttaacaagg taactacggc
     9841 ctgagtgcgt gagtgtaagg ctgtgtttgt ggtgggggtg tgtgtgtgtg tatctgtgca
     9901 cacatacaca cgtctgtgcc tgtgtgtgtg tgtttgtgtg tgtgtgtgtg tgtggaatta
     9961 cattgatgca tttattgaga aaggtgcaag aatttcacct acacagaggg acacatctgc
    10021 tttgttattt ataatagaaa gctaaatttt aattttttaa aggacactgc taatgattga
    10081 gaatcaagtt tttagttttg ctattttttt taattggtag aggattttta tatatttttt
    10141 ccattttgtt gggttgtgtc cttatttata taaatacttt atccgtaaga ggcaaggagg
    10201 aaaccttctt tgcttttaca tattgtggtt gtcatcgtcc ctattttatt tctggtgtga
    10261 tttctctgtc ttaccttcta aatgagaaaa tgttttcttg tatttgtaca ttgtcagatt
    10321 ctatagtttc ctagataatt taaccaaatt gctctatgta ttattattct gtgagtataa
    10381 agttctattt taatgtctgt aaatacttca gaactggctt cttttctcaa actcccactg
    10441 tggggttatt gtttacatca cagaaactgt agaatctcta tgctcatgta ctgtaaatag
    10501 tgaagtgatc tgcttataaa taaacttaac aaatacacta tggagattaa aaacaaaata
    10561 ccacccaca
//
